CN107334458A - A kind of lung cancer detection method and system for asian ancestry crowd - Google Patents
A kind of lung cancer detection method and system for asian ancestry crowd Download PDFInfo
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Abstract
The present invention discloses a kind of lung cancer detection method and system for asian ancestry crowd, and this method has more preferable specific aim to the lung cancer detection of asian ancestry crowd；Calculate the weight of all test point bit attribute values of patient, remove the test point position that weighted value is less than setting value, standard testing point position is regarded as into remaining test point position, during follow-up lung cancer detection, lung cancer detection can be completed by only gathering the information of the standard testing point position, substantially increase detection efficiency and Consumer's Experience；Each test point position of subject is measured at least three times, the final average value for taking Pu Luolang values corresponding to measurement every time judges whether to suffer from lung cancer accordingly, avoids the unstable situation of measurement data caused by human users' error as test result, stability is good, and reliability is high.
Description
Technical field
The present invention relates to cancer detection technical field, more particularly to a kind of lung cancer detection method for asian ancestry crowd and it is
System.
Background technology
In recent years, the incidence of disease of whole world tumor disease is in the morbidity and mortality of continuous ascendant trend, wherein lung cancer
Growth is most fast, is one of malignant tumour maximum to population health and life threat.Lung cancer is all very normal in a kind of global range
The cancer seen, because clinical manifestation has been late period, therefore there is very high fatal rate.75% patients with lung cancer be there are about when making a definite diagnosis
Through being that late period or cancer cell are transferred, therefore 5 years survival rates of patients with lung cancer are less than 15%.Some are used to reduce lung cancer death
The screening strategy of rate is also employed, and such as Chest X-rays, heavy smoker, which does LDCT examinations, can make the death rate reduce by 20%,
But very high false positive and high cost prevent LDCT from turning into a kind of good screening method, therefore, new diagnosis side
Method is urgently developed.United States Patent (USP) (patent publication No.：US7603171B2, US7536220B2) and document (Yung R C, Zeng M
Y,Stoddard G J,et al.Transcutaneous computed bioconductance measurement in
lung cancer:A treatment enabling technology useful for adjunctive risk
stratification in the evaluation of suspicious pulmonary lesions[J].Journal
of Thoracic Oncology,2012,7(4):681-9) propose a kind of by determining patient body conductivity signal come really
Determine the method for lung cancer, but it still suffers from following deficiency：First, the change that human tissue structure and composition are formed for example fat, albumen,
The difference of Lean mass all has an impact to bioelectrical signals, and concrete condition refers to 1, Dong Xiu treasure's bio-electrical impedance technologies and ground
Study carefully progress [J] Chinese medicine physics magazines, 2004,06):311-7；2nd, Liu Wei, Wang Jianping, lifes of the Zhang Chongwei based on SVM
Research [J] the electronic surveyings of thing electrical impedance human body viscera fats measurement and instrument journal, 2011,07)：648-53；3rd, the auspicious of Qi Peng
Human body component test and research [D] based on bio-electrical impedance；China Science ＆ Technology University, 2009.American-European crowd is with simultaneously
Body body fat rate between state crowd etc. has differences, and specifically refers to document：Jiang Chongmin Chinese urban residents body fats
Distribution characteristics and body fat rate projectional technique research [D]；Beijing Sport University, 2006.United States Patent (USP) (patent publication No.：
) and patent (patent publication No. US7603171B2：US7536220B2) propose by determine patient body conductivity signal come
The method for determining lung cancer is the data model established based on American population, is not suitable for asian ancestry crowd, and asian ancestry crowd's lung cancer is examined
The accuracy rate of survey is very low.2nd, diagnosis is required for measuring the supplemental characteristic of 62 test point positions every time, and time-consuming, and efficiency is low.
3rd, stability is poor, and the reliability of testing result is low.
The content of the invention
It is an object of the invention to by a kind of lung cancer detection method and system for asian ancestry crowd, carried on the back to solve the above
The problem of scape technology segment is mentioned.
