CN107398012A - The charge compensating circuit and method of nerve stimulation and retinal prosthesis system - Google Patents
The charge compensating circuit and method of nerve stimulation and retinal prosthesis system Download PDFInfo
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- 238000007689 inspection Methods 0.000 claims abstract description 13
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- 208000005400 Synovial Cyst Diseases 0.000 description 39
- 210000002592 gangliocyte Anatomy 0.000 description 27
- 230000004936 stimulating effect Effects 0.000 description 23
- 238000010586 diagram Methods 0.000 description 16
- 210000004126 nerve fiber Anatomy 0.000 description 12
- 230000004438 eyesight Effects 0.000 description 9
- 201000007737 Retinal degeneration Diseases 0.000 description 8
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- 239000007943 implant Substances 0.000 description 7
- 208000002780 macular degeneration Diseases 0.000 description 7
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36142—Control systems for improving safety
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0543—Retinal electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention provides a kind of charge compensating circuit of nerve stimulation, and it is the charge compensating circuit for carrying out charge compensation to pulse current generation circuit, and pulse current generation circuit produces the Bipolar pulse current for nerve stimulation, and charge compensating circuit includes：Circuit is detected, it is used for a total amount of electric charge stimulated in the cycle for detecting the Bipolar pulse current signal generated by pulse current generation circuit；Decision circuitry, it is used to judge whether exceed safe charge amount by the total amount of electric charge of detection electric circuit inspection；And compensation circuit, it is used for when decision circuitry judges that total amount of electric charge exceedes safe charge amount, produces the compensated pulse current signal with net charge amount so that total amount of electric charge is within safe charge amount.In accordance with the invention it is possible in the case where not utilizing the larger bulky capacitor of footprint area, charge balance ability is fully improved in limited space.In addition, present invention also offers charge compensation method and retinal prosthesis system.
Description
The application isOn 09 30th, 2016, Application No.201610875326.8, it is entitledElectric charge Compensation circuit, charge compensation method and retinal prosthesis systemPatent application divisional application.
Technical field
The present invention relates to nerve stimulation field, and in particular to the charge compensating circuit and method of nerve stimulation and manually regards
Nethike embrane system.
Background technology
In nerve stimulation field, providing electro photoluminescence by stimulating electrode can make nerve fiber produce reaction, so as to obtain
Obtain desired function.Such as in the eyesight repair system of existing artificial retina, in order to give blind person recover visual experience, one
As need to be put into implant in the eyeball of blind person, such implant instead of for example because of retinal pigment degeneration (RP) or old
The function of year macular degeneration (AMD) etc. and impaired photosensory cell, in the case where other functions of pathways for vision obtain reservation,
Can be produced by the stimulating electrode in implant retaining retina intact other nerve pathways stimulates so as to allow blind person
Recovered part eyesight.In retinal prosthesis system, external camera captured video image, then image processing apparatus will regard
Frequency image is converted into electric signal and is sent to implant, and then, the implant positioned at intraocular converts electrical signals to stimulus signal,
And the gangliocyte of retina is stimulated by the stimulating electrode of implant, thus enable blind person on cerebral cortex
Experience light sensation, recovered part eyesight.
The content of the invention
It is caused for nerve stimulation however, in existing nerve stimulation device such as retinal prosthesis system
Stimulating current is likely to cannot be guaranteed that the quantity of electric charge is within safe charge amount within a stimulation cycle, the nerve fiber being stimulated
(such as the gangliocyte of retina or Beale's ganglion cells) causes god it is therefore possible to the net charges such as positive charge or negative electrical charge be present
Gangliocyte or Beale's ganglion cells through organizing such as retina sustain damage.
In order to ensure the gangliocyte of nerve fiber such as retina or stimulation electric charge that Beale's ganglion cells is received it is flat
Weighing apparatus property, also have consideration in pulse current generation circuit and be stimulated between position RC circuits are set, with equilibrium nerve ganglion cell or
Unnecessary electric charge on Beale's ganglion cells.However, the charge balance performance of RC circuits and the capacity positive correlation of the electric capacity in RC circuits, are
Thus the more positive charge of balance or negative electrical charge are needed greater area of, it is necessary to by the capacity boost of the electric capacity in RC circuits
Electric capacity.However, in nerve stimulation field, circuit design space tends to be limited, can not integrate area occupy it is larger big
Electric capacity, therefore, can not fully it be played come balancing charge ability using RC circuits.
The present invention is made in view of above-mentioned situation, its object is to provide it is a kind of can be in limited space
Charge compensating circuit, charge compensation method and the retinal prosthesis system of charge balance ability can be improved.
Therefore, the first aspect of the present invention provides a kind of charge compensating circuit, it is to be used to produce electricity to pulse current
Road carries out the charge compensating circuit of charge compensation, and the pulse current generation circuit produces the two--way pulse for nerve stimulation
Stream, the charge compensating circuit include：Circuit is detected, it is used to detect by the described double of pulse current generation circuit generation
To a total amount of electric charge stimulated in the cycle of pulsed current signal；Decision circuitry, it is used to judge by the detection circuit inspection
Whether the total amount of electric charge surveyed exceedes safe charge amount；And compensation circuit, it is used for when described in decision circuitry judgement
When total amount of electric charge exceedes safe charge amount, the compensated pulse current signal with net charge amount is produced so that the total amount of electric charge exists
Within the safe charge amount.
In the present invention, believed by detecting circuit to detect the Bipolar pulse current generated by pulse current generation circuit
Number one stimulate the cycle in total amount of electric charge, judge whether the total amount of electric charge by detection electric circuit inspection surpasses using decision circuitry
Safe charge amount is crossed, and when decision circuitry judges that total amount of electric charge exceedes safe charge amount, compensation circuit, which produces, has net electricity
The compensated pulse current signal of lotus amount so that total amount of electric charge within the safe charge amount.In this way, without using footprint area
In the case of larger bulky capacitor (RC circuits), by sending the compensated pulse current signal with net charge amount to bidirectional pulse
Electric current carries out charge balance, and thereby, it is possible to charge balance ability is fully improved in limited space.
In addition, in charge compensating circuit involved in the present invention, in the compensation circuit, when the decision circuitry is sentenced
Break the total amount of electric charge be on the occasion of when, produce with negative value compensation the quantity of electric charge compensated pulse current signal so that the electric charge
Within the safe charge amount, and when the decision circuitry judges the total amount of electric charge for negative value, generation has total amount
On the occasion of compensation the quantity of electric charge compensated pulse current signal so that the total amount of electric charge within the safe charge amount.Thus,
It can more efficiently ensure the total amount of electric charge for nerve stimulation within safe charge amount.
In addition, in charge compensating circuit involved in the present invention, alternatively, the amplitude of the compensated pulse current signal
Less than default amplitude, and the cycle of the compensated pulse current signal is less than the cycle of the Bipolar pulse current signal.
In this case, charge compensation can be rapidly completed with the mode repeatedly compensated.
In addition, in charge compensating circuit involved in the present invention, alternatively, in the Bipolar pulse current signal,
The waveform of forward pulse current signal is with the waveform of negative-going pulse current signal on the contrary, positive arteries and veins described in the detection electric circuit inspection
The absolute value of the quantity of electric charge of current signal and the quantity of electric charge of the negative-going pulse current signal is rushed, the decision circuitry, which passes through, to be compared
The absolute value of the quantity of electric charge of the forward pulse current signal and the quantity of electric charge of the negative-going pulse current signal is described to judge
Whether total amount of electric charge exceedes safe charge amount.
In addition, in charge compensating circuit involved in the present invention, alternatively, the detection electric circuit inspection is by pulse current
The average value of the Bipolar pulse current signal of generation circuit generation, the decision circuitry judge the absolute value of the average value
Whether preset value is more than, and when the absolute value of the average value is more than the preset value, compensation circuit, which produces, has net electricity
The compensated pulse current signal of lotus amount so that the total amount of electric charge within the safe charge amount.In this case, pass through
Whether detection average value is more than preset value, can easily determine the need for providing charge compensation.
In addition, in charge compensating circuit involved in the present invention, alternatively, the detection electric circuit inspection is by the pulse
The current average of the Bipolar pulse current signal of current generating circuit generation, and the current average is converted into voltage and put down
Average, and the decision circuitry judges whether the absolute value of the average voltage is more than preset voltage value, when the voltage
When the absolute value of average value is more than the preset voltage value, the compensation circuit produces the compensated pulse electric current with net charge amount
Signal so that the total amount of electric charge within the safe charge amount.In such a case, it is possible to current average is converted into
Average voltage detects, and by by the absolute value of average voltage compared with preset voltage value, when the average voltage
When the absolute value of value is more than the preset voltage value, the total amount of electric charge of nerve stimulation can be used in by the compensation of compensation circuit
Within the safe charge amount.
