CN107320094A - It is a kind of for gel of skin treatment and preparation method thereof - Google Patents
It is a kind of for gel of skin treatment and preparation method thereof Download PDFInfo
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- CN107320094A CN107320094A CN201610273664.4A CN201610273664A CN107320094A CN 107320094 A CN107320094 A CN 107320094A CN 201610273664 A CN201610273664 A CN 201610273664A CN 107320094 A CN107320094 A CN 107320094A
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- gel
- skin
- temperature plasma
- skin treatment
- atmos low
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
- H01B1/06—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances
- H01B1/08—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances oxides
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
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- Life Sciences & Earth Sciences (AREA)
- Plasma & Fusion (AREA)
- Pathology (AREA)
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- Spectroscopy & Molecular Physics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
The invention discloses a kind of for gel of skin treatment and preparation method thereof.The preparation method of gel provided by the present invention for skin treatment is：1) it is, more than or equal to 0%, in the aqueous hydrogen peroxide solution less than or equal to 3%, to act on 5 30min, obtain the activating solution rich in hydroxy radical atmos low-temperature plasma generating means to be goed deep into mass concentration；2) carbomer or/and sodium hydroxide are added into the activating solution, stirs, obtains the gel for skin treatment.Obtained gel, which is prepared by the method for the present invention, can directly be coated on skin surface, improve the contact impedance of keratoderma oxidation efficiency, reduction skin and electrode.Gel is easy to use, saves the time, improves measurement efficiency.The formula is affine to skin, bio-compatible, safety and stability, is not required to grinding, it is adaptable to sensitive skin crowd.
Description
Technical field
The present invention relates to electrodes conduct glue technical field, and in particular to a kind of for gel of skin treatment and preparation method thereof.
Background technology
Electrode for medical service is usually used in transmitting the electric signal (such as electric current) between patient body and external medical equipment.These electrodes are generally included
Conductor and the skin of a conductive compositions adhesion or contact patient that one is connected to conducing composite material.High-quality and stable electricity
Signal is to ensure that detecting system carries out the key and premise of subsequent treatment.In clinical monitoring, due to skin dry and/or containing old skin
There is keratoderma between skin and electrode, its main component is skin metabolism product and some dead cells, and they are all non-lead
Isoelectric substance.These materials result in the increase of contact impedance, and bring very big measurement noise.Therefore, clinical monitoring biological electricity
Exfoliating pretreatment can be carried out to skin, during signal to obtain the good contact with electrode.Current skin treatment has is dipped in using cotton swab
Alcohol, acetone, isopropanol etc. carry out multiple physical friction to skin and remove cutin, alcohol which is used, acetone, isopropyl
Alcohol volatility is big, easily stimulates patient.It is clinical also to commonly use scrub cream class product (such as NuPrep Skin Prep Gel, Chinese patent CN
Electrode frosted conductive paste disclosed in 103550795A), though cutin quickly can be removed effectively, excessive friction is easy to injured skin
It is not appropriate for sensitive skin crowd.Both the above skin processing method is all Wipe type, and the effect of exfoliating is by the dynamics of wiping and secondary
Several influences is larger.
The present invention is intended to provide a kind of for gel of skin treatment and preparation method thereof.The technical scheme taken is with through too high voltages
Gas breakdown and the atmos low-temperature plasma produced, it includes high energy electron, various ions, atom and living radical.
High energy charged particles therein and living radical are H2O2Catalyst, H can be excited2O2Decompose and discharge great amount of hydroxy group (OH)
Improve cuticula oxidation efficiency.Gel need to only be coated in skin surface, be not required to grinding, thereby using convenient, the saving time, improve
Measurement efficiency.Moisture energy moistening skin in gel, increases electric conductivity.
Gel provided by the present invention for skin treatment is prepared by the method comprising the following steps：
1st, a kind of preparation method of gel for skin treatment, comprises the steps：
1) atmos low-temperature plasma generating means is goed deep into aqueous hydrogen peroxide solution, after effect a period of time, be rich in
The activating solution of hydroxy radical.
