CN107247097A - Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously - Google Patents
Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously Download PDFInfo
- Publication number
- CN107247097A CN107247097A CN201710408509.3A CN201710408509A CN107247097A CN 107247097 A CN107247097 A CN 107247097A CN 201710408509 A CN201710408509 A CN 201710408509A CN 107247097 A CN107247097 A CN 107247097A
- Authority
- CN
- China
- Prior art keywords
- bisphenol
- sample
- ion
- detect
- content simultaneously
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Abstract
Proposed by the present invention to detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, method includes being pre-processed in sample, obtains sample to be checked；The sample to be checked is detected using LC MS/MS, the one or more in bisphenol-A, Bisphenol F, bisphenol S content are obtained.Energy of the invention is quick, accurate, Simultaneous Determination bisphenol-A, Bisphenol F, three kinds of materials of bisphenol S, and minimum detection limit detects time saving, reduce the workload of testing staff up to 0.01mg/kg, it is easy to accomplish mass processing, so as to greatly improve detection efficiency；Consumptive material toxicity used is low, and extraction agent usage amount is few, reduces the exposure risk of tester, while greatly reducing the cost of consumptive material consumption and liquid waste processing.
Description
Technical field
The present invention relates to Instrumental Analysis field, especially relating to one kind can be while detects bisphenol-A, Bisphenol F, bisphenol S
The method of content.
Background technology
In food contact material field, bisphenol S is as the substitute of bisphenol-A, and its security also enjoys people's always
Concern.
Research shows that the female hormone influence that bisphenol S is produced on organism is similar with bisphenol-A, is also that a kind of endocrine is done
Plain (Environmental Hormone) is disturbed, with the harm for upsetting reproductive system.The measure of bisphenol S (BPS) migration amount is to evaluate food contact
The Scientific Approaches of material safety.China GB 9685-2016《National food safety standard food contact material and product are with adding
Plus agent uses standard》The migration limitation for providing bisphenol S in food simulants is 0.05mg/kg.
Bisphenol F, also known as 4,4 dihydroxydiphenyl methane are a kind of synthetic material monomers.Available for synthesizing epoxy tree
Fat, polycarbonate resin, polyester resin He Fen Chuo resins, fire retardant, antioxidant and surfactant etc..
CN201310105282 discloses the purifying of a kind of packaging material for food and container migration stain thing bisphenol
Preprocess method is enriched with, this method comprises the following steps：C18 reverse phase solid phase extractions pillar through methanol and ultra-pure water activation after on
Sample, is first eluted with 20% methanol aqueous solution, and again with methanol elution, eluent is dried up through nitrogen, and residue, filtering are redissolved with acetonitrile
Liquid chromatogram-fluorescence detector detection is carried out afterwards.Using the preconditioning technique, 6 kinds of bisphenols (bisphenol-A (BPA), bisphenol bs
(BPB), bis-phenol E (BPE), Bisphenol F (BPF), bisphenol A diglycidyl ether (BADGE) and Bisphenol F diglycidyl ether
(BFDGE) rate of recovery) is between 75.92%~102.10%, and relative deviation is below 5%, and the degree of accuracy and precision are good.
CN201410247394 discloses a kind of assay method of bisphenol S migration amount in plastic food packaging materials, including
[step 1] prepares standard working solution, food simulants test solution and blank test solution；[step 2] uses high performance liquid chromatography-series connection
Triple quadrupole bar GC-MS carries out the triple level Four bar mass spectrums of liquid chromatogram-series connection to three kinds of solution of step one and surveyed respectively
It is fixed；The concentration x of bisphenol S using in standard working solution is abscissa, using the corresponding quota ion peak area y measured as vertical seat
Mark, draws standard working solution regression curve, and the linear equation y=ax+b obtained according to curve calculates the oblique of regression curve
Rate a and intercept b；[step 3] calculates bisphenol S concentration in food simulants test solution according to formula c=[(y moulds-y is empty)-b]/a.Should
Method can accurately measure the migration amount of bisphenol S in plastic food packaging materials, quantify accurately and reliably, and reappearance is good.
However, CN201310105282 belongs to the improvement to sample pretreatment process, and it is cumbersome, take long；
CN201410247394 can only analyze bisphenol S, though analysis time has shortened, and it is still not ideal enough.
