CN107298679B - A kind of synthetic method of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5- - Google Patents
A kind of synthetic method of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5- Download PDFInfo
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- CN107298679B CN107298679B CN201710513755.5A CN201710513755A CN107298679B CN 107298679 B CN107298679 B CN 107298679B CN 201710513755 A CN201710513755 A CN 201710513755A CN 107298679 B CN107298679 B CN 107298679B
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
The present invention relates to a kind of synthetic methods of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5-.Mainly solve the technical issues of wantage is combined to method.Synthetic method of the present invention generates compound 1 the following steps are included: the chloro- 7- azaindole of 4- reacts in tetrahydrofuran with sodium hydride, tri isopropyl chlorosilane at room temperature；Compound 1 is in tetrahydrofuran and s-butyl lithium, carbon trichloride low-temp reaction generate compound 2；Compound 2 and sodium azide, ammonium chloride react under n,N-Dimethylformamide high temperature, generate compound 3；Under palladium carbon catalytic action, compound 3 by hydrogenated at normal pressure, generates target compound 4 in ethanol.As expensive fine chemical product, chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5- is used widely in pharmaceutical industry.
Description
Technical field
The present invention relates to the synthetic methods of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5-.
Background technique
Chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine (CAS:1040683-00-8) of 5- is as very expensive fining
Chemical product is used widely in pharmaceutical industry.So far, the not disclosed report of synthetic method of quantization production.
Summary of the invention
The object of the present invention is to provide a kind of synthetic methods of chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5-, main to solve
Certainly wantage is combined to the technical issues of method.
Technical solution of the present invention are as follows: a kind of synthetic method of chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5-, feature
Being includes lower step: the first step, and the chloro- 7- azaindole of 4- is in tetrahydrofuran and sodium hydride, tri isopropyl chlorosilane room temperature are anti-
It answers, the active hydrogen on amino is protected by triisopropylsilyl, generates compound 1；Second step, compound 1 in tetrahydrofuran according to
Secondary and s-butyl lithium, carbon trichloride generate compound 2 in low-temp reaction；Third step, compound 2 and sodium azide, ammonium chloride,
It is reacted under n,N-Dimethylformamide high temperature, chlorine is replaced by nitrine based selective, while removing triisopropylsilyl, generates
Compound 3；4th step, under palladium carbon catalytic action, in ethanol by room temperature hydrogenated at normal pressure, azido is reduced compound 3
At amino, target compound 4 is generated.
Synthetic line is as follows:
。
First step reaction temperature is room temperature, and the reaction time is overnight；Second step reaction temperature be -30--70 DEG C, preferably -50
DEG C and the s-butyl lithium reaction time is 10-50 minutes, preferably 30 minutes and the reaction time of carbon trichloride is 2-6 hours, it is excellent
It selects 4 hours；Third step reaction temperature is 90-130 DEG C, and preferably 110 DEG C, the reaction time is 12-36 hours, preferably 24 hours.
The beneficial effects of the present invention are: the synthetic line of synthetic method design of the present invention is simple；In entire synthesis process,
Raw materials and reagents are cheap, and intermediate and target product are easy to purify；The blank in its synthetic method is filled up.
