CN107334783A - Nutritional supplementation and anti-decayed tooth complexing agent product composition and preparation method - Google Patents
Nutritional supplementation and anti-decayed tooth complexing agent product composition and preparation method Download PDFInfo
- Publication number
- CN107334783A CN107334783A CN201610277149.3A CN201610277149A CN107334783A CN 107334783 A CN107334783 A CN 107334783A CN 201610277149 A CN201610277149 A CN 201610277149A CN 107334783 A CN107334783 A CN 107334783A
- Authority
- CN
- China
- Prior art keywords
- complexing agent
- nutritional supplementation
- decayed tooth
- tooth complexing
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000008139 complexing agent Substances 0.000 title claims abstract description 62
- 230000009469 supplementation Effects 0.000 title claims abstract description 61
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- 239000000203 mixture Substances 0.000 title description 12
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The present invention provides a kind of nutritional supplementation and anti-decayed tooth complexing agent and preparation method thereof, the nutritional supplementation and anti-decayed tooth complexing agent include an acid water calcium phosphate compound and alkaline oxygenated calcium compound, and the nutritional supplementation and anti-decayed tooth complexing agent are single stable chewing gum, candy, cake, chewable tablets or buccal tablet.The calcium and phosphate ion discharged with remineralization and can repair decayed tooth, while suppress oral bacteria growth and plaque bio-film is formed, and it is acid neutralize oral cavity, there is provided calcium is as nutritional supplementation.The nutritional supplementation and anti-decayed tooth complexing agent can make active ingredient and be added to other external application delivery vehicles, including the japanning of toothpaste, dentistry, tooth pad pasting, mouthwash, gel, fissure sealant, dental cement, compound resin.
Description
Technical field
The present invention relates to a kind of nutrition and health care complementary goods, more particularly to a kind of nutritional supplementation and anti-decayed tooth complexing agent product
Composition and preparation method.
Background technology
Chewing gum on the market is all the material composition (including synthetic rubber, resin and wax) by synthesizing at present.Chewing gum
Confirm have the function that to take care of one's teeth by science, chew is ptyalized, and saliva can neutralize and wash away food by mouth
Acid caused by the decomposition of chamber bacterium.For a long time under acid, dental enamel can be decomposed, and tooth is easily corroded.Clinical test shows meal
After chew sugar-free chewing gum and can prevent within 20 minutes erosion of teeth, chewing gum simultaneously can also be when release prevention or the instrument of therapeutic agent.
Calcium is supplement bone, necessary to dental health.Chewing gum is that very easily formulation, chewing gum are added one kind
Enter antibiotic, mineral matter etc..Such as shown in international publication No. w098/18399, clinical test, which is shown, contains 10 % anhydrous phosphoric acids two
Calcium (Dicalcium phosphate anhydrous, DCPA), without obvious anti-decayed tooth effect (Finn ＆ Jamism,
1967. J. Am. Dent. Assoc. 74:987-995; Richardson, et al., 1972, J. Canad.
Dent. Assoc. 6:213-218).In another experiment, a water calcium phosphate (Monocalcium phosphate
Monohydrous, a water calcium phosphate) and etc. mole concentration anhydrous dicalcium phosphate and tetracalcium phosphate (Tetracalcium
Phosphate, TTCP) in chewing gum, a water calcium phosphate and DCPA/ TTCP are shown in crunching and can increased for 16 minutes for addition
The concentration of calcium and phosphoric acid (Chow et al., 1994, J. Deut. Res. 73 in saliva:26-32).United States Patent (USP)
5037639,5268167,5427768,5437857 disclose Amorphous calcium phosphate（Amorphous phosphorus
Sour calcium）And its derivative is made an addition in chewing gum for remineralization of teeth.