The content of the invention
The main object of the present invention can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously to provide, can be significantly
Ground reduces detection time, improves detection efficiency.
Present invention proposition is a kind of can to detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, comprise the following steps：
Sample is pre-processed, sample to be checked is obtained；
The sample to be checked is detected using LC-MS/MS, one kind in bisphenol-A, Bisphenol F, bisphenol S content is obtained
Or it is a variety of；
Wherein, LC-MS/MS liquid-phase condition is：
Liquid-phase chromatographic column：ACQUITYUPLC HSS or suitable chromatographic columns, a diameter of 1.8 μm of filler；Chromatogram column length is
100mm；Chromatogram column internal diameter is 2.1mm；
Flow phase composition and elution requirement：The acetonitrile and one-level water of chromatographically pure rank, condition of gradient elution is：
0min, 40% water, 60% acetonitrile；
3min, 40% water, 60% acetonitrile；
Sample size：1μL；
Column temperature：40℃；
Flow velocity：0.35mL/min；
Mass Spectrometry Conditions are：
Ion gun：ESI, Ionization mode ES (-)；
Capillary voltage：3.4kV；
Taper hole voltage：35.0V；
Collide cell voltage：3.55V；
Analyzer voltage：2.35V；
Ion source temperature：150℃
Desolvation temperature：500℃；
Scan pattern：Multiple-reaction monitoring (MRM)；
Collision energy is：
Bisphenol-A：Quota ion includes the daughter ion that m/z is 212, and collision energy is 27eV, and qualitative ion is including m/z
133 daughter ion, collision energy is 13eV；
Bisphenol F：Quota ion includes the daughter ion that m/z is 105, and collision energy is 22eV, and it is 93 that qualitative ion, which includes m/z,
Daughter ion, collision energy is 30eV；
Bisphenol S：Quota ion includes the daughter ion that m/z is 108, and collision energy is 26eV, and it is 92 that qualitative ion, which includes m/z,
Daughter ion, collision energy is 34eV.
Preferably, the sample is food contact material.
Preferably, the sample is food contact plastic products.
Preferably, it is described to be pre-processed sample, before acquisition sample to be checked, in addition to：
Set up the hybrid standard concentration curve of bisphenol-A, Bisphenol F, bisphenol S.
Preferably, it is described to set up bisphenol-A, Bisphenol F, bisphenol S hybrid standard concentration curve, including：
With 50%V/V ethanol prepare ultimate density be 0.01mg/kg, 0.02mg/kg, 0.05mg/kg, 0.10mg/kg,
0.20mg/kg bisphenol-A, Bisphenol F, bisphenol S hybrid standard working solution, then it is separately added into internal standard substance bisphenol-A-D16, bis-phenol
A-D16 concentration is 0.02mg/kg, is quantified by internal standard method, sets up the hybrid standard concentration of bisphenol-A, Bisphenol F, bisphenol S
Curve.
Preferably, the bisphenol-A, Bisphenol F, the linearly dependent coefficient of bisphenol S hybrid standard concentration curve are all higher than
0.998。
Preferably, in addition to：
Bisphenol-A, Bisphenol F, bisphenol S mixture that concentration is 0.01mg/kg are added in blank sample matrix, is then determined
Bisphenol-A, Bisphenol F, the content of bisphenol S, calculate the rate of recovery, bisphenol-A, Bisphenol F, the rate of recovery of bisphenol S 90% to 110% it
Between.
Preferably, it is described to be pre-processed sample, sample to be checked is obtained, including：
Take 1dm2Sample is in beaker, and addition is pre-heated to 70 DEG C of 50%V/V ethanol simulated solution 167mL, uses glass dish
Beaker is covered, and is transferred to and is pre-heated in 70 DEG C of baking oven, 2h is placed, then beaker is taken out, sample is removed immediately, then take
Appropriate simulated solution, is filtered, the liquid being transferred in sample bottle, sample bottle is sample to be checked through 0.22 μm of nylon leaching film.
Preferably, the lowest detection of methods described is limited to 0.01mg/kg.
Preferably, the detection time of methods described is 3min.
