CN107362126A - Power simulation extract freeze-drying powder and preparation technology - Google Patents

Power simulation extract freeze-drying powder and preparation technology Download PDF

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Publication number
CN107362126A
CN107362126A CN201710784905.6A CN201710784905A CN107362126A CN 107362126 A CN107362126 A CN 107362126A CN 201710784905 A CN201710784905 A CN 201710784905A CN 107362126 A CN107362126 A CN 107362126A
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CN
China
Prior art keywords
power simulation
precooling
freeze
degrees celsius
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710784905.6A
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Chinese (zh)
Inventor
尤俊杰
冉隆德
马玲霞
杨付秀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yinchuan Feng Yi Tang Biotechnology Co Ltd
Original Assignee
Yinchuan Feng Yi Tang Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yinchuan Feng Yi Tang Biotechnology Co Ltd filed Critical Yinchuan Feng Yi Tang Biotechnology Co Ltd
Priority to CN201710784905.6A priority Critical patent/CN107362126A/en
Publication of CN107362126A publication Critical patent/CN107362126A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

A kind of power simulation extract freeze-drying powder, as a kind of more peptide freeze-dried powders of earthworm for the bioactivity that can keep power simulation extract, including power simulation extract, mannitol, allantoin and deionized water, and successively using rate of charge as 5~10:1~5:0.3~0.5:93.7~84.5 feed intake preparation.The present invention also provides a kind of preparation technology of power simulation extract freeze-drying powder.The present invention is using freeze drying technology in skin protection cosmetics is prepared, after freeze-drying, anhydrous vacuum-packed condition, make cosmetics in sterile and in the case of not adding any preservative, the bioactivity kept in power simulation extract permanently effective at normal temperatures.

