CN107348940A - Retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting - Google Patents
Retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting Download PDFInfo
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- 230000017531 blood circulation Effects 0.000 title claims abstract description 29
- 230000002207 retinal effect Effects 0.000 title claims abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 23
- 210000001525 retina Anatomy 0.000 claims abstract description 14
- 241000276498 Pollachius virens Species 0.000 claims abstract description 12
- 238000005286 illumination Methods 0.000 claims abstract description 12
- 230000004501 retinal blood flow velocity Effects 0.000 claims abstract description 8
- 238000005259 measurement Methods 0.000 claims abstract description 5
- 238000012545 processing Methods 0.000 claims abstract description 5
- 230000003287 optical effect Effects 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 12
- 238000010146 3D printing Methods 0.000 claims description 5
- 230000004446 light reflex Effects 0.000 claims description 4
- 230000010363 phase shift Effects 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000010287 polarization Effects 0.000 claims description 3
- 229920005479 Lucite® Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 7
- 238000003384 imaging method Methods 0.000 description 5
- 230000002792 vascular Effects 0.000 description 4
- 238000002583 angiography Methods 0.000 description 3
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- 239000011521 glass Substances 0.000 description 3
- 238000012014 optical coherence tomography Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003733 optic disk Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 1
- 201000001949 Retinal Vasculitis Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 210000001957 retinal vein Anatomy 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0285—Measuring or recording phase velocity of blood waves
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Abstract
The invention discloses a kind of retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting, including near-infrared light source, kohler's illumination system, the first Amici prism, model eye, fixation object, collimation lens, the second Amici prism, image-forming objective lens, simultaneous phase-shifting camera and computer.Near-infrared light source produces near-infrared light beam, the uniform after kohler's illumination system, incident human eye to be measured and model eye is respectively perpendicular after the light splitting of the first Amici prism, the two-beam interference after the reflection of surface after human eye retina to be measured and model eye.Simultaneous phase-shifting camera carries out dynamic acquisition to the near-infrared interference light of incidence, and transmit to computer, eyeground dynamic interference image is handled using simultaneous phase-shifting interferometric phase algorithm, the data after processing are analyzed using Doppler range rate measurement model, realize the detection of retinal blood flow speed.The present invention improves the sensitivity of retinal blood flow velocity measuring, improves the accuracy and real-time of angiogram.
Description
Technical field
The invention belongs to biological tissue's parameter detecting field, is related to a kind of based on the interference of Linnik type near-infrareds simultaneous phase-shifting
Retinal blood flow speed detector.
Background technology
Numerous fine vasculars is dispersed with human eye retina, velocity of blood flow is to many ophthalmic diseases in these fine vasculars
Detection have higher directive significance, such as retinal vein obstruction, retinal vasculitis, BDR.Mesh
The retinal vessel angiographic method of main flow is, it is necessary to inject fluorescer, this method side effect and medical treatment on eyeground on preceding clinical ophthalmology
Risk is larger.
The U of Chinese patent CN 205391114 are disclosed《A kind of high-precision VPV detector》, including outer cover, liquid crystal
Display screen, emitter and contact pen.The system is combined using emitter and reception device, using energy converter by height
Frequency signal is launched, and is influenceed by blood flow, and Doppler effect can be produced after reflection, to the doppler shifted signal received
Handled to obtain flow velocity waveforms signal.But because human ocular tissues are complicated and delicate, the impact that can't stand high-frequency signal is held,
Therefore this method is not particularly suited for the detection of human eye retina's VPV.
U.S. Oregon Health＆Science University Yali Jia etc. exist《Quantitative OCT
angiography of optic nerve head blood flow》Ultrahigh speed Optical coherence tomography is used in one text,
The angiogram and VPV detection of retina are completed, and early stage is have detected using brand-new three-dimensional angiography algorithm
The change of the optic papilla of glaucoma.But because Optical coherence tomography is based primarily upon Overlap-scanning imaging, and eyeground is visited
The doppler angle of survey is close to 90 °, therefore the time interval between twice sweep can not effectively shorten, and blood flow detection is insensitive.
Existing blood flow detecting device has damage to human eye, and detection sensitivity is relatively low, can not realize in fine vascular
The accurate detection of faint blood flow, and lack real-time.
The content of the invention
It is an object of the invention to provide a kind of retinal blood flow velocity based on the interference of Linnik type near-infrareds simultaneous phase-shifting
Detection means is spent, overcome traditional Fundus angiography has damage to human eye, on the premise of Non-invasive detection, utilizes simultaneous phase-shifting
The method of interference, the advantages of interferometry is high to phse sensitivity is given full play to, shorten the time of blood flow detection, improve inspection
The sensitivity of survey.