Although foregoing invention has effect, each defective.For example, a water calcium phosphate can ptyalize, still
The acid-base value of saliva can be reduced, is unfavorable for dental health.Meanwhile it is also few to discharge calcium amount.DCPA/ TTCP processing procedures are difficult：
Then TTCP must be ground to required granular size, could be mixed with DCPA in 1500 DEG C of preparations.ACP must sink in aqueous phase
Form sediment, composition, size inequality and permanence be present.Calcium salt and phosphate can discharge calcium ion and phosphate ion, but also can
Release Astringent counterions（Convergence confrontation ion）.CPP-amorphous calcium phosphate at present（CPP-
ACP）(active ingredient in the chewing gum and candy of CN 450888A PCT/US00/02142 oral healths) makes extensively in clinic
With.The clinical laboratory data that the science panel (CSA) of American Dental Association (ADA) is recent shows, these evidences
It is not enough to recommend any mineral formula of prevention of dental caries treatment, including the product based on CPP-amorphous calcium phosphate
（Product based on CN 1450888A PCT/US00/02142 patents）(the floride-free pre- anti-caries of Rethman, M.P. et al.
Agent：Evidential clinical recommendation, which performs, summarizes J Am Dent Assoc 142,1065-1071 (2011)).Calcium phosphate
(Ca-P) many external application delivery vehicles are added into, while are applied to toothpaste, chewing gum, paint and mouthwash with being commercially used.
(Zero, D.T. toothpaste, mouthwash and remineralization/carious tooth suppress the tactful Suppl 1, S9 of BMC Oral Health 6
(2006)) major defect of CPPs-amorphous calcium phosphate is, acid microcosmic when remineralization of teeth occurs
Its solubility is relatively low under environment.How calcium ion and phosphonium ion are kept, be in the calcium phosphate of supply bioavailable whenever necessary
One significant challenge, which prevent the mass product application based on calcium phosphate for preventing and controlling carious tooth.Therefore, when tooth quilt
During the acid product attack of oral bacteria, the product based on CPP-amorphous calcium phosphate is difficult to rapidly enough
Concentration provides amorphous calcium phosphate for remineralization of teeth.Tooth stills need a more preferable calcium constituent and P elements supply system.
The content of the invention
The present invention by an acid water calcium phosphate and alkaline oxygenated calcium, arginine, and xylitol be added into chewing gum, candy,
Cake, chewable tablets or buccal tablet, it is acid to neutralize oral cavity so that remineralization of teeth, and suppress oral bacteria growth.An acid water
Both calcium phosphate and alkaline oxygenated calcium ratio (percentage by weight or mole concentration ratio) are tieed up when being set in product in saliva of buccal cavity
Acid-base value is held between 4.5 to 8, preferable acid-base value is between 5 to 7.5.Advantage using this two kinds of compounds is：
（1）One water calcium phosphate is that calcium phosphate dissolves most fast and solubility highest in water, can release the phosphorus of high concentration
Acid.Calcium oxide is to dissolve most calcium in calcium class in water, so discharging the calcium of high concentration.This two kinds of compounds are mixed, can
The constituent of high concentration is provided to carry out remineralization of teeth, without other unwanted ions.
（2）The acidity of one water calcium phosphate is unfavorable to tooth, but is neutralized by the calcium oxide of alkalescence and arginine, the two
Solubility is complementary.
（3）When a water calcium phosphate dissolves, the acid-base value of solution declines, and the acid-base value of decline can make the solubility of calcium oxide
Increase, Calcium oxide dissolution can rise acid-base value, and the acid-base value of rising can make water calcium phosphate solubility increase, so above-mentioned two
The solubility of kind compound is adjusted mutually to an optimal acid-base value and solubility ratio.Above-mentioned two kinds of compounds are fragrant in mouth
This reaction is not had in sugar, buccal tablet or other formulations, reaction is started in oral cavity, when chewing or sucking in the oral cavity, by
In saliva or moisture content being present simultaneously so that said two devices compound discharges.Said two devices compound is adjusted mutually to maintain most
Good calcium, phosphoric acid concentration and acid-base value, the calcium ion and phosphate ion of release are precipitated as calcium phosphate on tooth or in tooth,
It can repair and prevent to decay tooth.
（4）Arginine is basic amino acid, and it is essential amino acid, but people itself can not synthesize substantially, need to be from food
Supplement is drawn in thing or nutriment.Arginine suppresses oral bacteria growth, and it is acid to neutralize oral cavity.
（5）Xylitol is that natural materials are widely present in nature.Xylitol is a kind of crude sweet for coming from string
Taste agent.Xylitol is different from sucrose, and neutral pH can be kept in oral cavity.Xylitol can prevent to be adhered to the bacterium of tooth.