To use following technical scheme up to this purpose, the present invention：
A kind of lung cancer detection method for asian ancestry crowd, it comprises the following steps：
S101, the clinical information data set for establishing asian ancestry crowd；
S102, the clinical information data set according to the asian ancestry crowd, structure basic parameter space, wherein, it is described basic
There are its corresponding weights and threshold value for each parameter in parameter space, the parameter refers to each test point position of patient
Corresponding each attribute；
S103, the Pu Luolang value PLL for calculating patient, and judge whether patient suffers from lung cancer according to Pu Luolang values PLL；Its
In, PLL=(P1, P2, P3, P4 ... Pn)/I, P1, P2 ... Pn refer to the test point position of patient, and there are some category each test point position
Property, Pn is weights sum of the property value corresponding to more than all properties of the threshold value corresponding to the attribute in the n of test point position, and I is
Weights sum corresponding to all properties of all test point positions.
Especially, the step S101 includes：Filtering out some positions has the asian ancestry subject of benign protuberance in lung, surveys
Try and record some property values of each test point position of asian ancestry subject；Filtering out some positions has the Asia of Malignant Nodules in lung
Descendants subject, test and record some property values of each test point position of asian ancestry subject.
Especially, the step S102 includes：Using the threshold value of grid data service Optimal Parameters, wherein, the grid is searched
Rope method refers to parameter to be searched being divided into grid in the scope of search space, and optimal ginseng is found out by the point for traveling through all in grid
Number.
Especially, the step S102 also includes：The weight of all test point bit attribute values of patient is calculated, removes weight
Standard testing point position is regarded as less than the test point position of setting value in remaining test point position by value, during follow-up lung cancer detection, only gathers
The information of the standard testing point position.
Especially, the number of the standard testing point position is defined to 20.
Especially, the step S103 includes：Each test point position of subject is measured at least three times, finally taken every
The average value of Pu Luolang values corresponding to secondary measurement judges whether to suffer from lung cancer accordingly as test result.
The invention also discloses a kind of lung cancer detection system for asian ancestry crowd, the system is used for Asian using above-mentioned
The lung cancer detection method of group carries out the lung cancer detection of asian ancestry crowd.
Especially, the lung cancer detection system for asian ancestry crowd includes assembling computer, display, attachable defeated
Go out equipment, keyboard, probe, point type electrode and hand-held electrode；The display, attachable output equipment, keyboard, probe,
Point type electrode, hand-held electrode are connected with assembling computer.
It is proposed by the present invention to be used for asian ancestry compared with method of the tradition measure patient body conductivity signal to determine lung cancer
The lung cancer detection method and system of crowd have the following advantages that：First, there is more preferable specific aim to the lung cancer detection of asian ancestry crowd；
2nd, the weight of all test point bit attribute values of patient is calculated, the test point position that weighted value is less than setting value is removed, residue is surveyed
Standard testing point position is regarded as in pilot position, and during follow-up lung cancer detection, only gathering the information of the standard testing point position can complete
Lung cancer detection, substantially increase detection efficiency and Consumer's Experience；3rd, at least three are measured to each test point position of subject
It is secondary, finally take the average value of Pu Luolang values corresponding to measurement every time to judge whether to suffer from lung cancer accordingly, avoid people as test result
Member's operating error measurement data as caused by test probe Overexertion extruding skin causes recipient site deformation etc. is unstable, surely
Qualitative good, reliability is high.
Brief description of the drawings
Fig. 1 is the lung cancer detection method flow diagram provided in an embodiment of the present invention for asian ancestry crowd；
Fig. 2 is the lung cancer detection system structure diagram provided in an embodiment of the present invention for asian ancestry crowd.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In accompanying drawing
Give presently preferred embodiments of the present invention.But the present invention can realize in many different forms, however it is not limited to this paper institutes
The embodiment of description.On the contrary, the purpose for providing these embodiments is made to the more thorough of the disclosure understanding
Comprehensively.It should be noted that when an element is considered as " connection " another element, it can be directly to another
Element may be simultaneously present centering elements.Unless otherwise defined, all of technologies and scientific terms used here by the article with
The implication that the those skilled in the art for belonging to of the invention are generally understood that is identical.Made in the description of the invention herein
Term is intended merely to describe the purpose of specific embodiment, it is not intended that in the limitation present invention.Term as used herein
" and/or " include the arbitrary and all combinations of one or more related Listed Items.
It refer to shown in Fig. 1, Fig. 1 is the lung cancer detection method flow provided in an embodiment of the present invention for asian ancestry crowd
Figure.
