CN107296982A - A kind of preparation method of fiber artificial's blood vessel - Google Patents
A kind of preparation method of fiber artificial's blood vessel Download PDFInfo
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- CN107296982A CN107296982A CN201710397421.6A CN201710397421A CN107296982A CN 107296982 A CN107296982 A CN 107296982A CN 201710397421 A CN201710397421 A CN 201710397421A CN 107296982 A CN107296982 A CN 107296982A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/14—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyester as constituent
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/83—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with metals; with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/10—Animal fibres
- D06M2101/14—Collagen fibres
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/30—Synthetic polymers consisting of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/32—Polyesters
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- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Textile Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
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Abstract
The invention discloses a kind of preparation method of fiber artificial's blood vessel, comprise the following steps:Step 1, collagen is dissolved in the mixed solution of hexafluoroisopropanol and ethanol, collagen solution is made;Step 2, by polyester fiber add n methyl pyrrolidones in, matter polyester fiber solution is made;Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure.Step 4, the aqueous solution that fiber non-woven membrane tube is soaked in oxidized dextran and Nano Silver mixing, carry out crosslinking Treatment, that is, a kind of fiber artificial's blood vessel are made.Fiber artificial's blood vessel that the present invention is provided not only has good blood compatibility, and improve excellent elasticity and surface property, so as to solve, artificial small-caliber vascular blood compatibility is poor, plugging rate is higher, elastic low problem, preparation method is simple, cost is low, it is environmentally friendly, high financial profit.
Description
Technical field
Present invention relates particularly to a kind of preparation method of fiber artificial's blood vessel.
Background technology
Artificial blood vessel is the substitute of many Serious Stenosis or artery occlusive, is with nylon, terylene mostly(Dacron), it is poly-
Four fluorine ethylenes(PTFE)It is made Deng synthetic material, it is adaptable to the bypass art of whole body everywhere, big, the artificial blood of medium caliber
Pipe is applied to clinic and has obtained satisfied effect.Angiocardiopathy is to endanger one of common disease of human health, than more serious
Patient, the treatment means of its main and auxiliary are vasotransplantation, and therefore autologous vein limited source, clinically needs big
The artificial blood vessel of amount is used as graft substitute.During angiorrhoxis in human body, the artificial blood vessel of portable polyester material, but due to
Blood is easily set in artificial blood vessel's inwall, if artificial blood vessel is carefully easy for very much blocking, this is always exploitation artificial blood vessel
Difficulty.The manufacture of artificial blood vessel, external research, the overwhelming majority is to take medical macromolecular materials to be woven.It is existing to use
In the various high polymer materials of clinical vascular, two classes can be divided into, a class is synthetic material, such as terylene, expanded polytetrafluoroethyl-ne
Alkene, polyurethane, PGA, PHA class etc.;Another kind of is natural biologic material, such as collagen, hyaluronic acid, fibroin albumen, chitosan, thin
Fungin etc..The heavy caliber artificial blood vessel of these materials synthesis has clinically achieved remarkable effect, and realizes business
Industry.But in terms of small-caliber vascular of the bore less than 6mm is substituted, such as artery of extremity blood vessel, coronary artery are also present
Many serious the problem of, including blood compatibility is poor, plugging rate is higher etc..Although natural macromolecular material is than artificial synthesized material
Material has more advantages, still, and small-caliber vascular prepared by current natural macromolecular material still has low intensity, elasticity
The problems such as low, poor compatibility, antibiotic property are poor.
The content of the invention
It is an object of the invention to provide a kind of preparation method of fiber artificial's blood vessel.
To achieve these goals, the invention provides a kind of preparation method of fiber artificial's blood vessel, comprise the following steps:
Step 1, collagen is dissolved in mol ratio 1:In 2-3 hexafluoroisopropanol and the mixed solution of ethanol, quality is made
Percentage concentration is 15-30% collagen solution;
Step 2, by polyester fiber add n- methyl pyrrolidones in, in 35-45 DEG C stir 10-14 hours, quality percentage is made
Concentration is 20-40% polyester fiber solution;
Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure;
Step 4, fiber non-woven membrane tube is soaked in the aqueous solution of oxidized dextran and Nano Silver mixing 2-5 hours, handed over
Connection processing, that is, be made a kind of fiber artificial's blood vessel.
In the step 1, the mass percentage concentration of collagen solution is 20-25%.
In the step 1, collagen is pig source or fish source collagen albumen.
In the step 2, the mass percentage concentration of polyester fiber solution is 30-35%.
In the step 4, the mass percentage concentration of oxidized dextran in the aqueous solution of oxidized dextran and Nano Silver mixing
For 10-15%, the mass percentage concentration of Nano Silver is 5-10%.
Beneficial effect:Fiber artificial's blood vessel that the present invention is provided not only has good blood compatibility, and improves
Excellent elasticity and antibacterial surface performance, so as to solve, artificial small-caliber vascular blood compatibility is poor, plugging rate is higher, bullet
Property low problem, preparation method is simple, and cost is low, environmentally friendly, high financial profit.