It is proposed by the present invention to detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, can be quick, accurate, simultaneously fixed
Bisphenol-A, Bisphenol F, three kinds of materials of bisphenol S are determined in measurement, and minimum detection limit detects time saving, reduce detection people up to 0.01mg/kg
The workload of member, it is easy to accomplish mass processing, so as to greatly improve detection efficiency；Consumptive material toxicity used is low, extraction agent
Usage amount is few, reduces the exposure risk of tester, while greatly reducing the cost of consumptive material consumption and liquid waste processing.
Brief description of the drawings
Fig. 1 can detect bisphenol-A, Bisphenol F, the schematic flow sheet of the embodiment of method one of bisphenol S content simultaneously for the present invention；
Fig. 2 is the standard concentration curve of bisphenol-A；
Fig. 3 is the standard concentration curve of Bisphenol F；
Fig. 4 is the standard concentration curve of bisphenol S；
Fig. 5 is the chromatogram of bisphenol-A；
Fig. 6 is the chromatogram of Bisphenol F；
Fig. 7 is the chromatogram of bisphenol S.
The realization, functional characteristics and advantage of the object of the invention will be described further referring to the drawings in conjunction with the embodiments.
Embodiment
It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not intended to limit the present invention.
Reference picture 1, present invention proposition is a kind of can to detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, including following
Step：
S10, sample pre-processed, obtain sample to be checked；
S20, using LC-MS/MS the sample to be checked is detected, obtained in bisphenol-A, Bisphenol F, bisphenol S content
It is one or more.
In step S10, preprocess method can refer to GB 5009.156-2016《National food safety standard food contacts material
Material and product migration test preprocess method general rule》And GB31604.1-2015《National food safety standard food contact material
And product migration test general rule》, suitable food simulated solution, test temperature, testing time and test specimens liquor ratio are selected, is carried out
Migration test.
In step S20, LC-MS/MS liquid-phase condition is：
1) liquid-phase chromatographic column：ACQUITYUPLC HSS or suitable chromatographic columns, a diameter of 1.8 μm of filler；Chromatogram column length is
100mm；Chromatogram column internal diameter is 2.1mm；
2) flowing phase composition and elution requirement：The acetonitrile and one-level water of chromatographically pure rank, the condition of gradient elution such as institute of table 1
Show；
3) sample size：1μL；
4) column temperature：40℃；
5) flow velocity：0.35mL/min.
The liquid chromatogram elution requirement of table 1
Mass Spectrometry Conditions are：
1) ion gun：ESI, Ionization mode ES (-)；
2) capillary voltage：3.4kV；
3) taper hole voltage：35.0V；
4) cell voltage is collided：3.55V；
5) analyzer voltage：2.35V；
6) ion source temperature：150℃
7) desolvation temperature：500℃；
8) scan pattern：Multiple-reaction monitoring (MRM)；
9) collision energy is shown in Table 2-4；
The collision energy of the bisphenol-A of table 2
The collision energy of the Bisphenol F of table 3
The collision energy of the bisphenol S of table 4
Following examples are specific continuous mode：
First, the hybrid standard concentration curve of bisphenol-A, Bisphenol F, bisphenol S is set up.
With 50%V/V ethanol prepare ultimate density be 0.01mg/kg, 0.02mg/kg, 0.05mg/kg, 0.10mg/kg,
0.20mg/kg bisphenol-A (is represented, CAS with BPA:80-05-7), Bisphenol F (is represented, CAS with BPF:620-92-8), bisphenol S
(represented with BPS, CAS:80-09-1) hybrid standard working solution, then internal standard substance bisphenol-A-D16 is separately added into (with BPA-D16
Represent, CAS:96210-87-6), bisphenol-A-D16 concentration is 0.02mg/kg, is quantified by internal standard method.
Bisphenol-A, Bisphenol F, the hybrid standard concentration curve difference of bisphenol S are as shown in figs. 2 to 4.By Fig. 2~4 it can easily be seen that
Bisphenol-A, Bisphenol F, the linearly dependent coefficient of bisphenol S hybrid standard concentration curve are all higher than 0.998, meet quantitative requirement.
