CN107343966A - 一种人工心脏用纳米生物材料的制备方法 - Google Patents

一种人工心脏用纳米生物材料的制备方法 Download PDF

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CN107343966A
CN107343966A CN201710397414.6A CN201710397414A CN107343966A CN 107343966 A CN107343966 A CN 107343966A CN 201710397414 A CN201710397414 A CN 201710397414A CN 107343966 A CN107343966 A CN 107343966A
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金仲恩
全春兰
张帆
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Suzhou Cosmetic New Materials Co Ltd
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Abstract

本发明公开了一种人工心脏用纳米生物材料的制备方法，该方法包括以下步骤：步骤一、按照重量份称取各组分；步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；步骤三、将混合物料置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。本发明的制备方法流程较短，操作简单，成本低，对环境友好，经济效益高。本发明制得人工心脏用纳米生物材料具有优异的生物活性和生物相容性，并且其强度高、机械性能好。

Description

一种人工心脏用纳米生物材料的制备方法
技术领域
本发明属于生物材料领域，涉及一种人工心脏用纳米生物材料的制备方法。
技术背景
心脏病是人类死亡的第二大杀手。在人体心脏因病损而部分或完全丧失功能而不能维持全身正常循环时，可移植一种用人工材料制造的机械装置以暂时或永久地部分或完全代替心脏功能、推动血液循环，这种装置即人工心脏。制备人工心脏目前主要使用高分子聚合物材料，其发展方向是将其改性，在分子链上接枝硅橡胶和维生素e等以进一步改善其生物相容性。随着人工心脏向小型化、耐用性强及低阻力的发展，纳米材料的应用已经不可避免。纳米材料作为与聚合物共混制备得到的纳米复合材料比其它复合材料性能更优异。这主要是由于作为分散相的纳米粒子尺寸小，比表面积大而产生的量子效应和表面效应，使得纳米复合材料在众多方面表现出特有性能，如电、磁、热力学等。但是由于纳米粒子尺寸上的特殊性以及与聚合物基体的相容性等因素，使得纳米材料在聚合物中易发生团聚，产生相分离，反而降低了聚合物本身的性能。综上所述，急需提供一种相容性高、安全性高的人工心脏用纳米生物材料是本领域亟待解决的技术问题。
发明内容
本发明的目的在于针对现有技术的不足，提供一种人工心脏用纳米生物材料的制备方法。
本发明的目的是通过以下技术方案实现的：一种人工心脏用纳米生物材料的制备方法，所述方法包括以下步骤：
步骤一、按照重量份称取硅橡胶50-70份、碳纳米管25-40份、甲基丙稀酸缩水甘油酯1-6份、纳米银6-12份、聚乳酸纤维12-16份、纳米氧化钙粉4-6份、甘胆酸钠2-6份、纳米羟基磷灰石 10-15份、壳聚糖6-14份、聚乙二醇1-5份、甘薯淀粉12-18份、羧基化细菌纤维素5-9份、三羟甲基丙烷三甲基丙烯酸酯1-4份、蚕丝蛋白20-30份、六钛酸钾晶须2-5份、偶联剂3-5份和蒸馏水70-105份；
步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；
步骤三、将混合物料于180-190℃下置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。
所述纳米银粒径为30-50nm。
所述步骤二中，密炼的温度为60-80℃，时间为60-100分钟。
所述羧基化细菌纤维素和蚕丝蛋白的质量比为1:4。
所述壳聚糖的黏均相对分子质量为10-30万，脱乙酰度 >85％。
本发明具有以下有益效果：本发明的制备方法流程较短，操作简单，成本低，对环境友好，经济效益高。本发明制得人工心脏用纳米生物材料具有优异的生物活性和生物相容性，并且其强度高、安全性高、机械性能好。
具体实施方式
实施例1
一种人工心脏用纳米生物材料的制备方法，所述方法包括以下步骤：
步骤一、按照重量份称取硅橡胶50份、碳纳米管25份、甲基丙稀酸缩水甘油酯1份、纳米银6份、聚乳酸纤维12份、纳米氧化钙粉4份、甘胆酸钠2份、纳米羟基磷灰石 10份、壳聚糖6份、聚乙二醇1份、甘薯淀粉12份、羧基化细菌纤维素5份、三羟甲基丙烷三甲基丙烯酸酯1份、蚕丝蛋白20份、六钛酸钾晶须2份、偶联剂3份和蒸馏水70份；
步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；
步骤三、将混合物料于180-190℃下置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。
所述纳米银粒径为30-50nm。
所述步骤二中，密炼的温度为60-80℃，时间为60-100分钟。
所述壳聚糖的黏均相对分子质量为10-30万，脱乙酰度 >85％。
实施例2
一种人工心脏用纳米生物材料的制备方法，所述方法包括以下步骤：
步骤一、按照重量份称取硅橡胶60份、碳纳米管36份、甲基丙稀酸缩水甘油酯4份、纳米银9份、聚乳酸纤维14份、纳米氧化钙粉5份、甘胆酸钠4份、纳米羟基磷灰石 13份、壳聚糖10份、聚乙二醇3份、甘薯淀粉15份、羧基化细菌纤维素7份、三羟甲基丙烷三甲基丙烯酸酯2份、蚕丝蛋白28份、六钛酸钾晶须4份、偶联剂4份和蒸馏水90份；
步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；
步骤三、将混合物料于180-190℃下置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。
所述纳米银粒径为30-50nm。
所述步骤二中，密炼的温度为60-80℃，时间为60-100分钟。
所述壳聚糖的黏均相对分子质量为10-30万，脱乙酰度 >85％。
实施例3
一种人工心脏用纳米生物材料的制备方法，所述方法包括以下步骤：
步骤一、按照重量份称取硅橡胶70份、碳纳米管40份、甲基丙稀酸缩水甘油酯6份、纳米银12份、聚乳酸纤维16份、纳米氧化钙粉6份、甘胆酸钠6份、纳米羟基磷灰石 15份、壳聚糖14份、聚乙二醇5份、甘薯淀粉18份、羧基化细菌纤维素9份、三羟甲基丙烷三甲基丙烯酸酯4份、蚕丝蛋白30份、六钛酸钾晶须5份、偶联剂5份和蒸馏水105份；
步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；
步骤三、将混合物料于180-190℃下置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。
所述纳米银粒径为30-50nm。
所述步骤二中，密炼的温度为60-80℃，时间为60-100分钟。
所述壳聚糖的黏均相对分子质量为10-30万，脱乙酰度 >85％。
以上所述,仅是本发明的较佳实施例而已,并非对本发明作任何形式上的限制,虽然本发明已以较佳实施例揭露如上,然而并非用以限定本发明，任何熟悉本专业的技术人员,在不脱离本发明技术方案范围内,当可利用上述揭示的技术内容作出些许更动或修饰为等同变化的等效实施例,但凡是未脱离本发明技术方案的内容,依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰,均仍属于本发明技术方案 的范围内。