Description

Power simulation extract freeze-drying powder and preparation technology
Technical field：
The present invention relates to the power simulation extractive technique field in cosmetic art, more particularly to a kind of power simulation Extract freeze-drying powder and preparation technology.
Background technology：
Present skin-care cosmetics application conventional art process makes, and a certain proportion of preservative is typically all added, with suppression The growth of bacterium in inhibition and generation cosmetic.With the exploitation of power simulation extract, due to power simulation extract meeting under normal temperature Inactivation, so limits its application in cosmetics.
The content of the invention：
In view of this, it is necessary to which a kind of power simulation extract freeze-drying powder is provided.
It there is a need to and a kind of preparation technology of power simulation extract freeze-drying powder is provided.
A kind of power simulation extract freeze-drying powder, as a kind of bioactivity that can keep power simulation extract The more peptide freeze-dried powders of earthworm, including power simulation extract, mannitol, allantoin and deionized water, and successively with rate of charge For 5~10:1~5:0.3~0.5:93.7~84.5 feed intake preparation.
A kind of preparation technology of power simulation extract freeze-drying powder, comprises the following steps：
Step 1, temperature be 15 degrees Celsius~25 degrees Celsius in the environment of, by mannitol and allantoin be dissolved in from In sub- water, 38 DEG C~42 DEG C are heated to, is stirred until homogeneous；Power simulation is added after being cooled to 15 degrees Celsius~25 degrees Celsius to carry Thing is taken, forms transparency liquid, aseptic process is carried out in the environment of being then 15 degrees Celsius~25 degrees Celsius in temperature；
Step 2, the precooling in freezer by the transparency liquid in step 1, transparency liquid is set to form solid；
Step 3, after the completion of precooling, vacuum freeze drier is opened, makes vacuum freeze drier warehouse precooling, warehouse is pre- It is as cold as the temperature of water vessel on control panel and is reduced to -20 DEG C；
Step 4, the solid that the precooling in step 2 is formed is put into pre-cooled vacuum freeze drier, set After heating-up temperature is 45 DEG C, precooling is fixed under the 20Pa vacuums preset and freezed 24 hours~26 hours, finally taken out Finished product, pack, normal temperature preserves.
In the step of preparation technology of above-mentioned power simulation extract freeze-drying powder two, transparency liquid is subjected to precooling, in advance Cold temperature is -18 DEG C, pre-coo time 12h.
The present invention applies freeze drying technology in skin protection cosmetics is prepared, after freeze-drying, anhydrous vacuum-packed bar Part, make cosmetics in sterile and in the case of not adding any preservative, holding William's ring hair permanently effective at normal temperatures Bioactivity in earthworm extract.
The present invention can make cosmetics in the case where not adding preservative with freeze drying technology, permanently effective to guarantee the quality, complete It is complete to remove cosmetics because the stimulation of preservative is to side effect caused by skin；Freeze drying technology can keep power simulation to carry for a long time The bioactivity of thing is taken, the skin effect of earthworm polypeptide is really popularized for consumers in general；The present invention is carried with power simulation It is main component to take thing, and a small amount of mannitol is freeze-dried excipient, and a small amount of allantoin can reduce power simulation extract pair The issuable stimulation of skin.
Embodiment：
A kind of preparation technology of power simulation extract freeze-drying powder, comprises the following steps
Step 1, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stirring To uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process；
Step 2, by semi-finished product liquid precooling in freezer in step 1, temperature is -18 DEG C, time 12h, is formed Solid；
Step 3, after the completion of precooling, vacuum freeze drier is opened, makes vacuum freeze drier warehouse precooling, warehouse is pre- It is as cold as the temperature of water vessel on control panel and is reduced to -20 DEG C；
Step 4, the semi-finished product solid in step 2 is put into pre-cooled vacuum freeze drier, heating is set After temperature is 45 DEG C, semi-finished product are freezed into 24-26 hours under the 20Pa vacuums preset, finally take out finished product, sealed bundle Dress, normal temperature preserve.
The present invention provides several embodiments to feed intake：
Embodiment one, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 5:1:0.3:93.7.
Embodiment two, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 5:5:0.5:84.5.
Embodiment three, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 10:1:0.3:93.7.
Example IV, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 10:5:0.5:84.5.
Embodiment five, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 5:1:0.5:93.7.
Embodiment six, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 5:1:0.3:84.5.
Embodiment seven, at normal temperatures, mannitol and allantoin are dissolved in deionized water, are heated to 40 DEG C or so, stir Mix to uniform；Power simulation extract is added after being cooled to normal temperature, forms transparency liquid, carries out normal temperature aseptic process, wherein Power simulation extract, mannitol, the percentage by weight of allantoin and deionized water are followed successively by 8:3:0.4:88.
The present invention applies freeze drying technology in skin protection cosmetics is prepared, after freeze-drying, anhydrous vacuum-packed bar Part, make cosmetics in sterile and in the case of not adding any preservative, holding William's ring hair permanently effective at normal temperatures Bioactivity in earthworm extract.
Feature of the present invention：Cosmetics can be made in the case where not adding preservative with freeze drying technology, permanently effective guarantor Matter, cosmetics are removed completely because the stimulation of preservative is to side effect caused by skin；Freeze drying technology can keep William's ring for a long time The bioactivity of hair earthworm extract, makes the skin effect of earthworm polypeptide really be popularized for consumers in general；
The present invention is using power simulation extract as main component, and a small amount of mannitol is freeze-dried excipient, a small amount of allantois Element can reduce power simulation extract to the issuable stimulation of skin.

Claims (5)

