CN107280665A - Brain evoked potential signal acquisition method - Google Patents
Brain evoked potential signal acquisition method Download PDFInfo
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
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- A61B5/377—Electroencephalography [EEG] using evoked responses
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- A61B5/7235—Details of waveform analysis
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
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- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
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Abstract
The invention discloses a kind of brain evoked potential signal acquisition method, it includes：S1, give brain stimulation with a frequency, collection stimulates the waveform of the brain evoked potential signal of generation each time, and collects the waveform of the brain spontaneous potential signal randomly generated simultaneously, wherein, the brain spontaneous potential signal gathered every time is different；Whether S2, the wave amplitude of the waveform of any brain evoked potential signal judged in the waveform of brain evoked potential signal collected in a period are more than one first given threshold, if then entering step S3, otherwise into step S4；S3, lose the waveform for removing the brain evoked potential signal；S4, the brain spontaneous potential signal and brain evoked potential signal in the period are overlapped successively；S5, the oscillogram for showing brain evoked potential signal.The present invention can effective filter out the interference noise collected i.e. brain spontaneous potential signal waveform when gathering the waveform of brain evoked potential signal.
Description
Technical field
Lured the present invention relates to a kind of brain evoked potential signal acquisition method, more particularly to one kind using superimposing technique collection brain
Send out the acquisition method of electric potential signal.
Background technology
Brain evoked potential is the bioelectric that central nervous system is produced during the impression external world or intrinsic stimuli.Brain
Evoked ptential be for the spontaneous potential of brain.Electroencephalogram is shown what cerebral cortex was produced when without environmental stimuli
Point activity, he the characteristics of there is rhythmicity and continuity.And brain evoked potential is central nervous system is receiving particular stimulation bar
The bioelectric produced under part.In clinical practice, stimulated usually through to auditory system, vision system and body-sensing system
Gather corresponding brain evoked potential.Brain evoked potential is considered as the clinical Electrophysiology after electroencephalogram and electromyogram
The third-largest progress, the title for having " window for spying out spirit ".Its development clinically is used, it will further provide for experiencing from around
Device improves clinical diagnosis level to the information of the whole nervous function state of senior cerebral cortex.
The wave amplitude of brain evoked potential signal is very small, usual wave amplitude in 0.1uV-10uV or so, compared to brain from
Send out electric potential signal will be small a lot, so when gathering above-mentioned brain evoked potential signal at present, brain evoked potential signal is general
Covered by brain spontaneous potential signal, lead to not clearly collect brain evoked potential signal.
The content of the invention
There is provided a kind of brain evoked potential signal acquisition method for the problem of present invention exists for prior art and deficiency.
The present invention is to solve above-mentioned technical problem by following technical proposals：
The present invention provides a kind of brain evoked potential signal acquisition method, and its feature is that it comprises the following steps：
S1, give brain stimulation with a frequency, collection stimulates the waveform of the brain evoked potential signal of generation each time, and together
When collect the waveform of the brain spontaneous potential signal randomly generated, wherein, the brain spontaneous potential signal gathered every time is different；
S2, any brain evoked potential signal for judging in the waveform of brain evoked potential signal that is collected in a period
Whether the wave amplitude of waveform is more than one first given threshold, if then entering step S3, otherwise into step S4；
S3, lose the waveform for removing the brain evoked potential signal；
S4, the brain spontaneous potential signal and brain evoked potential signal in the period are overlapped successively；
S5, the oscillogram for showing brain evoked potential signal.
It is preferred that comprising the following steps between step S2 and S4：
SL, the waveform of any brain evoked potential signal judged in the waveform of the brain evoked potential signal in the period
Whether wave amplitude is more than one second given threshold, if then entering step S3, otherwise into step S4, wherein, the second setting threshold
Value is less than first given threshold.
It is preferred that step S2 comprises the following steps：
S21, the waveform to each brain evoked potential signal in the period carry out FFT Fast Fourier Transform (FFT)s, to obtain
Obtain the spectrum curve of each waveform；
S22, the spectrum curve for each waveform calculate the power spectral density of each spectrum curve；
S23, the corresponding power spectral density of any waveform judged in the waveform of the brain evoked potential signal in the period
Whether a power spectral density threshold value is more than, if then entering step S3, otherwise into step S4.
On the basis of common sense in the field is met, above-mentioned each optimum condition can be combined, and produce each preferable reality of the present invention
Example.
The positive effect of the present invention is：
The present invention provides a kind of brain evoked potential signal acquisition method, can when gathering the waveform of brain evoked potential signal
The interference noise collected i.e. brain spontaneous potential signal waveform is effective filtered out.
