CN107320689A - 一种用于治疗头痛的胶囊剂药物及其制备方法 - Google Patents
一种用于治疗头痛的胶囊剂药物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗头痛的认识机理而提供的一种用于治疗头痛的胶囊剂药物,所述药物的各个组分及其质量份比如下:钩藤270g、菊花80g、川芎95g、麻黄80g、麦冬(去心)115g、细辛70g、附子115g、天麻12g、白芍200g、羌活200g、川牛膝95g、独活95g、防风95g、丹参115g、地黄290g、当归115g、郁金95g、鸡血藤115g、桃仁115g、葛根120g、白芷95g、红花95g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种用于治疗头痛的胶囊剂药物,特别是供头痛患者使用的胶囊剂药物及其制备方法的领域。
背景技术
医者认为:头痛(headache) 是临床常见的症状,通常将局限于头颅上半部,包括眉弓、耳轮上缘和枕外隆突连线以上部位的疼痛统称头痛。头痛病因繁多,神经痛、颅内感染、颅内占位病变、脑血管疾病、颅外头面部疾病、以及全身疾病如急性感染、中毒等均可导致头痛。发病年龄常见于青年、中年和老年。
临床表现:头痛程度有轻有重,疼痛时间有长有短。疼痛形式多种多样,常见胀痛、闷痛、撕裂样痛、电击样疼痛、针刺样痛,部分伴有血管搏动感及头部紧箍感,以及恶心、呕吐、头晕等症状。继发性头痛还可伴有其他系统性疾病症状或体征,如感染性疾病常伴有发热,血管病变常伴偏瘫、失语等神经功能缺损症状等。头痛依据程度产生不同危害,病情严重可使患者丧失生活和工作能力。
那么,就如何找到一种可有效治疗头痛的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗头痛上,人们逐渐意识到了中医治疗头痛的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗头痛的现状,本发明的目的是在于提供一种用于治疗头痛的胶囊剂药物,以解决头痛患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述头痛。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种用于治疗头痛的胶囊剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤60~350g、菊花50~100g、川芎30~120g、麻黄30~100g、麦冬(去心)60~160g、细辛15~90g、附子30~150g、天麻10~15g、白芍100~250g、羌活100~250g、川牛膝60~120g、独活30~120g、防风50~120g、丹参50~160g、地黄100~380g、当归60~150g、郁金30~120g、鸡血藤90~160g、桃仁80~160g、葛根100~160g、白芷30~120g、红花30~120g。
一种用于治疗头痛的胶囊剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤70~310g、菊花58~90g、川芎38~105g、麻黄38~90g、麦冬(去心)68~130g、细辛17~80g、附子38~130g、天麻11~14g、白芍115~220g、羌活115~220g、川牛膝68~105g、独活35~105g、防风58~105g、丹参58~130g、地黄115~330g、当归68~130g、郁金38~105g、鸡血藤100~130g、桃仁90~130g、葛根115~140g、白芷38~105g、红花38~105g。
一种用于治疗头痛的胶囊剂药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
钩藤270g、菊花80g、川芎95g、麻黄80g、麦冬(去心)115g、细辛70g、附子115g、天麻12g、白芍200g、羌活200g、川牛膝95g、独活95g、防风95g、丹参115g、地黄290g、当归115g、郁金95g、鸡血藤115g、桃仁115g、葛根120g、白芷95g、红花95g。
一种用于治疗头痛的胶囊剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质、粉尘及干燥后,按照质量份比共研为极细末待用;
B、按照传统的常规工艺及辅料制备中药胶囊剂的方法,将研磨好的极细末药物过筛后,和辅料一并放入药器中混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),继而消毒、分装,密封即可。
一种用于治疗头痛的胶囊剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2g(4粒)/次,温开水送服。7天为一个疗程,服药1~2个疗程,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
钩藤,性味:甘苦、微寒,具有清热平肝、熄风止痉之功效,用于治疗小儿惊风、夜啼、热盛动风、子痫、肝阳眩晕、肝火头胀痛等症;
菊花,性味:甘、苦、微寒,具有散风清热、平肝明目之功效,用于治疗风热感冒、头痛眩晕、目赤肿痛、眼目昏花;
川芎,性味:味辛、性温,具有活血祛瘀、行气开郁、祛风止痛之功效,用于治疗月经不调、经闭痛经、产后瘀滞腥痛、癥瘕肿块、胸胁疼痛、头痛眩晕、风寒湿痹、跌打损伤、痈疽疮疡;
麻黄,性味:辛苦、温,具有发汗、平喘、利水之功效,用于治疗伤寒表实、发热恶寒无汗、头痛鼻塞、骨节疼痛、咳嗽气喘、风水浮肿、小便不利、风邪顽痹、皮肤不仁、风疹瘙痒;
麦冬(去心),性味:甘、微苦微寒,具有养阴润肺、益胃清心之功效,用于治疗阴虚肺燥、干咳痰稠、劳嗽咯血、津少口渴、心烦失眠、肠燥便秘;
细辛,性味:辛、温,小毒,具有散寒祛风、止痛、温肺化饮、通窍之功效,用于治疗风寒表证、头痛、牙痛、风湿痹痛、痰饮咳喘、鼻塞、鼻渊、口疮等症;
附子,性味:辛、甘、大热,有毒,具有回阳救逆、补火助阳、逐风寒湿邪之功效,用于治疗亡阳虚脱、肢冷脉微、阳萎、宫冷、心腹冷痛、虚寒吐泻、阴寒水肿、阳虚外感、寒湿痹痛;
天麻,性味:甘、辛、平,无毒,具有息风止痉、平肝阳、祛风通络之功效,用于治疗急慢惊风、抽搐拘挛、眩晕、头痛、半身不遂、肢麻、风湿痹痛;