  1. A kind of 1. power simulation extract freeze-drying powder, it is characterised in that：Power simulation extract freeze-drying powder is a kind of energy Keep power simulation extract bioactivity the more peptide freeze-dried powders of earthworm, including power simulation extract, mannitol, Allantoin and deionized water, and successively using rate of charge as 5~10:1~5:0.3~0.5:93.7~84.5 feed intake preparation.
  2. 2. power simulation extract freeze-drying powder as claimed in claim 1, it is characterised in that：Power simulation extract freezes Powder is obtained by following steps：
    Step 1, in the environment of temperature is 15 degrees Celsius~25 degrees Celsius, mannitol and allantoin are dissolved in deionized water In, 38 DEG C~42 DEG C are heated to, is stirred until homogeneous；Power simulation extraction is added after being cooled to 15 degrees Celsius~25 degrees Celsius Thing, transparency liquid is formed, aseptic process is carried out in the environment of being then 15 degrees Celsius~25 degrees Celsius in temperature；
    Step 2, the precooling in freezer by the transparency liquid in step 1, transparency liquid is set to form solid；
    Step 3, after the completion of precooling, vacuum freeze drier is opened, makes vacuum freeze drier warehouse precooling, warehouse is pre-chilled to The temperature of water vessel is reduced to -20 DEG C on control panel；
    Step 4, the solid that the precooling in step 2 is formed is put into pre-cooled vacuum freeze drier, heating is set After temperature is 45 DEG C, precooling is fixed under the 20Pa vacuums preset and freezed 24 hours~26 hours, finally take out finished product, Pack, normal temperature preserves.
  3. 3. power simulation extract freeze-drying powder as claimed in claim 2, it is characterised in that：In step 2, by transparency liquid Precooling is carried out, precooling temperature is -18 DEG C, pre-coo time 12h.
  4. A kind of 4. preparation technology of power simulation extract freeze-drying powder, it is characterised in that：Power simulation extract freeze-drying powder Preparation technology comprise the following steps：
    Step 1, in the environment of temperature is 15 degrees Celsius~25 degrees Celsius, mannitol and allantoin are dissolved in deionized water In, 38 DEG C~42 DEG C are heated to, is stirred until homogeneous；Power simulation extraction is added after being cooled to 15 degrees Celsius~25 degrees Celsius Thing, transparency liquid is formed, aseptic process is carried out in the environment of being then 15 degrees Celsius~25 degrees Celsius in temperature；
    Step 2, the precooling in freezer by the transparency liquid in step 1, transparency liquid is set to form solid；
    Step 3, after the completion of precooling, vacuum freeze drier is opened, makes vacuum freeze drier warehouse precooling, warehouse is pre-chilled to The temperature of water vessel is reduced to -20 DEG C on control panel；
    Step 4, the solid that the precooling in step 2 is formed is put into pre-cooled vacuum freeze drier, heating is set After temperature is 45 DEG C, precooling is fixed under the 20Pa vacuums preset and freezed 24 hours~26 hours, finally take out finished product, Pack, normal temperature preserves.
  5. 5. the preparation technology of power simulation extract freeze-drying powder as claimed in claim 4, it is characterised in that：Above-mentioned William's ring In the step of preparation technology of hair earthworm extract freeze-drying powder two, transparency liquid is subjected to precooling, precooling temperature is -18 DEG C, precooling Time is 12h.
CN201710784905.6A 2017-09-04 2017-09-04 Power simulation extract freeze-drying powder and preparation technology Pending CN107362126A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710784905.6A CN107362126A (en) 2017-09-04 2017-09-04 Power simulation extract freeze-drying powder and preparation technology

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Application Number Priority Date Filing Date Title
CN201710784905.6A CN107362126A (en) 2017-09-04 2017-09-04 Power simulation extract freeze-drying powder and preparation technology

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110897982A (en) * 2019-10-26 2020-03-24 银川凤仪堂生物工程有限公司 Lumbrukinase freeze-dried powder and application thereof in skin care products

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101407801A (en) * 2008-12-05 2009-04-15 郭秀华 Preparation of earthworm fibrinolytic enzyme from Pheretima guillelmi Michaelsen and lyophilized powder preparation for injection prepared thereby
CN103610630A (en) * 2013-12-13 2014-03-05 扈嘉正 Make-up cream with wrinkle removal and repairing functions
CN103845272A (en) * 2014-03-14 2014-06-11 江苏隆力奇生物科技股份有限公司 Earthworm extract having skin aging resisting effect and preparation method and application thereof
CN104337839A (en) * 2013-08-06 2015-02-11 天津鑫泽众生物技术有限公司 Method for preparing active earthworm powder
CN104887541A (en) * 2015-02-27 2015-09-09 济宁华能制药厂有限公司 Cosmetic containing earthworm active protein

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101407801A (en) * 2008-12-05 2009-04-15 郭秀华 Preparation of earthworm fibrinolytic enzyme from Pheretima guillelmi Michaelsen and lyophilized powder preparation for injection prepared thereby
CN104337839A (en) * 2013-08-06 2015-02-11 天津鑫泽众生物技术有限公司 Method for preparing active earthworm powder
CN103610630A (en) * 2013-12-13 2014-03-05 扈嘉正 Make-up cream with wrinkle removal and repairing functions
CN103845272A (en) * 2014-03-14 2014-06-11 江苏隆力奇生物科技股份有限公司 Earthworm extract having skin aging resisting effect and preparation method and application thereof
CN104887541A (en) * 2015-02-27 2015-09-09 济宁华能制药厂有限公司 Cosmetic containing earthworm active protein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110897982A (en) * 2019-10-26 2020-03-24 银川凤仪堂生物工程有限公司 Lumbrukinase freeze-dried powder and application thereof in skin care products

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Application publication date: 20171121

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