CN107315263A - The preparation method of Silica hydrogel contact lens surface method of modifying and its colorful contact lens - Google Patents
The preparation method of Silica hydrogel contact lens surface method of modifying and its colorful contact lens Download PDFInfo
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- CN107315263A CN107315263A CN201710520735.0A CN201710520735A CN107315263A CN 107315263 A CN107315263 A CN 107315263A CN 201710520735 A CN201710520735 A CN 201710520735A CN 107315263 A CN107315263 A CN 107315263A
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- contact lens
- coating
- silica hydrogel
- hydrogel contact
- pigment
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/046—Contact lenses having an iris pattern
Abstract
The invention provides the preparation method of a kind of Silica hydrogel contact lens surface method of modifying and its colorful contact lens, method of modifying is：The coating with network pattern structure with gradient water content is coated on Silica hydrogel contact lens surface；Wherein, the water content of the coating is higher than the Silica hydrogel contact lens of ground；Coating is colored or colourless；The material of coating is biopolymer；The Silica hydrogel contact lenses are polymerized by siliceous prepolymer or by the mixture of each monomer and siliceous prepolymer.By the present invention in that improving the surface property of Silica hydrogel contact lenses with the network structure coating of gradient water content, wearing effect is improved, sensation of dryness of the colorful contact lens in wearing is effectively reduced, while also improving wearing comfort sense.Appropriate coating water content ensure that exchanging for water liquid and ocular fluid, while also ensure that the oxygen permeability and appropriate moisture content volatilization and the wetability of coating surface of contact lenses and prevent protein from being deposited on the surface of coating.
Description
Technical field
The invention belongs to contact lens technique field, the surface modifying method of more particularly to a kind of Silica hydrogel contact lenses and
The preparation method of its colorful contact lens.
Background technology
The contact lenses that Silica hydrogel makes drastically increase the oxygen transmission rate of contact lenses to meeting a nitrile pair due to it
The demand of oxygen and drastically increase wearing effect, it overcomes the limitation of hydrogel itself oxygen transmission rate, and just increasingly by
The welcome of consumer.But Silica hydrogel has a limitation of itself water content, therefore the hydrophily on its surface is not good enough and then have impact on and matches somebody with somebody
Wear effect.The hydrophily of contact lens surface is not good to bring a series of risk, including dry and astringent, low comfort, and protein sinks
Form sediment.Dry and astringent is to have how much four people can feel dry and astringent in most common problem in contact lens (contact lenses), every five people, is done
The puckery generation mainly due to ocular fluid is uneven with discharge, so appropriate surface hydrophilicity controls appropriate moisture content to wave again simultaneously
Send out critically important to the balance for keeping ocular fluid.To overcome this shortcoming, conventional method is is surface-treated, including at plasma
Reason, wet-chemical treatment, lens surface connects skill hydrophilic monomer or polymer, one layer connect one layer the hydrophilic material of coating,
Hydrophilic high polymer or wetting agent or viscosity thickener are added in eyeglass packs liquid.Common method is United States Patent (USP)
6451871,6719929,6793973,6811805,6896926 coatings layer by layer illustrated and plasma treatment.More conventional
It is to carry out plasma treatment with ionized gas in United States Patent (USP) 4312575,4632844.These processing methods it is cumbersome and
Effect is limited, and particularly flood coating hydroaropic substance will influence Silica hydrogel final oxygen transmission rate in itself, and plasma treatment
Frequently result in the problems such as surface treatment is uneven and influence final mass.
The content of the invention
It is an object of the invention to provide the system of a kind of Silica hydrogel contact lens surface method of modifying and its colorful contact lens
Preparation Method, it is not good enough with the hydrophily for solving the presence of Silica hydrogel contact lenses, and then have impact on the problem of wearing effect.
To achieve the above object, the present invention uses following technical scheme：
A kind of Silica hydrogel contact lens surface method of modifying, by the coating with network pattern structure with gradient water content
It is coated on the Fei Guang areas of Silica hydrogel contact lens；
Wherein, the water content of the coating is higher than the Silica hydrogel contact lens of ground；Coating is colored or colourless；Apply
The material of layer is biopolymer；
The Silica hydrogel contact lenses are gathered by siliceous prepolymer or by the mixture of each monomer and siliceous prepolymer
Conjunction is formed.