2) thickener is added into the above-mentioned activating solution rich in hydroxy radical and is stirred and causes activation pension gelation, obtains being used for skin
The gel of processing.
2nd, atmos low-temperature plasma is that working gas is passed through into atmos low-temperature plasma generator through exciting generation.
3rd, preferably, the one kind or helium of the working gas of atmos low-temperature plasma generator in argon gas, helium, air are passed through
Gas/argon gas is with two kinds of gases of oxygen with the mixed gas of arbitrary proportion.
4th, preferably, step 1) in, the time of the effect is 5-30min.
5th, preferably, the mass concentration of hydrogen peroxide is more than or equal to 0%, less than or equal to 3% in aqueous hydrogen peroxide solution..
6th, the main component of thickener is that carbomer or carbomer and sodium hydroxide are mixed by a certain percentage.
7th, preferably, the proportioning of carbomer, sodium hydroxide and the activating solution is 0.01-1g：0.001-0.1g：50mL.
8th, preferably, the flow velocity that working gas is passed through in aqueous hydrogen peroxide solution is 2-5L/min, and atmos low-temperature plasma is excited
Power is 20-50W.
9th, the gel for skin treatment prepared by the above method.
Obtained gel, which is prepared by the method for the present invention, can directly be coated on skin surface, improve cuticula oxidation efficiency, reduction skin
The contact impedance of skin and electrode.Gel is easy to use, saves the time, improves measurement efficiency.The formula is affine to skin, biology
Compatible, safety and stability is not required to grinding, it is adaptable to sensitive skin crowd.
Brief description of the drawings
Fig. 1 is the preparation process schematic diagram of the gel for skin treatment of the present invention.1 is low-temperature plasma generator；2
Atmos low-temperature plasma；3 be aqueous hydrogen peroxide solution；4 working gas
Embodiment
Below by specific embodiment, the present invention will be described, but the invention is not limited in this.
Experimental method used in following embodiments is conventional method unless otherwise specified；Examination used in following embodiments
Agent, material etc., unless otherwise specified, are commercially obtained.
Embodiment 1
1) air is passed through with 5L/min flow velocity, atmos low-temperature plasma generator is goed deep into 20mL concentration for 2% mistake
1cm under the liquid level of hydrogen peroxide solution, the power for applying 35W carries out obtaining after exciting generation plasma, effect 20min to air
To the plasma-activated liquid rich in hydroxy radical；
2) 0.1g carbomer, 0.01g sodium hydroxide are added into plasma-activated liquid, tool is uniformly mixing to obtain at normal temperatures
There is the gel for skin treatment.
The above-mentioned gel prepared is applied to after 15 subject's skin of abdomen 1min, measuring electrode Skin Resistance, as a result
Show that electrode-skin impedance can drop to 5k ohm below, and traditional sucrose>20k ohm.
Embodiment 2
1) argon gas and oxygen are passed through with 5L/min flow velocity, atmos low-temperature plasma generator is goed deep into 20mL concentration is
1cm under the liquid level of 2% hydrogenperoxide steam generator, the power for applying 35W carries out exciting generation plasma to air, acts on 20min
The plasma-activated liquid rich in hydroxy radical is obtained afterwards.
2) 0.1g carbomer, 0.01g sodium hydroxide are added into plasma-activated liquid, tool is uniformly mixing to obtain at normal temperatures
There is the gel of skin treatment effect.
Choose 20 sensitive skin subjects and carried out hypersensitive test, by obtained gel application in 10 subject's chests, make
With commercially available prod NuPrep Skin Prep Gel for other 10 subjects as control, find for sensitive skin subject
For, after the gel of coating embodiment 2, do not find rubescent, the red and swollen or even allergic phenomena such as fester, and control group then has
1 occurs in that redness phenomenon.
Claims (9)
1. a kind of preparation method of gel for skin treatment, comprises the steps：
1) atmos low-temperature plasma generating means is goed deep into aqueous hydrogen peroxide solution, after effect a period of time, obtains the activating solution rich in hydroxy radical.