Followed by sample measuring liquid is treated in preparation, process is as follows：
Take 1dm2Sample is in beaker, and addition is pre-heated to 70 DEG C of 50%V/V ethanol simulated solution 167mL, uses glass dish
Beaker is covered, and is transferred to and is pre-heated in 70 DEG C of baking oven, 2h is placed.The sample that the present embodiment is used is moulded for food contact
Material products.Then beaker is taken out, sample is removed immediately, then take appropriate simulated solution, filtered, be transferred to through 0.22 μm of nylon leaching film
Sample measuring liquid is treated in sample bottle, acquisition.
Followed by sample measuring liquid examination with computer is treated, specific condition of work uses liquid-phase condition and matter in above-mentioned steps S20
Spectral condition.
Bisphenol-A, Bisphenol F, the chromatogram of bisphenol S are obtained as stated above, respectively as shown in Fig. 5~7.Can be with by Fig. 5~7
Find out, bisphenol-A, Bisphenol F, bisphenol S appearance time interval it is larger, do not overlap, thus can measure simultaneously.
The compound target thing that concentration is 0.01mg/kg is added in blank sample matrix, the method that the present invention is provided is entered
Row verification.As a result show, bisphenol-A, Bisphenol F, the rate of recovery of bisphenol S are as follows, between 90% to 110%, it is fixed to fully meet
Measure the requirement of examination.
Empirical tests, method provided in an embodiment of the present invention, lowest detection is limited to 0.01mg/kg, and detection time is 3min.
It is proposed by the present invention to detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, can be quick, accurate, simultaneously fixed
Bisphenol-A, Bisphenol F, three kinds of materials of bisphenol S are determined in measurement, and minimum detection limit detects time saving, reduce detection people up to 0.01mg/kg
The workload of member, it is easy to accomplish mass processing, so as to greatly improve detection efficiency；Consumptive material toxicity used is low, extraction agent
Usage amount is few, reduces the exposure risk of tester, while greatly reducing the cost of consumptive material consumption and liquid waste processing.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize
Equivalent structure or equivalent flow conversion that description of the invention is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (10)
1. a kind of can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that comprise the following steps：
Sample is pre-processed, sample to be checked is obtained；
The sample to be checked is detected using LC-MS/MS, bisphenol-A, Bisphenol F, one kind in bisphenol S content or many is obtained
Kind；
Wherein, LC-MS/MS liquid-phase condition is：
Liquid-phase chromatographic column：ACQUITYUPLC HSS or suitable chromatographic columns, a diameter of 1.8 μm of filler；Chromatogram column length is 100mm；
Chromatogram column internal diameter is 2.1mm；
Flow phase composition and elution requirement：The acetonitrile and one-level water of chromatographically pure rank, condition of gradient elution is：
0min, 40% water, 60% acetonitrile；
3min, 40% water, 60% acetonitrile；
Sample size：1μL；
Column temperature：40℃；
Flow velocity：0.35mL/min；
Mass Spectrometry Conditions are：
Ion gun：ESI, Ionization mode ES (-)；
Capillary voltage：3.4kV；
Taper hole voltage：35.0V；
Collide cell voltage：3.55V；
Analyzer voltage：2.35V；
Ion source temperature：150℃
Desolvation temperature：500℃；
Scan pattern：Multiple-reaction monitoring (MRM)；
Collision energy is：
Bisphenol-A：Quota ion includes the daughter ion that m/z is 212, and collision energy is 27eV, and it is 133 that qualitative ion, which includes m/z,
Daughter ion, collision energy is 13eV；
Bisphenol F：Quota ion includes the daughter ion that m/z is 105, and collision energy is 22eV, and qualitative ion includes the son that m/z is 93
Ion, collision energy is 30eV；
Bisphenol S：Quota ion includes the daughter ion that m/z is 108, and collision energy is 26eV, and qualitative ion includes the son that m/z is 92
Ion, collision energy is 34eV.
2. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
Sample is stated for food contact material.
3. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
Sample is stated for food contact plastic products.
4. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
State and pre-processed sample, before acquisition sample to be checked, in addition to：
Set up the hybrid standard concentration curve of bisphenol-A, Bisphenol F, bisphenol S.
