CN107375704A - A kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer - Google Patents

A kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer Download PDF

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CN107375704A
CN107375704A CN201710605437.1A CN201710605437A CN107375704A CN 107375704 A CN107375704 A CN 107375704A CN 201710605437 A CN201710605437 A CN 201710605437A CN 107375704 A CN107375704 A CN 107375704A
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parts
radiotherapy
body surface
chinese medicine
medicine
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CN107375704B (en
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孟宪泽
郭云良
封颖璐
李涛
任红贤
刘杰
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401th Hospital Of Pla
Affiliated Hospital of University of Qingdao
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Affiliated Hospital of University of Qingdao
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483Gleditsia (locust)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/898Orchidaceae (Orchid family)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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Abstract

A kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer, is made up of the Chinese medicine of following parts by weight:10 30 parts of the root of Dahurain angelica;20 40 parts of Asian puccoon;10 30 parts of spina gleditsiae;5 15 parts of frankincense;5 15 parts of myrrh;39 parts of borneol;5 15 parts of dragon's blood;20 40 parts of keel;10 30 parts of the bletilla striata;39 parts of alum;20 40 parts of edible tulip.The present invention can be clearing heat and detoxicating, dissipating bind sore, dissipates without bursting, and holds back without stagnant, plays a part of good anti-inflammatory, antitumor, myogenic pain relieving, protecting skin, promotes Wound healing.The pernicious body surface ulcer that the present invention solves the problems, such as still heal after current radiotherapy lacks effective medicine and method, reasonable recipe, various medicines mutually cooperate with drug effect, therapeutic action is played to greatest extent, medicine guides drugs to illness station, rapid-action, few side effects, and cost is cheap, convenient and practical, there has been no the traditional Chinese powder medicine of similar applications at present to be seen in report.