Brief description of the drawings
Fig. 1 is the flow chart of the brain evoked potential signal acquisition method of present pre-ferred embodiments
Fig. 2 is the oscillogram of the Auditory Evoked Potential of present pre-ferred embodiments.
Fig. 3 is the oscillogram of the jiggly Evoked ptential signal of baseline of present pre-ferred embodiments.
Fig. 4 is the oscillogram of the stable Evoked ptential signal of baseline of present pre-ferred embodiments.
Fig. 5 is the oscillogram of the Evoked ptential signal of present pre-ferred embodiments.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is
A part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment obtained on the premise of creative work is not made, belongs to the scope of protection of the invention.
The present embodiment provides a kind of brain evoked potential signal acquisition method, the interference noise in gatherer process is had
Effect is filtered out.
The wave amplitude of brain evoked potential signal is very small, usual wave amplitude in 0.1uV-10uV or so, compared to brain from
Send out electric potential signal will be small a lot, so the above-mentioned brain evoked potential signal of collection needs to use " superposition " technology.
As shown in figure 1, the brain evoked potential signal acquisition method comprises the following steps：
Step 101, give brain stimulation with a frequency, collection stimulates the ripple of the brain evoked potential signal of generation each time
Shape, and the waveform of the brain spontaneous potential signal randomly generated is collected simultaneously, wherein, the brain spontaneous potential signal gathered every time is not
Together；
Step 102, any brain evoked potential judged in the waveform of brain evoked potential signal that is collected in a period
Whether the wave amplitude of the waveform of signal is more than one first given threshold, if then entering step 103, otherwise into step 104；
Step 103, lose the waveform for removing the brain evoked potential signal；
Step 104, the brain spontaneous potential signal and brain evoked potential signal in the period are overlapped successively；
Step 105, the oscillogram for showing brain evoked potential signal.
Name a specific example to illustrate the present invention, to cause those skilled in the art to better understood when this
The technical scheme of invention：
By taking auditory evoked potential as an example, the external world gives ear with Click stimulation sound, frequency of stimulation generally in 15Hz or so,
Sound stimulat each time, a fixed response waveform can be recorded in cortex, and this waveform is relative to the time of stimulation
Interval is changeless, and the auditory evoked potential waveform of standard is as shown in Figure 2.
Relation during due to there is lock between the waveform of induction and stimulation, so by the stimulation of 15 times per second, each time
Waveform all adds up carry out arithmetic average, then with stimulating the induction waveform of relation during with lock to be kept in these additive processes
It is constant, and those unordered random brain spontaneous potential signals and interference signal can all be intended to 0 during this, then when folded
Plus after number of times reaches to a certain degree, we induce waveform with regard to that can obtain high-visible brain.Here it is superimposing technique.
In collection additive process, because the signal sensitivity of collection is very high, extraneous any slight interference or
The unusual fluctuation of patient person can all produce larger interference to waveform, therefore can all set a threshold to the waveform for participating in superposition every time
(such as the first given threshold), if the wave amplitude that this waveform has any point on a timeline is more than first given threshold,
The waveform will be so weeded out, superposition is not involved in, to avoid this interference waveform from have impact on the waveform being superimposed before.
Further, it can be seen that depending this method of threshold value alone to reject interference waveform during Clinical practice
And imperfection, the wave amplitude of many interference waveforms is not high, and target waveform is quite, but these interference waveforms can have a strong impact on again
Baseline to waveform is steady, such as in gatherer process, and patient's blink, pharynx saliva, the mild action such as grit one's teeth can all trigger as above
The interference waveform stated, they the characteristics of to be that wave amplitude is not very big, but baseline is very unstable, as shown in Figure 3.
So, the waveform of the brain evoked potential signal after above-mentioned processing need to be further processed, specifically：Sentence
Whether the wave amplitude of the waveform of any brain evoked potential signal in the waveform of the brain evoked potential signal in the disconnected period is more than
One second given threshold, if then entering step 103, otherwise into step 104, wherein, second given threshold be less than this
One given threshold.Then after the step process, one glitch-free, and the steady waveform of the single of standard is as shown in Figure 4.
Therefore the present embodiment is directed to above two waveform (waveform of brain evoked potential signal and the ripple of brain spontaneous potential signal
Shape) it is overlapped respectively, the waveform for filtering out above-mentioned interference is reached by given threshold, reaches that baseline is steady, waveform is more accurate
Purpose.