5. according to claim 4 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
State and set up bisphenol-A, Bisphenol F, bisphenol S hybrid standard concentration curve, including：
With 50%V/V ethanol prepare ultimate density be 0.01mg/kg, 0.02mg/kg, 0.05mg/kg, 0.10mg/kg,
0.20mg/kg bisphenol-A, Bisphenol F, bisphenol S hybrid standard working solution, then it is separately added into internal standard substance bisphenol-A-D16, bis-phenol
A-D16 concentration is 0.02mg/kg, is quantified by internal standard method, sets up the hybrid standard concentration of bisphenol-A, Bisphenol F, bisphenol S
Curve.
6. according to claim 4 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
State bisphenol-A, Bisphenol F, the linearly dependent coefficient of bisphenol S hybrid standard concentration curve and be all higher than 0.998.
7. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that also
Including：
Bisphenol-A, Bisphenol F, bisphenol S mixture that concentration is 0.01mg/kg are added in blank sample matrix, bis-phenol is then determined
A, Bisphenol F, the content of bisphenol S, calculate the rate of recovery, bisphenol-A, Bisphenol F, the rate of recovery of bisphenol S are between 90% to 110%.
8. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
State and pre-processed sample, obtain sample to be checked, including：
Take 1dm2Sample is in beaker, and addition is pre-heated to 70 DEG C of 50%V/V ethanol simulated solution 167mL, and burning is covered with glass dish
Cup, and be transferred to and be pre-heated in 70 DEG C of baking oven, 2h is placed, then beaker is taken out, sample is removed immediately, then take appropriate mould
Intend liquid, filtered through 0.22 μm of nylon leaching film, the liquid being transferred in sample bottle, sample bottle is sample to be checked.
9. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
The lowest detection for stating method is limited to 0.01mg/kg.
10. according to claim 1 can detect bisphenol-A, Bisphenol F, the method for bisphenol S content simultaneously, it is characterised in that institute
The detection time for stating method is 3min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710408509.3A CN107247097A (en) | 2017-06-02 | 2017-06-02 | Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710408509.3A CN107247097A (en) | 2017-06-02 | 2017-06-02 | Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107247097A true CN107247097A (en) | 2017-10-13 |
Family
ID=60017816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710408509.3A Pending CN107247097A (en) | 2017-06-02 | 2017-06-02 | Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107247097A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110095422A (en) * | 2019-05-24 | 2019-08-06 | 山东师范大学 | For quickly detecting aptamers, aptamer nanogold material, kit and its application of bisphenol-A |
| CN111198242A (en) * | 2018-11-19 | 2020-05-26 | 广州质量监督检测研究院 | Method for determining bisphenol compounds in food simulants |
| CN111707737A (en) * | 2020-05-06 | 2020-09-25 | 深圳市农产品质量安全检验检测中心(深圳市动物疫病预防控制中心) | Method for improving detection precision of bisphenol A content in animal derived food and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102495145A (en) * | 2011-11-11 | 2012-06-13 | 深圳天祥质量技术服务有限公司 | Method for detecting bisphenol A in plastic product |
| CN104007218A (en) * | 2014-06-06 | 2014-08-27 | 北京礼来科技发展中心 | Determination method of bisphenol S transfer volume in plastic food packaging materials |
| CN106290691A (en) * | 2016-11-01 | 2017-01-04 | 中国检验检疫科学研究院 | The fast quantitative measurement method for detecting of bisphenol compound in a kind of milk product |
-
2017
- 2017-06-02 CN CN201710408509.3A patent/CN107247097A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102495145A (en) * | 2011-11-11 | 2012-06-13 | 深圳天祥质量技术服务有限公司 | Method for detecting bisphenol A in plastic product |
| CN104007218A (en) * | 2014-06-06 | 2014-08-27 | 北京礼来科技发展中心 | Determination method of bisphenol S transfer volume in plastic food packaging materials |
| CN106290691A (en) * | 2016-11-01 | 2017-01-04 | 中国检验检疫科学研究院 | The fast quantitative measurement method for detecting of bisphenol compound in a kind of milk product |
Non-Patent Citations (3)