Lung cancer detection method in the present embodiment for asian ancestry crowd specifically comprises the following steps：
S101, the clinical information data set for establishing asian ancestry crowd.Filtering out some positions has the Asia of benign protuberance in lung
Descendants subject, tested using biological conductance detection device and record some property values of each test point position of asian ancestry subject；Sieve
Selecting some positions has the asian ancestry subject of Malignant Nodules in lung, tested using biological conductance detection device and record asian ancestry by
Some property values of each test point position of examination person.In practical operation, comprehensive consideration, lung has the asian ancestry of benign protuberance tested
Person has screened 25, and there is the asian ancestry subject of Malignant Nodules to have screened 100 for lung.
S102, the clinical information data set according to the asian ancestry crowd, structure basic parameter space, wherein, it is described basic
There are its corresponding weights and threshold value for each parameter in parameter space, the parameter refers to each test point position of patient
Corresponding each attribute.
United States Patent (USP) (patent publication No.：) and patent (patent publication No. US7603171B2：US7536220B2) propose
Determine it is to enter each property value threshold value corresponding with it in the method for lung cancer by determining patient body conductivity signal
Row is relatively it is then determined that whether it contributes to final testing result.In order that the present invention is in asian ancestry crowd's such as Chinese population
In there is higher accuracy rate, the present invention uses the threshold value of grid search Optimal Parameters, wherein, the grid data service refer to by
Parameter to be searched is divided into grid in the scope of search space, and optimized parameter is found out by the point for traveling through all in grid.This side
Method is sufficiently large in optimizing section and can find out globally optimal solution in the case that step pitch is sufficiently small.Search space in this optimization process
Structure it is as follows：Its 50%, 75%, 125% and 150% value is taken to form parameter space for the threshold value of each property value.Example
The threshold value for such as assuming a certain attribute is 100, then parameter space is 50,75,125 and 150.If two threshold values so then it
The search space that forms be (50,50), (50,75), (50,125), (50,150), (75,50), (75,75), (75,125),
(75,150) ..., the rest may be inferred draws parameter space.Index is needed to carry out evaluation model in optimization process.Here we
Use the concept of the degree of accuracy.It is explained as follows：
The degree of accuracy：(a+b)/(a+b+c+d)
Our purpose is exactly that the model of the highest degree of accuracy is obtained in the parameter space established.
In addition, United States Patent (USP) (patent publication No.：) and patent (patent publication No. US7603171B2：US7536220B2) carry
It come the total amount for the parameter for determining to be related in the method for lung cancer is 62 (test point positions by determining patient body conductivity signal to go out
Number) × 8 the attribute of position (each point)=496, so, carrying out a lung cancer detection then needs to take a long time,
Detection efficiency is not only reduced, and influences customer experience, for the time needed for further optimal inspection, the present invention calculates
The weight of all test point bit attribute values of patient, the test point position that weighted value is less than setting value is removed, by remaining test point position
Regard as standard testing point position, during follow-up lung cancer detection, only gather the information of the standard testing point position, mark in the present embodiment
The number of quasi- test point position is defined to 20.
S103, the Pu Luolang value PLL for calculating patient, and judge whether patient suffers from lung cancer according to Pu Luolang values PLL；Its
In, PLL=(P1, P2, P3, P4 ... Pn)/I, P1, P2 ... Pn refer to the test point position of patient, and there are some category each test point position
Property, Pn is weights sum of the property value corresponding to more than all properties of the threshold value corresponding to the attribute in the n of test point position, and I is
Weights sum corresponding to all properties of all test point positions.
Explained the main points briefly below from program layer in face of the present invention：If the first, test point position has M, each test point position passes through life
The value that thing Conductivity detection equipment obtains N number of attribute is N number of parameter, then M × N matrix is basic parameter space, for each
Parameter has its corresponding weight w[Mi,Ni]And threshold θ[Mi,Ni].The present invention is based on the decision tree on this parameter space
Model, Pu Luolang value PLL calculation procedures are as follows：
2nd, the algorithm optimization based on Chinese population
The weights of the parameters in original method are have updated by the clinical data of Chinese population.
In order to avoid human users' error such as test probe Overexertion extruding skin causes recipient site deformation etc. to cause
Measurement data it is unstable, it is good to improve the stability of detection, and reliability is high, and each test point position of subject is measured at least
Three times, the average value of Pu Luolang values corresponding to measurement every time is finally taken to judge whether to suffer from lung cancer accordingly as test result.