Specific embodiment
Embodiment 1:
Step 1:
The addition chloro- 7- azaindole of 4- (50 g, 329 mmol) and tetrahydrofuran (700 mL) into three-necked flask, 0
DEG C when sodium hydride (60%, 9.5 g, 395 mmol) and tri isopropyl chlorosilane (94.8 g, 494 mmol) is successively added, instead
Liquid is answered to be stirred overnight at room temperature.Saturated aqueous ammonium chloride (200 mL) is added at 0 DEG C, ethyl acetate extracts (100 mL x 3);
Organic phase merges, and is washed with saturated salt solution (100 mL), sodium sulphate dries, filters.Filtrate is spin-dried for, crude product purified by silica gel column color
Spectrum separation (petroleum ether), obtains colourless liquid, compound 1 (92.1 g, 299 mmol, 91%).1H NMR (400 MHz,
DMSO-d6): 8.19 (m, 1H), 7.58 (m, 1H), 7.23 (m, 1H), 6.69-6.67 (m, 1H), 1.89-
1.84 (m, 3H), 1.07-1.04 (m, 18H) ppm。GC-MS (ESI): m/z 309 [M+H]+；
Step 2:
Compound 1 (72.9 g, 236.8 mmol) and tetrahydrofuran (880 mL) are added into three-necked flask.-50℃
When be added dropwise s-butyl lithium tetrahydrofuran solution (1.3 M, 364 mL, 474 mmol), reaction solution stir 30 minutes.Add at -50 DEG C
Enter carbon trichloride (83.0 g, 355 mmol), reaction solution stirs 4 hours at this temperature；Saturated ammonium chloride water is added at 0 DEG C
(100 mL x 3) is extracted with ethyl acetate in solution (100 mL), water phase;Organic phase merges, and is washed with saturated salt solution (100 mL)
It washs, sodium sulphate dries, filters.Filtrate is spin-dried for, and crude product purified by silica gel pillar layer separation (petroleum ether) obtains colourless liquid, chemical combination
Object 2 (52.2 g, 153 mmol, 65%).1H NMR (400 MHz, DMSO-d6): 8.37 (s, 1H), 7.68 (m,
1H), 6.72 (m, 1H), 1.92-1.82 (m, 3H), 1.05-1.01 (m, 18H) ppm。GC-MS (ESI): m/z
343 [M+H]+；
Step 3:
Compound 2(46.0 g, 134.5 mmol are added into three-necked flask), and sodium azide (43.7 g, 672.5
Mmol), ammonium chloride (35.6 g, 672.5 mmol) and n,N-Dimethylformamide (690 mL)；It is stirred 24 hours at 110 DEG C.
It is cooled to room temperature, reaction solution is diluted with water (1000 mL), and ethyl acetate extracts (500 mL x 3);Organic phase merges, with full
It is washed with saline solution (500 mL), sodium sulphate dries, filters.Filtrate is spin-dried for, crude product purified by silica gel pillar layer separation (petroleum ether:
Ethyl acetate volume ratio=8:1), obtain faint yellow solid, compound 3(18.0 g, 93.0 mmol, 70%).LC-MS
(ESI): m/z 194.29 [M+H]+；
Step 4:
Compound 3(9.0 g, 46.5 mmol are added into three-necked flask), palladium carbon (0.9 g, 10%) and ethyl alcohol (118
ML)；Room temperature hydrogenated at normal pressure 6 hours.Filtration of catalyst, filtrate are spin-dried for, crude product purified by silica gel pillar layer separation (petroleum
Ether: ethyl acetate volume ratio=8:1), obtain yellow solid, compound 4(7.27 g, 43.3 mmol, 93%).1H NMR
(400 MHz, DMSO-d6): 11.31 (s, 1H), 7.82 (s, 1H), 7.12 (t, 1H), 6.60 (d, 1H),
6.41 (s, 2H) ppm。LC-MS (ESI): m/z 168.14 [M+H]+。
Embodiment 2: -70 DEG C of second step reaction temperature, compound 1 and s-butyl lithium reaction time are 50 minutes and chlordene
The ethane reaction time is 6 hours；90 DEG C of third step reaction temperature, the reaction time is 36 hours；Remaining is the same as embodiment 1.
Embodiment 3: -30 DEG C of second step reaction temperature and s-butyl lithium reaction time reacted for 10 minutes and carbon trichloride
Time is 2 hours；130 DEG C of third step reaction temperature, the reaction time is 12 hours；Remaining is the same as embodiment 1.
Claims (4)
1. a kind of synthetic method of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5-, it is characterized in that the following steps are included: first
Step, the chloro- 7- azaindole of 4- react at room temperature in tetrahydrofuran with sodium hydride, tri isopropyl chlorosilane, the active hydrogen on amino
It is protected by triisopropylsilyl, generates compound 1；Second step, compound 1 in tetrahydrofuran successively and s-butyl lithium, chlordene
Ethane is reacted at -30--70 DEG C, generates compound 2；Third step, compound 2 and sodium azide, ammonium chloride, in N, N- dimethyl
90-130 DEG C of reaction in formamide, chlorine is replaced by nitrine based selective, while removing triisopropylsilyl, generates compound 3；The
Four steps, under palladium carbon catalytic action, for compound 3 in ethanol by room temperature hydrogenated at normal pressure, azido is reduced into amino, generates
Target compound 4, synthetic line is as follows:
。
2. a kind of synthetic method of chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5- according to claim 1, feature
It is that second step compound 1 and s-butyl lithium are reacted 10-50 minutes.
3. a kind of synthetic method of chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5- according to claim 1, feature
It is that second step compound 1 and carbon trichloride react 2-6 hours.
4. a kind of synthetic method of chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5- according to claim 1, feature
It is that third step is reacted 12-36 hours.
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