CN107260682A - A kind of ion VC powder sprays and preparation method thereof - Google Patents
A kind of ion VC powder sprays and preparation method thereof Download PDFInfo
- Publication number
- CN107260682A CN107260682A CN201710402307.8A CN201710402307A CN107260682A CN 107260682 A CN107260682 A CN 107260682A CN 201710402307 A CN201710402307 A CN 201710402307A CN 107260682 A CN107260682 A CN 107260682A
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- Prior art keywords
- parts
- ion
- pharmaceutical carrier
- sodium
- vitamine
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of ion VC powder sprays and preparation method thereof, it is made up of the raw material of following weight proportion：1 100 parts of vitamine C sodium, 1 300 parts of pharmaceutical carrier, pharmaceutical carrier is：One or more in glucose, mannitol, xylitol, sucrose, stevioside, isomalt etc.；Invention formulation is to be filled with doser after fully being mixed with vitamine C sodium nano level superfine powder and pharmaceutical carrier nano level superfine powder, affected part is reached after administration in the form of being atomized medicinal powder, it can make medicine performance targeting, efficient, quick-acting, safe treatment canker sore effect simultaneously and have to be convenient to use and carry, patient compliance is good, the advantages of nonirritant to mucous membrane, atomization medicinal powder is directly fully contacted with affected part, it is uniformly distributed, absorbs rapidly in affected part and play drug effect, ion VC clinical indication scope is further expanded.
Description
Technical field
The invention belongs to medicine field, it is related to a kind of ion VC powder sprays and preparation method thereof.
Background technology
Increasing data shows that vitamin C treatment canker sore is evident in efficacy, can substantially shorten ulcer symptoms disappearance
Time, recurrence rate is reduced, improve treatment satisfaction, and security is preferable；Clinically often tie up life using high dose intravenous
Plain C is locally applied for canker sore caused by treating cancer Chemotherapy in Patients, radiotherapy later stage or by VITAMIN C TABLET grind into powder
Smear or take vitamin C oral formulations.
But, because the vitamin C aqueous solution is in highly acid, hyperuricemia, gouty joint can be caused on Clinical practice
Inflammation breaking-out or kidney stone etc. adverse reaction；Particularly large bolus injection stimulates blood vessel to cause in use, because concentration is higher
Pain, causes adverse reaction more, so get blood vessel express developed to isotonic solution after need to being administered or be administered using deep venouspuncture,
Mitigate stimulation of the Vc to blood vessel；It is also restrained in terms of drug combination, it need to as far as possible be used alone, not used with alkaline medicine 5,
In order to avoid reduction potency, it is very inconvenient that this needs drug combination to bring to great difficult and complicated illness；Simultaneously as it is highly acid material,
The oxidizable failure in alkaline decoction, therefore need now to match somebody with somebody when in use, keep away light and heat, more bothered in clinical practice；Vitamin C
Slice lapping is into powder partial smearing or oral vitamin C oral formulations, also because ascorbic highly acid is to stomach, throat, mouth
Chamber mucous membrane and tooth have certain infringement.
Vitamine C sodium（That is L-AA sodium）Effect it is identical with vitamin C, but due to being sodium salt, so performance is more
It is stable, while there is no ascorbic highly acid, can simultaneously be taken with multi-medicament, better than vitamin C；Vitamine C sodium
Exist after into human body with ion vc state, it is easier to be absorbed by the body, participate in internal a variety of metabolic processes of human body.
The content of the invention
For background technology problem encountered, it is an object of the invention to provide a kind of ion VC for treating canker sore
Powder spray and preparation method thereof.
In order to achieve the above object, the present invention is adopted the following technical scheme that：A kind of ion VC powder sprays, it is characterised in that
It is made up of the raw material of following weight proportion：1-100 parts of vitamine C sodium, 1-300 parts of pharmaceutical carrier.
As an improvement, being made up of the raw material of following weight proportion：3 parts of vitamine C sodium, 8 parts of pharmaceutical carrier.
As an improvement, being made up of the raw material of following weight proportion：89 parts of vitamine C sodium, 280 parts of pharmaceutical carrier.
As an improvement, being made up of the raw material of following weight proportion：47 parts of vitamine C sodium, adds 170 parts of pharmaceutical carrier.
Another object of the present invention is to provide a kind of preparation method of ion VC powder sprays, comprise the following steps：Dimension life
Plain C sodium is respectively crushed into nanoscale fine powder with pharmaceutical carrier, and particle diameter is 1000nm-5000nm, is mixed by the method for equal increments
Uniformly, it is filling in doser, pack and produce.
As an improvement, pharmaceutical carrier is：In glucose, mannitol, xylitol, sucrose, stevioside, isomalt etc.
One or more.
Compared with prior art, the invention has the advantages that：Invention formulation is super with vitamine C sodium nanoscale
Fine powder is filled with special doser after fully being mixed with pharmaceutical carrier nano level superfine powder, is arrived after administration in the form of being atomized medicinal powder
Up to affected part, can target medicine performance,
Efficiently, quick-acting, safe treatment canker sore effect is simultaneously again with being convenient to use and carry, and patient compliance is good, to viscous
The advantages of film is nonirritant, atomization medicinal powder is directly fully contacted with affected part, is uniformly distributed, is absorbed rapidly in affected part and plays medicine
Effect, makes ion VC clinical indication scope further be expanded.
Embodiment
In order to be better understood from the purpose of the present invention, feature and effect etc., with reference to specific embodiment to the present invention
Technical scheme be described further.
Embodiment 1
A kind of ion VC powder sprays, are made up of the raw material of following weight proportion：3 parts of vitamine C sodium, 8 parts of pharmaceutical carrier.