In above-mentioned technical proposal, gradient water content refers to that the Silica hydrogel contact lens water content of coating and ground differs
Sample and overall final eyeglass is formed water content gradient from the inside to surface；So as to further improve the hydrophily of lens surface, lubrication
Property, anti-protein precipitation.The water content of coating is 38%-55%, more preferably for 40% to 50%.
Purpose of the coating with network pattern structure is so that oxygen does not have to be directed through at coating at these holes
Ground silica gel eyeglass and enter intraocular, the network pattern of coating is by putting the various patterns constituted with line, being coated on lens surface
Fei Guang areas, specific layout refers to United States Patent (USP) 5 414 477, and it discloses how to design more in iris area simultaneously
Colourful pattern true to nature reaches more natural decorative effect.This coating is network structure pattern, and it is different from conventional silica gel
The all surfaces of lens surface cover the hydroaropic substance of one layer of again-layer, including light area and Fei Guang areas.
Coating is colored or colourless, and colored can then be used as color silica gel contact lenses.
The preparation method of biopolymer can refer to conventional hydrophilic Polymer Synthesizing route, be synthesized by monomer, used
Monomer is hydroxy acrylate, carboxy acrylic ester, acrylic acid, methyl methacrylate, methylmethacrylate, propylene acid glycerol
Ester, N- vinyl gives a tongue-lashing pyrrolidone, N- vinylsuccinimides, N- caprolactams, N- vinyl glutarimides, second
The one or more of alkenyl pyridine；Solvent for use is methoxypropionate, ethyl cellosolve, ethyl lactate, the tert-butyl alcohol, ring penta
One or more in ketone, cyclohexanone are mixed；Initiator used is that radical polymerization shares initiator, including the isobutyl of azo two
Nitrile, benzoyl peroxide, peroxidized t-butyl perbenzoate, tert-butyl group perchlorhydria；Molecular regulation agent is 2 mercapto ethanol, 12
The one or more of alkanethiol；Polymerization terminator used is methylnaphthohydroquinone THQ, 1,4-benzoquinone PBQ, hydroquinones at the end of reaction
HQ, MEHQ HQMME, 2- TBHQ MTBHQ, 2,5- di-tert-butyl hydroquinones 2, the one of 5-DTBHQ
Plant or a variety of.
To strengthen viscosity of the above-mentioned polymer in lens surface, using attachment when coating is coated on Silica hydrogel contact lenses
Power accelerator, adhesion promoter is isocyanates, alkyl silicon, amide-type, epoxy base class.More preferential adhesion promoter
For two isocyanates.
Coating is coated on the arcuate surface of Silica hydrogel contact lenses, or Silica hydrogel contact lenses concave surface and inside.It can use
Pad printer transfer printing coating is in the convex surface of eyeglass, concave surface or inside.
A kind of preparation method of colorful contact lens, comprises the following steps：
Step one, it polymerize by siliceous prepolymer or by each monomer with the mixture of siliceous prepolymer and prepares silicon and coagulate
Glue contact lens；
Step 2, prepares biopolymer：Monomer is used to synthesize biopolymer of the water content for 38-55%；
Step 3, prepares coloured coating：According to mass fraction, 50-80 parts of high polymer, 15-30 parts of pigment, solvent 4-15
Part, each component is mixed evenly, then entered with grinding distribution machine by 0.5-2 parts of pigment dispersing agent, 0.4-1.2 parts of wetting agent
Row grinding, pigment fineness is less than 10 microns；
Coloured coating, the surface of Silica hydrogel contact lens is coated on pad printer by step 4, and is pre-designed each
Plant colored network pattern；
Step 5, curing of coatings：The Silica hydrogel contact lens for producing colored network pattern are placed in baking oven,
Dried at 80-140 DEG C of temperature, baking oven used can be routine or with vacuum, obtain colorful contact lens piece；
Step 6, colour lens aquation：Colorful contact lens piece is placed in the salt solution that pH value is 8-11.0, in temperature
Hydration process is carried out in 60-90 DEG C 8-20 hours；
Colorful contact lens piece after above-mentioned aquation, is then shifted stable to swollen in pH is 7.2 salt solution by step 7
Swollen rate is constant, and the good color silica gel contact lenses of the aquation can enter bottle in clean room and carry out wet method moise-heat sterilization i.e.