During the detection model of the present invention is established double sampling is carried out using Bootstrap methods.The Bootstrap
Method be it is a kind of data have been carried out putting back to random sampling obtain sample, detailed process refers to document Stine R.An
introduction to bootstrap methods:Examples and ideas[J].Sociological Methods&
Research,1989,18(2-3):243-91.The sample that some are pumped to using Bootstrap samplings is as training set, together
The sample that Shi Wei is pumped to collects as checking.Parameter using the model with 20 parameters referred to above and structure is empty
Between carry out model foundation.One group with the highest degree of accuracy is finally selected from parameter space.It is it should be noted that of the invention
It is to be based on United States Patent (USP) (patent publication No.：) and patent (patent publication No. US7603171B2：US7536220B2 what is) carried out changes
Enter, therefore the prior art part to being applied in the present invention will not be repeated here.
Illustrate as shown in Fig. 2 Fig. 2 is the lung cancer detection system architecture provided in an embodiment of the present invention for asian ancestry crowd
Figure.
Lung cancer detection system in the present embodiment for asian ancestry crowd uses the above-mentioned lung cancer detection side for asian ancestry crowd
Method carries out the lung cancer detection of asian ancestry crowd.The lung cancer detection system for asian ancestry crowd includes assembling computer 201, display
Device 202, attachable output equipment (not shown), keyboard 203, probe 204, point type electrode 205 and hand-held electrode
206；Wherein, point type electrode 205 and hand-held electrode are reference electrode 206.The display 202, attachable output equipment,
Keyboard 203, probe 204, point type electrode 205, hand-held electrode 206 are connected with assembling computer 201.
Technical scheme has the following advantages that：First, there is more preferable specific aim to the lung cancer detection of asian ancestry crowd；
2nd, the weight of all test point bit attribute values of patient is calculated, the test point position that weighted value is less than setting value is removed, residue is surveyed
Standard testing point position is regarded as in pilot position, and during follow-up lung cancer detection, only gathering the information of the standard testing point position can complete
Lung cancer detection, substantially increase detection efficiency and Consumer's Experience；3rd, at least three are measured to each test point position of subject
It is secondary, finally take the average value of Pu Luolang values corresponding to measurement every time to judge whether to suffer from lung cancer accordingly, avoid people as test result
Member's operating error measurement data as caused by test probe Overexertion extruding skin causes recipient site deformation etc. is unstable, surely
Qualitative good, reliability is high.
One of ordinary skill in the art will appreciate that realize all or part of flow in above-described embodiment method, being can be with
The hardware of correlation is instructed to complete by computer program, described program can be stored in a computer read/write memory medium
In, the program is upon execution, it may include such as the flow of the embodiment of above-mentioned each method.Wherein, described storage medium can be magnetic
Dish, CD, read-only memory (Read-Only Memory, ROM) or random access memory (Random Access
Memory, RAM) etc..
Pay attention to, above are only presently preferred embodiments of the present invention and institute's application technology principle.It will be appreciated by those skilled in the art that
The invention is not restricted to specific embodiment described here, can carry out for a person skilled in the art various obvious changes,
Readjust and substitute without departing from protection scope of the present invention.Therefore, although being carried out by above example to the present invention
It is described in further detail, but the present invention is not limited only to above example, without departing from the inventive concept, also
Other more equivalent embodiments can be included, and the scope of the present invention is determined by scope of the appended claims.
Claims (8)
- A kind of 1. lung cancer detection method for asian ancestry crowd, it is characterised in that comprise the following steps：S101, the clinical information data set for establishing asian ancestry crowd；S102, the clinical information data set according to the asian ancestry crowd, structure basic parameter space, wherein, the basic parameter There are its corresponding weights and threshold value for each parameter in space, it is corresponding that the parameter refers to each test point position of patient Each attribute；S103, the Pu Luolang value PLL for calculating patient, and judge whether patient suffers from lung cancer according to Pu Luolang values PLL；Wherein, PLL =(P1, P2, P3, P4 ... Pn)/I, P1, P2 ... Pn refer to the test point position of patient, and there are some attributes each test point position, and Pn is Property value is more than the weights sum corresponding to all properties of the threshold value corresponding to the attribute in the n of test point position, and I is all tests Weights sum corresponding to all properties of point position.