Moreover, the present embodiment carries out FFT fast Fourier changes to each waveform of patient's brain evoked potential signal acquisition
Change, obtain the spectrum curve of each waveform, then the spectrum curve for each waveform calculates its power spectral density, passes through
The threshold value of power spectral density is set, to be filtered out to interference waveform, waveform of the power spectrum in threshold range is overlapped, work(
Rate spectrum is rejected more than the waveform of threshold range and is not involved in superposition.
Such as first waveform of Fig. 5 is the waveform for not using power spectral filter, and Article 2 is by the filtered ripple of power spectrum
Shape, hence it is evident that visible, the baseline of Article 2 waveform is more steady, for judging I ripples, II ripples, III ripples, IV ripples, the crest ripple of V ripples
Paddy is more accurate.
Although the foregoing describing the embodiment of the present invention, it will be appreciated by those of skill in the art that these
It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back
On the premise of principle and essence from the present invention, various changes or modifications can be made to these embodiments, but these are changed
Protection scope of the present invention is each fallen within modification.
Claims (3)
1. a kind of brain evoked potential signal acquisition method, it is characterised in that it comprises the following steps：
S1, give brain stimulation with a frequency, collection stimulates the waveform of the brain evoked potential signal of generation each time, and adopts simultaneously
Collect the waveform of the brain spontaneous potential signal randomly generated, wherein, the brain spontaneous potential signal gathered every time is different；
S2, any brain evoked potential signal judged in the waveform of brain evoked potential signal that is collected in a period waveform
Wave amplitude whether be more than one first given threshold, if then enter step S3, otherwise into step S4；
S3, lose the waveform for removing the brain evoked potential signal；
S4, the brain spontaneous potential signal and brain evoked potential signal in the period are overlapped successively；
S5, the oscillogram for showing brain evoked potential signal.
2. brain evoked potential signal acquisition method as claimed in claim 1, it is characterised in that include between step S2 and S4
Following steps：
SL, the waveform of any brain evoked potential signal judged in the waveform of the brain evoked potential signal in the period wave amplitude
Whether one second given threshold is more than, if then entering step S3, otherwise into step S4, wherein, second given threshold is small
In first given threshold.
3. brain evoked potential signal acquisition method as claimed in claim 1, it is characterised in that step S2 comprises the following steps：
S21, the waveform to each brain evoked potential signal in the period carry out FFT Fast Fourier Transform (FFT)s, every to obtain
The spectrum curve of one waveform；
S22, the spectrum curve for each waveform calculate the power spectral density of each spectrum curve；
S23, judge whether is the corresponding power spectral density of any waveform in the waveform of the brain evoked potential signal in the period
More than a power spectral density threshold value, if then entering step S3, otherwise into step S4.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109512394A (en) * | 2018-12-06 | 2019-03-26 | 深圳技术大学（筹） | Multichannel Evoked ptential detection method and system based on independent component analysis |
| CN110833407A (en) * | 2019-09-17 | 2020-02-25 | 首都医科大学宣武医院 | MATLAB-based cortical-intercortical evoked potential data processing method |
| CN113520409A (en) * | 2021-05-31 | 2021-10-22 | 杭州回车电子科技有限公司 | SSVEP signal identification method, device, electronic device and storage medium |
| US20220266022A1 (en) * | 2021-02-12 | 2022-08-25 | Boston Scientific Neuromodulation Corporation | Neural Feedback Assisted DBS |
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| US20110015503A1 (en) * | 2009-07-17 | 2011-01-20 | WAVi | Medical apparatus for collecting patient electroencephalogram (eeg) data |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512394A (en) * | 2018-12-06 | 2019-03-26 | 深圳技术大学（筹） | Multichannel Evoked ptential detection method and system based on independent component analysis |
| CN109512394B (en) * | 2018-12-06 | 2021-07-13 | 深圳技术大学（筹） | Multichannel evoked potential detection method and system based on independent component analysis |
| CN110833407A (en) * | 2019-09-17 | 2020-02-25 | 首都医科大学宣武医院 | MATLAB-based cortical-intercortical evoked potential data processing method |
| US20220266022A1 (en) * | 2021-02-12 | 2022-08-25 | Boston Scientific Neuromodulation Corporation | Neural Feedback Assisted DBS |
| CN113520409A (en) * | 2021-05-31 | 2021-10-22 | 杭州回车电子科技有限公司 | SSVEP signal identification method, device, electronic device and storage medium |
| CN113520409B (en) * | 2021-05-31 | 2024-03-26 | 杭州回车电子科技有限公司 | SSVEP signal identification method, device, electronic device and storage medium |
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Application publication date: 20171024 |