Claims (5)

1.一种人工心脏用纳米生物材料的制备方法，其特征在于，所述方法包括以下步骤：步骤一、按照重量份称取硅橡胶50-70份、碳纳米管25-40份、甲基丙稀酸缩水甘油酯1-6份、纳米银6-12份、聚乳酸纤维12-16份、纳米氧化钙粉4-6份、甘胆酸钠2-6份、纳米羟基磷灰石10-15份、壳聚糖6-14份、聚乙二醇1-5份、甘薯淀粉12-18份、羧基化细菌纤维素5-9份、三羟甲基丙烷三甲基丙烯酸酯1-4份、蚕丝蛋白20-30份、六钛酸钾晶须2-5份、偶联剂3-5份和蒸馏水70-105份；
步骤二、将各组分于混合搅拌机中混合均匀后，进行密炼，得混合料；
步骤三、将混合物料于180-190℃下置于双螺杆挤出机中挤出样条经水冷、风干、切粒，即得。
2.根据权利要求1所述的一种人工心脏用纳米生物材料的制备方法，其特征在于：所述纳米银粒径为30-50nm。
3.根据权利要求1所述的一种人工心脏用纳米生物材料的制备方法，其特征在于：所述步骤二中，密炼的温度为60-80℃，时间为60-100分钟。
4.根据权利要求1所述的一种人工心脏用纳米生物材料的制备方法，其特征在于：所述羧基化细菌纤维素和蚕丝蛋白的质量比为1:4。
5.根据权利要求1所述的一种人工心脏用纳米生物材料的制备方法，其特征在于：所述壳聚糖的黏均相对分子质量为10-30万，脱乙酰度 >85％。
CN201710397414.6A 2017-05-31 2017-05-31 一种人工心脏用纳米生物材料的制备方法 Pending CN107343966A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787213A (zh) * 2010-03-30 2010-07-28 上海工程技术大学 晶须硫酸钙改性的硅橡胶复合材料及其制备方法
CN103108920A (zh) * 2010-09-17 2013-05-15 泰尔茂株式会社 硅橡胶组合物
CN104945887A (zh) * 2015-06-30 2015-09-30 苏州佑君环境科技有限公司 一种人工心脏用复合材料的制备方法
CN104987703A (zh) * 2015-06-30 2015-10-21 苏州乔纳森新材料科技有限公司 一种人工心脏用聚醚氨醋材料的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787213A (zh) * 2010-03-30 2010-07-28 上海工程技术大学 晶须硫酸钙改性的硅橡胶复合材料及其制备方法
CN103108920A (zh) * 2010-09-17 2013-05-15 泰尔茂株式会社 硅橡胶组合物
CN104945887A (zh) * 2015-06-30 2015-09-30 苏州佑君环境科技有限公司 一种人工心脏用复合材料的制备方法
CN104987703A (zh) * 2015-06-30 2015-10-21 苏州乔纳森新材料科技有限公司 一种人工心脏用聚醚氨醋材料的制备方法

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Application publication date: 20171114