In addition, in charge compensating circuit involved in the present invention, alternatively, when the absolute value of the average voltage is big
In preset voltage value, and the average voltage be on the occasion of when, the compensation circuit produces the benefit of the net charge amount with negative value
Pulsed current signal is repaid to be used in the total amount of electric charge of nerve stimulation within the safe charge amount, and works as the electricity
The absolute value for flattening average is more than preset voltage value, and when the average voltage is negative value, the compensation circuit generation has
On the occasion of net charge amount compensated pulse current signal to be used in the total amount of electric charge of nerve stimulation in the safe charge
Within amount.
In addition, the second aspect of the present invention provides a kind of charge compensation method, it is used for pulse current generation circuit
The charge compensation method of charge compensation is carried out, the pulse current generation circuit produces the two--way pulse for nerve stimulation
Stream, the charge compensation method include：The Bipolar pulse current signal that detection is generated by the pulse current generation circuit
One stimulate the cycle in total amount of electric charge；Judge to be less than or equal to safety by the total amount of electric charge of the detection electric circuit inspection
The quantity of electric charge；And when the decision circuitry judges that the total amount of electric charge exceedes safe charge amount, produce with net charge amount
Compensated pulse current signal so that the total amount of electric charge within the safe charge amount.
In addition, in charge compensation method involved in the present invention, alternatively, when judge the total amount of electric charge on the occasion of
When, the compensated pulse current signal of the compensation quantity of electric charge with negative value is produced so that the total amount of electric charge is in the safe charge amount
Within, and when judging the total amount of electric charge for negative value, produce with the occasion of the compensation quantity of electric charge compensated pulse electric current letter
Number so that the total amount of electric charge within the safe charge amount.Thereby, it is possible to more efficiently ensure for nerve stimulation
Total amount of electric charge is within the safe charge amount.
In addition, the third aspect of the present invention also provides a kind of retinal prosthesis system, including：Implanted device, it at least has
There is the charge compensating circuit described in above-mentioned any one；Camera device, it is used to capturing video image, and by the video figure
As being converted into visual signal；And video process apparatus, it is connected with the camera device, and the visual signal is carried out
Handle and generate modulated signal, the modulated signal is transmitted to the implanted device, the institute that the implanted device will be received
State modulated signal and be converted into the Bipolar pulse current signal as electrical stimulation signal, so as to the gangliocyte to retina
Or Beale's ganglion cells provides the Bipolar pulse current signal to produce light sensation.
According to the present invention, pass through charge compensating circuit Active Compensation nerve fiber (such as gangliocyte or Beale's ganglion cells)
On the unnecessary net charge that there may exist, it is possible to increase to the efficiency for the charge balance for stimulating electric charge, it is ensured that nerve stimulation
Safety and reliability.In addition, it can be filled in the case where not utilizing the larger bulky capacitor of footprint area in limited space
Ground is divided to improve charge balance ability.
Brief description of the drawings
Fig. 1 is the structural representation for showing the retinal prosthesis system involved by embodiments of the present invention；
Fig. 2 is that the stimulating electrode structure for showing the retinal prosthesis system involved by embodiments of the present invention is implanted to
Intraocular schematic diagram；
Fig. 3 is the part that the stimulating electrode structure (stimulated side) for showing shown in Fig. 2 is attached on intraocular retina
Schematic diagram；
Fig. 4 is the electricity for showing the pulse current generation circuit for nerve stimulation involved by embodiments of the present invention
The schematic diagram of road module；
Fig. 5 is the schematic diagram for showing the Bipolar pulse current signal involved by embodiments of the present invention.
Fig. 6 is the schematic diagram for the precision for showing the different pulse current amplitudes involved by embodiments of the present invention
Fig. 7 is the schematic diagram for the circuit module for showing the charge compensating circuit involved by embodiments of the present invention；
Fig. 8 is the schematic diagram for showing the compensated pulse electric current involved by embodiments of the present invention；And
Fig. 9 is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.
Embodiment
Hereinafter, refer to the attached drawing, the preferred embodiment of the present invention is explained.In the following description, for identical
Part assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, accompanying drawing is simply schematical, the mutual chi of part
Very little ratio or the shape of part etc. can be with the differences of reality.
(retinal prosthesis system)
Fig. 1 is the structural representation for showing the retinal prosthesis system involved by embodiments of the present invention.Fig. 2 is
Show that the stimulating electrode structure of the retinal prosthesis system involved by embodiments of the present invention is implanted to intraocular signal
Figure.It is partially schematic on intraocular retina that Fig. 3 is that the stimulating electrode structure (stimulated side) for showing shown in Fig. 2 is attached to
Figure.
In the present embodiment, as shown in figure 1, retinal prosthesis system (sometimes referred to as " artificial retina ") includes in vivo
Implant part is implanted device 1 and outer body i.e. external device 3.In the artificial retina system involved by present embodiment
In system, implanted device 1 can couple with external device 3 via wireless mode.In some instances, implanted device 1 with setting in vitro
Standby 3 can be coupled through reception antenna 11 as shown in Figure 1 with transmitting antenna 33.In addition, in the present embodiment, implantation dress
The coupled modes not limited to this of 1 and external device 3 is put, such as implanted device 1 can also be via infrared receiver with external device 3
Mode is realized.
In some instances, implanted device 1 mainly includes matrix (not shown) and the Electronic Packaging being arranged on matrix
Body 11, stimulating electrode structure 12 and reception antenna 13.In addition, the matrix in implanted device 1 can be consolidated by such as suture way
It is scheduled on eyeball 2.
In addition, as shown in Fig. 2 the stimulated side 12a (stimulating electrode array) of the stimulating electrode structure 12 in implanted device 1 can
To enter via the otch of eyeball 2 in the vitreous chamber of eyeball 2, and retina is close to, so as to retina (especially
It is gangliocyte or the Beale's ganglion cells of retina) carry out electro photoluminescence (such as providing Bipolar pulse current) (referring to Fig. 3).
In general, such as the patient such as retinal pigment degeneration (RP) or age-related macular degeneration (AMD) and
Speech, because retinal pigment degeneration (RP) or age-related macular degeneration (AMD) and caused by photosensory cell decline or death, namely normally
Pathways for vision because photosensory cell disease lesion and it is hindered, vision telecommunications can not be transformed into by normally entering the light of intraocular
Number, cause patient to blind.In the present embodiment, the stimulated side 12a of stimulating electrode structure 12 is photosensitive equivalent to instead of
The effect of cell, stimulated side 12a for example provide Bipolar pulse current signal by producing electrical stimulation signal, so as to retina god
Stimulated (referring to Fig. 3) through ganglion cell or Beale's ganglion cells.Because most of retinal pigment degeneration (RP) or age-related macular become
Other pathways for visions of property (AMD) patient in addition to photosensory cell obtain intact reservation mostly, therefore, gangliocyte or bipolar
By after producing electrical stimulation signal stimulation by stimulating electrode structure 12, the electrical stimulation signal regards cell via intact downstream is retained
Feel that path (optic nerve) is transferred to cerebral cortex and produces light sensation, so as to partly recover the vision of patient.
Furthermore, it is necessary to explanation, although the optic nerve stimulation that present embodiment is conceived to retinal prosthesis system is carried out
Description, however, present embodiment is not limited to artificial retina field, on the contrary, the charge compensation electricity involved by present embodiment
Road 101 is readily applicable to other nerve stimulation fields such as artificial cochlea, deep brain stimulation, pacemaker, spinal cord stimulation
Device, etc..
In the present embodiment, as shown in figure 1, external device 3 can include camera device 31, the and of video process apparatus 32
Transmitting antenna 33.In vitro in equipment 3, camera device 31 can be used for capturing video image, and the video figure that will be captured
As being converted into visual signal.
In some instances, camera device 31 can be the equipment with camera function for example video camera, digital camera,
CCD camera etc..By the camera device 31, so as to capture for example extraneous image.In addition, use for convenience, can be with
By the video camera of small volume on glasses.Alternatively, it is also possible to be used as by wearing the light glasses with camera function
Camera device 31 captures video image.Furthermore camera device 31 can also be usedEtc. realizing.In addition, at this
Image can also be obtained by using ultrasonic imaging (such as sonar) or electromagnetic wave imaging (such as radar) in embodiment,
Or the equipment that other can also be used to be capable of formation range and angle information.
