CN107320088A - Noninvasive continuous arteries and veins blood pressure measuring method - Google Patents
Noninvasive continuous arteries and veins blood pressure measuring method Download PDFInfo
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- CN107320088A CN107320088A CN201710487953.9A CN201710487953A CN107320088A CN 107320088 A CN107320088 A CN 107320088A CN 201710487953 A CN201710487953 A CN 201710487953A CN 107320088 A CN107320088 A CN 107320088A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0247—Pressure sensors
Abstract
The present invention relates to noninvasive continuous BP measurement method, comprise the following steps：（1）Arterial pressure signal sequence x [n] is obtained, DC component MeanValue is removed, obtains x1 [n]=x [n] MeanValue；（2）Zoomed in and out to removing remaining AC compounent after DC component, obtain x2 [n]=x1 [n] * Kr；（3）AC compounent after scaling adds compensating direct current component MeanValue', and waveform is reduced into arterial pressure signal, i.e. x'[n]=x2 [n]+MeanValue'；（4）Seek pulse pressure sequence x'[n] maximum max' and minimum value min', respectively obtain systolic pressure SP=g (max') and diastolic pressure DP=g (min'), wherein g (x) is the functional relation between signal and arterial pressure.The present invention carries out going the processing such as straight, scaling, reduction by the blood pressure signal for exporting pressure sensor, occur the pressure loss during passing through blood pressure signal the organized deliveries such as tendon, skin to pressure sensor to be compensated, it is ensured that the precision of blood pressure measurement.
Description
Technical field
The application is related to physiological parameter measurement field, particularly noninvasive continuous BP measurement technology.
Background technology
Blood pressure is the basic vital signs parameter of human body, is also clinically very important monitoring key element, in operating room, again
All kinds of medical treatment centers such as disease ICU, casualty department, it is often necessary to which continuously monitoring of blood pressure is carried out to patient.Continuously measure
The arterial pressure of patient's each cardiac cycle, the situation for reflecting the trend of blood pressure and instantaneously changing, so that medical personnel
Deeply, comprehensively understand the state of an illness, corresponding processing can be made in the very first time, the basic condition of medical safety is to ensure that.
The importance of continuous blood pressure monitoring is：(1) for severe shock and urgent patient need to through arterial infusion or blood transfusion,
It can race against time, improve blood pressure, improve the blood supply of the vitals such as the heart, brain, kidney；(2) for the complicated state of an illness, critical and big hand
The controlling of blood pressure of art patient plays a positive role；(3) controlled hypotension is implemented for the patient for losing blood more in surgical procedure,
There is provided accurate data information, so as to effectively control blood pressure, the surface of a wound is lost blood and significantly reduce.
Blood pressure measuring method is divided into invasive mensuration and non-invasive measurement method.Invasive measuring method is exactly arteriopuncture conduit
Method, implementation process is that conduit is inserted in arteries, then detects human blood-pressure by pressure sensor.Non-invasive measurement method
It is to measure human blood-pressure indirectly, it is whether continuous according to measurement result, two major classes of discontinuous measurement and continuous measurement are divided into again.Its
In, discontinuous measurement includes Korotkoff's Sound stethoscopy and oscillographic method；Continuous measurement includes vascular unloading technique, tensionapplanation mensuration, arteries and veins
Fight ripple wave speed measurement method, pulse wave characteristic parameters mensuration etc..
Tensionapplanation mensuration is placed on the skin directly over arteries using pressure sensor, according to angiosthenia
Theory carries out blood pressure measurement, and this method is directly changed by the pressure value measured and obtains pressure value.Although this method can
Realize and human blood-pressure is continuously monitored in the long period, but because blood pressure signal passes through the organized deliveries such as tendon, skin to pressure
The pressure loss is there are during sensor, it is therefore necessary to make great efforts to reduce penalty values, just can guarantee that the precision of measurement.