Description

A kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer
Technical field
The present invention relates to a kind of external Chinese medicament, specifically a kind of Combined with Radiotherapy treats the Chinese medicine external of pernicious body surface ulcer Powder.
Background technology
Breast cancer, lymthoma, Subcutaneous metastasis knurl etc. easily form ulceration close to the malignant tumour of body surface, and such ulceration is extremely difficult more Close, and easily concurrent infection, so as to form pernicious intractable body surface ulcer.
For the basic treatment method of pernicious body surface ulcer to kill tumour, such as local radiotherapy, radiotherapy can kill ulcer surface majority Tumor tissues, so as to provide possibility for ulcer healing, but most pernicious body surface ulcers Jing Guo radiotherapy can not still reach reason Want to heal, reason is as follows:1st, radiotherapy can cause Changes of Radiation Damaged Skin, consequently, it is possible to increase ulcer surface, aggravates ulcer on the contrary; 2nd, radiotherapy causes massive tumor necrosis, and slough is easily complicated by infection, such as can not be effectively controlled, it is also possible to add Weight ulcer;3rd, still there is Partial tumors tissue remaining after radiotherapy, such as control not in time, may cause to revive.
For the pernicious body surface ulcer that can not be still healed after radiotherapy, currently used treatment method has:1st, operation is clear Wound --- however, since non-selected operation before Patients Treated by Radiotherapy, illustrates that this tumour majority can not thoroughly be cut off, after ulceration namely nothing The thorough debridement of method, operation wound clearing have little significance, it is also possible to cause tumour diffusion or the surface of a wound to expand;2nd, local dressing:Keep wound Cleaning, it is to prevent and treat infected wound, promote the conventional therapeutic modality of Wound healing to sterilize dressing in time, but the malignant ulcer surface of a wound it is deep, Infection is heavy and residual tumor, simple dressing are difficult to prove effective;3rd, antibiosis extract for treating, but malignant ulcer blood supply are applied during concurrent infection Difference, antibiosis extract for treating are often ineffective.
At present it is not yet found that document report, which is directly used in pernicious body surface ulcer or Combined with Radiotherapy, treats pernicious body surface ulcer External Chinese medicament.
The content of the invention
The purpose of the present invention is that the specificity of background condition is taken into full account to overcome the shortcomings of background technology, with reference to the traditional Chinese medical science Traditional theory and modern medicine study, there is provided a kind of Combined with Radiotherapy easy to use, effective treats pernicious body surface ulcer Chinese medicine external powder.
The object of the present invention is achieved like this:
A kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer, it is characterised in that is by following parts by weight Chinese medicine be made:Root of Dahurain angelica 10-30 parts;Asian puccoon 20-40 parts;Spina gleditsiae 10-30 parts;Frankincense 5-15 parts;Myrrh 5-15 parts;Borneol 3- 9 parts;Dragon's blood 5-15 parts;Keel 20-40 parts;Bletilla striata 10-30 parts;Alum 3-9 parts;Edible tulip 20-40 parts.
The Chinese medicine external powder that above-mentioned Combined with Radiotherapy treats pernicious body surface ulcer can also be prepared using formula as below:Respectively The parts by weight of Chinese medicine are:20 parts of the root of Dahurain angelica;30 parts of Asian puccoon;20 parts of spina gleditsiae;10 parts of frankincense;10 parts of myrrh;6 parts of borneol;Dragon's blood 10 parts;30 parts of keel;20 parts of the bletilla striata;6 parts of alum;30 parts of edible tulip.
The method that the Chinese medicine of the pernicious body surface ulcer of Combined with Radiotherapy treatment is prepared using above-mentioned powder:All medicines are fully mixed It is even, be crushed to powder, drying for standby.
The application method that above-mentioned Combined with Radiotherapy treats the Chinese medicine of pernicious body surface ulcer is:In use, after wound sterilization, take suitable Amount dry medication powder uniformly spreads on affected part, and breathable gauze is wrapped up, one time a day.
The effect of ten a herbs is as follows:
Monarch drug in a prescription:The root of Dahurain angelica, Asian puccoon, spina gleditsiae.
Monarch drug in a prescription for malignant ulcer essence, and after radiotherapy easily be complicated by infection and Changes of Radiation Damaged Skin etc. feature, rise Acted on to main anti-inflammatory, antitumor, skin protection etc.
The root of Dahurain angelica:Clearing damp apocenosis, myogenic pain relieving.Modern medicine study shows that it has anti-inflammatory sterilization, expelling pus and promoting granulation, skin The multiple action such as protection, antitumor.
Asian puccoon:Clearing heat and detoxicating, cool blood treats sore.Modern medicine study shows that it has antitumor, antibacterial and anti-inflammation functions.
Spina gleditsiae:Mass dissipating and swelling eliminating, apocenosis of drawing out pus by applying a plaster to the affected part.Modern medicine study shows that it has antitumor, anti-inflammatory sterilization etc. multiple Effect.
Ministerial drug:Frankincense, myrrh, borneol.
Ministerial drug, without scattered feature, promoting the circulation of qi dissipating bind, is removed necrosis and promoted granulation for malignant tumour knot.
Frankincense:Promoting qi circulation and relieving pain, detumescence and promoting granulation
Myrrh:Scattered stasis pain, detumescence and promoting granulation
Borneol:It is clearing heat and detoxicating, mass dissipating and swelling eliminating, remove necrosis and promote granulation.
Adjutant:Dragon's blood, keel, the bletilla striata
Adjutant is burst without the feature held back for malignant ulcer, restrains astringent or styptic treatment for spontaneous sweating, myogenic sore.
Dragon's blood:Blood-activating analgetic, expelling pus and promoting granulation.
Keel:Restrain astringent or styptic treatment for spontaneous sweating, myogenic sore
The bletilla striata:Astringing to arrest bleeding, detumescence and promoting granulation
Make medicine:Alum, edible tulip
Strengthen monarch drug in a prescription antibacterial, antitumor action
