CN107281152A - A kind of drug osmotic pump preparation based on ALD claddings and preparation method thereof - Google Patents
A kind of drug osmotic pump preparation based on ALD claddings and preparation method thereof Download PDFInfo
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- CN107281152A CN107281152A CN201710465610.2A CN201710465610A CN107281152A CN 107281152 A CN107281152 A CN 107281152A CN 201710465610 A CN201710465610 A CN 201710465610A CN 107281152 A CN107281152 A CN 107281152A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/22—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of inorganic material, other than metallic material
- C23C16/30—Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
- C23C16/40—Oxides
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/455—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into reaction chamber or for modifying gas flows in reaction chamber
- C23C16/45523—Pulsed gas flow or change of composition over time
- C23C16/45525—Atomic layer deposition [ALD]
- C23C16/45555—Atomic layer deposition [ALD] applied in non-semiconductor technology
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of drug osmotic pump preparation coated based on ALD, including medicine core and ALD coatings, ALD coatings include soluble ald thing and insoluble ald thing.In addition, present invention also offers the preparation method based on the ALD drug osmotic pump preparations coated.The invention is using semi-transparent film layer of the ALD coatings as osmotic pump preparation, ALD coatings are using soluble ald thing and the composite sedimentary layer of insoluble ald thing simultaneously, the soluble ald thing dissolving under gastrointestinal environment, so as to form porous clad structure, reach the effect of medicaments uniformity release, ALD coatings are evenly coated, it is fine and close, ALD coatings thickness is small, other auxiliary materials need not be added, compared to traditional penetration pump preparation, its coating amount is substantially reduced, and without laser boring, under conditions of drug osmotic pump preparation total amount is certain, effectively improve active medicine content.
Description
Technical field
The invention belongs to technical field of medicine, and in particular to it is a kind of based on ALD coat drug osmotic pump preparation and
Its preparation method, it is adaptable to water soluble drug and poorly water soluble drugs, especially low-solubility drug or pH dependent drugs
Control release.
Background technology
Osmotic pump preparation is made up of medicine, semipermeable membrane material, osmotic pressure active material and push agent etc., is made with osmotic pressure
For the controlled release tablet for the energy that releases the drug, its basic structure is that medicine and proper auxiliary materials first are pressed into label, one layer of semi permeability thing of outsourcing
Plasma membrane, rear that an aperture is made a call on film with laser, gastrointestinal water enters label through pellicle after the oral medicine makes medicine molten
Solution, produces osmotic pressure and can pass through pellicle by moisture endlessly into label, due to pellicle internal volume after medicine dissolving
Limitation, the nearly saturated concentration solution of medicine constantly shifted to outside piece by laser hole again, thus makes medicine with constant speed
Rate is discharged into outside piece.
And existing this osmotic pump preparation is possible to film calcination by laser boring or aperture is differed, and release the drug
When duct is less, oral rear duct is easily blocked in intestines and stomach and causes random drug release.In addition, in order to ensure laser on film
Punching does not cause the rupture of film semipermeable substance film is reached certain thickness, it is necessary to increase substantial amounts of auxiliary material, adds medicine
Coating amount, so as to reduce the content of effective active medicine.
The content of the invention
The purpose of the present invention is to overcome existing osmotic pump preparation to easily cause film calcination, aperture by laser boring to differ, with
And drug coating amount is big, the problem of reducing effective active medicament contg.
Therefore, the invention provides a kind of drug osmotic pump preparation coated based on ALD, including medicine core and be coated on
The ALD coatings of medicine core surfaces, the ALD coatings include being soluble in the soluble ald of gastrointestinal environment solution
Thing and the insoluble ald thing insoluble in gastrointestinal environment solution.
Further, the medicine core is tablet or particle.
Further, the thickness of the ALD coatings is 1~100nm.
Further, the soluble ald thing is ZnO, MgO, Al2O3, Fe2O3In one or more of mixing
Thing.
Further, the insoluble ald thing is SiO2,ZrO2,TiO2In one or more of mixtures；By
PH value is about between 7.0~7.2 when stomach is in emptying, and when food group enters in stomach, pH value can be dropped up between 2~3, these oxidations
Thing and HCl react to be formed metal chloride such as SiCl4, TiCl4 can at once with water reaction regenerate oxide.
Further, in the ALD coatings soluble ald thing account for ALD coatings gross masses 10~
90%.