Because the oral bacteria for causing carious tooth can not digest xylitol, the growth rate of oral bacteria is greatly reduced.Xylitol and arginine
Synergy, cooperatively suppresses oral bacteria growth and plaque bio-film is formed, and it is acid to neutralize oral cavity.
There is provided it is stable, anhydrous, comprising a water calcium phosphate and calcium oxide, chewing gum, candy, the cake of arginine and xylitol
Point, chewable tablets or buccal tablet, remineralization of teeth can be effectively realized, calcium also provides the supplement of body nutrition simultaneously,
And suppress oral bacteria growth and plaque bio-film is formed, it is acid to neutralize oral cavity.Disclosed herein a kind of nutritional supplementation
With anti-decayed tooth complexing agent, other many external application delivery vehicles, including the japanning of toothpaste, dentistry can also be added into, tooth pad pasting, is gargled
Saliva, gel, fissure sealant, dental cement, compound tree purport.Further, product, which can add, prevents calcium phosphate from sinking
The stabilization agent in shallow lake strengthens validity, and stabilization agent includes magnesium carbonate and sodium pyrophosphate, these stabilization agents can prevent a water phosphoric acid
Calcium and calcium oxide react in storage.It is simultaneously molten when they are being chewed with a water calcium phosphate and calcium oxide in the oral cavity
Solution, further stable calcium ion and phosphate ion, so calcium ion and phosphate ion can penetrate into tooth reprecipitation
Into calcium phosphate.
Technique according to the invention scheme, the present invention provide a kind of nutritional supplementation and anti-decayed tooth complexing agent, and the nutrition is mended
Fill and anti-decayed tooth complexing agent includes an acid water one-lime phosphate compound and alkaline oxygenated calcium compound, the nutritional supplementation and anti-
The complexing agent that decays tooth is single stable chewing gum, candy, cake, chewable tablets or buccal tablet.The nutritional supplementation and anti-decayed tooth
Complexing agent can also make active ingredient and be added to other external application delivery vehicles, including toothpaste, dentistry are painted, tooth pad pasting, mouthwash,
Gel, fissure sealant, dental cement, compound tree purport.
Wherein, the oxidation calcium compound is calcium oxide.
Wherein, the oxidation calcium compound is calcium hydroxide.
Wherein, the water calcium phosphate accounts for percentage by weight as 0.1% to 15%.
Wherein, the water calcium phosphate accounts for percentage by weight as 1% to 10%.
Wherein, the mole concentration ratio of the water calcium phosphate and the calcium oxide is 5 to 0.2.
Wherein, the mole concentration ratio of the water calcium phosphate and the calcium oxide is 2 to 0.5.
Wherein, the nutritional supplementation and anti-decayed tooth complexing agent include stabilization agent.
Wherein, the stabilization agent is magnesium carbonate.
Wherein, the stabilization agent is sodium pyrophosphate.
Wherein, the nutritional supplementation and anti-decayed tooth complexing agent include basic amino acid.
Wherein, the basic amino acid is arginine.
Wherein, the basic amino acid is lysine.
Wherein, the nutritional supplementation and anti-decayed tooth complexing agent include non-degradable replacement sugar alcohol.
Wherein, the non-degradable replacement sugar alcohol is xylitol.
Wherein, the non-degradable replacement sugar alcohol is sorbierite.
Technique according to the invention scheme, the nutritional supplementation and anti-decayed tooth complexing agent include an acid water calcium phosphate chemical combination
Thing and alkaline glycerol calcium phosphate, the nutritional supplementation and it is anti-decayed tooth complexing agent be single stable chewing gum, candy, cake or
Buccal tablet.
Wherein, the nutritional supplementation and anti-decayed tooth complexing agent include basic amino acid.
Wherein, the basic amino acid is arginine.
Wherein, the basic amino acid is lysine.
Wherein, the nutritional supplementation and anti-decayed tooth complexing agent include non-degradable replacement sugar alcohol.
Wherein, the non-degradable replacement sugar alcohol is xylitol.
Wherein, the non-degradable replacement sugar alcohol is sorbierite.
