CN107349186A - Dogbane flower leaf volatile oil soft capsule and preparation method thereof - Google Patents
Dogbane flower leaf volatile oil soft capsule and preparation method thereof Download PDFInfo
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- CN107349186A CN107349186A CN201710509458.3A CN201710509458A CN107349186A CN 107349186 A CN107349186 A CN 107349186A CN 201710509458 A CN201710509458 A CN 201710509458A CN 107349186 A CN107349186 A CN 107349186A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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Abstract
The present invention relates to dogbane flower leaf volatile oil technical field, is a kind of dogbane flower leaf volatile oil soft capsule and preparation method thereof；Raw materials by weight portion includes 5 parts to 60 parts dogbane flower leaf volatile oils, 0 part to 20 parts soybean lecithin, 0 part to 2 parts vitamin E, 0 part to 15 parts capsulation stabilizer, 10 parts to 70 parts diluents.The invention discloses a kind of dogbane flower leaf volatile oil soft capsule, capsule product steady quality made by dogbane flower leaf volatile oil, dogbane flower leaf volatile oil preparation is filled up and effect has no the blank of report, relatively other its bioavilability of formulation are higher, the medicine absorption of human body in capsule is more preferable, it is safe under the conditions of clinical dosage, the capsule made by dogbane flower leaf volatile oil has reducing blood lipid, decompression, antioxidation.
Description
Technical field
The present invention relates to dogbane flower leaf volatile oil technical field, is a kind of dogbane flower leaf volatile oil soft capsule and its system
Preparation Method.
Background technology
Bluish dogbane have lowering blood pressure and blood fat, relieving cough and reducing sputum, diuresis anti-inflammatory, heat-clearing and fire-reducing, suppressing hyperactive liver for calming endogenous wind, improve sleep,
Anti-aging, it is anti-it is melancholy, improve human body respiration and digestion, treatment are had a dizzy spell with edema and other effects.At present, on for spreading out
Fried dough twist leaf volatile oil composition Study has document report, but has no report for dogbane flower leaf volatile oil preparation and effect, leads
Cause can not be utilized effectively.
The content of the invention
The invention provides a kind of dogbane flower leaf volatile oil soft capsule and preparation method thereof, above-mentioned prior art is overcome
Deficiency, it can effectively solve unclear for dogbane flower leaf volatile oil preparation and effect, and lead to not effectively utilize asks
Topic.
One of technical scheme is realized by following measures：A kind of dogbane flower leaf volatile oil flexible glue
Capsule, raw materials by weight portion include 5 parts to 60 parts dogbane flower leaf volatile oils, 0 part to 20 parts soybean lecithin, 0 part to 2 parts dimension life
Plain E, 0 part to 15 parts capsulation stabilizer, 10 parts to 70 parts diluents.
Here is the further optimization and/or improvements to one of foregoing invention technical scheme：
Above-mentioned dogbane flower leaf volatile oil soft capsule obtains as follows：The first step, the desired amount of diluent is heated to 25
DEG C to 75 DEG C, add that the desired amount of soybean lecithin, capsulation stabilizer are well mixed to obtain mixed once liquid；Second step, once mix
Liquid is closed when temperature is down to 25 DEG C to 35 DEG C, vitamin E is added and stirs to obtain secondary mixed liquor；3rd step, by dogbane flower
Leaf volatile oil is added in secondary mixed liquor to stir and is down to room temperature and obtains capsule 's content, and capsule 's content is placed in colloid mill
Make to be pressed into soft capsule after degassing and obtain dogbane flower leaf volatile oil soft capsule.
Above-mentioned capsulation stabilizer is beeswax, suet, methylcellulose, ethyl cellulose, polyethylene glycol monostearate, told
Temperature -80, cetomacrogol 1000, polyethylene glycol 1500, Macrogol 4000, Macrogol 6000, PLURONICS F87, Bo Luosha
One or more of nurse 407.
Above-mentioned diluent be sunflower oil, peanut oil, soya-bean oil, safflower oil, Seabuckthorn Oil, tea oil, salad oil, polyethylene glycol 400,
More than one of corn oil and propane diols.