In addition, present invention also offers the above-mentioned preparation method based on the ALD drug osmotic pump preparations coated, it is including as follows
Step：
1) medicine core is placed in ALD coating reactions room；
2) according to the species of soluble ald thing and insoluble ald thing in ALD coatings, select respectively
Select the first presoma needed for obtaining soluble ald thing reaction and react required with insoluble ald thing is obtained
The second presoma, set deposition process parameters：Depositing temperature is 50~350 DEG C, and deposition pressure is 0.1~100torr；
3) the first precursor vapor and the second precursor vapor are incorporated into reative cell simultaneously in the case where nitrogen or argon gas are carried
In, the retention time is 60~120 seconds；
4) with nitrogen or argon gas purging reative cell, oxygen source steam is incorporated into reative cell in the case where nitrogen or argon gas are carried,
Retention time is 60~120 seconds；
5) with nitrogen or argon gas purging reative cell, dissolvable oxides and insoluble oxide are obtained in medicine core surfaces
Composite sedimentary layer；
6) repeat step 3)~5), MULTILAYER COMPOSITE sedimentary is obtained until required ALD coatings thickness.
Further, the step 2) in the first presoma and the second presoma be volatile metal alkylamino salt,
One or more of mixtures in metallo-organic compound, halide, alkoxide, metal p-diketonates complex compound；Before described first
It is the one or more in zinc, magnesium, aluminium, iron to drive the metal in body；Metal in second presoma is in silicon, zirconium, titanium
It is one or more of.
Further, the step 4) in oxygen source steam be water, hydrogen peroxide, oxygen, ozone or elemental oxygen.
Further, the step 6) in soluble oxygen in the every layer of composite sedimentary layer of control ALD coatings from outside to inside
Compound content is successively incremented by.
Compared with prior art, beneficial effects of the present invention：
(1) ALD coatings are used as infiltration in this drug osmotic pump preparation coated based on ALD that the present invention is provided
The semi-transparent film layer of pump preparation, while ALD coatings answering using soluble ald thing and insoluble ald thing
Sedimentary is closed, the soluble ald thing dissolving under gastrointestinal environment, so as to form porous ALD claddings, reaches that medicine is equal
The effect of even release.
(2) this drug osmotic pump preparation coated based on ALD that the present invention is provided is using ALD coatings cladding, cladding
Uniformly, fine and close, ALD coatings thickness is small, and without adding other auxiliary materials, compared to traditional penetration pump preparation, its coating amount drops significantly
It is low, under conditions of drug osmotic pump preparation total amount is certain, effectively improve active medicine content.
(3) this preparation method based on the ALD drug osmotic pump preparations coated that the present invention is provided is simple to operate, without
The complicated infiltration pump technique such as drying, laser boring, improves the efficiency for preparing drug osmotic pump preparation.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
All other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
Embodiment 1：
A kind of drug osmotic pump preparation coated based on ALD is present embodiments provided, including medicine core and is coated on medicine
The ALD coatings of thing core surfaces, the ALD coatings include being soluble in the ZnO of gastrointestinal environment solution and insoluble in stomach ring
The TiO of border solution2, medicine core is granular medicament in the present embodiment, and the thickness of the ALD coatings is 1nm.
Preparation method of the present embodiment based on the ALD drug osmotic pump preparations coated, detailed process is as follows：
First, medicine core material particles are put into a porous container with micropore size, porous container is put into instead
Answer in room, vacuumize, replace nitrogen three times, reative cell is warming up to 50 DEG C, reative cell maintains 0.1torr pressure, then rotates
Porous container so that drug particles are sufficiently mixed in porous container cavity.
Then, by the first presoma Zn (C of ald2H5)2With the second presoma TiCl4In 30sccm flow velocitys
N2Carrying under pulse enter reative cell, adsorb in medicine core material particles, the burst length is 60s, until air pressure reaches
1torr, uses 500sccm N afterwards2Purge and take away remaining Zn (C2H5)2And TiCl4, N2Flushing times are 90s, same oxygen source
Steam H2O2In 30sccm N2Carrying under pulse enter reative cell, and with the Zn (C that have been chemisorbed on drug particles2H5)2
And TiCl4Reaction, generates ZnO and TiO2, the time is 60s, then excessive H2O2And accessory substance is by 700sccm N2Purging is taken out of
Reative cell, flushing times are 45s, this completes an ALD deposition cycle, obtain layer of ZnO and TiO2Composite deposition
Layer.