Alum:Removing toxic substances eliminating dampness, dissolving phlegm sore.Modern study shows that its external application has broad-spectrum antibacterial action.
Edible tulip:It is clearing heat and detoxicating, reducing phlegm and resolving masses.Modern medicine study shows that it has to kinds of tumors preferably suppresses Effect.
All medicines share, clearing heat and detoxicating, dissipating bind sore, dissipate without bursting, hold back without stagnant.Anti-inflammatory, antitumor, myogenic are played jointly Analgesic, protecting skin, the effect for promoting Wound healing.
Invention advantage
The present invention has advantages below:
First, it is capable of the Chinese medicine external powder of the pernicious body surface ulcer of Combined with Radiotherapy treatment the invention provides a kind of, and obtains Good clinical practice effect, alleviates the painful and uncomfortable of patient, solve can not still heal after current radiotherapy it is pernicious Body surface ulcer lacks the problem of effective medicine and method.
2nd, malignant ulcer is treated using traditional Chinese powder medicine, medicine guides drugs to illness station, rapid-action, few side effects.
3rd, reasonable recipe, by the application repeatedly and practice of clinic, the most rational all medicine compositions of monarch have been obtained, Various medicines mutually cooperate with drug effect, play therapeutic action to greatest extent, detoxicating and resolving a mass, have receipts in dissipating, and dissipate without bursting, hold back and It is not stagnant.
4th, strong innovation, there has been no the traditional Chinese powder medicine of similar applications at present to be seen in report.
5th, the various medicinal material relative inexpensiveness, convenient and practical of invention, are easy to prepare, are not only advantageous to medical personnel's Quick to prepare and use, more patient saves medical cost, alleviates financial burden.
Embodiment
The present invention is described in detail in conjunction with instantiation:
Example 1
This example shows to be made up of following parts by weight Chinese medicine:
20 parts of the root of Dahurain angelica;30 parts of Asian puccoon;20 parts of spina gleditsiae;10 parts of frankincense;10 parts of myrrh;6 parts of borneol;10 parts of dragon's blood;Keel 30 parts;20 parts of the bletilla striata;6 parts of alum;30 parts of edible tulip.
Its preparation method:All medicines fully mix, are crushed to smalls, drying for standby, in use, after wound sterilization, take Appropriate dry medication powder uniformly spreads on affected part, and breathable gauze is wrapped up, one time a day.
Example 2
This example shows to be made up of following parts by weight material medicine:
25 parts of the root of Dahurain angelica;25 parts of Asian puccoon;20 parts of spina gleditsiae;10 parts of frankincense;10 parts of myrrh;3 parts of borneol;10 parts of dragon's blood;Keel 25 parts;20 parts of the bletilla striata;6 parts of alum;25 parts of edible tulip.
This example preparation method is the same as example 1.
Example 3
This example shows to be made up of following parts by weight material medicine:
30 parts of the root of Dahurain angelica;20 parts of Asian puccoon;15 parts of spina gleditsiae;5 parts of frankincense;5 parts of myrrh;3 parts of borneol;10 parts of dragon's blood;Keel 30 Part;20 parts of the bletilla striata;6 parts of alum;25 parts of edible tulip.
This example preparation method is the same as example 1.
Typical case 1,
Patient, female, 80 years old, the pernicious small circle cell knurl of skin of buttock and a small amount of ulceration, there is glycosuria at tumor size about 10*6cm Medical history, row local radiotherapy after 1 week ulceration scope significantly increase, and fester and suppurate.
Originally, we, which give, strengthens local dressing, keeps surface of a wound dry cleansing as far as possible, but does not work, and wound continues to increase And foul smelling, wound exudates culture, which is looked into, sees EHEC, gives antibiosis extract for treating 9 days, does not work.Thus, we attempt to pass System therapy, first, we refer to pressure sore proved recipe, local to use white sugar, do not take effect, wound continues to expand, deepened;Then, we Sore medicine is applied in trial, is produced little effect.Thus, it is contemplated that malignant ulcer has its complexity, its merge tumour, infection, The many factors such as deep skin ulceration and radioactive damage, the thinking based on " holding back " that need to be broken traditions, and to consider whole Body opinion is controlled, and we conscientiously study such ulcer feature, finally have developed the powder being made up of above medicinal material.The powder realize from Four aspect wholistic therapy below, 1, it is antitumor, remove slough, i.e. mass dissipating and swelling eliminating;2nd, anti-inflammatory, sterilization, i.e. removing toxic substances apocenosis;3rd, sore is given birth to Flesh;4th, skin protection.Thus, the complete prescription of this invention is formed, effect is vertical aobvious after grinding external application, and stench disappears substantially after three days Lose, secretion is significantly reduced, and wound is substantially restrained after five days, and wound heals substantially after ten days.
Typical case 2,
Patient, man, 73 years old, Cervical Malignant lymthoma ulceration, scope about 5*7cm, sepage suppurated, do not recover for a long time, and gives part Radiotherapy, the surface of a wound has reduced after radiotherapy, but still can not heal, and still has sepage to suppurate, and gives eight pairs of top, wound heals substantially.Control Obvious adverse reaction is had no during treatment.
Typical case 3,
Patient, female, 55 years old, advanced breast cancer, local skin ulceration sepage was suppurated, and gives local Radiotheropy, Patients During Radiotherapy External application above middle cooperation, wound heals quickly after radiotherapy.Obvious adverse reaction is had no in therapeutic process.
Typical case 4,
Patient, man, 21 years old, lower limb osteosarcoma ulceration was simultaneously infected, and sepage is suppurated, and gave local Radiotheropy, in Patients During Radiotherapy Coordinate top external application, radiotherapy 13 times, give 17 pairs of this side, Wound healing is good.Obvious adverse reaction is had no in therapeutic process.
In summary case is visible, curative for effect, no obvious adverse reaction of the invention, using facilitating, at present, further Scale trials are in progress.