The content of the invention
In order to overcome existing continuous non-invasive blood pressure measurement technology especially tensionapplanation e measurement technology to pass through because of blood pressure signal
The problem of organized deliveries such as tendon, skin are reduced to accuracy of measurement caused by the pressure loss during pressure sensor,
The application proposes a kind of blood pressure measuring method, and method includes：
Step 1：Arterial pressure signal sequence x [n] is obtained, DC component MeanValue is removed, obtains AC compounent x1
[n]=x [n]-MeanValue；
Step 2：Zoomed in and out to removing the AC compounent obtained after DC component, the AC compounent x2 after being scaled
Kr is zoom factor in [n]=x1 [n] * Kr, formula；
Step 3：AC compounent after scaling adds compensating direct current component, waveform is reduced into arterial pressure signal, i.e.,
The arterial pressure signal x'[n of reduction]=x2 [n]+MeanValue', MeanValue' is compensating direct current component in formula；
Step 4：Seek arterial pressure signal sequence x'[n] maximum max' and minimum value min', respectively obtain systolic pressure
G (x) refers to the function between blood pressure signal and arterial pressure signal in SP=g (max') and diastolic pressure DP=g (min'), formula
Relation.
It is preferred that, methods described also includes blood pressure measurement calibration steps, and the calibration steps includes following sub-step：
Step A：Judge whether arterial pressure waveform is stablized, such as unstable rule adjustment arterial pressure signal sampling device；
Step B：Current pressure value is obtained as reference value；
Step C：Obtain the systolic pressure SP' and diastolic pressure DP' with reference to pressure value；
Step D：Obtain the arterial pressure signal sequence x [n] of a cycle and take maximum max and minimum value min,
Max and min difference it is corresponding value be Pmax=g (max) and Pmin=g (min), then zoom factor Kr=(SP'-DP')/
(Pmax-Pmin)。
It is preferred that, the acquisition methods of the DC component are：By to signal sequence averaged, obtaining DC component
MeanValue。
It is preferred that, in the step 3, it is to the method that DC component is compensated：G (MeanValue')=DP'+
(SP'-DP') * K, wherein K values are within 0 to 1 interval.
It is preferred that, inputted with reference to pressure value from manual calibration.
It is preferred that, automatic calibration input is derived from reference to pressure value, i.e., electronic sphygmomanometer is controlled by data processing centre
Measure what is obtained.
The blood pressure signal that the present invention is exported by pressure sensor carries out going the processing such as straight, scaling, reduction, to blood pressure signal
By organized deliveries such as tendon, skins to pressure sensor during occur the pressure loss compensated, it is ensured that blood pressure
The precision of measurement.
Brief description of the drawings
Fig. 1 is signal component schematic diagram；
Fig. 2 is blood pressure calculation flow chart；
Fig. 3 is blood pressure calibration parameter schematic diagram；
Fig. 4 is blood pressure calibration flow chart；
Fig. 5 is DC component operation chart；
Fig. 6 is signal scaling schematic diagram.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
The application is illustrated with reference to Figure of description 1-6.
The signal that pressure sensor is measured is made up of two parts, and a portion is work of the tension force to sensor of vascular wall
The component of signal Fb firmly produced；Another part is skin meeting when system is placed the sensors on and pressed down on skin
There is a reaction force to sensor, the power is a constant power, the component of signal Fc of generation within the regular hour.
According to Fig. 1 as can be seen that the component of input signal can be obtained as shown in figure 1, being divided into two parts Fb and Fc, wherein Fc is
DC component, Fb is that AC compounent is mixed with DC component.
The flow diagram of blood pressure computational algorithm according to Fig. 2, the blood pressure computational methods that the application is proposed, including：
Step 1：Arterial pressure signal sequence x [n] is obtained, DC component MeanValue is removed, obtains AC compounent x1
[n]=x [n]-MeanValue；
Step 2：Zoomed in and out to removing remaining AC compounent after DC component, the AC compounent x2 after being scaled
Kr is zoom factor in [n]=x1 [n] * Kr, formula；
Step 3：AC compounent after scaling adds compensating direct current component, waveform is reduced into arterial pressure signal, i.e.,
The arterial pressure signal x'[n of reduction]=x2 [n]+MeanValue', MeanValue' is compensating direct current component in formula；
Step 4：Seek arterial pressure sequence x'[n] maximum voltage value max' and minimum amount of voltage that min', respectively obtain receipts
G (x) refers between blood pressure signal and arterial pressure signal in contractive pressure SP=g (max') and diastolic pressure DP=g (min'), formula
Functional relation.
