CN107290277A - The integrated structure of optical biologic sensor and microfluidic device - Google Patents
The integrated structure of optical biologic sensor and microfluidic device Download PDFInfo
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- CN107290277A CN107290277A CN201610194613.2A CN201610194613A CN107290277A CN 107290277 A CN107290277 A CN 107290277A CN 201610194613 A CN201610194613 A CN 201610194613A CN 107290277 A CN107290277 A CN 107290277A
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- biologic sensor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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Abstract
The present invention provides the integrated structure of a kind of optical biologic sensor and microfluidic device, including：One bearing part, to carry and house an optical biologic sensor；One flow channel layer, for an at least flow of fluid；And a covering, for the stream into and out of an at least fluid, an at least fluid is flowed into from an at least fluid intake, and the optical biologic sensor is flowed through by an at least runner, to be sensed, then from the outflow of an at least fluid issuing.The optical biologic sensor of the present invention and the integrated structure of microfluidic device can detect optical signalling produced by optical biologic sensor, transmit fluid, avoid seepage, it is adaptable to integrate the optical biologic sensor and microfluidic device of diversified forms.
Description
Technical field
The present invention is the integrated structure about a kind of optical biologic sensor and microfluidic device.
Background technology
With the sustainable development of electronics technology, its feeler applied also constantly deploys cross-cutting exploration and combination.
Wherein, in fast-developing biology or medical science and technology field, the appearance of biology sensor is not less than being modern age life
One quantum jump of thing relevant technical.Biology sensor is commonly defined as：Through the biomolecule of immobilization
(immobilized biomolecules) combines transducer or biochip, to detect in organism or in vitro
Chemical substance or biomolecule or play a kind of device that response is produced after specific reciprocation therewith.
Biology sensor meets the demand of many important measurements, especially in medicine, metabolism and other biological point
Between son in interactive measure.Although traditional analysis instrument can also reach similar purpose, biology is passed
Sensor most unique place be exactly from biological sensing component and biomolecule possesses thereon high sensitivity,
High specific or high selectivity, the characteristic with its detection (real-time detection) in real time.Its reason is to give birth to
Object inherently has miscellaneous chemocepter, in other words, and organism is actually a change in itself
The aggregate of acceptor (chemoreceptors) is learned, these chemoreceptors are respectively provided with the specific or selective of height
With sensitivity.With gradually ripe, the bio-sensing of more and more and assorted form of biosensor technology
Device is also listed one after another.Wherein, with reference to optics mechanism biology sensor be even more to protein or nucleic acid or other
There is very big application potential in biochemical molecule detection.
On the other hand, through the artificial or mechanically actuated needed for conventional biochemical is analyzed, with micro- side Pu, micro-
The microfluid components such as valve, micro-filter, micro-mixer, microchannel, microsensor and microreactor are concentrated
It is made on microfluidic device, to carry out the programs such as sample pre-treatments, mixing, transmission, separation and detecting,
Even more it is actively used on biology sensor.Its application field can cover such as new drug development, biological and doctor
The research such as learn, or it is strong examine, the detection of disease detection, pathogenic infection, the clinical examination such as blood screening, even
It is such as national defense and military detecting, legal medical expert's identification identification, environment and Food Inspection non-medical applications field.
However, the integrated structure of existing biology sensor and microfluidic device is often because application is integrated with existing
The limitation of processing procedure, it is impossible to which quality conformance, structural intergrity and the processing procedure height production of detection module are provided.
Therefore, how the whole of optical biologic sensor and microfluidic device of a kind of effective and tool using elasticity is provided
Close the important issue that structure is current industry.