As shown in figure 1, video process apparatus 32 is connected with camera device 31, and receives and regarded by what camera device 31 provided
Feel signal.After the visual signal captured by camera device 31 is transmitted to video process apparatus 32, video process apparatus 32 can be with
The visual signal is handled.In some instances, video process apparatus 32 can include microprocessor, application specific integrated circuit
(ASIC), DSP etc., to carry out image procossing (such as sampling, coding, modulation, filtering etc.) to the visual signal.In addition, regard
Frequency processing device 32 also has a power supply, the power supply can for example via the mode being wirelessly transferred provide energy signal to
Implanted device 1 so that the implanted device 1 being implanted in eyeball 2 is powered.
Analog signal transmitting device (i.e. transmitting antenna 33) will can be believed comprising the energy provided by video process apparatus 32
Number and processing after visual signal the implanted device 1 of artificial retina is sent to as modulated signal (such as RF modulated signals).
On the other hand, implanted device 10 is used to receive by video process apparatus 30 via the tune that for example transmitting antenna 33 is launched
Signal processed, and the modulated signal is further processed, generation Bipolar pulse current is as the stimulation for nerve stimulation
Electric current (stimulus signal).Specifically, the reception antenna 11 shown in Fig. 1 receives the modulated signal, and is transmitted to follow-up
Electronic packing body 12 is handled.Finally, will be by electronic packing body 12 (being specifically the process circuit in electronic packing body 12) root
Electrical stimulation signal is produced according to the modulated signal and is sent to stimulated side 12a (such as the stimulating electrode battle arrays of stimulating electrode structure 12
Row), stimulated (referring to Fig. 3) so as to the gangliocyte to such as retina or Beale's ganglion cells, gangliocyte or
Beale's ganglion cells produces excited response so as to produce light sensation after receiving pulse current.In these cases, stimulating current is possible to pierce
Swash the gangliocyte of retina or the Beale's ganglion cells of retina, it is also possible to while the gangliocyte stimulated to retina
Or Beale's ganglion cells.
(pulse current generation circuit)
Fig. 4 is to show to include charge compensating circuit and pulse current generation circuit involved by embodiments of the present invention
Circuit module schematic diagram.
As shown in figure 4, the charge compensating circuit 101 and pulse current for nerve stimulation involved by present embodiment are produced
Raw circuit 102.In the present embodiment, charge compensating circuit 101 and pulse current generation circuit 102 can apply to Fig. 1 institutes
The retinal prosthesis system shown.In this case, charge compensating circuit 101 and pulse current generation circuit 102 can be located at
In implanted device 10 shown in Fig. 1 (such as in electronic packing body 12).In some instances, such as in above-mentioned artificial retina
In the implanted device 10 of system, pulse current generation circuit 102 can be produced for stimulating retinal ganglial cells or bipolar
The Bipolar pulse current signal of cell (referring to Fig. 5).In addition, in some instances, pass through the thorn being arranged in implanted device 10
Swash electrode structure 12 stimulated side 12a (with reference to figure 2), can will as caused by pulse current generation circuit 102 two--way pulse
Stream signal is issued to gangliocyte or the Beale's ganglion cells of such as retina.
As described above, pulse current generation circuit 102 can produce the Bipolar pulse current signal for nerve stimulation.
In present embodiment, because the pulse current generation circuit 102 for nerve stimulation can be in the width of increase boost pulse electric current
The high accuracy of pulse current is kept in the case of degree, therefore more effective electric current effect of stimulation can be provided, such as can be effective
Ground stimulates the Beale's ganglion cells to retina.On the other hand, due to broader impulse modulation scope can be realized, therefore, it is possible to
Hardware view adapts to higher processing requirement such as stimulating algorithm optimization.
Specifically, pulse current generation circuit 102 can generate the pulse current of two kinds of different accuracies.Show at other
In example, pulse current generation circuit 102 can generate the pulse current of 3 kinds, 4 kinds, 5 kinds or more than 5 kinds of different accuracy.Separately
Outside, the different accuracy multiple between adjacent different pulse currents can be 2 times, for example, generating the 1st pulse electricity in current feedback circuit
The feelings of the pulse current of stream, the 2nd pulse current, the 3rd pulse current, the 4th pulse current and the 5th 5 kinds of different accuracies of pulse current
Under condition, the precision of the 5th pulse current is 2 times of the 4th pulse current precision, and the precision of the 4th pulse current is the 3rd pulse current
2 times of precision, the precision of the 3rd pulse current are 2 times of the precision of the 2nd pulse current, and the precision of the 2nd pulse current is the 1st arteries and veins
Rush the precision of electric current 2 times.In addition, present embodiment is not limited to this, the pulse current of other different accuracies can also be used.
As shown in figure 4, pulse current generation circuit 102 to nerve fiber etc. carry out nerve stimulation when equivalent to be connected to resistance
Anti-loading 103.For example, when the current generating circuit 100 involved by present embodiment is used for the nerve stimulation of artificial retina,
The gangliocyte of retina in tissue liquid or Beale's ganglion cells can simplifiedly be equivalent to impedance load 103.
In some instances, pulse current generation circuit 102 can generate the 1st impulse amplitude precision (high accuracy) and the 2nd
The Bipolar pulse current of impulse amplitude precision (low precision) two kinds of different accuracies.Such as it is 1 μ that can make the 1st impulse amplitude precision
A/ walks (step), and the scope of current amplitude is 0~8 μ A；The 2nd impulse amplitude precision is made to be walked for 8 μ A/, the scope of current amplitude is 8
~512 μ A (referring to Fig. 7).Here, here, precision (the μ A/ of the 1st impulse amplitude precision 1 of the impulse amplitude of high-precision pulse electric current
Step) be more than low precision pulse current impulse amplitude precision (the 2nd impulse amplitude precision be 8 μ A/ step).In addition, other one
In a little examples, pulse current generation circuit 102 can provide the pulse current of more different accuracies.
(Bipolar pulse current signal)
Fig. 5 shows the schematic diagram of the Bipolar pulse current signal involved by embodiments of the present invention.Fig. 6 is to show
The schematic diagram of the precision of different pulse current amplitudes involved by embodiments of the present invention
In some instances, one of the Bipolar pulse current signal generated by pulse current generation circuit 102 stimulates week
Total amount of electric charge in phase T is within the safe charge amount.Specifically, in nerve stimulation field, in order to prevent that pulse is electric
Signal is flowed to the gangliocyte of human nerve tissue such as retina or Beale's ganglion cells generation net charge and to human nerve group
Knit and damage, it is necessary to ensure Bipolar pulse current signal in a total amount of electric charge stimulated in cycle T in the safe charge
Within amount.
Here, " safe charge amount " is nerve fiber (such as the gangliocyte of retina or Beale's ganglion cells) in safe model
The maximum of net charge is can bear in enclosing.Net charge more than the safe charge amount is possible to that nerve fiber can be caused to damage
Wound.Therefore, it is necessary to which the total amount of electric charge for ensureing to stimulate one in cycle T is controlled described during the nerve stimulation of reality
Within safe charge amount.Here, one stimulates cycle T to produce the cycle time of a stimulus signal.Total amount of electric charge refers to double
The total amount of electric charge of the net charge in cycle T is stimulated to one of pulsed current signal.In some instances, for convenience's sake,
It is zero that safe charge amount, which can also be made,.
As described above, pulse current generation circuit 102 can generate Bipolar pulse current signal.The Bipolar pulse current is believed
Number can include effective stimulating current signal and balance current signal.Wherein, effective stimulus current signal can be that nerve is pierced
Sharp object such as gangliocyte or Beale's ganglion cells have the current signal of stimulation, and balanced balanced current signal can be used to balance
The current signal of electric charge caused by effective stimulus current signal.If in general, effectively stimulus signal be direct impulse,
Balanced balanced current signal is negative-going pulse；If effective stimulus signal is negative-going pulse, balanced balanced current signal is direct impulse.By
This, it can be ensured that the total amount of electric charge of Bipolar pulse current signal (example within the safe charge amount in a stimulation cycle T
Such as zero) total amount of electric charge is.
As specific example, stimulated at one in cycle T, the negative-going pulse signal of Bipolar pulse current signal is in time
Integration can be equal or close with the absolute value of the integration of the direct impulse signal of Bipolar pulse current signal in time, by
This, the total amount of electric charge of the Bipolar pulse current signal in cycle T (such as electricity within the safe charge amount is stimulated at one
Zero) lotus total amount is.In addition, referring again to Fig. 5, as shown in figure 5, being stimulated at one in cycle T, the duration of negative-going pulse signal
(negative-going pulse width) is t1, and the duration (direct impulse width) of direct impulse signal is t2, then negative-going pulse is in t1
The absolute value of integration of the absolute value of integration in length with direct impulse in t2 durations is equal or close, i.e. Bipolar pulse current
The total amount of electric charge of signal within the safe charge amount (such as the total amount of electric charge is zero).