The technical solution for realizing the object of the invention is：A kind of regarding based on the interference of Linnik type near-infrareds simultaneous phase-shifting
Nethike embrane VPV detection means, it is characterised in that：Including near-infrared light source, kohler's illumination system, the first Amici prism, model
Eye, fixation object, collimation lens, the second Amici prism, image-forming objective lens, simultaneous phase-shifting camera and computer；Common optical axis is set successively
Near-infrared light source, kohler's illumination system, the first Amici prism and model eye are put, optical axis where above-mentioned part is primary optic axis；Altogether
Optical axis sets gradually human eye, the second Amici prism, the first Amici prism, image-forming objective lens and simultaneous phase-shifting camera to be measured, above-mentioned portion
Optical axis where part is the second optical axis；Common optical axis sets gradually the second Amici prism, collimation lens and fixation object, above-mentioned part institute
It is the 3rd optical axis in optical axis；Wherein primary optic axis and the 3rd optical axis is parallel to each other, and perpendicular to the second optical axis, and model eye is positioned at the
On the transmitted light path of one Amici prism, human eye to be measured is located on the reflected light path of the first Amici prism, and human eye to be measured is away from first
The distance of Amici prism is equal with the distance of the Amici prism of model eye distance first；Simultaneous phase-shifting camera is connected with computer.
The self luminous collimated collimated of fixation object is incident to the second Amici prism, is reflexed to through the second Amici prism
Human eye to be measured, while near-infrared light source produces near-infrared light beam, the uniform after kohler's illumination system, through the first Amici prism
Light splitting, is divided into the first reflected light and the first transmitted light, the first reflected light enters human eye to be measured, and the first transmitted light enters model eye；
First reflected light reflexes to the first Amici prism through human eye to be measured again, and the first transmitted light is through model eye reflex to the first light splitting rib
Mirror, two-beam interference, the near-infrared interference light formed after interference, regarded comprising human eye to be measured in the near-infrared interference light after interference
The dynamic blood flow information of nethike embrane, concentrated lens converge to simultaneous phase-shifting camera, and simultaneous phase-shifting camera is done to the near-infrared of incidence
Relate to light and carry out dynamic acquisition, obtain eyeground dynamic interference image, and transmit to computer, utilize simultaneous phase-shifting interferometric phase algorithm
The eyeground dynamic interference image collected is handled, the data after processing analyzed using Doppler range rate measurement model,
Realize the detection of retinal blood flow speed.
The present invention compared with prior art, its remarkable advantage：
(1) using the combination of simultaneous phase-shifting camera and simultaneous phase-shifting Non-Interference Algorithm, realize that single acquisition obtains VPV
Information, compared with traditional intraocular fluoroscopic visualization and optical coherence chromatography imaging method, on the premise of lossless decomposition, greatly
The speed for improving blood flow detection, shorten the detection time of human eye, improve the speed and precision of blood flow detection；(2) select
With Linnik type interference systems, the accurate imaging to eyeground fine vascular or even visual cell can be realized, improves fundus imaging
Imaging resolution；(3) reference is used as using the 3D printing model eye based on China opthalmic optics digital model parameter, instead of
Traditional plane mirror, can farthest eliminate human eye to be measured caused by aberration, improve the accuracy of detection.
Brief description of the drawings
Fig. 1 is the retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting of the present invention
Index path.
Fig. 2 is in the retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting of the present invention
Model eye schematic diagram.
Fig. 3 is in the retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting of the present invention
Simultaneous phase-shifting camera pixel array schematic diagram.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
With reference to Fig. 1, a kind of retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting, its
It is characterised by：It is saturating including near-infrared light source 1, kohler's illumination system 2, the first Amici prism 3, model eye 4, fixation object 5, collimation
Mirror 6, the second Amici prism 7, image-forming objective lens 8, simultaneous phase-shifting camera 9 and computer 10；Common optical axis sets gradually near-infrared light source
1st, kohler's illumination system 2, the first Amici prism) and model eye 4, optical axis where above-mentioned part is primary optic axis；Common optical axis is successively
Human eye, the second Amici prism 7, the first Amici prism 3, image-forming objective lens 8 and simultaneous phase-shifting camera 9 to be measured, above-mentioned part institute are set
It is the second optical axis in optical axis；Common optical axis sets gradually the second Amici prism 7, collimation lens 6 and fixation object 5, above-mentioned part institute
It is the 3rd optical axis in optical axis；Wherein primary optic axis and the 3rd optical axis is parallel to each other, and is located at perpendicular to the second optical axis, model eye 4
On the transmitted light path of first Amici prism 3, human eye to be measured is located on the reflected light path of the first Amici prism 3, and human eye to be measured away from
The distance of first Amici prism 3 is equal with distance of the model eye 4 away from the first Amici prism 3；Simultaneous phase-shifting camera 9 and computer 10
It is connected；
The self luminous collimated collimated incident of lens 6 of fixation object 5 is anti-through the second Amici prism 7 to the second Amici prism 7
Human eye to be measured is incident upon, while near-infrared light source 1 produces near-infrared light beam, the uniform after kohler's illumination system 2, through first point
Light prism 3 is divided, and is divided into the first reflected light and the first transmitted light, and the first reflected light enters human eye to be measured, and the first transmitted light enters
Model eye 4；First reflected light reflexes to the first Amici prism 3 through human eye to be measured again, and the first transmitted light reflexes to through model eye 4
One Amici prism 3, two-beam interference, the near-infrared interference light formed after interference, include in the near-infrared interference light after interference
The dynamic blood flow information of human eye retina to be measured, concentrated lens 8 converge to simultaneous phase-shifting camera 9, and simultaneous phase-shifting camera 9 is to entering
The near-infrared interference light penetrated carries out dynamic acquisition, obtains eyeground dynamic interference image, and transmits to computer 10, utilizes synchronous shifting
Interference phase algorithm is handled the eyeground dynamic interference image collected, using Doppler range rate measurement model to processing after
Data are analyzed, and realize the detection of retinal blood flow speed.