Final products are made.
In step one, monomer used in the preparation of Silica hydrogel contact lens is containing acid amides (NH), or containing carboxyl
(COOH) vinyl monomer of one or more functional groups or in hydroxyl (OH).
In step 3, pigment used is inorganic or organic pigment in the coloured coating, and purity grade should be cosmetics
Level, medicine equipment level or more；Pigment used is：The yellow of iron oxide series, brown, red, black pigment is iron oxide
Or carbon black, blue pigment is phthalocyanine blue, and viridine green is chrome green, and Chinese white is titanium dioxide；Height can be used in pigment
Pure calcium carbonate is used as filler.
In coloured coating, pigment volume concentration (PVC) is 5%-35%.More preferably for 10%-30%.
Beneficial effect：The present invention is color by the network pattern structure that one layer of gradient water content is coated with Silica hydrogel lens surface
Color coating reaches a variety of purposes：First, because the appropriate gradient water content hydrophily on surface solves the profit on Silica hydrogel surface
It is moist；Second, surface graded water content, which solves eyeball surface, will internally enough moisture content, and externally then suppress the mistake of moisture content
Divide volatilization, so as to keep appropriate moisture content, so as to meet the balance that ocular fluid is produced and volatilized, and then solve contact lens wear
The common sensation of dryness of person and its complication-uncomfortable and foreign body sensation；3rd, coating of the present invention is network pattern structure, extraneous oxygen
Gas can pass through Silica hydrogel at no coating of large area and hydrophilic coating is not influenceed oxygen transmission rate；4th, if this coating is made
Silica hydrogel eyeglass is then set to turn into color silica gel eyeglass into colour.Technical scheme provides three aspect functions：Correction is regarded
Power, improves the wearing effect of Silica hydrogel contact lenses, beautifying and decorating eyes.Under normal circumstances, contact lenses are because add
One layer of coating its wear effect and can not show a candle to former contact lenses (i.e. no coating).It is of the invention then broken this routine, pass through essence
The heart designs coating, is not influenceed on wearing effect, further improves improving wearing effect on the contrary.
By the present invention in that improve the surface property of Silica hydrogel contact lenses with the network structure coating of gradient water content,
Wearing effect is improved, sensation of dryness of the colorful contact lens in wearing is effectively reduced, while also improving wearing comfort sense.
Appropriate coating water content ensure that exchanging for water liquid and ocular fluid, while also ensure that the oxygen permeabilities of contact lenses and appropriate
Moisture content volatilize and coating surface wetability and prevent protein coating surface deposit.
Embodiment
With reference to specific embodiment, the present invention is described further.
Embodiment 1：It is prepared by Silica hydrogel contact lens
Silica hydrogel contact lens used in the present invention can be photopolymerization or the made casting of thermal polymerization or be lathed
The Silica hydrogel contact lenses of type.Casting used or turning moulding process can refer to common document and industrial practice.It is raw materials used can
To be siliceous prepolymer or by each monomer and the mixture of siliceous prepolymer.It is preferred that, monomer used is by containing acyl
Amine (NH), or the vinyl monomer containing one or more functional groups in carboxyl (COOH) or hydroxyl (OH).About siliceous pre-
The preparation of polymers is referred to United States Patent (USP) 4136250A, 5962548A, 5563184A.In the present embodiment, raw materials are matched somebody with somebody
Fang Wei：The macromonomer of 26.97% silicone-containing, 16.75% TRIS (3- tri- (methyl-siloxy) monosilanes
Base propyl methacrylate), 32.64% DMA (N,N-DMAA), 22.64% denatured ethyl alcohol and 1.0%
2- hydroxy-2-methyl -1- phenyl -1- acetone (1173).It is prepared by the Silica hydrogel contact lens of the present embodiment
The explanation present invention is only intended to, and actually used Silica hydrogel contact lens are not limited to described in the present embodiment.