The content of the invention
Embodiments of the invention disclose the integrated structure of a kind of optical biologic sensor and microfluidic device, bag
Include：A kind of integrated structure of optical biologic sensor and microfluidic device, including：One bearing part, is set
There is an at least groove, to carry and house an at least optical biologic sensor, wherein, the optical profile type
Biology sensor possesses biological sensing layer；One flow channel layer, is arranged above the bearing part, and comprising at least
One runner, for an at least flow of fluid；And a covering, it is arranged above the flow channel layer, and have
Have an at least fluid intake and an at least fluid issuing, for the stream into and out of an at least fluid, it is described extremely
A few fluid intake and an at least fluid issuing are connected with an at least runner for the flow channel layer；
Wherein, an at least fluid is flowed into from an at least fluid intake, is flowed through by an at least runner
The optical biologic sensor and biological sensing layer thereon, to be sensed, then from described at least first-class
Body outlet outflow.
Further, the optical biologic sensor is fixed on the bearing part using a bonding fixed structure
The groove in, the groove is one of a concave surface, a recess and an emptying aperture.
Further, the upper surface of the optical biologic sensor and the upper surface of the bearing part are located at same
One horizontal level.
Further, the bearing part is made up of an opaque material, and sets an optical transmission window, in carrying
When the optical transmission window is directed at the optical biologic sensor；And the optical transmission window is by a transparent material
Material is made or is a hollow out opening.
Further, the surfaction of the flow channel layer is into hydrophily or hydrophobic surface.
Further, the flow channel layer also includes at least a gang of Pu component, at least a valve member, at least one
At least one of mixed liquid component, other microfluid components, to carry out at least flowing of a fluid and pre-
Processing.
Further, the flow channel layer be a multilayered structure, with multiple numbers of plies, and its surfaction into
Hydrophily or hydrophobic surface.
Further, the covering is made up of an opaque material, and sets an optical transmission window, in covering
Afterwards, the optical transmission window is directed at the optical biologic sensor；And the optical transmission window is by a transparent material
Material is made or is a hollow out opening.
Further, the flow channel layer is integrated or the flow channel layer and the carrying with the covering
Part is integrated.
Another embodiment of the present invention discloses the integrated structure of a kind of optical biologic sensor and microfluidic device,
Including：One bearing part, is provided with an at least groove, to carry and house at least optical biologic sensing
Device, wherein, possess one first biological sensing layer and one second biological response on the optical biologic sensor
Layer；One upper channel layer, is arranged above the bearing part, and comprising an at least first flow, at least
One first fluid flows；Once flow channel layer, is arranged at below the bearing part, and include an at least second
Road, so that an at least second fluid flows；Covering on one, is arranged above the upper channel layer, and have
Have an at least first fluid entrance and the outlet of an at least first fluid, at least inflow of a first fluid and
Outflow, an at least first fluid entrance and an at least first fluid outlet and the upper channel layer
An at least first flow is connected；And once covering, it is arranged at below the dirty channel layer, and
Exported with an at least second fluid entrance and an at least second fluid, for the inflow of an at least second fluid
And outflow, an at least second fluid entrance and an at least second fluid outlet and the dirty channel layer
An at least second flow channel be connected；Wherein, an at least first fluid and described at least one second
Fluid respectively as an at least first fluid entrance described in the upper covering and the lower covering and it is described extremely
A few second fluid entrance is flowed into, and the optical biologic sensor is flowed through by an at least first flow
And thereon the first biological sensing layer and an at least second flow channel flow through the optical biologic sensor and
The second biological sensing layer thereon, to be sensed, then respectively from least first fluid outlet and institute
State at least second fluid outlet outflow.
Further, the optical biologic sensor is fixed on the bearing part using a bonding fixed structure
The groove in, the groove is one of a concave surface, a recess and an emptying aperture.
Further, the upper surface of the optical biologic sensor and the upper surface of the bearing part are located at same
One horizontal level.
Further, the bearing part is made up of an opaque material, and sets an optical transmission window, in carrying
When the optical transmission window is directed at the optical biologic sensor；And the optical transmission window is by a transparent material
Material is made or is a hollow out opening.
Further, the surfaction of the upper channel layer and the dirty channel layer is into hydrophily or hydrophobic
Surface.
Further, the upper channel layer and the dirty channel layer also include at least a gang of Pu component, at least one
At least one of valve member, at least one mixed liquid component, other microfluid components, with carry out it is described at least
The flowing and pretreatment of one first fluid and an at least second fluid.