The two of technical scheme are realized by following measures：A kind of cloth fried dough twist leaf volatile oil soft capsule
Preparation method, carry out in the steps below：The first step, the desired amount of diluent is heated to 25 DEG C to 75 DEG C, added the desired amount of
Soybean lecithin, capsulation stabilizer are well mixed to obtain mixed once liquid；Second step, mixed once liquid treat that temperature is down to 25 DEG C to 35
DEG C when, add vitamin E and stir to obtain secondary mixed liquor；3rd step, dogbane flower leaf volatile oil is added into secondary mixed liquor
In stir and be down to room temperature and obtain capsule 's content, capsule 's content is placed to make to be pressed into soft capsule after degassing and obtained in colloid mill
To dogbane flower leaf volatile oil soft capsule.
Here is two further optimization and/or improvements to foregoing invention technical scheme：
Above-mentioned capsulation stabilizer be beeswax, suet, methylcellulose, ethyl cellulose, polyethylene glycol monostearate, tween-
80th, cetomacrogol 1000, polyethylene glycol 1500, Macrogol 4000, Macrogol 6000, PLURONICS F87, poloxamer
One or more of 407.
Above-mentioned diluent be sunflower oil, peanut oil, soya-bean oil, safflower oil, Seabuckthorn Oil, tea oil, salad oil, polyethylene glycol 400,
More than one of corn oil and propane diols.
The invention discloses a kind of dogbane flower leaf volatile oil soft capsule and preparation method thereof, dogbane flower leaf volatile oil institute
Manufactured capsule product steady quality, has filled up dogbane flower leaf volatile oil preparation and effect has no the blank of report, with respect to it
Its bioavilability of its formulation is higher, the medicine absorption of human body in capsule is more preferable, is safe under the conditions of clinical dosage, spreads out
Capsule made by fried dough twist leaf volatile oil has reducing blood lipid, decompression, antioxidation.
Embodiment
The present invention is not limited by following embodiments, can technique according to the invention scheme and actual conditions it is specific to determine
Embodiment.Percentage in the present invention is mass percent, room temperature is 25 DEG C as not having specified otherwise.
Embodiment 1, the dogbane flower leaf volatile oil soft capsule, raw materials by weight portion include 5 parts to 60 parts dogbane flowers
Leaf volatile oil, 0 part to 20 parts soybean lecithin, 0 part to 2 parts vitamin E, 0 part to 15 parts capsulation stabilizer, 10 parts to 70 parts dilutions
Agent.
Embodiment 2, the dogbane flower leaf volatile oil soft capsule, raw materials by weight portion include 5 parts or 60 parts of dogbane flowers
Leaf volatile oil, 0 part or 20 parts of soybean lecithins, 0 part or 2 parts of vitamin Es, 0 part or 15 parts of capsulation stabilizers, 10 parts or 70 parts of dilutions
Agent.
Embodiment 3, the dogbane flower leaf volatile oil soft capsule, is obtained as follows：The first step, by the desired amount of dilution
Agent is heated to 25 DEG C to 75 DEG C, adds the desired amount of soybean lecithin, capsulation stabilizer is well mixed and obtains mixed once liquid；Second
Step, mixed once liquid add vitamin E and stirred to obtain secondary mixed liquor when temperature is down to 25 DEG C to 35 DEG C；3rd step, will
Dogbane flower leaf volatile oil adds in secondary mixed liquor to stir and is down to room temperature and obtains capsule 's content, and capsule 's content is in glue
Body mill placement, which makes to be pressed into soft capsule after degassing, obtains dogbane flower leaf volatile oil soft capsule.The bluish dogbane floral leaf that the present invention obtains
Soft capsules of volatile oil passes through the capsule product steady quality made by dogbane flower leaf volatile oil, its biology profit of relatively other formulations
Expenditure is higher, the medicine absorption of human body in capsule is more preferable, and the capsule made by dogbane flower leaf volatile oil has reducing blood lipid, drop
Pressure, antioxidation, have filled up dogbane flower leaf volatile oil preparation and effect have no the blank of report.The dogbane flower of the present invention
Leaf volatile oil can take Folium Apocyni Veneti by volatile oil extractor and flower adds 10 times of amount water, and temperature is 90 DEG C to 100 DEG C and decocts three
Secondary, each 1h, the volatile oil for collecting evaporation gained is dogbane flower leaf volatile oil.
