CN107375450B - Method for processing cimicifugae rhizoma traditional Chinese medicine decoction pieces - Google Patents
Method for processing cimicifugae rhizoma traditional Chinese medicine decoction pieces Download PDFInfo
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Abstract
The invention discloses a processing method of cimicifugae foetidae Chinese medicinal decoction pieces, which comprises the steps of firstly cleaning cimicifugae foetidae by adopting an optimized cleaning process, then moistening the cimicifugae foetidae by river sand under an acidic condition, and then steaming the cimicifugae foetidae under high pressure to promote the generation of caffeic acid, ferulic acid, isoferulic acid and the like in the raw cimicifugae foetidae; then the mixture is processed at high temperature and high pressure after being mixed with honey and then is processed by microwave radiation, so that the phenolic acid active ingredients can be stabilized, and the situations of uneven heating, sugar pasting and the like caused by stir-frying with high-temperature open fire can be avoided. And the microwave heating efficiency is high, so that the refined honey can be uniformly distributed on the surface of the decoction pieces and can permeate into the medicinal materials, and the processing effect can be greatly improved. The invention provides a strong scientific basis for establishing a new processing method of the cimicifuga foetida Chinese medicinal decoction pieces, and has important application prospect.
Description
Technical Field
The invention relates to a new processing method of traditional Chinese medicine decoction pieces, in particular to a processing method of cimicifuga foetida traditional Chinese medicine decoction pieces, and belongs to the technical field of traditional Chinese medicine pharmacy.
Background
The Cimicifuga foetida is dried rhizome of Cimicifuga trifoliata Cimicifuga herculeolia Kom, Cimicifuga dahurica (Turcz.) Maxim or Cimicifuga foetida L. Digging in autumn, removing silt, burning or removing fibrous root when dried, and sun drying. Sheng Ma is pungent, slightly sweet and slightly cold. It enters lung, spleen, stomach and large intestine meridians. Has effects in relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang qi, and can be used for treating headache due to wind-heat, toothache, aphtha, sore throat, measles without adequate eruption, and macula due to yang toxin; prolapse of the anus and uterine prolapse. The rhizoma cimicifugae can be processed by removing impurities, soaking, cleaning, moistening, slicing, and drying. The existing processing method can not carry out scientific processing according to the active ingredients of the largetrifoliolious bugbane rhizome, can not promote the transformation of the active ingredients and improve the clinical curative effect.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to overcome the defects of the prior art and provide the processing method which has reasonable process design and strong operability and can obviously improve the organic acid active ingredients in the cimicifuga foetida, improve the active ingredients of the processed cimicifuga foetida and achieve better clinical curative effect.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a processing method of cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the following steps:
(1) taking a raw cimicifugae foetidae, cleaning the raw cimicifugae foetidae by using a high-pressure washing machine, then carrying out fine washing by using a bubble type cleaning machine, and blowing and drying the raw cimicifugae foetidae by using an air blower after the fine washing;
(2) burying the fine-washed and dried rhizoma cimicifugae in the river sand in the step (1), adding acetic acid, keeping the humidity of the river sand at 70-85%, keeping the temperature at 35-45 ℃, absorbing moisture and sweating for 12-24 hours, and taking out;
(3) putting the hygroscopic and sweating rhizoma cimicifugae into a high-pressure tank, introducing high-pressure hot steam, keeping the pressure in the high-pressure tank at 1-2 MPa, steaming at high pressure and high temperature for 0.5-2 hours, taking out, and slicing while hot to obtain rhizoma cimicifugae decoction pieces;
(4) taking the cimicifugae rhizoma decoction pieces obtained in the step (3), adding refined honey accounting for 30-35% of the weight of cimicifugae rhizoma, uniformly stirring, putting into a pressure cooker, keeping the pressure in the pressure cooker at 1.5-3 MPa, steaming at high pressure and high temperature for 1-2 hours, and stewing thoroughly to allow sugar molecules to permeate;
(5) and (5) putting the honey-refined and smoldered cimicifugae foetidae obtained in the step (4) into a microwave heating instrument, and carrying out microwave heating treatment for 5-10 minutes to obtain the processed cimicifugae foetidae.
Preferably, the processing method of the cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the steps of (1) burying the finely washed and dried cimicifugae rhizoma in river sand, adding 50-100% acetic acid by volume concentration to adjust the pH value to 5-7, keeping the humidity of the river sand at 75%, keeping the temperature at 45 ℃, and absorbing moisture and sweating for 24 hours. The invention carries out moisture absorption and sweating treatment on the cimicifuga foetida under the acidic condition. Can promote the conversion of aromatic acid compounds such as caffeic acid and isoferulic acid.