A kind of preparation method of ion VC powder sprays, comprises the following steps：Vitamine C sodium is respectively crushed into pharmaceutical carrier
Nanoscale fine powder, particle diameter is 1000nm-5000nm, is well mixed by the method for equal increments, filling in doser, sealing
Packaging is produced.
Pharmaceutical carrier is：One kind in glucose, mannitol, xylitol, sucrose, stevioside, isomalt etc. or
It is several.
Embodiment 2
A kind of ion VC powder sprays, are made up of the raw material of following weight proportion：89 parts of vitamine C sodium, 280 parts of pharmaceutical carrier.
A kind of preparation method of ion VC powder sprays, comprises the following steps：Vitamine C sodium is respectively crushed into pharmaceutical carrier
Nanoscale fine powder, particle diameter is 1000nm-5000nm, is well mixed by the method for equal increments, filling in doser, sealing
Packaging is produced.
Pharmaceutical carrier is：One kind in glucose, mannitol, xylitol, sucrose, stevioside, isomalt etc. or
It is several.
Embodiment 3
A kind of ion VC powder sprays, are made up of the raw material of following weight proportion：47 parts of vitamine C sodium, adds pharmaceutical carrier 170
Part.
A kind of preparation method of ion VC powder sprays, comprises the following steps：Vitamine C sodium is respectively crushed into pharmaceutical carrier
Nanoscale fine powder, particle diameter is 1000nm-5000nm, is well mixed by the method for equal increments, filling in doser, sealing
Packaging is produced.
Pharmaceutical carrier is：One kind in glucose, mannitol, xylitol, sucrose, stevioside, isomalt etc. or
It is several.
Embodiment 4
A kind of ion VC powder sprays, are made up of the raw material of following weight proportion：5 parts of vitamine C sodium, 30 parts of xylitol.
A kind of preparation method of ion VC powder sprays, comprises the following steps：By 30 parts points of 5 parts of vitamine C sodium and xylitol
Nano level superfine powder is not ground into, particle diameter is 1000nm-5000nm, be well mixed by the method for equal increments, it is filling in special
In doser, pack and produce.
Embodiment 5
A kind of ion VC powder sprays, are made up of the raw material of following weight proportion：20 parts of isomalt, vitamine C sodium 10
Part, 10 parts of xylitol.
A kind of preparation method of ion VC powder sprays, comprises the following steps：By 20 parts of isomalt, vitamine C sodium
10 parts, 10 parts of xylitol be respectively crushed into nano level superfine powder, particle diameter is 1000nm-5000nm, by equal increments method mix
Close uniform, it is filling in special doser, pack and produce.
Detailed description above is only the explanation of the preferred embodiments of the invention, non-therefore the limitation present invention the scope of the claims,
So, all equivalence techniques changes with carried out by this creation description are both contained in the scope of the claims of the present invention.
Claims (6)
1. a kind of ion VC powder sprays, it is characterised in that be made up of the raw material of following weight proportion：1-100 parts of vitamine C sodium,
1-300 parts of pharmaceutical carrier.
2. a kind of VC containing ion as claimed in claim 1 granule, it is characterised in that by the raw material group of following weight proportion
Into：3 parts of vitamine C sodium, 8 parts of pharmaceutical carrier.
3. a kind of ion VC powder sprays as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportion：
89 parts of vitamine C sodium, 280 parts of pharmaceutical carrier.
4. a kind of ion VC powder sprays as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportion：
47 parts of vitamine C sodium, adds 170 parts of pharmaceutical carrier.
5. a kind of ion VC powder sprays as described in Claims 1-4, it is characterised in that：Described pharmaceutical carrier is：Grape
One or more in sugar, mannitol, xylitol, sucrose, stevioside, isomalt etc..
6. the preparation method of a kind of ion VC powder sprays as described in Claims 1-4, it is characterised in that comprise the following steps：
Vitamine C sodium is respectively crushed into nanoscale fine powder with pharmaceutical carrier, and particle diameter is 1000nm-5000nm, by the method for equal increments
It is well mixed, it is filling in doser, pack and produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710402307.8A CN107260682A (en) | 2017-06-01 | 2017-06-01 | A kind of ion VC powder sprays and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710402307.8A CN107260682A (en) | 2017-06-01 | 2017-06-01 | A kind of ion VC powder sprays and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107260682A true CN107260682A (en) | 2017-10-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710402307.8A Pending CN107260682A (en) | 2017-06-01 | 2017-06-01 | A kind of ion VC powder sprays and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832763A (en) * | 2016-05-11 | 2016-08-10 | 广西圣保堂健康产业股份有限公司 | Medicine composition containing sodium L-ascorbate and preparing method of medicine composition |
| CN106310236A (en) * | 2016-08-29 | 2017-01-11 | 陈石良 | Antioxidation SOD oral spray and preparing method thereof |
| CN106727449A (en) * | 2016-12-20 | 2017-05-31 | 大连丹特生物技术有限公司 | A kind of Xylitol nicotinamide spray and preparation method thereof |
-
2017
- 2017-06-01 CN CN201710402307.8A patent/CN107260682A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832763A (en) * | 2016-05-11 | 2016-08-10 | 广西圣保堂健康产业股份有限公司 | Medicine composition containing sodium L-ascorbate and preparing method of medicine composition |
| CN106310236A (en) * | 2016-08-29 | 2017-01-11 | 陈石良 | Antioxidation SOD oral spray and preparing method thereof |
| CN106727449A (en) * | 2016-12-20 | 2017-05-31 | 大连丹特生物技术有限公司 | A kind of Xylitol nicotinamide spray and preparation method thereof |
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Application publication date: 20171020 |