Embodiment 4, as the optimization of above-described embodiment, capsulation stabilizer is beeswax, suet, methylcellulose, ethyl fibre
Tie up element, polyethylene glycol monostearate, Tween-80, cetomacrogol 1000, polyethylene glycol 1500, Macrogol 4000, poly- second two
One or more of alcohol 6000, PLURONICS F87, poloxamer188.
Embodiment 5, as the optimization of above-described embodiment, diluent is sunflower oil, peanut oil, soya-bean oil, safflower oil, sea-buckthorn
One or more of oil, tea oil, salad oil, polyethylene glycol 400, corn oil and propane diols.
Embodiment 6, the dogbane flower leaf volatile oil soft capsule, is obtained as follows：The first step, by the desired amount of dilution
Agent is heated to 25 DEG C to 75 DEG C, adds the desired amount of soybean lecithin, capsulation stabilizer is well mixed and obtains mixed once liquid；Second
Step, mixed once liquid add vitamin E and stirred to obtain secondary mixed liquor when temperature is down to 25 DEG C to 35 DEG C；3rd step, will
Dogbane flower leaf volatile oil adds in secondary mixed liquor to stir and is down to room temperature and obtains capsule 's content, and capsule 's content is in glue
Body mill placement, which makes to be pressed into soft capsule after degassing, obtains dogbane flower leaf volatile oil soft capsule；Raw materials by weight portion includes 10 parts
Dogbane flower leaf volatile oil, 79 parts of polyethylene glycol 400s, 8 parts of propane diols, 3 parts of cetomacrogol 1000s.
Embodiment 7, the dogbane flower leaf volatile oil soft capsule, is obtained as follows：The first step, by the desired amount of dilution
Agent is heated to 25 DEG C to 75 DEG C, adds the desired amount of soybean lecithin, capsulation stabilizer is well mixed and obtains mixed once liquid；Second
Step, mixed once liquid add vitamin E and stirred to obtain secondary mixed liquor when temperature is down to 25 DEG C to 35 DEG C；3rd step, will
Dogbane flower leaf volatile oil adds in secondary mixed liquor to stir and is down to room temperature and obtains capsule 's content, and capsule 's content is in glue
Body mill placement, which makes to be pressed into soft capsule after degassing, obtains dogbane flower leaf volatile oil soft capsule；Raw materials by weight portion includes 50 parts
Dogbane flower leaf volatile oil, 2 parts of vitamin Es, 40 parts of tea oil, 5 parts of beeswaxs, 3 parts of polyethylene glycol monostearates.
Pharmacodynamics test is carried out to above-described embodiment 6 and the products obtained therefrom of embodiment 7 below and stability experiment is as follows：
First, pharmacodynamics test：Reducing blood lipid is tested
1.1 experimental design：Male Wistar rat 50, body weight 160g to 180g is chosen, basal feed adaptability is fed one week
Afterwards, tail blood is taken, determines serum cholesterol.Rat is divided into 5 groups, every group 10 according to cholesterol levels and body weight.If basis is raised
Expect control group, high lipid food control group and basic, normal, high three dosage groups, the people that dogbane flower leaf volatile oil soft capsule is recommended
Daily intake is 1.0g/60kg, and the dogbane flower of the gained of embodiment 10 should be taken in daily by thus calculating each dosage group of rat
Leaf volatile oil soft capsule is respectively：Low dose group, 0.083g/kgbW；Middle dose group, 0.167g/kgbW；High dose group,
0.500g/kgbw.It is respectively equivalent to 5 times, 10 times and 30 times of the daily per kilogram of body weight intake of people.After experiment starts, except base
Outside plinth feed control rats feeding basal feed, remaining each group rat is fed with high lipid food.Due to tested material poorly water-soluble,
Tested material is configured to gavage liquid with 3% starch solution, daily oral gavage gives tested material, and gavage amount is 1ml/l00gbW.
