CN107375512A - 一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺 - Google Patents
一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺 Download PDFInfo
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Abstract
本发明公布了一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺。该工艺在鱼腥草药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，冷冻干燥，收集冻干产物，经粉碎后真空包装。此法制备的鱼腥草粉末饮片，最大限度地保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药鱼腥草饮片的加工工艺。
背景技术
中药鱼腥草为三白草禾斗植物蕺菜Houttuynia cordata Thunb.的新鲜全草或干燥地上部分。本品味辛，性寒凉，归肺经。本品具有清热解毒、消肿疗疮、利尿除湿、清热止痢、健胃消食的功效，临床可用来治疗实热、热毒、湿邪、疾热为患的肺痈、疮疡肿毒、痔疮便血、脾胃积热等。
常用的鱼腥草饮片的加工方式为：夏季茎叶茂盛花穗多时采割，除去杂质，晒干，再打包储运。饮片厂加工时再用水淋洗、切段、晒干。此类草药饮片，体积庞大，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效，甚至给患者带来隐性的危害。
目前，市场上也有鱼腥草药材经过提取后制成的颗粒饮片销售。颗粒饮片的制备过程，提取不仅耗时耗能，而且因常用大量的水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的鱼腥草药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保鱼腥草药材的临床有效、质量稳定，一种新型的鱼腥草饮片亟待开发。
发明内容
本发明公布了 “一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺”。本工艺可以最大限度的保留鱼腥草药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保鱼腥草饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在鱼腥草采收期采集其全草，洗净，切成1~2cm宽的片，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得鱼腥草药汁。将得到的鱼腥草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.25的浸膏，并将此浸膏于-20~-80℃冰箱中冻结6~24小时，再冷冻干燥，压力为0.06~0.09MPa，温度为-15~-40℃，冷冻时间为12~48小时，收集冻干物后,经粉碎，过筛，包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、饮片生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上鱼腥草的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜采集的鱼腥草药材，净选洗涤后直接压榨、过滤、减压浓缩、冷冻干燥，所得到的粉末饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，真空包装，使得饮片质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的鱼腥草药材，洗净，切成1cm宽的片，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨取汁。所得药渣加3倍量的自来水，搅拌20min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述3次药汁合并，用100目筛网过滤。滤液减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.15时，将浸膏于-80℃冰箱中冻结6小时。取出东结物，冷冻干燥，压力为0.09Mpa，温度为-20℃，干燥24小时。取出冻干物，低温粉碎，过80目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
实施例2
将新鲜采集的鱼腥草药材，洗净，切成1cm宽的片，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨取汁。所得药渣加5倍量的自来水，搅拌30min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述3次药汁合并，用80目筛网过滤。滤液减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.10时，将浸膏于-80℃冰箱中冻结8小时。取出东结物，冷冻干燥，压力为0.08Mpa，温度为-40℃，干燥48小时。取出冻干物，低温粉碎，过60目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (2)
1.一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺，其特征在于：在鱼腥草采收期采集其全草，洗净，切成1~2cm宽的片，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得鱼腥草药汁。
2.根据权利要求1所述的一种鱼腥草鲜榨冷冻干燥粉末饮片的制备工艺，其特征在于：将得到的鱼腥草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.25的浸膏，并将此浸膏于-20~-80℃冰箱中冻结6~24小时，再冷冻干燥，压力为0.06~0.09MPa，温度为-15~-40℃，冷冻时间为12~48小时，收集冻干物后,经粉碎，过筛，包装即可。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105362309A (zh) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | 一种马齿苋鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN105998132A (zh) * | 2016-07-23 | 2016-10-12 | 徐漫 | 一种半边莲鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN106109560A (zh) * | 2016-07-23 | 2016-11-16 | 徐自升 | 一种槐花鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN106214741A (zh) * | 2016-07-24 | 2016-12-14 | 徐漫 | 一种半枝莲鲜榨冷冻干燥粉末饮片及其制备工艺 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362309A (zh) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | 一种马齿苋鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN105998132A (zh) * | 2016-07-23 | 2016-10-12 | 徐漫 | 一种半边莲鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN106109560A (zh) * | 2016-07-23 | 2016-11-16 | 徐自升 | 一种槐花鲜榨冷冻干燥粉末饮片及其制备工艺 |
| CN106214741A (zh) * | 2016-07-24 | 2016-12-14 | 徐漫 | 一种半枝莲鲜榨冷冻干燥粉末饮片及其制备工艺 |
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