Embodiment 2：The preparation of yellow contact lenses
Weigh 45 grams of HEMA, 0.8 gram of methacrylic acid, 1.5 grams of methyl methacrylate, lactic acid
15.70 grams of ethyl ester, 37.5 grams of cyclopentanone and fine 0.04 gram of the isobutyl of azo two, 0.6 gram of 2 mercapto ethanol, it is placed in glass reaction bottle
Well mixed, in 70 degree polymerisations 6 hours, then 0.04 gram of methylether hydroquinone of addition stirred simultaneously in glass reaction bottle
Stop reaction, the biopolymer with gradient water content is that synthesis is finished.
Above-mentioned 412 grams of biopolymer, 88 grams of yellow iron oxide pigment, 3.1 grams of EFKA5054 auxiliary agents are weighed, Byk307 adds
Plus 2.2 grams of agent, 46 grams of cyclopentanone is placed in disperse mill, is added appropriate abrasive media, is ground to pigment particles fineness and is less than
10 μm, the colour-wash with gradient water content is to be made with slurry.Then colour-wash slurry obtained above is weighed
Expect 50 grams, 3 grams of isocyanates, 19 grams of biopolymer is mixed and stirred for uniformly, obtaining the colored painting with gradient water content
Layer.
The appropriate above-mentioned coloured coating with gradient water content is extracted, the coating is coated on Silica hydrogel stealth with pad printer
The surface of eyeglass is simultaneously pre-designed various colored network patterns；Then the contact lens for producing multicolour pattern are placed in
In baking oven, dried 5 hours at 100 degree；Then the colorful contact lens dry plate with gradient water content being cured is placed in
PH carries out hydration process 16 hours for 9.0 salt solution in 90 degree, then gradient water content color invisible eye after above-mentioned aquation
Mirror shifts stable constant to expansion rate in pH is 7.2 salt solution, and the good color silica gel contact lenses of the aquation can be at 100 grades
Enter bottle in clean room and carry out wet method moise-heat sterilization and final products are made.
Embodiment 3：The preparation of purple contact lenses
Weigh N- vinyl and give a tongue-lashing 7.5 grams of pyrrolidone, 37.8 grams of HEMA, 0.5 gram of methacrylic acid,
0.4 gram of acrylic acid, 1.4 grams of methyl methacrylate, 16.1 grams of ethyl lactate, 35.7 grams of cyclopentanone and the isobutyl of azo two are fine
0.035 gram, 0.55 gram of 2 mercapto ethanol, be placed in glass reaction bottle and be well mixed, in 75 degree of polymerisations 5 hours, then exist
Add 0.033 gram of methylether hydroquinone in glass reaction bottle to stir and stop reaction, the biology with gradient water content is high to be gathered
Thing is that synthesis is finished.
Weigh above-mentioned 404 grams of biopolymer, 132 grams of high-purity violet pigment, 9.28 grams of EFKA5054 auxiliary agents, Byk307
6.24 grams of additive, 26 grams of cyclopentanone is placed in disperse mill, is added appropriate abrasive media, is ground to pigment particles fineness and exists
Less than 10 μm, the colour-wash with gradient water content is to be made with slurry.Then colour-wash obtained above is weighed
With 50 grams of slurry, 3.3 grams of isocyanates, 45 grams of high polymer is mixed and stirred for uniformly, obtaining the colored painting with gradient water content
Layer.
The appropriate above-mentioned coloured coating with gradient water content is extracted, the coating is coated on Silica hydrogel stealth with pad printer
The surface of eyeglass is simultaneously pre-designed various multicolour patterns；The contact lens for producing multicolour pattern are then placed in baking oven
It is interior, dried 5 hours at 100 degree；Then the colorful contact lens dry plate with gradient water content being cured is placed in into pH is
8.5 salt solution carries out hydration process 20 hours in 85 degree, and then gradient water content colorful contact lens after above-mentioned aquation are turned
Move stable constant to expansion rate in pH is 7.2 salt solution, the good colorful contact lens of the aquation can be in clean room
Enter bottle and carry out wet method moise-heat sterilization and final products are made.