Preferably, the processing method of the cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the steps of (3) keeping the pressure in a high-pressure tank at 1.5MPa, steaming at high pressure and high temperature for 1 hour, taking out, and slicing while hot. The invention adopts the optimal high-pressure steaming pressure and steaming time through a large amount of experimental screening. Under high temperature and high pressure, the conversion of the effective components can be promoted, and the content of the effective components can be improved.
Preferably, the processing method of the cimicifugae rhizoma traditional Chinese medicine decoction pieces is characterized in that the cimicifugae rhizoma decoction pieces obtained in the step (4) are added with refined honey accounting for 30-35% of the weight of the cimicifugae rhizoma, stirred uniformly, put into a pressure cooker, kept in a high-pressure tank at the pressure of 2MPa, steamed at high pressure and high temperature for 1.5 hours, and tightly sealed to allow sugar molecules to permeate. The invention adopts the preferred pressure to steam the refined honey, which can promote the permeation of sugar molecules, improve the refined honey effect and improve the processing quality of the cimicifuga foetida.
Preferably, in the processing method of the cimicifugae foetidae traditional Chinese medicine decoction pieces, the microwave power of a microwave heating instrument is 5 KW. In particular, the honey is processed by adopting a microwave heating mode instead of open fire heating, the microwave heating mode is uniform in heating and high in heating efficiency, the processing efficiency is 5-10 times that of the existing open fire frying mode, and the honey refining method can prevent honey refining on the surface of medicinal materials from being burnt due to nonuniform heating, so that the quality of refined honey can be greatly improved.
First, the optimization of the processing technology of the traditional Chinese medicine decoction pieces of rhizoma cimicifugae
1. Method for measuring contents of caffeic acid, ferulic acid and isoferulic acid
1.1 extraction of index component
Extracting phenolic acid components of cimicifuga foetida: pulverizing cimicifugae rhizoma, sieving with No. 2 sieve, accurately weighing 10.0g cimicifugae rhizoma powder in 250mL flat-bottomed flask, adding ethanol, reflux-extracting in water bath for 2 times (each for 1 hr), cooling, filtering, mixing filtrates, and concentrating.
1.2 measurement of index Components
Determination of the standard curve: precisely weighing appropriate amount of caffeic acid, ferulic acid, and isoferulic acid, adding methanol to obtain reference substances with concentration of 47 mg.L-1，145mg·L-1，247mg·L-1According to the chromatographic conditions, the mixed reference solution is 2, 5, 8, 10, 15 and 18 mu L, and the chromatographic conditions comprise a chromatographic column of YMC-Pack-ODS-C4(250 × 4.6.6 mm, 5 mu m), a flowing acetonitrile-0.1 percent formic acid solution (0-12 min, 5-13 percent A, 12-23 min, 13-18 percent A, 23-30 min, 18-5 percent A) and a flow rate of 1.0 mL/min-1(ii) a Column temperature: 30 ℃; detection wavelength: 320 nm; sample introduction amount: 10 mu L, calculating the content of phenolic acid components, and performing statistical regression on the sample amount (X) by using the peak area (Y) to obtain the regression equations of caffeic acid, ferulic acid and isoferulic acid, which are respectively as follows:
Y＝273287X-1149084650(r＝0.9999),
Y＝745351X+38143(r＝0.9999)
Y＝1000000X+283628(r＝0.9995)。
1.3 screening test in the present invention examining the different treatment methods in step (2)
In the step (2), river sand is adopted to carry out moisture absorption and sweating treatment under acidic and non-acidic conditions, and the measurement result of the content of the blood activating components is shown in the following table:
TABLE 1 measurement results of phenolic acid component content at different pH values
The test results of the above table 1 show that the cimicifuga foetida can promote the conversion of acidic phenolic acid components by screening a large number of tests, preferably adjusting the optimum pH value condition of the cimicifuga foetida in river sand by using acetic acid, and the test results show that the cimicifuga foetida can promote the conversion of acidic phenolic acid components by being placed under the acidic condition with the pH value of 5-7, especially when the pH value is 5.
1.4, on the basis of 1.3, the content of the active phenolic acid component after steaming for 1 hour in the step (3) under different steaming pressures (atmospheric steaming, 0.5MPa, 1MPa, 1.5MPa, 2MPa, 2.5MPa and 3MPa) is considered. Specific results are shown in table 2.