Basal feed control group and high lipid food control group give 3% isometric starch solution gavage, continuous gavage 30 days, claim weekly
Body weight.Each group animal ad lib, drinking-water.After 30 days, femoral artery takes blood, separates serum；
1.2 test rating：Serum total cholesterol (TC), triglycerides (TG), HDL-C (HDL-C), use
Enzyme process determines on the automatic clinical chemistry analyzer of Hitachi 7020, and reagent uses Britain's Landau (Randox) biochemical reagents；
1.3 assay
1.3.1 dogbane flower leaf volatile oil soft capsule regulation blood fat experimental rat body weight is shown in Table 1, dogbane flower leaf volatile oil flexible glue
Each dosage group rat body weight of capsule no significant difference compared with high lipid food control group；
1.3.2 influence of the dogbane flower leaf volatile oil soft capsule to rat fat is shown in Table 2；
1.3.2.1 basal feed control rats serum TC and TG contents are substantially less than high lipid food control group, show high fat mould
The foundation of type.
Each dosage group Serum TC of dogbane flower leaf volatile oil soft capsule is horizontal to be less than high lipid food control group, difference tool
There is conspicuousness (P ＜ 0.05)；
1.3.2.3 dogbane flower leaf volatile oil soft capsule is low, middle dose group rat blood serum TG is less than high lipid food control group, difference
With conspicuousness (P ＞ 0.05)；
1.3.2.4 each dosage group rat blood serum HDL-C of dogbane flower leaf volatile oil soft capsule nothings compared with high lipid food control group
Significant change (P ＞ 0.05)；
1.4 result brief summaries：Rat dogbane flower leaf volatile oil soft capsule submitted sample was given through continuous 30 days, in hyperlipidemia mould
On the premise of type is set up, each dosage group serum total cholesterol (TC) of dogbane flower leaf volatile oil soft capsule is raised significantly lower than high fat
Expect control group, low, middle dose group triglycerides (TG) is significantly lower than high lipid food control group, and HDL-C is in height
No significant difference between fat feed control group and each dosage group of dogbane flower leaf volatile oil soft capsule.Therefore, provable bluish dogbane
Floral leaf soft capsules of volatile oil has the function of auxiliary reducing blood lipid；
2nd, pharmacodynamics test：Oxidation Resistance Test
1.1 experimental design：
Experimental animal selects SPF levels Kunming kind male 8-10 monthly ages mouse 50.Experiment sets 3 dosage groups, a solvent control
Group and a control group are commercially available vitamin E soft capsule, every group 10.If the basic, normal, high dosage of sample is respectively 0.083 g/
Kg.bw, 0.167 g/kg.bw, 0.500 g/kg.bw (5,10,30 times that are respectively equivalent to human body recommended amounts).Basic, normal, high dose
When amount is prepared by test solution, dogbane flower leaf volatile oil soft capsule content 0.83g, 1.67g of the gained of difference Example 2,
5.00g adds vegetable oil to give animal subject gavage respectively, gavage volume is 0.1ml/10g.bw, one time a day, even to 100mL oil
It is continuous 30 days.Before experiment, after aged mouse is weighed, adopt tail point blood 20ul addition 0.48ml distilled water and 4% hemolysate is made, by examination
MDA in agent box specification time-and-motion study hemolysate is horizontal.Mouse is divided into control group and three dosage groups by MDA levels.