Finally, repeat above-mentioned ALD deposition cycle and the gross thickness of MULTILAYER COMPOSITE sedimentary is deposited to drug particles for 1nm；
Wherein, the first presoma Zn (C in control ALD deposition cycle cyclic process each time2H5)2With the second presoma TiCl4Quality
Than so that ZnO content successively increases from outside to inside in each layer of composite sedimentary layer, and the outermost layer of the present embodiment ALD coatings is answered
It is 90% to close ZnO content in sedimentary, and ZnO content is successively increased with 1% increment in every layer of composite sedimentary layer from outside to inside.
Embodiment 2：
A kind of drug osmotic pump preparation coated based on ALD is present embodiments provided, including medicine core and is coated on medicine
The ALD coatings of thing core surfaces, the ALD coatings include being soluble in the Al of gastrointestinal environment solution2O3With insoluble in stomach ring
The ZrO of border solution2, medicine core is flake drug in the present embodiment, and the thickness of the ALD coatings is 10nm.
Preparation method of the present embodiment based on the ALD drug osmotic pump preparations coated, detailed process is as follows：
First, medicine core tablet is put into a porous container with micropore size, porous container is put into instead
Answer in room, vacuumize, replace nitrogen three times, reative cell is warming up to 150 DEG C, and reative cell maintains 0.1torr pressure.
Then, by the first precursor A l (CH of ald3)3With the second presoma Zr (OC (CH3)3)4
The N of 800sccm flow velocitys2Carrying under pulse enter reative cell, adsorb on medicine core tablet, the burst length is 90s, until
Air pressure reaches 50torr, and 500sccm N are used afterwards2Purge and take away remaining Al (CH3)3With Zr (OC (CH3)3)4, N2During purging
Between be 60s, same oxygen source steam H2O is in 500sccm N2Carrying under pulse enter reative cell, and with being chemisorbed on medicine
Al (CH on tablet3)3With Zr (OC (CH3)3)4Reaction, generates Al2O3And ZrO2, the time is 90s, then excessive H2O and pair
Product is by 800sccm N2Purging takes reative cell out of, and flushing times are 45s, this completes an ALD deposition cycle, are obtained
One layer of Al2O3And ZrO2Composite sedimentary layer.
Finally, repeat above-mentioned ALD deposition cycle and the gross thickness of MULTILAYER COMPOSITE sedimentary is deposited to drug particles for 10nm；
Wherein, the first precursor A l (CH in control ALD deposition cycle cyclic process each time3)3With the second presoma Zr (OC (CH3)3)4
Mass ratio so that Al in each layer of composite sedimentary layer2O3Content successively increases from outside to inside, and the present embodiment ALD coatings are most
Al in outer layer composite sedimentary layer2O3Content is 60%, Al in every layer of composite sedimentary layer from outside to inside2O3Content is with 0.4% increasing
Amount successively increases.
Embodiment 3：
A kind of drug osmotic pump preparation coated based on ALD is present embodiments provided, including medicine core and is coated on medicine
The ALD coatings of thing core surfaces, the ALD coatings include being soluble in the Al of gastrointestinal environment solution2O3And Fe2O3, and not
It is dissolved in the SiO of gastrointestinal environment solution2, medicine core is flake drug in the present embodiment, and the thickness of the ALD coatings is
50nm。
Preparation method of the present embodiment based on the ALD drug osmotic pump preparations coated, detailed process is as follows：
First, medicine core tablet is put into a porous container with micropore size, porous container is put into instead
Answer in room, vacuumize, replace nitrogen three times, reative cell is warming up to 200 DEG C, and reative cell maintains 1torr pressure.
Then, by the first precursor A l (CH of ald3)3、Fe(C5H5)2With the second presoma (CH3CH2C
(CH3)2O)3Ns of the SiOH in 1200sccm flow velocitys2Carrying under pulse enter reative cell, adsorb on medicine core tablet, arteries and veins
The time is rushed for 120s, until air pressure reaches 50torr, 600sccm N are used afterwards2Purge and take away remaining Al (CH3)3、Fe
(CH3)3And TiCl4, N2Flushing times are 60s, and same ozone is in 500sccm N2Carrying under pulse enter reative cell, and with
It is chemisorbed on the Al (CH on medicinal tablet3)3、Fe(C5H5)2(CH3CH2C(CH3)2O)3SiOH reacts, and generates Al2O3、
Fe2O3And SiO2, the time is 120s, and then excessive ozone and accessory substance are by 800sccm N2Purging takes reative cell out of, during purging
Between be 60s, this completes an ALD deposition cycle, obtain one layer of Al2O3、Fe2O3And SiO2Composite sedimentary layer.