2) thickener is added into the above-mentioned activating solution rich in hydroxy radical and is stirred and causes activation pension gelation, the gel for skin treatment is obtained.
2. according to the method described in claim 1, it is characterised in that the atmos low-temperature plasma is that working gas is passed through into atmos low-temperature plasma generator through exciting generation.
3. atmos low-temperature plasma according to claim 1 is characterized in that, be passed through the one kind or helium/argon gas and two kinds of gases of oxygen of the working gas of atmos low-temperature plasma generator in argon gas, helium, air with the mixed gas of arbitrary proportion.
4. according to the method described in claim 1, it is characterised in that step 1), described action time is 5-30min.
5. according to the method described in claim 1, it is characterised in that step 1), the mass concentration of hydrogen peroxide is more than or equal to 0%, less than or equal to 3% in the excessively described aqueous hydrogen peroxide solution.
6. thickener according to claim 1, it is characterised in that the main component of the thickener is that carbomer or carbomer and sodium hydroxide are mixed by a certain percentage.
7. according to the method described in claim 1, it is characterised in that the proportioning of carbomer, sodium hydroxide and the activating solution is 0.01-1g：0.001-0.1g：50mL.
8. method according to claim 3, it is characterised in that：The flow velocity that the working gas is passed through in aqueous hydrogen peroxide solution is 2-5L/min, and atmos low-temperature plasma exciting power is 20-50W.
9. the gel for skin treatment that the method as any one of claim 1-8 is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610273664.4A CN107320094A (en) | 2016-04-28 | 2016-04-28 | It is a kind of for gel of skin treatment and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610273664.4A CN107320094A (en) | 2016-04-28 | 2016-04-28 | It is a kind of for gel of skin treatment and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107320094A true CN107320094A (en) | 2017-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610273664.4A Pending CN107320094A (en) | 2016-04-28 | 2016-04-28 | It is a kind of for gel of skin treatment and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109890121A (en) * | 2019-04-01 | 2019-06-14 | 西安交通大学 | A kind of plasma producing apparatus and plasma gel process for preparing |
| CN111434707A (en) * | 2019-01-11 | 2020-07-21 | 北京大学 | Antibacterial hydrogel |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972272A (en) * | 2010-10-31 | 2011-02-16 | 无锡龙腾画材有限公司 | Chlorine dioxide skin gel and preparation method thereof |
| CN103340756A (en) * | 2013-07-10 | 2013-10-09 | 北京大学 | Preparation method of tooth whitening gel based on barometric low-temperature plasma |
| CN105166030A (en) * | 2015-08-07 | 2015-12-23 | 北京大学 | Method for keeping fruits fresh through atmospheric pressure low temperature plasma activated water |
| CN106420373A (en) * | 2015-08-06 | 2017-02-22 | 北京大学 | Gel for tooth whitening and preparation method thereof |
-
2016
- 2016-04-28 CN CN201610273664.4A patent/CN107320094A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972272A (en) * | 2010-10-31 | 2011-02-16 | 无锡龙腾画材有限公司 | Chlorine dioxide skin gel and preparation method thereof |
| CN103340756A (en) * | 2013-07-10 | 2013-10-09 | 北京大学 | Preparation method of tooth whitening gel based on barometric low-temperature plasma |
| CN106420373A (en) * | 2015-08-06 | 2017-02-22 | 北京大学 | Gel for tooth whitening and preparation method thereof |
| CN105166030A (en) * | 2015-08-07 | 2015-12-23 | 北京大学 | Method for keeping fruits fresh through atmospheric pressure low temperature plasma activated water |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111434707A (en) * | 2019-01-11 | 2020-07-21 | 北京大学 | Antibacterial hydrogel |
| CN109890121A (en) * | 2019-04-01 | 2019-06-14 | 西安交通大学 | A kind of plasma producing apparatus and plasma gel process for preparing |
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