The mouse of each dosage group of the sample solution of the design various concentrations of basic, normal, high dosage, the solvent that control group receives, control group,
The continuous gavages such as gavage 30 days.Basic, normal, high dosage design various concentrations sample solution each dosage group mouse,
The solvent that control group receives, control group, isometric 30 days of gavage.31st day, adopt the hemolysate lipid peroxidation of tail point hematometry 4%
Matter catabolite MDA (MDA) content, whole blood polyphenoils reductive glutathione (GSH) content；Pluck eyeball take a blood sample from
The heart, take serum measure protein oxidation products content of protein carbonyl group, antioxidant enzyme superoxide mutase (SOD) vigor；
1.2 test rating：
MDA (MDA) content, whole blood polyphenoils reductive glutathione (GSH) content, protein oxidation products albumen
Matter carbonyl content, antioxidant enzyme superoxide mutase (SOD) vigor；
1.3 assay
1.3.1 influence of the dogbane flower leaf volatile oil soft capsule to aged mouse body weight, during experiment, each group growth of animal is just
Often.Each dosage group animal original body mass, mid-term body weight, whole opisthosoma weight and experimental period between weight gain value compared with solvent control group
There was no significant difference (P>0.05) 3 are shown in Table；
1.3.2 influence of the dogbane flower leaf volatile oil soft capsule to the hemolysate lipid peroxide of aged mouse 4%, the examination of high dose group
Test last hemolysate MDA levels has conspicuousness (P with solvent control group comparing difference<0.05) 4 are shown in Table, it is stronger to show that the sample has
Reduction lipid peroxidation；
1.3.3 influence of the dogbane flower leaf volatile oil soft capsule to aged mouse serum superoxide dismutases (SOD) vigor,
The sample of orally administration various dose is after 30 days, and low, middle dosage dogbane flower leaf volatile oil soft capsule is to aged mouse SOD in serum
Without remarkable effect, high dose group serum activity of SOD is significantly higher than and solvent control group (P vigor<0.05) bluish dogbane floral leaf, is shown
Soft capsules of volatile oil has the serum activity of SOD effect of rise aged mouse.In high dose, SOD vigor highests；
1.3.4 influence of the dogbane flower leaf volatile oil soft capsule to aged mouse whole blood reductive glutathione (GSH) content,
There is low dose group, be not significantly different between middle dose group and solvent control group, prompt sieve of whole blood glutathione Aged Mice
Cloth fried dough twist leaf volatile oil capsule, low dose oral dosage do not have significant effect, and only whole blood high dose group GSH is significantly high,
There is a significant difference (P<0.05)；
1.3.5 influence of the dogbane flower leaf volatile oil soft capsule to aged mouse serum proteins carbonyl content, orally administration is not
After the sample 30 days of dosage, each dosage group serum proteins carbonyl content there was no significant difference compared with solvent control group (P ＞
0.05)；
1.3.6 dogbane flower leaf volatile oil soft capsule is lived to aged mouse whole blood reductive glutathione (GSH) content and SOD
The influence of power, there is between high dose group and control group that there were significant differences, and SOD vigor is significantly higher than and control group (P<0.05) it is shown in Table
4；
1.4 result brief summaries：Rat dogbane flower leaf volatile oil soft capsule sample is orally given within continuous 30 days, high dose group has
Notable difference.Therefore, provable dogbane flower leaf volatile oil soft capsule has oxidation resistant function；
3rd, human body takes experiment
Mr. Wang, 42 years old, common office worker, high fat hyperpietic, take dogbane flower leaf volatile oil flexible glue obtained by embodiment 2
Capsule, daily 2, take 1 tablet each time, through examining fasting plasma lipid, T-CHOL CT, triglycerides TG and HDL HDL,
Carry out drinking front and rear contrast test, then carry out curative effect comparison, subject TC, TG are remarkably decreased, and HDL substantially rises.As a result show,
The dogbane flower leaf volatile oil soft capsule of the present invention, it is a kind of safely and effectively preparation.
In summary, the dogbane flower leaf volatile oil soft capsule that the present invention obtains passes through made by dogbane flower leaf volatile oil
Capsule product steady quality, relatively other its bioavilability of formulation are higher, the medicine absorption of human body in capsule is more preferable, spread out
Capsule made by fried dough twist leaf volatile oil has reducing blood lipid, decompression, antioxidation, has filled up dogbane flower leaf volatile oil preparation
And effect has no the blank of report.
Above technical characteristic constitutes embodiments of the invention, and it has stronger adaptability and implementation result, can basis
The non-essential technical characteristic of increase and decrease is actually needed, to meet the needs of different situations.
Claims (7)
1. a kind of dogbane flower leaf volatile oil soft capsule, it is characterised in that raw materials by weight portion includes 5 parts to 60 portions bluish dogbanes
Floral leaf volatile oil, 0 part to 20 parts soybean lecithin, 0 part to 2 parts vitamin E, 0 part to 15 parts capsulation stabilizer, 10 parts to 70 parts it is dilute
Release agent.