Further, the upper channel layer and dirty channel layer are a multilayered structure, with multiple numbers of plies, and
Its surfaction is into hydrophily or hydrophobic surface.
Further, the upper covering is made up with lower covering of an opaque material, and sets one respectively
First optical transmission window and one second optical transmission window, after covering, first optical transmission window and described second saturating
Light window is respectively aligned to the optical biologic sensor；And first optical transmission window and described second saturating
Light window is made up of a transparent material or is a hollow out opening.
Further, the upper channel layer is integrated with the upper covering, and the dirty channel layer
Integrated with the lower covering or the upper channel layer and the dirty channel layer and bearing part integration
It is integrated.
Brief description of the drawings
Fig. 1 for the present invention a kind of optical biologic sensor and microfluidic device integrated structure it is first real
Apply the schematic diagram of example；
Fig. 2 for the present invention a kind of optical biologic sensor and microfluidic device integrated structure it is first real
Apply the profile of example；
Fig. 3 for the present invention a kind of optical biologic sensor and microfluidic device integrated structure it is second real
Apply the profile of example.
Description of reference numerals：
110- bearing parts；111- grooves；112- optical biologic sensors；113- biological sensings layer；120- flows
Channel layer；130- coverings；131- fluid intakes；132- fluid issuings；310- bearing parts；313- first is biological
Sensed layer；The biological sensings of 314- second layer；320- upstream channel layer；330- flows down channel layer；The upper coverings of 340-；
Covering under 350-；A- binds fixed structure.
Embodiment
Illustrate embodiments of the present invention, those skilled in the art the following is by particular specific embodiment
Other advantages and effect of the present invention can be understood easily by content disclosed in the present specification.The present invention also may be used
Implemented or applied by other different instantiations, every details in description of the invention also can base
In different viewpoints with applying in the lower various modifications of progress without departing from the spirit and change.
It should be clear that structure, ratio, size that this specification institute accompanying drawings are illustrated etc., only to coordinate explanation
Content disclosed in book, so that those skilled in the art is understood with reading, being not limited to the present invention can
Qualifications of implementation, therefore do not have technical essential meaning, the modification of any structure, proportionate relationship change
Change or the adjustment of size, all should in the case where not influenceing effect of the invention that can be generated and the purpose that can reach
Fall in the range of disclosed technology contents can be covered.
Fig. 1 and Fig. 2 is respectively a kind of optical biologic sensor of the present invention and the integration knot of microfluidic device
The schematic diagram and profile of the first embodiment of structure.The integration of optical biologic sensor and microfluidic device
Structure is applied to integrate an optical biologic sensor and a micro runner device and encapsulated.Such as Fig. 1 and Fig. 2 institutes
Show, the integrated structure of optical biologic sensor and microfluidic device sequentially includes from lower to upper：One bearing part
110th, a flow channel layer 120 and a covering 130.
Bearing part 110 is provided with an at least groove 111, to carry and house at least optical biologic sensing
Device 112, at least an optical biologic sensor 112 have a biological sensed layer 113.Flow channel layer 120 is set
In the top of bearing part 110, and including an at least runner, for an at least flow of fluid.Covering 130, if
The top of flow channel layer 120 is placed in, and there is an at least fluid intake 131 and an at least fluid issuing 132, for
The stream into and out of an at least fluid, at least an at least fluid intake 131 and a fluid issuing 132 and runner
An at least runner for layer is connected, wherein, an at least fluid is flowed into from an at least fluid intake 131, is passed through
An at least runner flows through optical biologic sensor 112, and biological sensing layer 113 thereon, to be sensed,
Flowed out again from an at least fluid issuing 132.
It is worth noting that, in preferred embodiment, optical biologic sensor 112 is solid using a bonding
Determine structure A to be fixed in the groove 111 of bearing part 110；Also, optical biologic sensor 112 is inserted
When its upper surface can be located at same level position with the upper surface of bearing part 110.Groove 111 can for a concave surface,
One recess or an emptying aperture.Bearing part 110 can be made up of a transparent material or opaque material, for example, high score
Sub- material, plastics, ceramics, metal, Silicon Wafer, glass or other composites.When bearing part 110
When being made up of an opaque material, bearing part 110 need to set an optical transmission window (not shown), will in carrying
Optical transmission window is directed at optical biologic sensor 112；And optical transmission window is made up of a transparent material or engraved for one
Air switch mouthful.