As described above, pulse current generation circuit 102 provides two kinds of different impulse amplitude precision, the 1st impulse amplitude
Precision and the 2nd impulse amplitude precision, wherein, the 1st impulse amplitude precision is 1 μ A/ steps, and amplitude range is 0~8 μ A (such as 1 μ A, 2
μA、3μA、……、8μA)；2nd impulse amplitude precision is 8 μ A/ steps, and amplitude range is 8~512 μ A (such as 8 μ A, 16 μ A, 24 μ
A ..., 512 μ A) (referring to Fig. 6).In some instances, as shown in fig. 7, when the nerve of nerve stimulation object such as retina
When ganglion cell or Beale's ganglion cells need relatively low pulse current stimulating, it is higher that pulse current generation circuit 102 can provide precision
Impulse amplitude precision (such as 1 μ A/ step), such as when the current amplitude that gangliocyte or Beale's ganglion cells need is less than or equal to
During 8 μ A, generation impulse amplitude precision is the electric current of 1 μ A/ steps, can provide 1 μ A, 2 μ A, 3 μ A, 4 μ A, 5 μ A, 6 μ A, 7 μ A, 8 μ A
The electric current of totally 8 kinds of impulse amplitudes；When the electric current that gangliocyte or Beale's ganglion cells need is more than 8 μ A, generation impulse amplitude essence
Spend for the electric current of 8 μ A/ steps, can provide 16 μ A, 24 μ A, 32 μ A, 40 μ A ... the electric current of 512 μ A totally 64 kinds of impulse amplitudes.Such as
This, pulse current generation circuit 102 can provide the impulse amplitude of at least two different precision, and generation at least two is different
The pulse current of precision, thus, it is possible to provide more efficient electric current stimulation mode.
In some instances, pulse current generation circuit 102 can generate low precision pulse electricity according to pulse current parameter
Stream or high-precision pulse electric current.Specifically, pulse current generation circuit 102 judges institute after pulse current parameter is received
Whether the impulse amplitude for the Bipolar pulse current signal to be generated is less than critical value.When the Bipolar pulse current signal to be generated
Impulse amplitude when being less than or equal to critical value, pulse current generation circuit 102 generates high-precision pulse electric current；When being generated
The impulse amplitude of Bipolar pulse current signal when being more than critical value, pulse current generation circuit 102 generates low precision pulse electricity
Stream.
In the present embodiment, critical value can be set in advance.In addition, the amplitude precision of high-precision pulse electric current and
The amplitude precision of low precision pulse current can also be set in advance.For example, as shown in fig. 6, critical value could be arranged to 8 μ
A, the amplitude precision of high-precision pulse electric current walk for 1 μ A/, and the amplitude precision of low precision pulse current walks for 8 μ A/.In this feelings
Under condition, when pulse current generation circuit 102 judges that the amplitude for the Bipolar pulse current signal to be generated is less than or equal to 8 μ A
When, pulse current generation circuit 102 generates high accuracy (1 μ A/ steps) pulse current；When pulse current generation circuit 102 judges institute
When the amplitude for the Bipolar pulse current signal to be generated is more than 8 μ A, pulse current generation circuit 102 generates low precision (8 μ A/ steps)
Pulse current.In this way, pulse current generation circuit 102 can provide the pulse current of two kinds of different accuracies, work as gangliocyte
Or Beale's ganglion cells need pulse current it is smaller when, there is provided high-precision pulse current, can more accurately stimulate view
The Beale's ganglion cells of film, using the teaching of the invention it is possible to provide more efficient stimulation mode.
In some instances, when the direct impulse width of Bipolar pulse current signal is more than preset duration and direct impulse width
When degree is less than critical value, or when the negative-going pulse width of Bipolar pulse current signal is more than preset duration and negative-going pulse amplitude
During less than critical value, pulse current generation circuit 102 produces high-precision pulse electric current.
For the width (stimulation time) of boost pulse electric current, although the mechanism of action is not completely clear and definite yet at present, lead to
Cross extension boost pulse width (such as negative-going pulse width), more likely stimulate arrive deeper into nerve cell, thus, it is possible to
Obtain significantly more efficient nerve stimulation.Such as retinal prosthesis system, wide boost pulse can be pierced more effectively
The Beale's ganglion cells of retina is swashed, thus, it is possible to provide more effective and more accurately nerve stimulation.Specifically, bidirectional pulse is worked as
When the negative-going pulse width of current signal is more than preset duration and negative-going pulse amplitude and is less than critical value, the Bipolar pulse current
Signal can more accurately stimulate the Beale's ganglion cells of retina, due to one-to-one corresponding of the Beale's ganglion cells on pathways for vision
It is more superior than gangliocyte, therefore more accurately stimulate the Beale's ganglion cells of retina to form more accurate light sensation, carry
Height stimulates efficiency.In addition, also higher processing requirement can be adapted to such as stimulating algorithm optimization in hardware view.
In the present embodiment, when the direct impulse width of Bipolar pulse current signal is more than preset duration and direct impulse
When amplitude is less than critical value, or when the negative-going pulse width of Bipolar pulse current signal is more than preset duration and negative-going pulse width
When degree is less than critical value, pulse current generation circuit 102 produces high-precision pulse electric current, accurately stimulates Beale's ganglion cells, is formed
More accurate light sensation, more efficient stimulation mode can be provided to blind person.
(charge compensating circuit)
Fig. 7 is the schematic diagram for the circuit module for showing the charge compensating circuit involved by embodiments of the present invention.Fig. 8
It is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.Fig. 9 is to show this hair
The schematic diagram of compensated pulse electric current involved by bright embodiment.
In the present embodiment, as shown in fig. 7, charge compensating circuit (can also claim " active charge compensating circuit ") 101
Including detection circuit 1011, decision circuitry 1012 and compensation circuit 1013.Detection circuit 1011 can be used for detection by pulse electricity
Flow a total amount of electric charge stimulated in cycle T of the Bipolar pulse current signal that generation circuit 102 generates.In addition, decision circuitry
Whether 1012 total amount of electric charge that can be used for judging to be detected by detection circuit 1011 exceed safe charge amount.In addition, compensation circuit
1013 can be used for when decision circuitry 1012 judges that total amount of electric charge exceedes safe charge amount, produce the compensation with net charge amount
Pulsed current signal is to be used in the total amount of electric charge of nerve stimulation within the safe charge amount.Here, net charge amount according to
Situation about compensating is needed, can be the quantity of electric charge of negative electrical charge, or the quantity of electric charge of positive charge.
In the present embodiment, charge compensating circuit 101 can apply to the retinal prosthesis system shown in Fig. 1.At this
In the case of kind, charge compensating circuit 101 can be located in the implanted device 10 shown in Fig. 1.Specifically, pulse current produces electricity
Road 102 can be located at the electronic packing body 12 shown in Fig. 1.In the present embodiment, charge compensating circuit 101 can be used for arteries and veins
Rush current generating circuit 102 and carry out charge compensation.
In theory, can be by setting the pulse current parameter of Bipolar pulse current signal (for example, pulse current parameter can
With including direct impulse width, direct impulse amplitude, negative-going pulse width, negative-going pulse amplitude, pulse spacing etc.) and cause
Bipolar pulse current signal is in a total amount of electric charge stimulated in cycle T within the safe charge amount.However, actually should
With the Bipolar pulse current signal that in circuit, pulse current generation circuit 102 is generated because various factors stimulates week at one
Total amount of electric charge in phase T is likely to exceed safe charge amount.In this case, what Bipolar pulse current signal was accumulated is net
Electric charge is possible to cause damage to human body ocular nerve ganglion cell or Beale's ganglion cells.In the present embodiment, mended by electric charge
Repay the unnecessary net charge that circuit 101 comes in Active Compensation nerve fiber (such as gangliocyte or Beale's ganglion cells) to accumulate, energy
Enough charge balance abilities improved to stimulating electric charge, it is ensured that the safety and reliability of nerve stimulation.
In the present embodiment, detection circuit 1011 can be used for detecting the two-way of the generation of pulse current generation circuit 102
One of pulsed current signal stimulates the total amount of electric charge in cycle T.Next, it is determined that circuit 1012 judges to be examined by detection circuit 1011
One of the Bipolar pulse current signal of survey stimulates whether the total amount of electric charge in cycle T exceedes safe charge amount.If two-way arteries and veins
A total amount of electric charge stimulated in cycle T of current signal is rushed within safe charge amount, then compensation circuit 1013 does not work；Such as
One of fruit Bipolar pulse current signal stimulates the total amount of electric charge in cycle T to exceed safe charge amount, then compensation circuit 1013 is produced
The raw compensated pulse current signal with net charge amount so that for nerve stimulation total amount of electric charge the safe charge amount with
It is interior.