Embodiment
Describe to be used to disclose the present invention below so that those skilled in the art can realize the present invention.It is excellent in describing below
Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.Define in the following description
General principle of the invention can apply to other embodiments, deformation program, improvement project, equivalent and do not carry on the back
From the other technologies scheme of the spirit and scope of the present invention.
According to a preferred embodiment of the invention, there is provided a kind of nutritional supplementation and anti-decayed tooth complexing agent and preparation method thereof, institute
State nutritional supplementation and anti-decayed tooth complexing agent includes an acid water calcium phosphate compound and alkaline oxygenated calcium compound, the nutrition is mended
Fill and anti-decayed tooth complexing agent be single stable chewing gum, candy, cake, chewable tablets or buccal tablet, promote remineralization of teeth,
Suppress oral bacteria growth, it is acid to neutralize oral cavity, there is provided calcium is as nutritional supplementation.The nutritional supplementation and anti-decayed tooth complexing agent
Active ingredient can be made and be added to other external application delivery vehicles, including the japanning of toothpaste, dentistry, tooth pad pasting, mouthwash, gel, nest
Fissure seal, dental cement, compound tree purport.
It will be appreciated by those skilled in the art that " chewing gum ", " unicity " and " stability " that the present invention refers to is fixed respectively
Justice is：
" chewing gum " includes what any formulation can chew in oral cavity, such as bubble gum, candy etc..
" unicity " is to represent that acidity and alkaline calcium compound are simultaneously or sequentially put into a medium in the present invention,
Rather than be put into two media, and the present invention adds stabilization agent to be allowed to feasible.
" stability " refers to that a water calcium phosphate in product and calcium oxide do not have suitable journey in storage in the present invention
The effect of degree, this stability can add stabilization agent in the product to reach.
Invention shows a kind of method and product for being obviously improved remineralization of teeth.Using chewing gum, candy, cake,
The dosage form products such as buccal tablet, comprising stabilization agent, acid calcium phosphate and water-soluble calcium compound, caused calcium ion and phosphate ion
Gratifying remineralization sediment can be reacted into, is deposited in tooth structure, the calcium discharged is also the nutrition needed for body
Supplement.
Summarize above-mentioned, the present invention includes：
（A）The water calcium phosphate of aqueous acidic one.
（B）Water-soluble alkaline calcium oxide.
（C）One stabilization agent for having enough effect amounts, can effectively suppress the reaction between a water calcium phosphate and calcium oxide.
When being chewed in oral cavity, due to saliva be present, stabilization agent can stabilize the phosphate ion discharged by a water calcium phosphate, can also stabilize
The calcium ion discharged by calcium oxide, phosphate ion and calcium ion is promoted to reach and be deposited on tooth or in tooth.
（D）Single Medium.
" effective " calcium and phosphatic amount refer to, it is sufficient to promote damage under dental surface significantly remineralization, and/
Or promote the dental canaliculus (dentinal tubules) that exposes significantly mineralising.In the relatively specific manifestation of preference, this hair
Bright chewing gum includes a water calcium phosphate of approximate weight percentage 0.1 to 15%, mole of the water calcium phosphate to calcium oxide
Concentration ratio is 5 to 0.2, and more preferably specific manifestation is, percentage by weight is 1 to arrive l0 %, a water calcium phosphate to calcium oxide not
Ear concentration ratio is 2 to 0.5.
（E）Non-degradable replacement sugar alcohol-xylitol.
（F）Basic amino acid-arginine.