- 2. the lung cancer detection method according to claim 1 for asian ancestry crowd, it is characterised in that the step S101 bags Include：Filtering out some positions has the asian ancestry subject of benign protuberance in lung, tests and records each test point of asian ancestry subject Some property values of position；Filtering out some positions has the asian ancestry subject of Malignant Nodules in lung, tests and to record asian ancestry tested Some property values of each test point position of person.
- 3. the lung cancer detection method according to claim 2 for asian ancestry crowd, it is characterised in that the step S102 bags Include：Using the threshold value of grid data service Optimal Parameters, wherein, the grid data service refers to parameter to be searched in search space It is divided into grid in scope, optimized parameter is found out by the point for traveling through all in grid.
- 4. the lung cancer detection method according to claim 3 for asian ancestry crowd, it is characterised in that the step S102 is also Including：The weight of all test point bit attribute values of patient is calculated, the test point position that weighted value is less than setting value is removed, by residue Standard testing point position is regarded as in test point position, during follow-up lung cancer detection, only gathers the information of the standard testing point position.
- 5. the lung cancer detection method according to claim 4 for asian ancestry crowd, it is characterised in that the standard testing point The number of position is defined to 20.
- 6. the lung cancer detection method for asian ancestry crowd according to one of claim 1 to 5, it is characterised in that the step Rapid S103 includes：Each test point position of subject is measured at least three times, finally takes Pu Luolang values corresponding to measurement every time Average value as test result, judge whether to suffer from lung cancer accordingly.
- 7. a kind of lung cancer detection system for asian ancestry crowd, it is characterised in that the system is using any one of claim 1 to 6 The described lung cancer detection method for asian ancestry crowd carries out the lung cancer detection of asian ancestry crowd.
- 8. the lung cancer detection system according to claim 7 for asian ancestry crowd, it is characterised in that described to be used for Asian The lung cancer detection system of group includes assembling computer, display, attachable output equipment, keyboard, probe, point type electrode and hand Hold formula electrode；The display, attachable output equipment, keyboard, probe, point type electrode, hand-held electrode are counted with assembling Calculation machine connects.
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| CN201710525625.3A CN107334458A (en) | 2017-06-30 | 2017-06-30 | A kind of lung cancer detection method and system for asian ancestry crowd |
| PCT/CN2018/080624 WO2019001040A1 (en) | 2017-06-30 | 2018-03-27 | Lung cancer detection method and system for asian population |
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| CN108245161A (en) * | 2017-12-26 | 2018-07-06 | 北京医拍智能科技有限公司 | The assistant diagnosis system of lung's common disease |
| WO2019001040A1 (en) * | 2017-06-30 | 2019-01-03 | 普罗朗生物技术（无锡）有限公司 | Lung cancer detection method and system for asian population |
| CN111248913A (en) * | 2020-01-21 | 2020-06-09 | 山东师范大学 | Chronic obstructive pulmonary disease prediction system, equipment and medium based on transfer learning |
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| CN106137193B (en) * | 2016-07-29 | 2023-03-17 | 普罗朗生物技术（无锡）有限公司 | Human body biological conductance multiple value simulator |
| CN107334458A (en) * | 2017-06-30 | 2017-11-10 | 普罗朗生物技术（无锡）有限公司 | A kind of lung cancer detection method and system for asian ancestry crowd |
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- 2017-06-30 CN CN201710525625.3A patent/CN107334458A/en active Pending
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| US20090124924A1 (en) * | 2007-10-25 | 2009-05-14 | Eror Steven C | Method for diagnosing a disease |
| CN201253209Y (en) * | 2008-07-02 | 2009-06-10 | 浙江大学 | Three freedom-degree shifting manipulator back-shu points anti-detection system |
| CN101806805A (en) * | 2010-03-16 | 2010-08-18 | 华中师范大学 | Blood serum metabolism biological marker for lung cancer patients |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019001040A1 (en) * | 2017-06-30 | 2019-01-03 | 普罗朗生物技术（无锡）有限公司 | Lung cancer detection method and system for asian population |
| CN108245161A (en) * | 2017-12-26 | 2018-07-06 | 北京医拍智能科技有限公司 | The assistant diagnosis system of lung's common disease |
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| CN111248913B (en) * | 2020-01-21 | 2023-04-07 | 山东师范大学 | Chronic obstructive pulmonary disease prediction system, equipment and medium based on transfer learning |
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Application publication date: 20171110 |