Similarly, flow channel layer 120 can be made up of a transparent material or opaque material, for example, macromolecule material
Material, plastics, ceramics, metal, Silicon Wafer, glass or other composites.The surface of flow channel layer 120
Hydrophily or hydrophobic surface can be modified to.Flow channel layer 120 can further include at least a gang of Pu component, at least
One valve member, at least one mixed liquid component, other microfluid components or its any combination, to carry out at least one
The flowing and pretreatment of fluid.Furthermore, flow channel layer 120 can be also a multilayered structure, with multiple numbers of plies,
Its surface can be modified to hydrophily or hydrophobic surface.
Covering 130 can be made up of a transparent material or opaque material, for example, high polymer material, plastics,
Ceramics, metal, Silicon Wafer, glass or other composites.When covering 130 is by an opaque material
When being made, covering 130 need to set an optical transmission window (not shown), and after covering, optical transmission window is to quasi-optical
Formula biology sensor 112；And optical transmission window is made up of a transparent material or is a hollow out opening.Furthermore,
Flow channel layer 120 can integrate the structure of shaping, or flow channel layer 120 and bearing part 110 with covering 130
The structure that shaping can be integrated reduces the program subsequently encapsulated.
Significantly, since being applicable the optical biologic sensor 112 of the present invention needs the side with irradiation
Formula receives the optical signalling of its sensing to excite the optical signalling of biological sensing layer, and the mode of printing opacity,
Therefore, when bearing part 110 or covering 130 are made up of opaque material, it is necessary to which a printing opacity is set in addition
Window is directed at optical biologic sensor 112, is obtained with the entrance of sharp irradiation with optical signalling produced after sensing
To show, wherein, it is made of clear material shown in Fig. 1 and Fig. 2 first embodiment.Also, this
The overall structure of invention, in addition to runner, the junction of other components, for example, bearing part 110, biological sense
The junction surveyed between layer 113, the covering 130 of flow channel layer 120 and one can all completely cut off fluid, it is to avoid stream
Body seepage.
Fig. 3 show the of a kind of optical biologic sensor of the present invention and the integrated structure of microfluidic device
The profile of two embodiments.The integrated structure of optical biologic sensor and microfluidic device includes：One carrying
Covering 340 and once covering on the upper channel layer 320 of part 310, one, once flow channel layer 330, one
350。
Bearing part 310, is provided with an at least groove, to carry and house an at least optical biologic sensor,
Wherein, an at least optical biologic sensor has one first biological sensing layer 313 and one second biological sensing
Layer 314.Upper channel layer 320, is arranged at the top of bearing part 310, and including an at least first flow, for
An at least first fluid flows.Flow down channel layer 330, is arranged at the lower section of bearing part 310, and including at least 1 the
Two runners, so that an at least second fluid flows.Upper covering 340, is arranged at the upper top of channel layer 320,
And exported with an at least first fluid entrance and an at least first fluid, for the stream of an at least first fluid
Into and out, at least a first fluid entrance and an at least first fluid are exported with upper channel layer 320 at least
One first flow is connected.Lower covering 350, is arranged at the lower section of dirty channel layer 330, and with least 1 the
Two fluid intakes and the outlet of an at least second fluid, for the stream into and out of an at least second fluid, at least
One second fluid entrance and the outlet of an at least second fluid are connected with an at least second flow channel for the channel layer 330 that flows down
Connect, wherein, an at least first fluid and at least a second fluid are respectively by upper covering 340 and lower covering
A 350 at least first fluid entrance and an at least second fluid entrance are flowed into, and pass through an at least first flow stream
The first biological sensing layer 313 through an at least optical biologic sensor and thereon, and an at least second flow channel stream
The second biological sensing layer 314 through an at least optical biologic sensor and thereon, to be sensed, then distinguishes
From the outlet of an at least first fluid and at least second fluid outlet outflow.
