CN107312787B - Fusion protein gene, engineering bacterium and application of fusion protein gene and engineering bacterium in preparation of 9 α -hydroxy-androstenedione - Google Patents
Fusion protein gene, engineering bacterium and application of fusion protein gene and engineering bacterium in preparation of 9 α -hydroxy-androstenedione Download PDFInfo
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- CN107312787B CN107312787B CN201710586367.XA CN201710586367A CN107312787B CN 107312787 B CN107312787 B CN 107312787B CN 201710586367 A CN201710586367 A CN 201710586367A CN 107312787 B CN107312787 B CN 107312787B
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- androstenedione
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
- C12N9/0081—Cholesterol monooxygenase (cytochrome P 450scc)(1.14.15.6)
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- C12Y114/13142—3-Ketosteroid 9alpha-monooxygenase (1.14.13.142)
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- C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
- C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
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Citations (5)
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CN101565709A (en) * | 2009-05-20 | 2009-10-28 | 华东理工大学 | 3-sterone-9Alpha-hydroxylation enzyme gene, 3-sterone-9Alpha-hydroxylation enzyme reductase gene, relevant carriers, engineering bacteria and applications thereof |
CN102747052A (en) * | 2012-07-24 | 2012-10-24 | 浙江大学宁波理工学院 | Cytochrome P450 BM-3 (L148S/Q 229R) variant enzyme and coding gene and use thereof |
CN102757944A (en) * | 2012-07-24 | 2012-10-31 | 浙江大学宁波理工学院 | Cytochrome P450BM-3 (D168L/E435T) variant enzyme as well as coding genes and application thereof |
WO2015173590A1 (en) * | 2014-05-16 | 2015-11-19 | The Unversity Of York | Novel cytochrome p450 fusion protein |
CN105473730A (en) * | 2013-06-17 | 2016-04-06 | 赛诺菲 | Whole-cell system for cytochrome P450 monooxygenases biocatalysis |
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CN101565709A (en) * | 2009-05-20 | 2009-10-28 | 华东理工大学 | 3-sterone-9Alpha-hydroxylation enzyme gene, 3-sterone-9Alpha-hydroxylation enzyme reductase gene, relevant carriers, engineering bacteria and applications thereof |
CN102747052A (en) * | 2012-07-24 | 2012-10-24 | 浙江大学宁波理工学院 | Cytochrome P450 BM-3 (L148S/Q 229R) variant enzyme and coding gene and use thereof |
CN102757944A (en) * | 2012-07-24 | 2012-10-31 | 浙江大学宁波理工学院 | Cytochrome P450BM-3 (D168L/E435T) variant enzyme as well as coding genes and application thereof |
CN105473730A (en) * | 2013-06-17 | 2016-04-06 | 赛诺菲 | Whole-cell system for cytochrome P450 monooxygenases biocatalysis |
WO2015173590A1 (en) * | 2014-05-16 | 2015-11-19 | The Unversity Of York | Novel cytochrome p450 fusion protein |
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Title |
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"P450 BM3: the very model of a modern flavocytochrome";Andrew W. Munro等;《Trends in Biochemical Sciences》;20020501;第27卷(第5期);第252页左栏倒数第1段-右栏第2段,第254页图4,图5 * |
"Rhodococcus rhodochrous DSM 43269 3-Ketosteroid 9α-Hydroxylase,a Two-Component Iron-Sulfur-Containing Monooxygenase with Subtle Steroid Substrate Specificity";M. Petrusma等;《Applied And Environmental Microbiology》;20090626;第75卷(第16期);第5300页右栏第2段,第5301页图1,第5301页右栏第4段,第5302有右栏第1段 * |
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