Specifically, when decision circuitry 1012 judges that Bipolar pulse current signal is total in an electric charge stimulated in cycle T
Measure for positive charge when, compensation circuit 1013 produce negative current pulse, to be used in the total amount of electric charge of nerve stimulation in the peace
Within the full quantity of electric charge；When decision circuitry 1012 judges that Bipolar pulse current signal is in a total amount of electric charge stimulated in cycle T
During negative electrical charge, compensation circuit 1013 produces forward current pulse, to be used in the total amount of electric charge of nerve stimulation in the safety electricity
Within lotus amount.
In the present embodiment, compensation circuit 1013 can actively carry out charge compensation.Once decision circuitry 1012 judges
One caused by the pulse current generation circuit 102 detected as detection circuit 1011 the total amount of electric charge stimulated in the cycle exceedes peace
The full quantity of electric charge, therefore compensation circuit 1013 can carry out charge compensation in time, improve charge balance efficiency or ability, it is ensured that pierced
The security of sharp nerve fiber.
In some instances, when decision circuitry 1012 judges that one of Bipolar pulse current signal stimulates the electricity in cycle T
When lotus total amount exceedes safe charge amount, compensation circuit 1013 can produce the compensated pulse current signal with net charge amount, make
The total amount of electric charge of nerve stimulation must be used within the safe charge amount.In addition, when decision circuitry 1012 judges bidirectional pulse
When one of the current signal total amount of electric charge stimulated in cycle T is less than zero, compensation circuit 1013 can produce with the occasion of it is net
The compensated pulse current signal of the quantity of electric charge causes total amount of electric charge for nerve stimulation within the safe charge amount.
For example, when decision circuitry 1012 judge one of the Bipolar pulse current signal total amount of electric charge stimulated in cycle T for-
1×10-7During the negative electrical charge of coulomb, it is 1 × 10 that compensation circuit 1013, which produces total amount of electric charge,-7The positive charge of coulomb is (for example, compensation
Circuit 1013 can produce the direct impulse that a pulse width is 1 millisecond, pulse amplitude is 100 microamperes, or compensation circuit
1013 can produce a pulse width as 10 milliseconds, and pulse amplitude is 10 microamperes of direct impulse) so that for nerve stimulation
The total amount of electric charge within the safe charge amount.In another example when decision circuitry 1012 judges Bipolar pulse current signal
One stimulate cycle T in total amount of electric charge be 1 × 10-7Coulomb positive charge when, compensation circuit 1013 produce total amount of electric charge for-
1×10-7Coulomb negative electrical charge (for example, compensation circuit 1013 can produce a pulse width as 1 millisecond, pulse amplitude 100
The negative-going pulse of microampere, or compensation circuit 1013 can produce a pulse width as 10 milliseconds, and pulse amplitude is 10 microamperes
Negative-going pulse) so that the total amount of electric charge for nerve stimulation is within the safe charge amount.
In the present embodiment, the amplitude of compensated pulse current signal can be less than default amplitude, and compensated pulse electricity
The cycle of Bipolar pulse current signal can be less than by flowing the cycle of signal.Here, default amplitude be can to nerve fiber (such as
Gangliocyte or Beale's ganglion cells) minimum current magnitude of stimulation is played, by by the amplitude of compensated pulse current signal
Default amplitude is set below, thus it can be prevented that compensated pulse current signal may be to nerve fiber (such as gangliocyte
Or Beale's ganglion cells) caused by by mistake stimulate, suppress nerve fiber (such as gangliocyte or Beale's ganglion cells) be likely to be received compensation
Pulsed current signal and produce unnecessary excitement.It is two-way alternatively, it is also possible to set the cycle of compensated pulse current signal to be less than
In the cycle of pulsed current signal, thus, it is possible to carry out charge compensation in the short period of time, it can quickly carry out charge compensation.
In some instances, the waveform of the forward pulse current signal in Bipolar pulse current signal can be with negative-going pulse
The waveform of current signal is opposite.That is, in Bipolar pulse current signal, the waveform of forward pulse current signal except with negative sense
Pulsed current signal is anti-phase outer, and the waveform shape of pulse current is identical.In this way, detection circuit 1011 can detect direct impulse electricity
Flow the absolute value of the quantity of electric charge of signal and the quantity of electric charge of negative-going pulse current signal.Then, decision circuitry 1012 is by than calibration
Judge whether total amount of electric charge surpasses to the absolute value of the quantity of electric charge and the quantity of electric charge of negative-going pulse current signal of pulsed current signal
Cross safe charge amount.
Referring again to Fig. 5, Fig. 5 shows the schematic diagram of the Bipolar pulse current signal involved by embodiments of the present invention.
As shown in figure 5, Bipolar pulse current signal can include direct impulse signal and negative-going pulse signal, and forward pulse current
The waveform of signal is opposite with the waveform of negative-going pulse current signal.Now, detection circuit 1011 can detect forward pulse current
The absolute value of the quantity of electric charge of signal and the quantity of electric charge of negative-going pulse current signal.For example, the quantity of electric charge of forward pulse current signal
For Q1=I1 × t1, the absolute value of the quantity of electric charge of negative-going pulse current signal is Q2=| I2 × t2 |, | I2 × t2 | i.e. I2 × t2
Absolute value.Next, it is determined that circuit 1012 judges difference i.e. net charge total amount=Q1- between quantity of electric charge Q1 and quantity of electric charge Q2
Q2.When quantity of electric charge Q1 is equal with quantity of electric charge Q2, it is determined that total amount of electric charge zero.When quantity of electric charge Q1 and quantity of electric charge Q2 are unequal
When, it is determined that total amount of electric charge is not zero, wherein, when quantity of electric charge Q1 is more than quantity of electric charge Q2, it is on the occasion of (existing to determine total amount of electric charge
Net positive charge), when quantity of electric charge Q1 is less than quantity of electric charge Q2, it is negative value (net negative charge being present) to determine total amount of electric charge.As long as in addition,
Ensure above-mentioned total amount of electric charge whether net positive charge or net negative charge within safe charge amount.
In some instances, detection circuit 1011 can detect the bidirectional pulse generated by pulse current generation circuit 102
The average value of current signal.Specifically, by directly calculate the negative charge amount of Bipolar pulse current signal and positive charge amount it
Between net charge amount, and average value is measured to the net charge, generated it is possible thereby to obtain by pulse current generation circuit 102
The total amount of electric charge of Bipolar pulse current signal whether there is net charge.Then, decision circuitry 1012 may determine that average value
Whether absolute value is more than preset value, and when the absolute value of average value is more than preset value, compensation circuit 1013 can produce tool
There is the compensated pulse current signal of net charge amount to be used in the total amount of electric charge of nerve stimulation within safe charge amount.
In the present embodiment, the average value of Bipolar pulse current signal can be the average electricity of Bipolar pulse current signal
Flow valuve, mean charge value etc..In addition, preset value can be pre-set current value, default charge value etc..
In some instances, the average value of Bipolar pulse current signal can be the average current of Bipolar pulse current signal
Value.In this case, the average current value that detection circuit 1011 can detect Bipolar pulse current signal is Ia=| (I1 ×
T1+I2 × t2)/(t1+t2) |, wherein I2 is negative value.It is I ' (I ' to make pre-set current value>0), decision circuitry 1012 may determine that
IaWhether I ' is more than.If IaMore than I ', then the compensated pulse current signal that the generation of compensation circuit 1013 has net charge amount makes
The total amount of electric charge of nerve stimulation must be used within safe charge amount；If IaLess than or equal to I ', then compensation circuit 1013 is not
Work.
In some instances, the average value of Bipolar pulse current signal can be the mean charge of Bipolar pulse current signal
Value.In this case, the mean charge value that detection circuit 1011 can detect Bipolar pulse current signal is Qa=| (I1 ×
T1+I2 × t2)/2 |, wherein I2 is negative value.The default charge value of order is Q ' (Q '>0), decision circuitry 1012 may determine that QaWhether
More than Q '.If QaMore than Q ', then compensation circuit 1013 produces the compensated pulse current signal with net charge amount to be used in
The total amount of electric charge of nerve stimulation is within safe charge amount；If QaLess than or equal to Q ', then compensation circuit 1013 does not work.
In some instances, detection circuit 1011 can detect the bidirectional pulse generated by pulse current generation circuit 102
The current average of current signal, and current average is converted into average voltage.In this case, decision circuitry 1012
It may determine that whether the absolute value of the average voltage is more than preset voltage value.In this case, it is exhausted when average voltage
When being more than preset voltage value to value, compensation circuit 1013 can produce the compensated pulse current signal with net charge amount to use
In nerve stimulation total amount of electric charge within safe charge amount.