The wavelength of described near-infrared light source 1 is 1330nm.
The model eye 4 uses 3D printing, and parameter derives from China's opthalmic optics' digital model, and material is organic glass
Glass.
The parameter of the model eye 4 derives from China's opthalmic optics' digital model, and parameter is as shown in the table：
The structural parameters of China's opthalmic optics' digital model of table 1
Simultaneous phase-shifting camera (9) polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
Described simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods, and corresponding amount of phase shift is respectively 0, pi/2, π and 3 π/
2。
Embodiment 1
With reference to Fig. 1, from 1330nm near-infrared solid laser device 1, its major advantage includes：Human eye scatters at the wavelength
Coefficient is high, readily available more optical fundus blood vessel blood flow informations, improves the sensitivity of blood flow detection, and the laser stability
It is good, to human eye not damaged.Kohler's illumination system 2 is arranged on the light-emitting window of near-infrared light source 1, it is therefore intended that makes near-infrared light source 1
The light sent can uniform, do not produce filament picture.The hot spot of uniform is divided by the first Amici prism 3, is divided into
One reflected light and the first transmitted light, the first reflected light enter human eye to be measured, and the first transmitted light enters model eye 4；First reflected light
Converged at through human lenses to be measured on retina, then the first Amici prism 3 is scattered to through retina, the first transmitted light is through model
Artificial crystal in eye 4 is assembled away from artificial retina, then scatters to the first Amici prism 3 through artificial retina, is thus formed
Linnik types interfere microscopic system.Two-beam interference, the near-infrared interference light formed after interference, the near-infrared interference after interference
The dynamic blood flow information of human eye retina to be measured is included in light, concentrated lens 8 converge to simultaneous phase-shifting camera 9, simultaneous phase-shifting
Camera 9 carries out dynamic acquisition to the near-infrared interference light of incidence, obtains eyeground dynamic interference image, and transmits to computer 10,
The eyeground dynamic interference image collected is handled using simultaneous phase-shifting interferometric phase algorithm, utilizes Doppler range rate measurement model
Data after processing are analyzed, realize the detection of retinal blood flow speed.To ensure the accuracy of testing result, hair is utilized
The fixation object 5 of light realizes being relatively fixed for position of human eye to be measured in detection process.
With reference to Fig. 2, the parameter of model eye 4 of the 3D printing derives from China's opthalmic optics' digital model, and material is to have
Machine glass.China opthalmic optics digital model parameter is as shown in the table：
The structural parameters of China's opthalmic optics' digital model of table 1
In China opthalmic optics digital model, the 1st, 2 faces be cornea front and rear surfaces, represented with quadratic surface；
3rd face is the pupil position of human eye；4th, 5 face is lenticular front and rear surfaces, is also represented using double cubic surface face shape
Method, and refractive index is gradient distribution form；6th face is retina, is expressed with standard sphere, the retinal surface type of bending
It can be good at correcting the curvature of field of angle pencil of ray.
With reference to Fig. 3, the simultaneous phase-shifting camera 6 is pel array profile, and every four pixels form a small array,
Obtain the interference pattern of a certain position of human eye to be measured.The simultaneous phase-shifting camera polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
I.e. once collection can obtain four width interference patterns simultaneously, eliminate the process of conventional interference phase shift, highly shortened data and adopt
Collect the time, while improve the sensitivity of VPV detection.Described simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods,
Corresponding amount of phase shift is respectively 0, pi/2, π and 3 pi/2s.