And for this method, it is also possible to it is related to blood pressure measurement calibration, (sensor is in suitable position in one-shot measurement
Put, no skew), it is necessary to be calibrated before blood pressure is calculated, calibration main contents include acquisition and the calibration ginseng of blood pressure reference value
Several determinations.The acquisition of blood pressure reference value, before measurement blood pressure is started, carries out numerical value calibration, it is necessary to obtain current pressure value
It is used as blood pressure reference value.Blood pressure reference value is obtained in two kinds of situation, and one kind is is manually entered, and another is to calibrate defeated automatically
Enter.It is the input that calibration value is carried out by interface operation to be manually entered, and automatic calibration is to control electronics by data processing centre
Sphygmomanometer is measured, and operator need to only select one in both.Obtain the systolic pressure (SP') and diastolic pressure with reference to pressure value
(DP') next it is by reference to value and the signal of change of input scaling ratio Kr after.Obtain the signal sequence of a cycle
And maximum and minimum value are taken, it is x [n] now to obtain signal sequence, DC component of being averaged to obtain to x [n] summations
MeanValue, maximum and minimum value are respectively max and min.As shown in figure 3, max and min correspond respectively to the contraction calculated
(SP) and diastolic pressure (DP) are pressed, max and the corresponding values of min are Pmax=g (max) and Pmin=g (min).By reference to being worth
Theoretical pulse pressure difference is SP'-DP', and the pulse pressure difference that undressed arterial pressure signal is acquired in practice is Pmax-
Pmin.During measurement, the conductive process of power has the loss of energy, and pulse pressure difference and blood pressure values have diminution, it is assumed that
With pulse pressure difference linearly, ratio Kr=(SP'-DP')/(Pmax-Pmin) is the scaling of signal for the loss of energy.
Due to will not be completely the same within each cycle time in the amplitude of input signal, in order to reduce error, in calibration
During obtain the signal sequence in 3-5 cycle, then now signal sequence is x [n], the maximum in acquisition each signal period
Value and minimum value, obtain maximum and minimum value sequence max [i] and min [i], average to obtain max to max min sequence
With min values, so as to obtain Kr, average to obtain MeanValue to signal sequence.Calibrate flow chart as shown in Figure 4.
For blood pressure signal scaling, in one-shot measurement, after calibration, acquisition signal sequence is x [n], calculates signal week
Phase, signal is zoomed in and out, the waveform after scaling just can be used for blood pressure calculating, the scaling of signal include going DC component,
Bi-directional scaling, three steps of reduction.
First, DC component is removed, in the design of this algorithm, in one-shot measurement, and device is not moved, so directly
Flow component will not be changed, and be the MeanValue values calculated in calibration process, and the operation for going DC component is x1 [n]=x
[n]-MeanValue, its effect is as shown in Figure 5.
After DC component is gone, now waveform only remains AC portion, is zoomed in and out by the AC portion to signal.Hand over
The scaling of stream is that the energy loss in transmitting procedure is supplemented, and specific mode is x2 [n]=x1 [n] * Kr, and it is illustrated
Effect such as Fig. 6, wherein block curve are the signal before scaling, and dotted line is the signal after scaling.
, it is necessary to along with waveform is reduced to arterial pressure signal by DC component, directly after AC portion is by scaling
Flow component includes two parts, the reaction that the direct current component and device sensor that arteries is produced are produced during pushing
The direct current component of power, because the process of propagation is different, therefore two-part DC component loss than different.Due to direct current
Component can not be split two parts of DC component by calculating, and the loss of the DC component produced by reaction force can not
It is determined that, carry out effective compensation so can not be zoomed in and out to the part of DC component.
In the present invention, after compensation direct current component be converted into pressure value must blood pressure calibration value systolic pressure SP' and relax
Open pressure DP' interval, then can be DP'+ (SP'-DP') * K by its positional representation, wherein K values are within 0 to 1 interval.Assuming that through
DC component after overcompensation is MeanValue', and a certain numerical value of the corresponding pressure value between DP' and SP' can then obtain formula
(1), wherein g (x) refers to the functional relation between blood pressure signal and arterial pressure signal.