Embodiment
Embodiment 1
A kind of preparation method of fiber artificial's blood vessel, comprises the following steps:
Step 1, by fish source collagen protein dissolution in mol ratio 1:In 2-3 hexafluoroisopropanol and the mixed solution of ethanol, it is made
Mass percentage concentration is 15% collagen solution;
Step 2, by polyester fiber add n- methyl pyrrolidones in, in 35-45 DEG C stir 10-14 hours, quality percentage is made
Concentration is 20% polyester fiber solution;
Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure;
Step 4, fiber non-woven membrane tube is soaked in the aqueous solution of oxidized dextran and Nano Silver mixing 2-5 hours, handed over
The mass percentage concentration of oxidized dextran is 10% in connection processing, the aqueous solution of oxidized dextran and the Nano Silver mixing, is received
Meter Yin mass percentage concentration is 5%, that is, a kind of fiber artificial's blood vessel is made.
Embodiment 2
A kind of preparation method of fiber artificial's blood vessel, comprises the following steps:
Step 1, by fish source collagen protein dissolution in mol ratio 1:In 2-3 hexafluoroisopropanol and the mixed solution of ethanol, it is made
Mass percentage concentration is 30% collagen solution;
Step 2, by polyester fiber add n- methyl pyrrolidones in, in 35-45 DEG C stir 10-14 hours, quality percentage is made
Concentration is 40% polyester fiber solution;
Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure;
Step 4, fiber non-woven membrane tube is soaked in the aqueous solution of oxidized dextran and Nano Silver mixing 2-5 hours, handed over
The mass percentage concentration of oxidized dextran is 15% in connection processing, the aqueous solution of oxidized dextran and the Nano Silver mixing, is received
Meter Yin mass percentage concentration is 10%, that is, a kind of fiber artificial's blood vessel is made.
Embodiment 3
A kind of preparation method of fiber artificial's blood vessel, comprises the following steps:
Step 1, pig source collagen is dissolved in mol ratio 1:In 2-3 hexafluoroisopropanol and the mixed solution of ethanol, it is made
Mass percentage concentration is 25% collagen solution;
Step 2, by polyester fiber add n- methyl pyrrolidones in, in 35-45 DEG C stir 10-14 hours, quality percentage is made
Concentration is 35% polyester fiber solution;
Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure;
Step 4, fiber non-woven membrane tube is soaked in the aqueous solution of oxidized dextran and Nano Silver mixing 2-5 hours, handed over
The mass percentage concentration of oxidized dextran is 12% in connection processing, the aqueous solution of oxidized dextran and the Nano Silver mixing, is received
Meter Yin mass percentage concentration is 8%, that is, a kind of fiber artificial's blood vessel is made.
Claims (5)
1. a kind of preparation method of fiber artificial's blood vessel, it is characterised in that comprise the following steps:
Step 1, collagen is dissolved in mol ratio 1:In 2-3 hexafluoroisopropanol and the mixed solution of ethanol, quality is made
Percentage concentration is 15-30% collagen solution;
Step 2, by polyester fiber add n- methyl pyrrolidones in, in 35-45 DEG C stir 10-14 hours, quality percentage is made
Concentration is 20-40% polyester fiber solution;
Step 3, collagen solution and polyester fiber solution blending be subjected to electrostatic spinning, form fiber non-woven membrane tube structure;
Step 4, fiber non-woven membrane tube is soaked in the aqueous solution of oxidized dextran and Nano Silver mixing 2-5 hours, handed over
Connection processing, that is, be made a kind of fiber artificial's blood vessel.
2. a kind of preparation method of fiber artificial's blood vessel according to claim 1, it is characterised in that:In the step 1, glue
The mass percentage concentration of former protein solution is 20-25%.
3. a kind of preparation method of fiber artificial's blood vessel according to claim 1, it is characterised in that:In the step 1, glue
Former albumen is pig source or fish source collagen albumen.
4. a kind of preparation method of fiber artificial's blood vessel according to claim 1, it is characterised in that:In the step 2, gather
The mass percentage concentration of ester fiber solution is 30-35%.
5. a kind of preparation method of fiber artificial's blood vessel according to claim 1, it is characterised in that:In the step 4, oxygen
The mass percentage concentration for changing oxidized dextran in the aqueous solution of glucan and Nano Silver mixing is 10-15%, the quality of Nano Silver
Percentage concentration is 5-10%.
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CN201710397421.6A CN107296982A (en) | 2017-05-31 | 2017-05-31 | A kind of preparation method of fiber artificial's blood vessel |
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CN201710397421.6A CN107296982A (en) | 2017-05-31 | 2017-05-31 | A kind of preparation method of fiber artificial's blood vessel |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103147225A (en) * | 2013-02-06 | 2013-06-12 | 东华大学 | Preparation method for protein-polyose-polylactic acid polycaprolactone vascular stent |
CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
-
2017
- 2017-05-31 CN CN201710397421.6A patent/CN107296982A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103147225A (en) * | 2013-02-06 | 2013-06-12 | 东华大学 | Preparation method for protein-polyose-polylactic acid polycaprolactone vascular stent |
CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
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Application publication date: 20171027 |