Embodiment 4：The preparation of green contact lenses
Weigh 1.1 grams of glycerol acrylate, 37.7 grams of HEMA, ethylene glycol dimethacrylate
0.63 gram, 0.26 gram of methacrylic acid, 1.05 grams of methyl methacrylate, 15.7 grams of ethyl lactate, 42.9 grams of cyclopentanone and even
Fine 0.044 gram of the isobutyl of nitrogen two, 0.78 gram of 2 mercapto ethanol, be placed in glass reaction bottle be well mixed, it is small in 75 degree of polymerisations 5
When, 0.034 gram of methylether hydroquinone is then added in glass reaction bottle and is stirred and stop reaction, with gradient water content
Biopolymer is that synthesis is finished.
Weigh above-mentioned 363 grams of biopolymer, 172 grams of viridine green, 7.5 grams of EFKA5054 auxiliary agents, Byk307 additives
5.2 grams, 48 grams of cyclopentanone is placed in disperse mill, adds appropriate abrasive media, be ground to pigment particles fineness 10 μm with
Lower, the colour-wash with gradient water content is to be made with slurry.Then colour-wash slurry obtained above is weighed
50 grams, 2.9 grams of isocyanates, 37 grams of high polymer are mixed and stirred for uniformly, obtaining the coloured coating with gradient water content.
The appropriate above-mentioned coloured coating with gradient water content is extracted, the coating is coated on hidden silica gel eye with pad printer
The surface of mirror eyeglass is simultaneously pre-designed various multicolour patterns；The contact lens for producing multicolour pattern are then placed in baking oven
It is interior, dried 3 hours at 120 degree；Then the colorful contact lens dry plate with gradient water content being cured is placed in into pH is
8.0 salt solution carries out hydration process 18 hours in 90 degree, and then gradient water content colorful contact lens after above-mentioned aquation are turned
Move stable constant to expansion rate in pH is 7.2 salt solution, the good colorful contact lens of the aquation can be in clean room
Enter bottle and carry out wet method moise-heat sterilization and final products are made.
Contact lenses prepared by Silica hydrogel contact lenses white tiles and the present invention, progress pair are worn by the people of trier 26 respectively
Than table 1 below is shown, the people for having about 82% after 6 hours, still in wearing product of the present invention still feels comfortable, and has about 76%
Ren No have sensation of dryness, and this result is much better than the 42% and 25% of Silica hydrogel contact lenses white tiles.Prove that the present invention greatly changes
It has been apt to the wearing effect of colorful contact lens.
The clinical wear trial result of table 1.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Silica hydrogel contact lens surface method of modifying, it is characterised in that：By the band network pattern with gradient water content
The coating of structure is coated on the Fei Guang areas of Silica hydrogel contact lens；
Wherein, the water content of the coating is higher than the Silica hydrogel contact lens of ground；Coating is colored or colourless；Coating
Material is biopolymer；
The Silica hydrogel contact lenses be polymerize with the mixture of siliceous prepolymer by siliceous prepolymer or by each monomer and
Into.
2. Silica hydrogel contact lens surface method of modifying according to claim 1, it is characterised in that：The coating it is aqueous
Measure as 38%-55%.
3. Silica hydrogel contact lens surface method of modifying according to claim 1, it is characterised in that：The network of the coating
Pattern is by putting the various patterns constituted with line.
4. Silica hydrogel contact lens surface method of modifying according to claim 1, it is characterised in that：The biopolymer
Synthesized by monomer, monomer used is hydroxy acrylate, carboxy acrylic ester, acrylic acid, methyl methacrylate, isobutyl
E pioic acid methyl ester, glycerol acrylate, N- vinyl gives a tongue-lashing pyrrolidone, N- vinylsuccinimides, N- caprolactams, N-
Vinyl glutarimide, the one or more of vinylpyridine；Solvent for use is methoxypropionate, ethyl cellosolve,
One or more in ethyl lactate, the tert-butyl alcohol, cyclopentanone, cyclohexanone are mixed；Initiator used shares for radical polymerization
Initiator, including azodiisobutyronitrile, benzoyl peroxide, peroxidized t-butyl perbenzoate, tert-butyl group perchlorhydria；Molecule is adjusted
Section agent is 2 mercapto ethanol, the one or more of dodecyl mercaptans；Polymerization terminator used is methylnaphthohydroquinone at the end of reaction
THQ, 1,4-benzoquinone PBQ, hydroquinones HQ, MEHQ HQMME, 2- TBHQ MTBHQ, 2,5- di-t-butyls
Hydroquinones 2,5-DTBHQ one or more.