TABLE 2 measurement results of phenolic acid component content under different steaming pressures
The experimental results in table 2 show that the conversion rates of the effective components of the cimicifuga phenolic acids are obviously different under different steaming pressures, and the conversion rate of the effective components of the cimicifuga phenolic acids is the highest when the steaming pressure is 1.5-3 MPa, particularly 1.5-2 MPa. Considering the experiment cost and the safety, the effective steaming pressure is 1.5 MPa.
1.5 on the basis of 1.4, the invention considers the screening of different steaming time in the step (3)
The present invention considers cimicifuga foetida, the content of active phenolic acid components after different steaming times (0.5 hours, 1 hour, 1.5 hours, 2 hours and 3 hours) at 1.5 MPa. Specific results are shown in table 3.
TABLE 3 measurement results of phenolic acid component content at different steaming times
As shown in Table 3, the contents of phenolic acid components and the steaming time are closely related, the steaming time is prolonged, the content of phenolic acid is increased, and the content is almost the highest after the steaming time reaches 1.5 hours, so that 1.5 hours is preferred.
1.6, on the basis of 1.5, the invention considers the screening experiment of different steaming pressures and steaming times after the honey mixing in the step (4)
The content determination of the phenolic acid components under different steaming pressures after the cimicifugae foetidae and the refined honey are uniformly mixed in the step (4) is considered, and the specific results are shown in the table 4:
TABLE 4 measurement results of phenolic acid component content under different steaming pressures
1.7, on the basis of 1.6, the content determination of the phenolic acid components under different steaming time under the pressure of 2MP after the cimicifuga foetida and the refined honey are uniformly mixed in the step (4) is considered, and the specific result is shown in the table 5:
TABLE 5 measurement results of phenolic acid component content at different steaming times
As shown in Table 5, the contents of phenolic acid components and the steaming time are closely related, and the steaming time is prolonged, the content of phenolic acid is increased, and the content is almost the highest after the steaming time reaches 2 hours, so that 2 hours is preferred.
1.8, step (5) screening by heat treatment process
The invention considers the cimicifuga foetida steamed by honey refining for 1.5 hours after steaming at 2MPa, and adopts the processes of stir-frying with open fire, oven heating, microwave treatment and the like. Experimental results show that when a microwave heating instrument (5KW) is adopted, the microwave heating treatment is carried out for 5-10 minutes, the obtained phenolic acid active ingredients are stable, and the situations of uneven heating, sugar pasting and the like caused by high-temperature open fire frying are avoided. And the microwave heating efficiency is high, so that the refined honey can be uniformly distributed on the surface of the decoction pieces and can permeate into the medicinal materials, and the processing effect can be greatly improved.
Has the advantages that: compared with the prior art, the processing method of the cimicifuga foetida traditional Chinese medicine decoction pieces provided by the invention has the following advantages:
according to the invention, active ingredients of the cimicifuga foetida clinically applied, such as the phenolic acid ingredient caffeic acid, ferulic acid and isoferulic acid, are taken as evaluation indexes, a new processing technology capable of improving the phenolic acid active ingredients of the cimicifuga foetida is screened out through a large number of experimental researches on the basis of the traditional processing method of the cimicifuga foetida, so that the processed cimicifuga foetida product has better clinical curative effects; then the active ingredients of phenolic acid can be stabilized by adopting the preferable refined honey high-pressure high-temperature steaming and adopting the preferable microwave heating mode, and the situations of uneven heating, sugar pasting and the like caused by stir-frying with high-temperature open fire can be avoided. And the microwave heating efficiency is high, so that the refined honey can be uniformly distributed on the surface of the decoction pieces and can permeate into the medicinal materials, and the processing effect can be greatly improved. The invention provides a strong scientific basis for establishing a new processing method of the cimicifuga foetida Chinese medicinal decoction pieces, and has important application prospect.
Detailed Description
The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the specific material ratios, process conditions and results thereof described in the examples are illustrative only and should not be taken as limiting the invention as detailed in the claims.
Example 1
1. A processing method of cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the following steps:
(1) taking a raw cimicifugae foetidae, cleaning the raw cimicifugae foetidae by using a high-pressure washing machine, then carrying out fine washing by using a bubble type cleaning machine, and blowing and drying the raw cimicifugae foetidae by using an air blower after the fine washing;
(2) burying the fine-washed and dried rhizoma cimicifugae in the river sand in the step (1), adding 80 vol% acetic acid to adjust pH to 5, maintaining river sand humidity at 75%, temperature at 45 deg.C, absorbing moisture and sweating for 24 hr, and taking out;
(3) placing the hygroscopic and sweating rhizoma cimicifugae into a high-pressure tank, introducing high-pressure hot steam, keeping the pressure in the high-pressure tank at 1.5MPa, steaming at high pressure and high temperature for 1 hour, taking out, and slicing while hot to obtain rhizoma cimicifugae decoction pieces;
(4) taking the cimicifugae rhizoma decoction pieces obtained in step (3), adding refined honey 30% of cimicifugae rhizoma weight, stirring, placing into a pressure cooker, keeping pressure in a pressure tank at 2MPa, steaming at high pressure and high temperature for 1.5 hr, and sealing thoroughly to allow sugar molecules to permeate;
(5) and (5) putting the honey-refined and smoldered cimicifugae foetidae obtained in the step (4) into a microwave heating instrument (with the power of 5KW), and carrying out microwave heating treatment for 6 minutes to obtain the processed cimicifugae foetidae.