Finally, repeat above-mentioned ALD deposition cycle and the gross thickness of MULTILAYER COMPOSITE sedimentary is deposited to drug particles for 50nm；
Wherein, the first precursor A l (CH in control ALD deposition cycle cyclic process each time3)3、Fe(CH3)3With the second presoma
(CH3CH2C(CH3)2O)3SiOH mass ratio so that Al in each layer of composite sedimentary layer2O3、Fe2O3Content is from outside to inside successively
Al in increase, the outermost layer composite sedimentary layer of the present embodiment ALD coatings2O3And Fe2O3Content is 50%, from outside to inside every
Al in layer composite sedimentary layer2O3Content is successively increased with 0.1% increment.
Embodiment 4：
A kind of drug osmotic pump preparation coated based on ALD is present embodiments provided, including medicine core and is coated on medicine
The ALD coatings of thing core surfaces, the ALD coatings include being soluble in the MgO of gastrointestinal environment solution, and insoluble in stomach
The TiO of environment solution2And ZrO2, medicine core is granular medicament in the present embodiment, and the thickness of the ALD coatings is
100nm。
Preparation method of the present embodiment based on the ALD drug osmotic pump preparations coated, detailed process is as follows：
First, medicine core tablet is put into a porous container with micropore size, porous container is put into instead
Answer in room, vacuumize, replace nitrogen three times, reative cell is warming up to 350 DEG C, and reative cell maintains 100torr pressure.
Then, by the first presoma Mg (CpEt) of ald2, and the second presoma Zr (OC (CH3)3)4With
TiCl4In the N of 1500sccm flow velocitys2Carrying under pulse enter reative cell, adsorb on medicine core tablet, the burst length is
120s, until air pressure reaches 300torr, uses 800sccm N afterwards2Purge and take away remaining Mg (CpEt)2、Zr(OC
(CH3)3)4And TiCl4, N2Flushing times are 60s, same oxygen source steam H2O2In 500sccm N2Carrying under pulse enter reaction
Room, and with the Mg (CpEt) that has been chemisorbed on medicinal tablet2、Zr(OC(CH3)3)4And TiCl4Reaction, generates MgO, ZrO2
And TiO2, the time is 120s, then excessive H2O2And accessory substance is by 600sccm N2Purging takes reative cell out of, and flushing times are
60s, this completes an ALD deposition cycle, obtains one layer of MgO, ZrO2And TiO2Composite sedimentary layer.
Finally, repeat above-mentioned ALD deposition cycle the gross thickness of MULTILAYER COMPOSITE sedimentary deposited to drug particles be
100nm；Wherein, the first presoma magnesium ethide and the second presoma Zr (OC in control ALD deposition cycle cyclic process each time
(CH3)3)4And TiCl4Mass ratio so that content of MgO successively increases from outside to inside in each layer of composite sedimentary layer, the present embodiment
Content of MgO is content of MgO in 10%, every layer of composite sedimentary layer from outside to inside in the outermost layer composite sedimentary layer of ALD coatings
Successively increased with 0.1% increment.
The obtained drug osmotic pump preparation coated based on ALD of above example, is examined through transmission electron microscope TEM respectively
Survey shows that drug osmotic pump preparation surface forms uniform, fine and close, free from admixture, imperforate ALD coatings.By above-described embodiment
Obtained drug osmotic pump preparation is respectively placed in being similar in the solution of gastrointestinal environment after 2 hours again through transmitted electron of preparation
Microscope TEM detects the drug osmotic pump preparation, as a result shows that drug osmotic pump preparation surface forms multiple microcellular structures.
In summary, the drug osmotic pump preparation for this ALD claddings that the present invention is provided is coated using ALD coatings, bag
Uniform, densification is covered, ALD coatings thickness is small, without adding other auxiliary materials, compared to traditional penetration pump preparation its coating amount significantly
Reduction, under conditions of drug osmotic pump preparation total amount is certain, effectively improves active medicine content.
It is exemplified as above be only to the present invention for example, do not constitute the limitation to protection scope of the present invention, it is all
It is to be belonged to the same or analogous design of the present invention within protection scope of the present invention.
Claims (10)
1. a kind of drug osmotic pump preparation coated based on ALD, it is characterised in that：Including medicine core and being coated on medicine core
The ALD coatings on surface, the ALD coatings include being soluble in the soluble ald thing of gastrointestinal environment solution and insoluble
In the insoluble ald thing of gastrointestinal environment solution.