| Title |
|---|
| SHAN XIAO MEI等: "Simultaneous Determination of Bisphenols and Alkylphenols in Water by Solid Phase Extraction and Ultra Performance Liquid Chromatography-tandem Mass Spectrometry", 《BIOMED ENVIRON SCI》 * |
| 中华人民共和国国家卫生和计划生育委员会: "《中华人民共和国国家标准GB 31604.1-2015》", 22 September 2015 * |
| 余建龙: "七种双酚类化合物雌激素活性评价及其在食品中检测方法的建立和应用", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111198242A (en) * | 2018-11-19 | 2020-05-26 | 广州质量监督检测研究院 | Method for determining bisphenol compounds in food simulants |
| CN110095422A (en) * | 2019-05-24 | 2019-08-06 | 山东师范大学 | For quickly detecting aptamers, aptamer nanogold material, kit and its application of bisphenol-A |
| CN111707737A (en) * | 2020-05-06 | 2020-09-25 | 深圳市农产品质量安全检验检测中心(深圳市动物疫病预防控制中心) | Method for improving detection precision of bisphenol A content in animal derived food and application thereof |
| CN111707737B (en) * | 2020-05-06 | 2022-12-20 | 深圳市质量安全检验检测研究院(深圳市动物疫病预防控制中心) | Method for improving detection precision of bisphenol A content in animal derived food and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104991017B (en) | Liquid chromatogram-tandem mass spectrometry method for determining isothiazolinone bactericides contained in water-based adhesive | |
| CN107247097A (en) | Bisphenol-A, Bisphenol F, the method for bisphenol S content can be detected simultaneously | |
| CN104007218B (en) | The assay method of bisphenol S migration amount in a kind of plastic food packaging materials | |
| CN107543876A (en) | A kind of method that SPE liquid chromatography tandem mass spectrometry detects 9 kinds of estrogenic chemicalses in water body simultaneously | |
| CN107449841A (en) | A kind of detection method based on Derivatization Determination monoamine neurotransmitter | |
| CN106153801A (en) | A kind of method of seven kinds of mycotoxins in Chinese liquor supplementary material of detection simultaneously | |
| CN109406690B (en) | Method for detecting related substances in chloral hydrate | |
| CN111812242B (en) | Method for simultaneously detecting multiple toxic and harmful substances in consumer product | |
| CN106841457B (en) | The measuring method of methaqualone and diazepam residual quantity in a kind of animal derived food | |
| CN105319296A (en) | Measuring method for methyl alcohol content | |
| CN110045037A (en) | A kind of kit and detection method detecting nilotinib drug concentration in dry blood cake | |
| Wilks Jr et al. | The isolation of 4-methylimidazole from caramel color and its determination by thin-layer and gas-liquid chromatography | |
| CN102944635B (en) | Method for determining tris (2,3-dibromopropyl) phosphate content of water | |
| CN111366659A (en) | Method for detecting trace PFOA (perfluorooctanoic acid) in powdery fluoropolymer product | |
| CN105334282B (en) | Co-detecting method for environmental estrogens in surface water body | |
| Gilliland et al. | Simultaneous determination of vitamins D2 and D3 by LC-MS/MS in infant formula and adult nutritionals: First Action 2011.13 | |
| CN109060982B (en) | Method for rapidly detecting low-molecular chlorinated organic matters in household paper and application | |
| CN109254087A (en) | A kind of HPLC detection method of lauryl sodium sulfate in Ezetimibe piece sample | |
| CN103808822A (en) | LC-QTOF (Liquid Chromatography-Quadrupole Time Of Flight) analysis method for distinguishing resveratrol of different resources | |
| CN110361485A (en) | Oxcarbazepine monitor drug concentration kit and its detection method in a kind of blood | |
| CN109828066A (en) | Liquid chromatography mass is combined the method and application of chemical component in method measurement Chinese medicine | |
| Di et al. | Use of Ionic liquids as additives in ion exchange chromatography for the analysis of cations | |
| CN102998395A (en) | Method for determining tetrabromobisphenol A content | |
| CN107561186A (en) | Method that is a kind of while detecting three kinds of alkaloids in lycoris plants | |
| CN114487165A (en) | Method for simultaneously determining bisphenol A and bisphenol S in dairy products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171013 |
|
| RJ01 | Rejection of invention patent application after publication |