It is worth noting that, second embodiment is similar with first embodiment, its Main Differences is, first is real
Apply example and use three layers structure, and second embodiment uses five layered structures；Through on the upper strata of bearing part 310
Upper channel layer 320, the channel layer 330 that flows down and upper covering 340, lower covering 350 are set respectively with lower floor,
Different fluid can be injected separately into by upper strata and lower floor, therefore be applicable to more complicated or multiple tracks reaction process
Sensing application.Each component in a second embodiment is similar with first embodiment, and its implementation detail is not repeated.
Sum it up, embodiments of the invention disclose the whole of a kind of optical biologic sensor and microfluidic device
Structure is closed, through combination optical biologic sensor and microfluidic device, optical biologic sensor can be detected
Produced optical signalling, and its overall structure, in addition to runner, the junctions of other components all can be every
Exhausted fluid, avoid seepage, it is adaptable to integrate the optical biologic sensor and microfluidic device of diversified forms.
However, effect of above-described embodiment only illustrative present invention, not for the limitation present invention, appoints
What one skilled in the art can enter under the spirit and scope without prejudice to the present invention to above-described embodiment
Row modification is with changing.In addition, the quantity of the component in these above-mentioned embodiments is only illustrative, and
It is non-to be used to limit the present invention.
Claims (18)
1. the integrated structure of a kind of optical biologic sensor and microfluidic device, it is characterised in that including：
One bearing part, is provided with a groove, to carry and house an optical biologic sensor, wherein,
Possesses a biological sensed layer on the optical biologic sensor；
One flow channel layer, is arranged above the bearing part, and comprising an at least runner, for an at least fluid
Flowing；And
One covering, is arranged above the flow channel layer, and with an at least fluid intake and an at least fluid
Outlet, for the stream into and out of an at least fluid, an at least fluid intake and an at least fluid
Outlet is connected with an at least runner for the flow channel layer；
Wherein, an at least fluid is flowed into from an at least fluid intake, passes through an at least runner
Flow through the optical biologic sensor and thereon biological sensing layer, to be sensed, then from it is described at least
One fluid issuing flows out.
2. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the optical biologic sensor is fixed on described in the bearing part using a bonding fixed structure
In groove, the groove is one of a concave surface, a recess and an emptying aperture.
3. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the upper surface of the optical biologic sensor and the upper surface of the bearing part are located at same level
Position.
4. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the bearing part is made up of an opaque material, and an optical transmission window is set, in carrying by institute
State optical transmission window and be directed at the optical biologic sensor；And the optical transmission window is made up of a transparent material
Or be a hollow out opening.
5. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the surfaction of the flow channel layer is into hydrophily or hydrophobic surface.
6. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the flow channel layer also includes at least a gang of Pu component, at least a valve member, at least one mixed liquid group
At least one of part, other microfluid components, to carry out the flowing and pretreatment of an at least fluid.
7. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the flow channel layer is a multilayered structure, with multiple numbers of plies, and its surfaction is into hydrophily
Or hydrophobic surface.
8. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the covering is made up of an opaque material, and an optical transmission window, after covering, institute are set
State optical transmission window and be directed at the optical biologic sensor；And the optical transmission window is made up of a transparent material
Or be a hollow out opening.
9. the integrated structure of optical biologic sensor as claimed in claim 1 and microfluidic device, it is special
Levy and be, the flow channel layer is integrated with the covering or the flow channel layer is integrated with the bearing part
It is integrated.