For example, current average can be converted into average voltage by current-to-voltage converting circuit, and make default
Magnitude of voltage is the magnitude of voltage of safety, when average voltage is less than preset voltage value, shows that pulse current generation circuit 102 generates
Bipolar pulse current signal the gangliocyte of human body or Beale's ganglion cells are not injured (without departing from safe charge amount), mend
Charge compensation can need not be carried out by repaying circuit 1013；When average voltage is higher than preset voltage value, show that pulse current produces
The Bipolar pulse current signal that raw circuit 102 generates may produce injury to the gangliocyte of human body or Beale's ganglion cells, then
Compensation circuit 1013 produces the compensated pulse current signal with net charge amount and pacified with being used in the total amount of electric charge of nerve stimulation
Within the full quantity of electric charge.
In the present embodiment, the current average of detection can be converted into decision circuitry by detecting circuit 1011
1012 are easily judged the average voltage of (for example, decision circuitry 1012 can use voltage comparator to be judged)
Value, decision circuitry 1012 can be facilitated to judge whether to need compensation circuit 1013 to carry out charge compensation, and judgement can be improved
The accuracy of the judged result of circuit 1012.
In addition, in some instances, when the absolute value of average voltage is more than preset voltage value, and average voltage is just
During value, compensation circuit 1013 can produce the compensated pulse current signal of the net charge amount with negative value to be used in nerve stimulation
Total amount of electric charge within safe charge amount；When the absolute value of average voltage is more than preset voltage value, and average voltage is
During negative value, compensation circuit 1013 produce with the occasion of net charge amount compensated pulse current signal to be used in nerve stimulation
Total amount of electric charge is within safe charge amount.
In the present embodiment, detection circuit 1011 can detect the two-way arteries and veins generated by pulse current generation circuit 102
The current average of current signal is rushed, and current average is converted into average voltage.Decision circuitry 1012 may determine that electricity
Whether the absolute value for flattening average is more than preset voltage value, when the absolute value of average voltage is more than preset voltage value, and electricity
Flatten average be on the occasion of when, compensation circuit 1013 produces the compensated pulse current signal of the net charge amount with negative value to be used in
The total amount of electric charge of nerve stimulation is within safe charge amount；When the absolute value of average voltage is more than preset voltage value, and electricity
Average is flattened when be negative value, compensation circuit 1013 produce have on the occasion of net charge amount compensated pulse current signal to be used in
The total amount of electric charge of nerve stimulation is within safe charge amount.
For example, if preset voltage value is 5 millivolts (mv), (average voltage when average voltage is more than 5 millivolts
When the absolute value of value is more than preset voltage value, and average voltage be on the occasion of when), compensation circuit 1013 produces net with negative value
The compensated pulse current signal of the quantity of electric charge is to be used in the total amount of electric charge of nerve stimulation within safe charge amount, for example, compensation
Compensated pulse current signal caused by circuit 1013 is negative-going pulse.In addition, (the electricity when average voltage is less than -5 millivolts
The absolute value of average is flattened when being more than preset voltage value, and when average voltage be negative value), the generation of compensation circuit 1013 is with just
The compensated pulse current signal of the net charge amount of value is to be used in the total amount of electric charge of nerve stimulation within safe charge amount, example
Such as, compensated pulse current signal caused by compensation circuit 1013 is direct impulse.
Fig. 8 is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.Such as Fig. 8
Shown, charge compensating circuit 101 can include detection circuit 1011, decision circuitry 1012 and compensation circuit 1013.In this implementation
In mode, detection circuit 1011 can specifically include the 1st resistance R1, the 2nd resistance R2 and electric capacity C1.Wherein, the negative pole of the 1st electric capacity
Terminated with the 1st of the 1st resistance R1 the into common electric voltage VSS, the positive pole of the 1st electric capacity electrically connects the 2nd electricity with the 1st resistance R1 the 2nd end
Hinder R2 the 2nd end, the 2nd resistance R2 the 1st end electrical connection pulse current generation circuit 102 and compensation circuit 1013.
In addition, decision circuitry 1012 can specifically include the 1st voltage comparator U1 and the 2nd voltage comparator U2.Wherein,
1 voltage comparator U1 in-phase input end and the 2nd voltage comparator U2 in-phase input end electrically connect the 2nd resistance R2 the 1st end,
The 1st voltage comparator U1 default positive voltage VTH+, the 2nd voltage comparator U2 of inverting input access anti-phase input termination
Enter default negative voltage VTH-, the 1st voltage comparator U1 feeder ear and the 2nd comparator U2 feeder ear access supply voltage
VDD, the 1st voltage comparator U1 earth terminal and the 2nd comparator U2 earth terminal access common electric voltage VSS, the 1st voltage ratio compared with
1st control terminal C+ of device U1 output end Out1 electrical connection compensation circuits 1013, the 2nd voltage comparator U2 output end Out2 electricity
Connect the 2nd control terminal C- of compensation circuit 1013, the feeder ear access supply voltage VDD of compensation circuit 1013, compensation circuit
1013 earth terminal access common electric voltage VSS, the input of the output end connection pulse current generation circuit 102 of compensation circuit 1013
End, the feeder ear access supply voltage VDD of pulse current generation circuit 102, the earth terminal access of pulse current generation circuit 102
Common electric voltage VSS, the output end connection impedance load 103 of pulse current generation circuit 102.
In addition, the Bipolar pulse current signal that detection circuit 1011 can detect the generation of pulse current generation circuit 102 exists
One total amount of electric charge stimulated in cycle T and a current average stimulated in cycle T, and one is stimulated in cycle T
Current average is converted to average voltage.Whether decision circuitry 1012 may determine that above-mentioned average voltage positioned at default positive electricity
Between pressing VTH+ and default negative voltage VTH-, if above-mentioned average voltage is located at default positive voltage VTH+ and default negative voltage
Between VTH-, then compensation circuit 1013 need not carry out charge compensation；If above-mentioned average voltage is not positioned at default positive voltage
Between VTH+ and default negative voltage VTH-, then compensation circuit 1013 carries out charge compensation, produces the compensation arteries and veins with net charge amount
Current signal is rushed, to be used in the total amount of electric charge of nerve stimulation within safe charge amount.
As specific example, it is assumed that the Bipolar pulse current signal that pulse current generation circuit 102 is generated is in a thorn
The absolute value of the total amount of electric charge of (for example, the cycle is 1 second) is more than 5 × 10 in flyback cycle T-7During coulomb, then compensation circuit 1013 is entered
Row charge compensation.That is, when the current average of Bipolar pulse current signal is more than 5 × 10-7Milliampere or less than -5 × 10-7
MAH, compensation circuit 1013 carry out charge compensation.If the 2nd resistance R2 resistance is 10 kilo-ohms, default positive electricity can be made
It is 5 millivolts to press VTH+, and it is -5 millivolts to preset negative voltage VTH-.When decision circuitry 1012 judges above-mentioned average voltage more than 5 millis
Fu Shi, the 1st voltage comparator U1 output end Out1 output high level, the 2nd voltage comparator U2 output end Out2 outputs are high
Level；When decision circuitry 1012 judges that above-mentioned average voltage is less than -5 millivolts, the 1st voltage comparator U1 output end Out1
Export low level, the 2nd voltage comparator U2 output end Out2 output low levels；When decision circuitry 1012 judges that above-mentioned voltage is put down
When average is between -5 millivolts~5 millivolts, the 1st voltage comparator U1 output end Out1 output low levels, the 2nd voltage ratio
Output end Out2 output high level compared with device U2.
In the present embodiment, the compensated pulse current signal and compensation circuit of the output end output of compensation circuit 1013
1013 the 1st control terminal C+ is related to the 2nd control terminal C- of compensation circuit 1013, refers to table 1 below.
Table 1
| 1st control terminal C+ | 2nd control terminal C- | Compensated pulse current signal |
| High level | High level | Negative-going pulse |
| Low level | Low level | Direct impulse |
| Low level | High level | Nothing |
When decision circuitry 1012 judges above-mentioned average voltage more than 5 millivolts, compensation circuit 1013 needs to compensate negative sense
Pulse, now, the 1st voltage comparator U1 output end Out1 export high level, and the 2nd voltage comparator U2 output end Out2 is defeated
Go out high level, i.e. the 1st control terminal C+ is high level, and the 2nd control terminal C- is high level, and as shown in table 1, compensation circuit 1013 generates
Compensated pulse current signal be negative-going pulse.