According to the above preferred embodiment of the present invention, the formula of the nutritional supplementation and anti-decayed tooth complexing agent is：
Concentration of component (percentage by weight %)
Gel matrix (Gum Base) 23.0
Lecithin (Lecithin) 0.6
Xylitol (Xylitol) 24.7
Sorbierite (Sorbitol) 23.0
Arginase 12 .0
One water calcium phosphate (Monocalcium Phosphate Monohydrous) 5.0
Calcium hydroxide (Calcium Hydroxide) 1.0
Mannitol (Mannitol) 9.0
Glycerine (Glycerol) 9.5
High sugariness agent (High density sweetener) 0.8
Flavouring (Flavor) 1.4
According to a preferred embodiment of the invention, arginine is basic amino acid, and it is essential amino acid, but people itself is basic
It can not synthesize, supplement need to be drawn from food or nutriment.As common amino acid, arginine is naturally occurring in saliva.L-
Arginine is a kind of nontoxic amino acid, and many bacterium increments need L-arginine.Researcher's confirmation, the L-arginine of high concentration
Cause biofilm breakup（Kolderman et al. L-Arginine Destabilizes Oral Multi-Species
Biofilm Communities Developed in Human Saliva. PLoS One. 6;10:e0121835. doi:
10.1371/journal.pone.0121835.）.L-arginine needs to be suspended in Suitable solutions, and concentration range is between 50mM
To 500mM, the biomembrane of generation is exposed to the L-arginine of the concentration.The concentration range is causing dental decayed tooth biofilm breakup
It is especially effective.Arginine bicarbonate/calcium carbonate chaw helps to maintain dental health, keeps normal oral cavity acid-base value.
Clinical random experiment is shown, includes the toothpaste of arginine-bicarbonate（Epstein SR, Mandel I,
Scopp IW. Salivary composition and calculus formation in patients undergoing
hemodialysis. J Periodontol 1980; 51(6): 336–338 ）And sugarless mint（Clancy A, Burne
RA. Construction and characterization of a recombinant ureolytic
Streptococcus mutans and its use to demonstrate the relationship of urease
activity to pH modulating capacity. FEMS Microbiol Lett 1997; 151(2): 205–
211. ）With significant anti-caries tooth effect.Report display, mouthwash addition arginine-bicarbonate, concentration as little as 2%
Be obviously improved the acid-base value of bacterial plaque, the acid-base value be higher than face sucrose challenge when dental enamel dissolution acid-base value (Wang X,
Peng D, Gan Y. Effects of urea and arginine-bicarbonate solutions on plaque
pH. Proceedings of International Association of Dental Research Annual
Meeting 2012; 20–23 June 2012) International Association of Dental Research
)。
Clinical test is shown, arginine/bicarbonate and the tooth paste product containing polcarb, is contained or without fluorination
Thing, closure and sealing dentinal tubule can significantly decrease dentine hypersensitivity degree (Schiff T, Delgado E, Zhang
YP, Cummins D, DeVizio W and Mateo LR.Clinical evaluation of the efficacy of
an in-office desensitizing paste containing 8% arginine and calcium carbonate
in providing instant and lasting relief of dentin hypersensitivity. Am J
Dent. 2009;22 (Spec No A): 8A-15A).Display is assessed in clinical research, arginine/bicarbonate and contains carbonic acid
The tooth paste product of calcium salt, contains or not fluoride, has significant anti-caries tooth characteristic (Kraivaphan P, Amornchat
C, Triratana T, et al. Two-year caries clinical study of the efficacy of
novel dentifrices containing 1.5% arginine, an insoluble calcium compound,
and 1450ppm fluoride. Caries Res. 2013;47:582-90).
Therefore, the essential amino acid as human body, arginine are natural and safe, can be used as nutriment.As
The active ingredient of the present invention, arginine have many beneficial oral health benefits.In short, arginine can suppress to cause carious tooth
Bacterial growth and promote healthy mouth bacterial growth, as acid acceptor assist maintain oral environment acid-base value.It is easy to
Remove and destroy the biomembrane of tooth, when combining calcium ion, efficiently reduce carious tooth and treat dentine hypersensitivity degree.Smart ammonia
Acid has other beneficial health characteristics.For example, arginine assists the blood pressure kept fit, the cholesterol levels of health are supported,
Blood flow is adjusted, supports the health of artery, diastole and loosens artery.
Xylitol is that natural materials are widely present in nature.Human body contains a small amount of xylitol.Xylitol is natural
With safety.WHO gives most security rating of the xylitol as food additive.Xylitol is that one kind comes from
The natural sweetener of string.Xylitol is different from sucrose, and neutral pH can be kept in oral cavity.Xylitol can be pre- anti-sticking
Invest bacterium (Lingstrom P, Lundgren F, Birkhed D, Takazoe I, the Frostell G. of tooth
Eur. J. Oral Sci. 1997)。
Take care of one's teeth from tooth erosion.Oral cavity characteristic based on xylitol, acidic materials time of attack is more than one and half
Hour (Miyasawa H, Iwami Y, Mayanagi H, Takahashi N.Oral Microbiol. Immunol.