2. the drug osmotic pump preparation as claimed in claim 1 coated based on ALD, it is characterised in that：The medicine core is
Tablet or particle.
3. the drug osmotic pump preparation as claimed in claim 1 coated based on ALD, it is characterised in that：The ALD coatings
Thickness is 1~100nm.
4. the drug osmotic pump preparation as claimed in claim 1 coated based on ALD, it is characterised in that：The soluble atom
Surface sediments are ZnO, MgO, Al2O3, Fe2O3In one or more of mixtures.
5. the drug osmotic pump preparation as claimed in claim 1 coated based on ALD, it is characterised in that：The insoluble atom
Surface sediments are SiO2,ZrO2,TiO2In one or more of mixtures.
6. the drug osmotic pump preparation as claimed in claim 1 coated based on ALD, it is characterised in that：In the ALD coatings
Soluble ald thing accounts for the 10~90% of ALD coatings gross masses.
7. the preparation method based on the ALD drug osmotic pump preparations coated as described in any one of claim 1~6, its feature
It is：Comprise the following steps：
1) medicine core is placed in ALD coating reactions room；
2) according to the species of soluble ald thing and insoluble ald thing in ALD coatings, select respectively
The first presoma needed for being reacted to soluble ald thing and obtain needed for the reaction of insoluble ald thing the
Two presomas, set deposition process parameters：Depositing temperature is 50~350 DEG C, and deposition pressure is 0.1~100torr；
3) the first precursor vapor and the second precursor vapor are incorporated into reative cell simultaneously in the case where nitrogen or argon gas are carried, protected
The time is held for 60~120 seconds；
4) with nitrogen or argon gas purging reative cell, oxygen source steam is incorporated into reative cell in the case where nitrogen or argon gas are carried, kept
Time is 60~120 seconds；
5) with nitrogen or argon gas purging reative cell, answering for dissolvable oxides and insoluble oxide is obtained in medicine core surfaces
Close sedimentary；
6) repeat step 3)~5), MULTILAYER COMPOSITE sedimentary is obtained until required ALD coatings thickness.
8. the preparation method as claimed in claim 7 based on the ALD drug osmotic pump preparations coated, it is characterised in that：It is described
Step 2) in the first presoma and the second presoma be volatile metal alkylamino salt, metallo-organic compound, halide,
One or more of mixtures in alkoxide, metal p-diketonates complex compound；Metal in first presoma is zinc, magnesium, aluminium,
One or more in iron；Metal in second presoma is the one or more in silicon, zirconium, titanium.
9. the preparation method as claimed in claim 7 based on the ALD drug osmotic pump preparations coated, it is characterised in that：It is described
Step 4) in oxygen source steam be water, hydrogen peroxide, oxygen, ozone or elemental oxygen.
10. the preparation method as claimed in claim 7 based on the ALD drug osmotic pump preparations coated, it is characterised in that：It is described
Step 6) in the every layer of composite sedimentary layer of control ALD coatings from outside to inside dissolvable oxides content be successively incremented by.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710465610.2A CN107281152A (en) | 2017-06-19 | 2017-06-19 | A kind of drug osmotic pump preparation based on ALD claddings and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710465610.2A CN107281152A (en) | 2017-06-19 | 2017-06-19 | A kind of drug osmotic pump preparation based on ALD claddings and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114007593A (en) * | 2019-04-26 | 2022-02-01 | 应用材料公司 | Coated pharmaceutical composition and preparation method thereof |
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| WO2007078304A2 (en) * | 2005-03-24 | 2007-07-12 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| CN103402503A (en) * | 2011-03-03 | 2013-11-20 | 默克专利股份有限公司 | Coated solid pharmaceutical preparation |
| CN104837484A (en) * | 2012-09-18 | 2015-08-12 | 诺瓦尔德制药有限责任公司 | A method for coating pharmaceutical substrates |
-
2017
- 2017-06-19 CN CN201710465610.2A patent/CN107281152A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007078304A2 (en) * | 2005-03-24 | 2007-07-12 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| CN103402503A (en) * | 2011-03-03 | 2013-11-20 | 默克专利股份有限公司 | Coated solid pharmaceutical preparation |
| CN104837484A (en) * | 2012-09-18 | 2015-08-12 | 诺瓦尔德制药有限责任公司 | A method for coating pharmaceutical substrates |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114007593A (en) * | 2019-04-26 | 2022-02-01 | 应用材料公司 | Coated pharmaceutical composition and preparation method thereof |
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Application publication date: 20171024 |