In addition, when decision circuitry 1012 judges that above-mentioned average voltage is less than -5 millivolts, compensation circuit 1013 needs to mend
Direct impulse is repaid, now, the 1st voltage comparator U1 output end Out1 output low levels, the 2nd voltage comparator U2 output end
Out2 exports low level, i.e. the 1st control terminal C+ is low level, and the 2nd control terminal C- is low level, as shown in table 1, compensation circuit
The compensated pulse current signal of 1013 generations is direct impulse.
In addition, when decision circuitry 1012 judges that above-mentioned average voltage is between -5 millivolts~5 millivolts, compensation circuit
1013 need not carry out charge compensation, and the 1st voltage comparator U1 output end Out1 exports low level, the 2nd voltage comparator U2's
Output end Out2 exports high level, i.e. the 1st control terminal C+ is low level, and the 2nd control terminal C- is high level, as shown in table 1, compensation
Circuit 1013 is without charge compensation.
In the present embodiment, Fig. 8 is only that a kind of specific electric charge involved by the preferred embodiment of the present invention is mended
Circuit is repaid, present embodiment is not limited to this.In charge compensating circuit 101, detection circuit 1011, decision circuitry 1012 and benefit
The specific implementation for repaying circuit 1013 can have various deformation.
In addition, the charge compensation method involved by present embodiment is to be used to carry out electric charge benefit to pulse current generation circuit
The charge compensation method repaid, pulse current generation circuit produce the Bipolar pulse current for nerve stimulation, charge compensation method
Including：Detect a total amount of electric charge stimulated in the cycle of the Bipolar pulse current signal generated by pulse current generation circuit；
Judge to be less than or equal to safe charge amount by the total amount of electric charge of detection electric circuit inspection；And when decision circuitry judges that total amount of electric charge surpasses
When crossing safe charge amount, produce with net charge amount compensated pulse current signal so that total amount of electric charge safe charge amount with
It is interior.
In addition, in charge compensation method, when judge total amount of electric charge on the occasion of when, produce the compensation quantity of electric charge with negative value
Compensated pulse current signal so that total amount of electric charge within safe charge amount, and when judging total amount of electric charge for negative value, production
It is raw with the occasion of the compensation quantity of electric charge compensated pulse current signal so that total amount of electric charge within safe charge amount.Thus, energy
Enough total amount of electric charge more efficiently ensured for nerve stimulation are within safe charge amount.
In addition, in one preferred embodiment, compensation method can be restrained with electric charge and progressively carry out charge compensation, carried
The accuracy of high charge compensation.In some instances, detection circuit 1011 can detect the generation of pulse current generation circuit 102
Bipolar pulse current signal is in a total amount of electric charge stimulated in cycle T.Decision circuitry 1012 may determine that Bipolar pulse current
Signal stimulates whether the absolute value of the total amount of electric charge in cycle T is more than safe charge amount at one, when decision circuitry 1012 judges
Bipolar pulse current signal is when one stimulates the absolute value of the total amount of electric charge in cycle T to exceed safe charge amount, compensation circuit
1013 carry out Partial charge compensation.For example, when decision circuitry 1012 judges that Bipolar pulse current signal is stimulated in cycle T at one
Total amount of electric charge be Q1, and Q1 absolute value>During Qs (Qs is safe charge amount), compensation circuit 1013 carries out Partial charge benefit
Repay.Here Partial charge compensation can be ratio charge compensation, such as according to 30%, 40%, 50%, 60%, 70%, 80%
Equal proportion value carries out charge compensation.
For example, it is assumed that safe charge amount is 5 × 10-8Coulomb, when decision circuitry 1012 judges that Bipolar pulse current signal exists
One total amount of electric charge stimulated in cycle T is 1 × 10-7Coulomb negative electrical charge when, compensation circuit 1013 can according to 50% ratio
Example carries out positive charge compensation, i.e. compensation circuit 1013 can carry out 5 × 10-8The positive charge compensation of coulomb.It is then detected that circuit
1011 can continue to detect the accumulative caused total amount of electric charge of pulse current generation circuit 102, if decision circuitry 1012 judges pulse
Total amount of electric charge caused by current generating circuit 102 is accumulative is 6 × 10-8The negative electrical charge of coulomb, compensation circuit 1013 carry out 3 × 10-8
The positive charge compensation of coulomb.Afterwards, it is total to continue the accumulative caused electric charge of detection pulse current generation circuit 102 for detection circuit 1011
Amount, when decision circuitry 1012 judge pulse current generation circuit 102 it is accumulative caused by total amount of electric charge more than safe charge amount (5 ×
10-8) when, compensation circuit 1013 continues to carry out charge compensation according to 50% ratio, until when decision circuitry 1012 judges pulse
When within safe charge amount, compensation circuit 1013 stops the absolute value of total amount of electric charge caused by current generating circuit 102 is accumulative
Carry out charge compensation.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect
Total amount of electric charge caused by pulse current generation circuit 102 is accumulative, in other words, detection circuit 1011 can be constantly in work
State, detected in real time, once detect the quantity of electric charge it is exceeded (pulse current generation circuit 102 it is accumulative caused by electric charge it is total
The absolute value of amount is more than safe charge amount), compensation circuit 1013 can carry out charge compensation.
In another example, it is assumed that safe charge amount is 5 × 10-8Coulomb, when decision circuitry 1012 judges Bipolar pulse current signal
It is 1 × 10 in the total amount of electric charge that one stimulates in cycle T-7During the negative electrical charge of coulomb, positive electricity can be carried out according to 60% ratio
Lotus is supplemented, i.e., compensation circuit 1013 carries out 6 × 10-8The positive charge compensation of coulomb (it should be noted that in real process, compensates
The electric charge that circuit 1013 compensates is not necessarily equal to 6 × 10-8The positive charge of coulomb), as shown in figure 5, then detecting circuit 1011
Continue to detect the accumulative caused total amount of electric charge of pulse current generation circuit 102, if decision circuitry 1012 judges that pulse current produces
Total amount of electric charge caused by circuit 102 is accumulative is 6 × 10-8The negative electrical charge of coulomb, compensation circuit 1013 carry out 3.6 × 10-8Coulomb
Positive charge compensates.Afterwards, it is total can to continue the accumulative caused electric charge of detection pulse current generation circuit 102 for detection circuit 1011
Amount.When decision circuitry 1012 judge pulse current generation circuit 102 it is accumulative caused by total amount of electric charge be more than safe charge amount (5 ×
10-8) when, compensation circuit 1013 continues to carry out charge compensation according to 60% ratio, until when decision circuitry 1012 judges pulse
When the absolute value of total amount of electric charge is less than safe charge amount caused by current generating circuit 102 is accumulative, compensation circuit 1013 stop into
Row charge compensation.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect arteries and veins
The accumulative caused total amount of electric charge of current generating circuit 102 is rushed, in other words, detection circuit 1011 can be constantly in work shape
State, detected in real time, once detect exceeded (the accumulative caused total amount of electric charge of pulse current generation circuit 102 of the quantity of electric charge
Absolute value be more than safe charge amount), compensation circuit 1013 can carry out charge compensation.
In some instances, detection circuit 1011 can detect the two--way pulse of the generation of pulse current generation circuit 102
Signal is flowed in a total amount of electric charge stimulated in cycle T.Decision circuitry 1012 may determine that Bipolar pulse current signal at one
Stimulate whether the total amount of electric charge in cycle T exceedes safe charge amount.When decision circuitry 1012 judges that Bipolar pulse current signal exists
When one total amount of electric charge stimulated in cycle T exceedes safe charge amount, compensation circuit 1013 can carry out Partial charge compensation.
For example, when decision circuitry 1012 judge Bipolar pulse current signal in a total amount of electric charge stimulated in cycle T for Q1, and Q1 surpasses
When crossing safe charge amount, compensation circuit 1013 can carry out Partial charge compensation, and Partial charge compensation here can be ratio
Charge compensation, such as carry out charge compensation according to 30%, 40%, 50%, 60%, 70%, 80% equal proportion value.
For example, when decision circuitry 1012 judges Bipolar pulse current signal in a total amount of electric charge stimulated in cycle T for 1
×10-7During the negative electrical charge of coulomb, positive charge supplement can be carried out according to 50% ratio, i.e. compensation circuit 1013 carries out 5 × 10-8The positive charge compensation of coulomb.It is then detected that circuit 1011 can continue to detect pulse current generation circuit 102 it is accumulative caused by
Total amount of electric charge.If it is determined that circuit 1012 judges the accumulative caused total amount of electric charge of pulse current generation circuit 102 for 6 × 10-8Storehouse
The negative electrical charge of human relations, then compensation circuit 1013 can continue 3 × 10-8 coulombs positive charge compensation.Afterwards, circuit is detected
1011 can continue to detect the accumulative caused total amount of electric charge of pulse current generation circuit 102.When decision circuitry 1012 judges pulse
When total amount of electric charge caused by current generating circuit 102 is accumulative exceedes safe charge amount, compensation circuit 1013 can continue according to
50% ratio carries out charge compensation, until when decision circuitry 1012 judges the accumulative caused electricity of pulse current generation circuit 102
When within safe charge amount, compensation circuit 1013 can stop carrying out electric charge benefit to pulse current generation circuit 102 lotus total amount
Repay.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect pulse current production
Total amount of electric charge caused by raw circuit 102 is accumulative.In other words, it can be constantly in working condition to detect circuit 1011, in real time
Ground is detected, once detecting that the quantity of electric charge exceedes safe charge amount, compensation circuit 1013 can carry out charge compensation.