10. the integrated structure of a kind of optical biologic sensor and microfluidic device, it is characterised in that including：
One bearing part, is provided with a groove, to carry and house an optical biologic sensor, wherein,
The optical biologic sensor possesses the first biological sensing layer and one second biological sensing layer；
One upper channel layer, is arranged above the bearing part, and comprising an at least first flow, at least
One first fluid flows；
Once flow channel layer, is arranged at below the bearing part, and comprising an at least second flow channel, at least
One second fluid flows；
Covering on one, is arranged above the upper channel layer, and with an at least first fluid entrance and extremely
Few first fluid outlet, for the stream into and out of an at least first fluid, an at least first fluid
Entrance and at least first fluid outlet are connected with an at least first flow for the upper channel layer；
And
Once covering, is arranged at below the dirty channel layer, and with an at least second fluid entrance and extremely
Few second fluid outlet, for the stream into and out of an at least second fluid, an at least second fluid
Entrance and at least second fluid outlet are connected with an at least second flow channel for the dirty channel layer；
Wherein, an at least first fluid and an at least second fluid respectively by the upper covering with
An at least first fluid entrance for the lower covering and an at least second fluid entrance are flowed into, and are led to
Cross an at least first flow flow through the optical biologic sensor and thereon the first biological sensing layer,
And an at least second flow channel flow through the optical biologic sensor and thereon the second biological sensing layer,
To be sensed, then respectively from least first fluid outlet and at least second fluid outlet stream
Go out.
11. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the optical biologic sensor is fixed on the institute of the bearing part using a bonding fixed structure
State in groove, the groove is one of a concave surface, a recess and an emptying aperture.
12. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the upper surface of the optical biologic sensor and the upper surface of the bearing part are located at same water
Prosposition is put.
13. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the bearing part is made up of an opaque material, and an optical transmission window is set, will in carrying
The optical transmission window is directed at the optical biologic sensor；And the optical transmission window is by a transparent material system
Into or for a hollow out opening.
14. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the surfaction of the upper channel layer and the dirty channel layer is into hydrophily or hydrophobic surface.
15. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the upper channel layer and the dirty channel layer also include at least a gang of Pu component, at least a valve
At least one of component, at least one mixed liquid component, other microfluid components, to carry out described at least 1 the
The flowing and pretreatment of one fluid and an at least second fluid.
16. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the upper channel layer and dirty channel layer are a multilayered structure, with multiple numbers of plies, and its table
Face is modified to hydrophily or hydrophobic surface.
17. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the upper covering is made up with lower covering of an opaque material, and sets one first respectively
Optical transmission window and one second optical transmission window, after covering, first optical transmission window and second light inlet window
Mouth is respectively aligned to the optical biologic sensor；And first optical transmission window and second light inlet window
Mouth is made up of a transparent material or is a hollow out opening.
18. the integrated structure of optical biologic sensor as claimed in claim 10 and microfluidic device, its
It is characterised by, the upper channel layer is integrated with the upper covering, and the dirty channel layer and institute
State that lower covering is integrated or the upper channel layer and the dirty channel layer are integrated into one with the bearing part
Body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610194613.2A CN107290277A (en) | 2016-03-31 | 2016-03-31 | The integrated structure of optical biologic sensor and microfluidic device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610194613.2A CN107290277A (en) | 2016-03-31 | 2016-03-31 | The integrated structure of optical biologic sensor and microfluidic device |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678398A (en) * | 2002-09-12 | 2005-10-05 | 英特尔公司 | Microfluidic apparatus with integrated porous-substrates/sensor for real-time biochemical molecule detection |
| US20100296972A1 (en) * | 2008-02-01 | 2010-11-25 | Toru Miura | Flow cell |
| CN205643133U (en) * | 2016-03-31 | 2016-10-12 | 光合声科技股份有限公司 | Optical profile type biosensor and little fluid means's structure of integrating |
-
2016
- 2016-03-31 CN CN201610194613.2A patent/CN107290277A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678398A (en) * | 2002-09-12 | 2005-10-05 | 英特尔公司 | Microfluidic apparatus with integrated porous-substrates/sensor for real-time biochemical molecule detection |
| US20100296972A1 (en) * | 2008-02-01 | 2010-11-25 | Toru Miura | Flow cell |
| CN205643133U (en) * | 2016-03-31 | 2016-10-12 | 光合声科技股份有限公司 | Optical profile type biosensor and little fluid means's structure of integrating |
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Application publication date: 20171024 |