白芍,性味:苦、酸、微寒,养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症;
羌活,性味:辛苦、温,具有散表寒、祛风湿、利关节之功效,用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
川牛膝,性味:甘、微苦、性平,具有活血祛瘀、祛风利湿之功效,用于治疗血瘀经闭、难产、胞衣不下、产后瘀血腹痛、热淋、石淋、痛经、风湿腰膝疼痛;
独活,性味:味苦、辛、性微湿,具有祛风胜湿、散寒止痛之功效,用于治疗风寒湿痹、腰膝疼痛、头痛齿痛等症;
防风,性味:味辛、甘、性微温,具有祛风解表、胜湿止痛、解痉、止痒之功效,用于治疗外感风寒、头痛身痛、风湿痹痛、骨节酸痛、腹痛泄泻、肠风下血、破伤风、风疹瘙痒、疮疡初起;
丹参,性味:味苦;性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
地黄,性味:甘、寒,具有清热凉血、养阴、生津之功效,用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹;
当归,性味:味甘、辛、苦、性温,具有补血、活血、调经止痛、润燥滑肠之功效,用于治疗血虚诸证、月经不调、经闭、痛经、癥瘕结聚、崩漏、虚寒腹痛、痿痹、肌肤麻木、肠燥便难、赤痢后重、痈疽疮疡、跌扑损伤;
郁金,性味:味辛、苦、性寒,具有活血止能、行气解郁、清心凉血、疏肝利胆之功效,用于治疗胸腹胁肋诸痛、妇女痛经、经闭、癥瘕结块、热病神昏、癫狂、惊痫、吐血、衄备、血淋、砂淋、黄疸等症;
鸡血藤,性味:苦、甘、温,具有补血、活血、通络之功效,用于治疗月经不调、血虚萎黄、麻木瘫痪、风湿痹痛;
桃仁,性味:苦甘、平,无毒,具有破血行瘀、润燥滑肠之功效,用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘等症;
葛根,性味:甘、辛、平,具有解肌退热、发表透诊、生津止渴、升阳止泻之功效,用于治疗外感发热、头项强痛、麻疹初起、疹出不畅、温病口渴、消渴病、泄泻、痢疾、高血压、冠心病等症;
白芷,性味:味辛、性温,具有祛风除湿、通窃止痛、消肿排脓之功效,用于治疗感冒头痛、眉棱骨痛、牙痛、鼻塞、鼻渊、湿胜久泻、妇女白带、痈疽疮疡、毒蛇咬伤;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛癥瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症。
本发明药物是基于中医治疗头痛的原则,从依据头痛的病理机制及药理作用认为:就头痛,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述头痛的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤270g、菊花80g、川芎95g、麻黄80g、麦冬(去心)115g、细辛70g、附子115g、天麻12g、白芍200g、羌活200g、川牛膝95g、独活95g、防风95g、丹参115g、地黄290g、当归115g、郁金95g、鸡血藤115g、桃仁115g、葛根120g、白芷95g、红花95g。
实施例2:
一种用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤310g、菊花90g、川芎105g、麻黄90g、麦冬(去心)130g、细辛80g、附子130g、天麻14g、白芍220g、羌活220g、川牛膝105g、独活105g、防风105g、丹参130g、地黄330g、当归130g、郁金105g、鸡血藤130g、桃仁130g、葛根140g、白芷105g、红花105g。
实施例3:
一种用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤350g、菊花100g、川芎120g、麻黄100g、麦冬(去心)160g、细辛90g、附子150g、天麻15g、白芍250g、羌活250g、川牛膝120g、独活120g、防风120g、丹参160g、地黄380g、当归150g、郁金120g、鸡血藤160g、桃仁160g、葛根160g、白芷120g、红花120g。
典型病例
经临床诊断治疗头痛患者共1000例,年龄为38岁以上的550例,只有450例为38岁以下。1000例患者中痊愈的910例,有效的90例。总有效率达100%。
Claims (3)
1.一种用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤60~350g、菊花50~100g、川芎30~120g、麻黄30~100g、麦冬(去心)60~160g、细辛15~90g、附子30~150g、天麻10~15g、白芍100~250g、羌活100~250g、川牛膝60~120g、独活30~120g、防风50~120g、丹参50~160g、地黄100~380g、当归60~150g、郁金30~120g、鸡血藤90~160g、桃仁80~160g、葛根100~160g、白芷30~120g、红花30~120g。
2.根据权利要求1所述的用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤70~310g、菊花58~90g、川芎38~105g、麻黄38~90g、麦冬(去心)68~130g、细辛17~80g、附子38~130g、天麻11~14g、白芍115~220g、羌活115~220g、川牛膝68~105g、独活35~105g、防风58~105g、丹参58~130g、地黄115~330g、当归68~130g、郁金38~105g、鸡血藤100~130g、桃仁90~130g、葛根115~140g、白芷38~105g、红花38~105g。
3.根据权利要求1至2所述的用于治疗头痛的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
钩藤270g、菊花80g、川芎95g、麻黄80g、麦冬(去心)115g、细辛70g、附子115g、天麻12g、白芍200g、羌活200g、川牛膝95g、独活95g、防风95g、丹参115g、地黄290g、当归115g、郁金95g、鸡血藤115g、桃仁115g、葛根120g、白芷95g、红花95g。
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