2003), because the oral bacteria for causing carious tooth can not digest xylitol, the growth rate of oral bacteria is greatly reduced.Produce acid
The bacterial number of product declines to a great extent 90%.Because sialic acid basicity make it that acidic materials can not be generated, bacterial plaque can not come off.
After adding xylitol, bacterium is no longer adhere closely to dental surface, thus bacterial plaque quantity reduce (Holgerson PL,
Sjostrom I, Stecksen-Blicks C, Twetman S. Int J Paediatr Dent 2007). Research
has shown that the use of xylitol also helps repair damage to the enamel
(Caglar E, Kavaloglu SC, Kuscu OO, Sandalli N, Holgerson PL, Twetman S. Clin
Oral Investig 2007)。
Display is assessed in research can help the infringement of repairing dental enamel using xylitol.Saliva autoprotection oral cavity and its tooth
Tooth.Simulation saliva comprising composition needed for whole repairs early stage decayed tooth.Oral cavity effect of xylitol also includes saliva.Contain xylose
Simulation saliva of the alkalescence of alcohol saliva apparently higher than other carbohydrate products.Add the product of xylitol, the primary amino acid of saliva
Concentration and ammonia density rise, and bacterial plaque acid-base value equally rises (Holgerson PL, Sjostrom I, Stecksen-
Blicks C, Twetman S. Int J Paediatr Dent 2007).Therefore, xylitol and arginine can cooperate
To suppress oral bacteria biomembrane, neutral pH is maintained in oral cavity.Xylitol have other beneficial to the effect of.Research is aobvious
Show, daily oral 8 grams of xylitols, prevent 40% ear infection.Xylitol is consistent with sweetness of cane sugar, xylitol compared with sucrose,
40% calorie is reduced, reduces by 75% carbohydrate.Especially, xylitol be only slowly absorbed and metabolism so that insulin fluctuate
It is extremely small.Based on xylitol characteristic, blood glucose will not be caused to rise.Therefore, since the sixties in 19th century, xylitol is as sugar
The preferable sweetener for urinating disease diet is used for Germany, Switzerland, Russia and Japan.
To sum up chatted, the present invention provides a kind of nutritional supplementation and anti-decayed tooth complexing agent product composition and preparation method, promotes
Calcium and phosphoric acid, arginine, xylitol form formula complexing agent with nutrition, can suppress oral bacteria growth, neutralize mouth
Chamber is acid, while by remineralization of teeth.Product composition includes the water calcium phosphate of soluble acidic calcium phosphate compound one and alkaline oxygenated
Calcium compound, arginine, xylitol, as chewing gum, candy, cake, chewable tablets, the additive of buccal tablet, make calcium and phosphoric acid
Ion maintains one effective in cure time in oral cavity, is slowly discharged.The calcium and phosphate ion discharged can be with remineralization
And decayed tooth is repaired, arginine and xylitol synergy, suppress oral bacteria growth, it is acid to neutralize oral cavity.The calcium discharged,
Arginine and xylitol can also turn into nutritious supplementary pharmaceutical, and this additive can avoid using calcium containing only calcium and phosphate ion
The holding back property and saltiness of salt and phosphate confrontation ion.
It should be understood by those skilled in the art that the embodiments of the invention shown in foregoing description be only used as citing and not
The limitation present invention.The purpose of the present invention completely and effectively realizes.The function and structural principle of the present invention is in embodiment
Middle displaying and explanation, under without departing from the principle, embodiments of the present invention can have any deformation or modification.
Claims (24)
1. a kind of nutritional supplementation and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and anti-decayed tooth complexing agent include acid
Property one water calcium phosphate compound, alkaline oxygenated calcium compound, basic amino acid and non-degradable replacement sugar alcohol, the nutritional supplementation and
Anti- decayed tooth complexing agent is single stable chewing gum, candy, cake, chewable tablets or buccal tablet, the nutritional supplementation and anti-moth
Tooth complexing agent can be added into other external application delivery vehicles, including the japanning of toothpaste, dentistry, tooth pad pasting, mouthwash, gel, nest ditch
Sealer, dental cement or compound resin.
2. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that it is described oxidation calcium compound be
Calcium oxide.
3. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that it is described oxidation calcium compound be
Calcium hydroxide.
4. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the water calcium phosphate accounts for weight
It is 0.1% to 15% to measure percentage.
5. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the water calcium phosphate accounts for weight
It is 1% to 10% to measure percentage.
6. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the water calcium phosphate and institute
The mole concentration ratio for stating calcium oxide is 5 to 0.2.
7. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the water calcium phosphate and institute
The mole concentration ratio for stating calcium oxide is 2 to 0.5.
8. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and anti-moth
Tooth complexing agent includes stabilization agent.
9. nutritional supplementation according to claim 8 and anti-decayed tooth complexing agent, it is characterised in that the stabilization agent is carbonic acid
Magnesium.
10. nutritional supplementation according to claim 8 and anti-decayed tooth complexing agent, it is characterised in that the stabilization agent is burnt phosphorus
Sour sodium.
11. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and anti-
Decayed tooth complexing agent includes basic amino acid.
12. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the basic amino acid is
Arginine.
13. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the basic amino acid is
Lysine.
14. nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and anti-
Decayed tooth complexing agent includes non-degradable replacement sugar alcohol.
15. nutritional supplementation according to claim 14 and anti-decayed tooth complexing agent, it is characterised in that the non-degradable replacement sugar
Alcohol is xylitol.
16. nutritional supplementation according to claim 14 and anti-decayed tooth complexing agent, it is characterised in that the non-degradable replacement sugar
Alcohol is sorbierite.
17. a kind of nutritional supplementation and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and anti-decayed tooth complexing agent include acid
Property one water calcium phosphate compound and alkaline glycerol calcium phosphate, the nutritional supplementation and anti-decayed tooth complexing agent are fragrant for single stable mouth
Sugar, candy, cake or buccal tablet.
18. nutritional supplementation according to claim 17 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and
Anti- decayed tooth complexing agent includes basic amino acid.
19. nutritional supplementation according to claim 18 and anti-decayed tooth complexing agent, it is characterised in that the basic amino acid
For arginine.
20. nutritional supplementation according to claim 18 and anti-decayed tooth complexing agent, it is characterised in that the basic amino acid
For lysine.
21. nutritional supplementation according to claim 17 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation and
Anti- decayed tooth complexing agent includes non-degradable replacement sugar alcohol.
22. nutritional supplementation according to claim 21 and anti-decayed tooth complexing agent, it is characterised in that the non-degradable replacement
Sugar alcohol is xylitol.
23. nutritional supplementation according to claim 21 and anti-decayed tooth complexing agent, it is characterised in that the non-degradable replacement
Sugar alcohol is sorbierite.
24. a kind of nutritional supplementation according to claim 1 and anti-decayed tooth complexing agent, it is characterised in that the nutritional supplementation
An acid water calcium phosphate compound is included with anti-decayed tooth complexing agent, and alkaline oxygenated calcium compound and non-degradable replaces basic amino acid
For sugar alcohol, it is characterised in that the nutritional supplementation and anti-decayed tooth complexing agent can make active ingredient added to other external applications delivery work
Tool, including the japanning of toothpaste, dentistry, tooth pad pasting, mouthwash, gel, fissure sealant, dental cement or compound resin.
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| CN201610277149.3A Pending CN107334783A (en) | 2016-04-30 | 2016-04-30 | Nutritional supplementation and anti-decayed tooth complexing agent product composition and preparation method |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101141945A (en) * | 2005-03-18 | 2008-03-12 | 株式会社Lg生活健康 | Tooth whitener |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101141945A (en) * | 2005-03-18 | 2008-03-12 | 株式会社Lg生活健康 | Tooth whitener |
Non-Patent Citations (1)
| Title |
|---|
| MICHEL KOUASSI ETAL: "Antibacterial Effect of a Hydraulic Calcium Phosphate Cement for Dental Applications", 《JOURNAL OF ENDODONTICS》 * |
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