The method that the present invention is interfered by simultaneous phase-shifting, by the use of 3D printing model eye as reference, obtain human eye to be measured
Retina interference pattern, four step phase-shifting methods are recycled to be demodulated interference fringe, so as to obtain weak vessel image in retina
And velocity of blood flow.Package unit is compact-sized, high sensitivity, is realized in the case of undamaged to human eye to retinal blood
The accurate detection of flow velocity degree, there is larger application prospect.
Claims (6)
- A kind of 1. retinal blood flow speed detector based on the interference of Linnik type near-infrareds simultaneous phase-shifting, it is characterised in that： Including near-infrared light source (1), kohler's illumination system (2), the first Amici prism (3), model eye (4), fixation object (5), collimation Lens (6), the second Amici prism (7), image-forming objective lens (8), simultaneous phase-shifting camera (9) and computer (10)；Common optical axis is set successively Near-infrared light source (1), kohler's illumination system (2), the first Amici prism (3) and model eye (4) are put, optical axis where above-mentioned part is Primary optic axis；Common optical axis set gradually human eye to be measured, the second Amici prism (7), the first Amici prism (3), image-forming objective lens (8) and Simultaneous phase-shifting camera (9), optical axis where above-mentioned part is the second optical axis；Common optical axis sets gradually the second Amici prism (7), collimation Lens (6) and fixation object (5), optical axis where above-mentioned part is the 3rd optical axis；Wherein primary optic axis and the 3rd optical axis are mutually flat OK, and perpendicular to the second optical axis, model eye (4) it is located on the transmitted light path of the first Amici prism (3), human eye to be measured is located at first On the reflected light path of Amici prism (3), and distance of the human eye to be measured away from the first Amici prism (3) and model eye (4) are away from first point The distance of light prism (3) is equal；Simultaneous phase-shifting camera (9) is connected with computer (10)；The collimated lens of self luminous fixation object (5) (6) collimated incident is to the second Amici prism (7), through the second Amici prism (7) human eye to be measured is reflexed to, while near-infrared light source (1) produces near-infrared light beam, uniformly goes out after kohler's illumination system (2) To penetrate, be divided through the first Amici prism (3), be divided into the first reflected light and the first transmitted light, the first reflected light enters human eye to be measured, the One transmitted light enters model eye (4)；First reflected light reflexes to the first Amici prism (3), the first transmitted light through human eye to be measured again The first Amici prism (3), two-beam interference, the near-infrared interference light formed after interference, after interference are reflexed to through model eye (4) Near-infrared interference light in include the dynamic blood flow information of human eye retina to be measured, concentrated lens (8) converge to simultaneous phase-shifting Camera (9), simultaneous phase-shifting camera (9) carry out dynamic acquisition to the near-infrared interference light of incidence, obtain eyeground dynamic interference image, And transmit to computer (10), using simultaneous phase-shifting interferometric phase algorithm at the eyeground dynamic interference image that collects Data after processing are analyzed, realize the detection of retinal blood flow speed by reason using Doppler range rate measurement model.
- 2. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrareds simultaneous phase-shifting Put, it is characterised in that：The wavelength of described near-infrared light source (1) is 1330nm.
- 3. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrareds simultaneous phase-shifting Put, it is characterised in that：The model eye (4) uses 3D printing, and parameter derives from China's opthalmic optics' digital model, and material is Lucite.
- 4. the retinal blood flow velocity measuring dress according to claim 3 based on the interference of Linnik type near-infrareds simultaneous phase-shifting Put, it is characterised in that：The parameter of the model eye (4) derives from China's opthalmic optics' digital model, and parameter is as shown in the table：The structural parameters of China's opthalmic optics' digital model of table 1
- 5. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrareds simultaneous phase-shifting Put, it is characterised in that：Simultaneous phase-shifting camera (9) polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
- 6. the retinal blood flow velocity measuring dress according to claim 5 based on the interference of Linnik type near-infrareds simultaneous phase-shifting Put, it is characterised in that：Described simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods, and corresponding amount of phase shift is respectively 0, pi/2, π and 3 pi/2s.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091108A (en) * | 2018-06-07 | 2018-12-28 | 南京理工大学 | Phase filter searching algorithm based on the segmentation of visual field sub-district |
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| WO2014031961A1 (en) * | 2012-08-23 | 2014-02-27 | University Of Washington Through Its Center For Commercialization | Methods and systems for determining volumetric properties of a tissue |
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- 2017-06-28 CN CN201710506273.7A patent/CN107348940B/en not_active Expired - Fee Related
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| JP2001321340A (en) * | 2000-05-12 | 2001-11-20 | Topcon Corp | Eye characteristics measuring device |
| US20060066869A1 (en) * | 2004-09-30 | 2006-03-30 | Nidek Co., Ltd. | Optical coherence tomography apparatus based on spectral interference and an ophthalmic apparatus |
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