In another example when decision circuitry 1012 judges Bipolar pulse current signal in a total amount of electric charge stimulated in cycle T
For 1 × 10-7Coulomb negative electrical charge when, can according to 60% ratio carry out positive charge supplement, i.e., compensation circuit 1013 carry out 6 ×
10-8The positive charge compensation of coulomb.It is then detected that circuit 1011 can continue to detect the accumulative generation of pulse current generation circuit 102
Total amount of electric charge.If it is determined that circuit 1012 judges the accumulative caused total amount of electric charge of pulse current generation circuit 102 for 6 × 10-8
Coulomb negative electrical charge, then compensation circuit 1013 continue 3.6 × 10-8 coulombs positive charge compensation.Afterwards, circuit is detected
1011 can continue to detect the accumulative caused total amount of electric charge of pulse current generation circuit 102, when decision circuitry 1012 judges pulse
When total amount of electric charge caused by current generating circuit 102 is accumulative exceedes safe charge amount, compensation circuit 1013 can continue according to
60% ratio carries out charge compensation, until when decision circuitry 1012 judges the accumulative caused electricity of pulse current generation circuit 102
When lotus total amount is equal to zero, compensation circuit 1013 can stop carrying out charge compensation.Certainly, stop carrying out electricity in compensation circuit 1013
After lotus compensation, detection circuit 1011 can continue to detect the accumulative caused total amount of electric charge of pulse current generation circuit 102.Namely
It is to say, detection circuit 1011 can be constantly in working condition, be detected in real time, once detect that the quantity of electric charge exceedes peace
The full quantity of electric charge, compensation circuit 1013 can carry out charge compensation.
Although being illustrated above in association with drawings and examples to the present invention, it will be appreciated that described above
The invention is not limited in any way.Those skilled in the art without departing from the true spirit and scope of the present invention may be used
To be deformed and be changed to the present invention as needed, these deformations and change are within the scope of the present invention.
Claims (10)
- A kind of 1. charge compensating circuit of nerve stimulation, it is characterised in thatIt is the charge compensating circuit for carrying out charge compensation to pulse current generation circuit, the pulse current generation circuit production The raw Bipolar pulse current for nerve stimulation,The charge compensating circuit includes：Circuit is detected, it is used to detect one of the Bipolar pulse current signal by pulse current generation circuit generation Stimulate the total amount of electric charge in the cycle；Decision circuitry, it is used to judge whether exceed safe charge amount by the total amount of electric charge of the detection electric circuit inspection；With AndCompensation circuit, it is used for when the decision circuitry judges that the total amount of electric charge exceedes safe charge amount, and producing has only The compensated pulse current signal of the quantity of electric charge so that the total amount of electric charge within the safe charge amount.
- 2. charge compensating circuit according to claim 1, it is characterised in thatIn the compensation circuit, when the decision circuitry judge the total amount of electric charge on the occasion of when, produce with negative value benefit The compensated pulse current signal of the quantity of electric charge is repaid so that the total amount of electric charge is within the safe charge amount, andWhen the decision circuitry judges the total amount of electric charge for negative value, produce with the occasion of compensation the quantity of electric charge compensated pulse Current signal so that the total amount of electric charge within the safe charge amount.
- 3. charge compensating circuit according to claim 1 or 2, it is characterised in thatThe amplitude of the compensated pulse current signal is less than default amplitude, and the cycle of the compensated pulse current signal is less than The cycle of the Bipolar pulse current signal.
- 4. charge compensating circuit according to claim 1, it is characterised in thatIn the Bipolar pulse current signal, the waveform of forward pulse current signal and the waveform phase of negative-going pulse current signal Instead,The electric charge of the quantity of electric charge of forward pulse current signal described in the detection electric circuit inspection and the negative-going pulse current signal The absolute value of amount, the quantity of electric charge and the negative-going pulse electric current of the decision circuitry by the forward pulse current signal The absolute value of the quantity of electric charge of signal judges whether the total amount of electric charge exceedes safe charge amount.
- 5. charge compensating circuit according to claim 1, it is characterised in thatThe average value for the Bipolar pulse current signal that the detection electric circuit inspection is generated by pulse current generation circuit,The decision circuitry judges whether the absolute value of the average value is more than preset value, and when the absolute value of the average value During more than the preset value, compensation circuit produces the compensated pulse current signal with net charge amount so that the total amount of electric charge exists Within the safe charge amount.
- 6. charge compensating circuit according to claim 1, it is characterised in thatThe current average for the Bipolar pulse current signal that the detection electric circuit inspection is generated by the pulse current generation circuit, And the current average is converted into average voltage, andThe decision circuitry judges whether the absolute value of the average voltage is more than preset voltage value, when the average voltage Absolute value when being more than the preset voltage value, the compensation circuit produce the compensated pulse current signal with net charge amount with Make the total amount of electric charge within the safe charge amount.
- 7. charge compensating circuit according to claim 6, it is characterised in thatWhen the absolute value of the average voltage is more than preset voltage value, and the average voltage be on the occasion of when, the compensation The compensated pulse current signal that circuit produces the net charge amount with negative value is existed with being used in the total amount of electric charge of nerve stimulation Within the safe charge amount, andWhen the absolute value of the average voltage is more than preset voltage value, and the average voltage is negative value, the compensation Circuit produce with the occasion of the compensated pulse current signal of net charge amount existed with being used in the total amount of electric charge of nerve stimulation Within the safe charge amount.
- A kind of 8. charge compensation method, it is characterised in thatIt is the charge compensation method for carrying out charge compensation to pulse current generation circuit, the pulse current generation circuit production The raw Bipolar pulse current for nerve stimulation,The charge compensation method includes：Detection is by the electricity in a stimulation cycle of the Bipolar pulse current signal of pulse current generation circuit generation Lotus total amount；Judge to exceed safe charge amount by the total amount of electric charge of the detection electric circuit inspection；AndWhen the decision circuitry judges that the total amount of electric charge exceedes the safe charge amount, the compensation with net charge amount is produced Pulsed current signal so that the total amount of electric charge within the safe charge amount.
- 9. charge compensation method according to claim 8, it is characterised in thatWhen judge the total amount of electric charge on the occasion of when, produce with negative value compensation the quantity of electric charge compensated pulse current signal so that The total amount of electric charge within the safe charge amount, andWhen judging the total amount of electric charge for negative value, produce with the occasion of compensation the quantity of electric charge compensated pulse current signal so that The total amount of electric charge is within the safe charge amount.
- A kind of 10. retinal prosthesis system, it is characterised in thatIncluding：Implanted device, it at least has the charge compensating circuit described in any one of claim 1 to 7；Camera device, it is used to capture video image, and the video image is converted into visual signal；AndVideo process apparatus, it is connected with the camera device, and the visual signal is handled and generates modulation letter Number, the modulated signal is transmitted to the implanted device,The modulated signal received is converted into the Bipolar pulse current as electrical stimulation signal by the implanted device Signal, so as to provide the Bipolar pulse current signal to retina to produce light sensation.
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| CN201610875326.8A CN106390285B (en) | 2016-09-30 | 2016-09-30 | Charge compensating circuit, charge compensation method and retinal prosthesis system |
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| US11097105B2 (en) * | 2016-09-30 | 2021-08-24 | Shenzhen Sibionics Technology Co., Ltd. | Pulse current generation circuit for neural stimulation, charge compensation circuit and method, and implantable electrical retina stimulator |
| CN106390285B (en) * | 2016-09-30 | 2017-10-17 | 深圳硅基仿生科技有限公司 | Charge compensating circuit, charge compensation method and retinal prosthesis system |
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| CN106390285B (en) | 2017-10-17 |
| CN106390285A (en) | 2017-02-15 |
| CN107398012B (en) | 2018-10-12 |
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Address after: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee after: Shenzhen Silicon Bionics Technology Co.,Ltd. Address before: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee before: SHENZHEN SIBIONICS TECHNOLOGY Co.,Ltd. |