5. Silica hydrogel contact lens surface method of modifying according to claim 1, it is characterised in that：The coating is coated on
Adhesion promoter is used when on Silica hydrogel contact lenses, adhesion promoter is isocyanates, alkyl silicon, amide-type or epoxy
Base class.
6. Silica hydrogel contact lens surface method of modifying according to claim 1, it is characterised in that：The coating is coated on
The arcuate surface of Silica hydrogel contact lenses, or Silica hydrogel contact lenses concave surface and inside.
7. a kind of preparation method of colorful contact lens, it is characterised in that：Comprise the following steps：
Step one, it polymerize that to prepare Silica hydrogel hidden with the mixture of siliceous prepolymer by siliceous prepolymer or by each monomer
Shape eyeglass；
Step 2, prepares biopolymer：Monomer is used to synthesize biopolymer of the water content for 38-55%；
Step 3, prepares coloured coating：According to mass fraction, 50-80 parts of high polymer, 15-30 parts of pigment, 4-15 parts of solvent, face
Expect 0.5-2 parts of dispersant, each component is mixed evenly, then ground with grinding distribution machine by 0.4-1.2 parts of wetting agent
Mill, pigment fineness is less than 10 microns；
Coloured coating, the surface of Silica hydrogel contact lens is coated on pad printer by step 4, and is pre-designed various coloured silks
Color network pattern；
Step 5, curing of coatings：The Silica hydrogel contact lens for producing colored network pattern are placed in baking oven, in temperature
Dried at 80-140 DEG C, obtain colorful contact lens piece；
Step 6, colour lens aquation：Colorful contact lens piece is placed in the salt solution that pH value is 8-11.0, in temperature 60-90
Hydration process is carried out in DEG C 8-20 hours；
Colorful contact lens piece after above-mentioned aquation, is then shifted stable to expansion rate in pH is 7.2 salt solution by step 7
Constant, the good color silica gel contact lenses of the aquation, which can enter bottle in clean room and carry out wet method moise-heat sterilization, to be made
Final products.
8. the preparation method of colorful contact lens according to claim 7, it is characterised in that：In step one, Silica hydrogel is hidden
Monomer used in the preparation of shape eyeglass is to contain acid amides, or the ethene containing one or more functional groups in carboxyl or hydroxyl
Base monomer.
9. the preparation method of colorful contact lens according to claim 7, it is characterised in that：In step 3, the colour
Pigment used is inorganic or organic pigment in coating, and purity grade should be cosmetics-stage, medicine equipment level or more；Used
Pigment is：The yellow of iron oxide series, brown is red, and black pigment is iron oxide or carbon black, and blue pigment is phthalocyanine blue, green
Color pigment is chrome green, and Chinese white is titanium dioxide.
10. the preparation method of the colorful contact lens according to claim 7 or 9, it is characterised in that：The coloured coating
In, pigment volume concentration (PVC) is 5% to 35%.
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| CN109188715A (en) * | 2018-09-21 | 2019-01-11 | 江苏富视优生物科技有限公司 | The method for directly preparing sandwich colorful contact lens using bare die |
| CN110194846A (en) * | 2019-06-26 | 2019-09-03 | 江苏彩康隐形眼镜有限公司 | The preparation method of the modified and its colored Ortho-K in Ortho-K surface |
| WO2021147919A1 (en) * | 2020-01-20 | 2021-07-29 | 爱博诺德(北京)医疗科技股份有限公司 | Medical device and manufacturing method therefor |
| CN113419357A (en) * | 2021-07-07 | 2021-09-21 | 武汉东持科技有限公司 | Preparation method of full-color-separation colored contact lens |
| CN113462019A (en) * | 2020-03-31 | 2021-10-01 | 望隼科技股份有限公司 | Blue light-proof contact lens, composition and manufacturing method thereof |
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| CN113419357A (en) * | 2021-07-07 | 2021-09-21 | 武汉东持科技有限公司 | Preparation method of full-color-separation colored contact lens |
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