G (MeanValue')=DP'+ (SP'-DP') * K (0 ＜ K ＜ 1) (1)
Draw after MeanValue', just waveform can be reduced, x'[n]=x2 [n]+MeanValue'.
Calculated for blood pressure, after signal is by scaling, just can carry out the evaluation of blood pressure.In signal period sequence,
The maximum max' and minimum value min' in sequence are obtained, then SP=g (max') and DP=g (min').
It should be noted that for each foregoing embodiment of the method, in order to be briefly described, therefore it is all expressed as to one it is
The combination of actions of row, but those skilled in the art should know, the application is not limited by described sequence of movement, because
For according to the application, certain some step can be carried out sequentially or simultaneously using other.Secondly, those skilled in the art also should
Know, embodiment described in this description belongs to preferred embodiment, involved action and unit not necessarily this Shen
Please be necessary.
In the above-described embodiments, the description to each embodiment all emphasizes particularly on different fields, and is not described in some embodiment
Part, may refer to the associated description of other embodiment.
One of ordinary skill in the art will appreciate that realize all or part of flow in above-described embodiment method, being can be with
The hardware of correlation is instructed to complete by computer program, described program can be stored in computer read/write memory medium
In, the program is upon execution, it may include such as the flow of the embodiment of above-mentioned each method.Wherein, described storage medium can be magnetic
Dish, CD, ROM, RAM etc..
Above disclosure is only preferred embodiment of present invention, can not limit the right model of the present invention with this certainly
Enclose, therefore the equivalent variations made according to the claims in the present invention, still belong to the scope that the present invention is covered.
Claims (6)
1. a kind of noninvasive continuous BP measurement method, it is characterised in that：The blood pressure measuring method includes：
Step 1：Obtain arterial pressure signal sequence x [n], remove DC component MeanValue, obtain x1 [n]=x [n]-
MeanValue；
Step 2：Zoomed in and out to removing remaining AC compounent after DC component, it is contracting to obtain Kr in x2 [n]=x1 [n] * Kr, formula
Put coefficient；
Step 3：AC compounent after scaling adds compensating direct current component, and waveform is reduced into arterial pressure signal, i.e. x'[n]
MeanValue' is compensating direct current component in=x2 [n]+MeanValue', formula；
Step 4：Seek arterial pressure signal sequence x'[n] maximum max' and minimum value min', respectively obtain systolic pressure SP=g
(max') and diastolic pressure DP=g (min'), g (x) refers to the functional relation between blood pressure signal and arterial pressure signal in formula.
2. a kind of noninvasive continuous BP measurement method as claimed in claim 1, it is characterised in that：Also include blood pressure measurement to calibrate
Step, the calibration steps includes following sub-step：
Step A：Judge whether arterial pressure waveform is stablized, such as unstable rule adjustment arterial pressure signal sampling device；
Step B：Current pressure value is obtained as reference value；
Step C：Obtain the systolic pressure SP' and diastolic pressure DP' with reference to pressure value；
Step D：Obtain the arterial pressure signal sequence x [n] of a cycle and take maximum max and minimum value min, max and
The corresponding value of min difference is Pmax=g (max) and Pmin=g (min), then zoom factor Kr=(SP'-DP')/(Pmax-Pmin).
3. a kind of noninvasive continuous BP measurement method as claimed in claim 1, it is characterised in that：The acquisition of the DC component
Method is：DC component MeanValue is obtained by being averaged to signal sequence.
4. a kind of noninvasive continuous BP measurement method as claimed in claim 1, it is characterised in that：In the step 3, to direct current
The method that component is compensated is：G (MeanValue')=DP'+ (SP'-DP') * K, wherein K values are within 0 to 1 interval.
5. a kind of noninvasive continuous BP measurement method as claimed in claim 1, it is characterised in that：Hand is derived from reference to pressure value
Dynamic calibration input.
6. a kind of noninvasive continuous BP measurement method as claimed in claim 2, it is characterised in that：Derived from certainly with reference to pressure value
Dynamic calibration input, i.e., control electronic sphygmomanometer to measure what is obtained by data processing centre.
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| CN201710487953.9A CN107320088B (en) | 2017-06-23 | 2017-06-23 | Non-invasive continuous pulse blood pressure measuring method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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