2. The ferulic acid, isoferulic acid and caffeic acid in the processed rhizoma cimicifugae materials are extracted and detected by the method in the specification, and the percentage content of isoferulic acid and caffeic acid is 0.199%, 0.439% and 0.305% respectively.
Example 2
1. A processing method of cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the following steps:
(1) taking a raw cimicifugae foetidae, cleaning the raw cimicifugae foetidae by using a high-pressure washing machine, then carrying out fine washing by using a bubble type cleaning machine, and blowing and drying the raw cimicifugae foetidae by using an air blower after the fine washing;
(2) burying the fine-washed and dried rhizoma cimicifugae in the river sand in the step (1), adding 100 vol% acetic acid to adjust pH to 6, maintaining river sand humidity at 80%, temperature at 35 deg.C, absorbing moisture and sweating for 24 hr, and taking out;
(3) placing the hygroscopic and sweating rhizoma cimicifugae into a high-pressure tank, introducing high-pressure hot steam, keeping the pressure in the high-pressure tank at 2MPa, steaming at high pressure and high temperature for 1.5 hours, taking out, and slicing while hot to obtain rhizoma cimicifugae decoction pieces;
(4) taking the cimicifugae rhizoma decoction pieces obtained in the step (3), adding refined honey accounting for 35% of the weight of cimicifugae rhizoma, stirring uniformly, placing into a pressure cooker, keeping the pressure in the pressure cooker at 2MPa, steaming at high pressure and high temperature for 2 hours, and stewing thoroughly to allow sugar molecules to permeate;
(5) and (5) putting the honey-refined and smoldered cimicifugae foetidae obtained in the step (4) into a microwave heating instrument (with the power of 5KW), and carrying out microwave heating treatment for 8 minutes to obtain the processed cimicifugae foetidae.
2. The ferulic acid, isoferulic acid and caffeic acid in the processed rhizoma cimicifugae materials are extracted and detected by the method in the specification, and the percentage content of isoferulic acid and caffeic acid is 0.197%, 0.429% and 0.298%, respectively.
The above embodiments are merely illustrative of the technical concept and features of the present invention, and the present invention is not limited thereto, and equivalent changes and modifications made according to the spirit of the present invention should be covered thereby.
Claims (1)
1. A processing method of cimicifugae rhizoma traditional Chinese medicine decoction pieces comprises the following steps:
(1) taking a raw cimicifugae foetidae, cleaning the raw cimicifugae foetidae by using a high-pressure washing machine, then carrying out fine washing by using a bubble type cleaning machine, and blowing and drying the raw cimicifugae foetidae by using an air blower after the fine washing;
(2) burying the fine-washed and dried rhizoma cimicifugae in the river sand in the step (1), adding 80 vol% acetic acid to adjust pH to 5, maintaining river sand humidity at 75%, temperature at 45 deg.C, absorbing moisture and sweating for 24 hr, and taking out;
(3) placing the hygroscopic and sweating rhizoma cimicifugae into a high-pressure tank, introducing high-pressure hot steam, keeping the pressure in the high-pressure tank at 1.5MPa, steaming at high pressure and high temperature for 1 hour, taking out, and slicing while hot to obtain rhizoma cimicifugae decoction pieces;
(4) taking the cimicifugae rhizoma decoction pieces obtained in step (3), adding refined honey 30% of cimicifugae rhizoma weight, stirring, placing into a pressure cooker, keeping pressure in a pressure tank at 2MPa, steaming at high pressure and high temperature for 1.5 hr, and sealing thoroughly to allow sugar molecules to permeate;
(5) and (5) taking the honey-refined and smoldering cimicifugae foetidae obtained in the step (4), putting the honey-refined and smoldering cimicifugae foetidae into a microwave heating instrument, wherein the power is 5KW, and carrying out microwave heating treatment for 6 minutes to obtain the processed cimicifugae foetidae.
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