Claims (3)

1. a kind of Combined with Radiotherapy treats the Chinese medicine external powder of pernicious body surface ulcer, it is characterised in that is made up of following medicinal material:In vain The root of Dahurian angelica, Asian puccoon, spina gleditsiae, frankincense, myrrh, borneol, dragon's blood, keel, the bletilla striata, alum, edible tulip;And the parts by weight of the medicinal material Respectively root of Dahurain angelica 10-30 parts;Asian puccoon 20-40 parts;Spina gleditsiae 10-30 parts;Frankincense 5-15 parts;Myrrh 5-15 parts;Borneol 3-9 parts; Dragon's blood 5-15 parts;Keel 20-40 parts;Bletilla striata 10-30 parts;Alum 3-9 parts;Edible tulip 20-40 parts.
2. Combined with Radiotherapy as claimed in claim 1 treats the traditional Chinese powder medicine of pernicious body surface ulcer, it is characterised in that the medicinal material Parts by weight be:20 parts of the root of Dahurain angelica;30 parts of Asian puccoon;20 parts of spina gleditsiae, 10 parts of frankincense;10 parts of myrrh;6 parts of borneol;10 parts of dragon's blood; 30 parts of keel;20 parts of the bletilla striata;6 parts of alum;30 parts of edible tulip.
3. the side of the Chinese medicine of the pernicious body surface ulcer of Combined with Radiotherapy treatment is prepared according to the Chinese medicine external powder of claim 1 or 2 Method, it is characterised in that all medicinal materials are fully mixed, are crushed to powdered, drying for standby.
CN201710605437.1A 2017-07-20 2017-07-20 A topical Chinese medicinal powder for treating malignant body surface ulcer in combination with radiotherapy Active CN107375704B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264196A (en) * 2008-04-30 2008-09-17 吴振林 Externally-applied medicinal composition for treating surgical wound and preparation of ointment thereof
CN101264178B (en) * 2008-04-26 2010-09-29 刘翠平 Preparation of Chinese medicine lotion for treating malignant skin ulcer
CN102688383A (en) * 2011-12-21 2012-09-26 河南科技大学 Traditional Chinese medicine composite for treating body surface ulcer or fester
CN105770275A (en) * 2016-04-27 2016-07-20 李英 Paste for removing blood stasis and necrotic and promoting granulation and paste preparation method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264178B (en) * 2008-04-26 2010-09-29 刘翠平 Preparation of Chinese medicine lotion for treating malignant skin ulcer
CN101264196A (en) * 2008-04-30 2008-09-17 吴振林 Externally-applied medicinal composition for treating surgical wound and preparation of ointment thereof
CN102688383A (en) * 2011-12-21 2012-09-26 河南科技大学 Traditional Chinese medicine composite for treating body surface ulcer or fester
CN105770275A (en) * 2016-04-27 2016-07-20 李英 Paste for removing blood stasis and necrotic and promoting granulation and paste preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
单旭蓉: "癌性溃疡", 《山东中医杂志》 *
边建良等: "中药合剂外涂预防乳腺癌根治术后放疗所致急性放射性皮肤损伤临床观察", 《河北中医》 *

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