2. dogbane flower leaf volatile oil soft capsule according to claim 1, it is characterised in that obtain as follows：First
Step, 25 DEG C to 75 DEG C are heated to by the desired amount of diluent, add the desired amount of soybean lecithin, capsulation stabilizer is well mixed
To mixed once liquid；Second step, mixed once liquid when temperature is down to 25 DEG C to 35 DEG C, add vitamin E stir two
Secondary mixed liquor；3rd step, dogbane flower leaf volatile oil is added in secondary mixed liquor to stir and is down to room temperature and obtains in capsule
Tolerant, capsule 's content is pressed into soft capsule after colloid mill placement makes degassing and obtains dogbane flower leaf volatile oil soft capsule.
3. dogbane flower leaf volatile oil soft capsule according to claim 1 or 2, it is characterised in that capsulation stabilizer is honeybee
Wax, suet, methylcellulose, ethyl cellulose, polyethylene glycol monostearate, Tween-80, cetomacrogol 1000, poly- second two
One or more of alcohol 1500, Macrogol 4000, Macrogol 6000, PLURONICS F87, poloxamer188.
4. the dogbane flower leaf volatile oil soft capsule according to claim 1 or 2 or 3, it is characterised in that diluent is sunflower
Oil, peanut oil, soya-bean oil, safflower oil, Seabuckthorn Oil, tea oil, salad oil, polyethylene glycol 400, corn oil and propane diols it is a kind of with
On.
5. a kind of preparation method of dogbane flower leaf volatile oil soft capsule according to claim 1, it is characterised in that press
State step progress：The first step, the desired amount of diluent is heated to 25 DEG C to 75 DEG C, adds the desired amount of soybean lecithin, encapsulated
Stabilizer is well mixed to obtain mixed once liquid；Second step, mixed once liquid add dimension life when temperature is down to 25 DEG C to 35 DEG C
Plain E stirs to obtain secondary mixed liquor；3rd step, dogbane flower leaf volatile oil is added in secondary mixed liquor to stir and is down to
Room temperature obtains capsule 's content, and capsule 's content is placed to make to be pressed into soft capsule after degassing and obtains bluish dogbane floral leaf and wave in colloid mill
Hair oil soft capsule.
6. the preparation method of dogbane flower leaf volatile oil soft capsule according to claim 5, it is characterised in that encapsulated is stable
Agent be beeswax, suet, methylcellulose, ethyl cellulose, polyethylene glycol monostearate, Tween-80, cetomacrogol 1000,
One or more of polyethylene glycol 1500, Macrogol 4000, Macrogol 6000, PLURONICS F87, poloxamer188.
7. the preparation method of the dogbane flower leaf volatile oil soft capsule according to claim 5 or 6, it is characterised in that diluent
For the one of sunflower oil, peanut oil, soya-bean oil, safflower oil, Seabuckthorn Oil, tea oil, salad oil, polyethylene glycol 400, corn oil and propane diols
More than kind.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710509458.3A CN107349186A (en) | 2017-06-28 | 2017-06-28 | Dogbane flower leaf volatile oil soft capsule and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476830A (en) * | 2003-07-17 | 2004-02-25 | 新疆特丰药业股份有限公司 | Tea-polyphenol soft capsule and its preparation process |
| CN1875949A (en) * | 2006-07-04 | 2006-12-13 | 邵爱霞 | Soft gastrodine capsule and preparation method thereof |
| CN104490961A (en) * | 2014-12-25 | 2015-04-08 | 长春师范大学 | Preparation method and application of folium apocyni veneti extract |
| CN106728533A (en) * | 2015-11-19 | 2017-05-31 | 新疆西域天境农业科技发展有限公司 | Bluish dogbane capsule and preparation method thereof |
-
2017
- 2017-06-28 CN CN201710509458.3A patent/CN107349186A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476830A (en) * | 2003-07-17 | 2004-02-25 | 新疆特丰药业股份有限公司 | Tea-polyphenol soft capsule and its preparation process |
| CN1875949A (en) * | 2006-07-04 | 2006-12-13 | 邵爱霞 | Soft gastrodine capsule and preparation method thereof |
| CN104490961A (en) * | 2014-12-25 | 2015-04-08 | 长春师范大学 | Preparation method and application of folium apocyni veneti extract |
| CN106728533A (en) * | 2015-11-19 | 2017-05-31 | 新疆西域天境农业科技发展有限公司 | Bluish dogbane capsule and preparation method thereof |
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