CN107236136A - A kind of preparation method of single particle size polymer micro-nano rice grain - Google Patents
A kind of preparation method of single particle size polymer micro-nano rice grain Download PDFInfo
- Publication number
- CN107236136A CN107236136A CN201710475057.0A CN201710475057A CN107236136A CN 107236136 A CN107236136 A CN 107236136A CN 201710475057 A CN201710475057 A CN 201710475057A CN 107236136 A CN107236136 A CN 107236136A
- Authority
- CN
- China
- Prior art keywords
- polymer
- preparation
- micro
- rice grain
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Abstract
The invention belongs to micro-nano granules preparing technical field, a kind of preparation method of single particle size polymer micro-nano rice grain is disclosed, is comprised the following steps：S1, amphipathic copolymer is dissolved in organic solvent, obtains polymer solution；S2, the drain insulating layer surface that polymer solution is coated on to Electrowetting device, after the solvent is volatilized, form thin polymer film；S3, polymeric film surface add water induced polymer segment reset, treat water volatilize naturally do；S4, water is added into Electrowetting device, apply voltage between aqueous phase system and Electrowetting device electrically-conductive backing plate, then remove water, obtain single particle size polymer micro-nano rice grain.The present invention can quickly, effectively prepare the polymer micro-nano rice grain of single particle size by electrowetting, and particle diameter deviation is in ± 5nm.
Description
Technical field
The invention belongs to micro-nano granules preparing technical field, specifically one kind is quickly prepared single using electrowetting principle
The method of the polymer self assembles micro-nano granules of particle diameter.
Background technology
Nano particle has special skin effect, quantum size effect, small-size effect and macroscopic quantum tunneling effect
Should, thus have in terms of photonic material, electronic equipment, biology sensor, catalyst particularly important application.
Amphipathic copolymer can form a series of different nanometers in selective solution by way of self assembly
The aggregation of size.The pattern that self assembly is produced can regulate and control its pattern, the chemical group of such as copolymer by many parameters
Into, the boundary of the length of the pH value of solution, temperature, block, cosolvent and the selection of selective solvent and solvent and hydrophobic block
Face tension force and additive etc., by the regulation and control of above-mentioned factor, the structure of the micella of formation can be spherical, vesica, tubulose,
The different morphologies such as bar-shaped and annular micella.Preparing the method for copolymer micelle has traditional direct method and indirect method, with right
In the research of preparation method, occur in that emulsified solvent evaporation method, blend method (after premix mix) and template etc. some
The new method for preparing micella, the most basic building block principle of these methods is similar.Emulsion-solvent evaporation method is by polymer
Organic solution is added drop-wise in the aqueous phase containing emulsifying agent, and by mechanical agitation or ultrasonic waveform into O/W type emulsions, dialysis removes interior
Phase organic solvent, polymer deposits formation microballoon.But, the micella appearance structure and size prepared by these methods is poor
It is very not big, it is impossible to the micro-nano granules of single particle size are fast and effeciently made.
Single particle size can be accomplished at present has template, etching method and microfluidic method.Template and etching method photoetching
Compare many, in addition to litho machine is very expensive, the cost of template is not also low, and operate cumbersome.The lower template of cost
Rule can only do micron particles.Microfluidic method operation requires higher, and yield is few, and pipeline is easily blocked or leakage, cannot
Large-scale continuous production.Therefore need research and development it is a kind of it is with low cost, fast and effectively method prepare the micro-nano of single particle size
Rice grain.
The content of the invention
It is an object of the invention to provide a kind of method for the micro-nano granules that single particle size is prepared by electrowetting.
To reach above-mentioned purpose, the present invention uses following technical scheme：
A kind of preparation method of single particle size polymer micro-nano rice grain, be specifically：By having containing amphipathic copolymer
Machine solvent is coated on the drain insulating layer of Electrowetting device, is polymerize under the electric field action of Electrowetting device by self assembly
Thing micro-nano granules.
Further, the preparation method comprises the following steps：
S1, amphipathic copolymer is dissolved in organic solvent, obtains polymer solution；
S2, the drain insulating layer surface that polymer solution is coated on to Electrowetting device, after the solvent is volatilized, form polymerization
Thing film；
S3, polymeric film surface add water induced polymer segment reset, treat water volatilize naturally do；
S4, water is added into Electrowetting device, apply voltage between aqueous phase system and Electrowetting device electrically-conductive backing plate, so
After remove water, obtain single particle size polymer micro-nano rice grain.
Further, the amphipathic copolymer is and hydrophobic chain segment or group containing hydrophilic segment or group
Polymer.
If hydrophilic section is macromolecule, hydrophobic section can also be replaced with hydrophobicity very strong organic molecule, such as stearic
Acid, palmitic acid etc.；In turn, if hydrophobic section is macromolecule, hydrophilic section can also be replaced with hydrophily very strong small molecule.
Further, the hydrophilic segment or group be polyacrylic acid, polyacrylamide, polyvinyl alcohol, glucan or
Hyaluronic acid, shown hydrophobic chain segment or group are polyacrylate, polyolefin, polyester or makrolon.
As long as organic solvent can dissolve amphipathic nature polyalcohol, (such as volatilization, heating evaporation), one are easily removed
As select volatile organic solvent, such as ethanol, dichloromethane, chloroform, methanol, toluene, n-hexane, ether, tetrahydrofuran etc..
The concentration of polymer solution does not have particular/special requirement, as long as viscosity is suitable, easily coating, according to amphipathic polymerization
The property of thing is determined, if the nature difference of hydrophobe section is sufficiently large, and concentration level influences very little on its self assembly, optional dense
Spend the non-constant width of scope；If difference is not big enough, concentration range is just smaller；Preferred concentration is 0.01~10mol/L.
Further, in the S2, using blade coating, spin coating, spraying or inkjet printing coated polymeric solution.
Further, in the S4,20~50V voltages, 0.5~5min is applied.
The water that S3 is added only is needed on a small quantity, and surface moisture film can be covered from the principle, the summary that can add in practical operation
It is many, to ensure all standing.In embodiment is the pixel compartments of 150 μm of 150 μ m (pixel wall is high 80 μm), with 1 μ m thick water
Film is calculated, and 1 pixel compartments only needs to 2.25 × 10-5μL.One piece of 3 × 3cm band pixel compartments slide, calculates and only needs to 0.9 μ
L, because self assembly is fettered by strand in layer, speed is not that quickly, but water can evaporate, especially higher in summer temperature
Or the autumn and winter, when dry very much, in order to ensure in layer self assembly fully, actual capabilities can be added to more than 100 μ L.
S4 needs to add a large amount of water, and one piece of 3 × 3cm band pixel compartments slide typically adds more than 2mL.
Further, the particle diameter of the polymer micro-nano rice grain is 10nm~5 μm.
The particle size of particle is similar with the granular size that other self-assembly methods are obtained, and this depends primarily on amphipathic copolymerization
The ratio between the hydrophilic and hydrophobic of thing hydrophilic section and hydrophobic section is strong and weak, and corresponding molecular size range and molecular weight.For example polyethylene glycol-
The segment molecule amount of b- PLAs two is 1000：If 5000, general particle diameter is just in the range of 30~60nm；If 1000：10000
If, then (average grain diameter that the inventive method is obtained is 65nm to particle diameter, and particle diameter deviation is left in ± 5nm between 60~90nm
It is right)；If 1000：If 20000, then more than 100nm, (average grain diameter that the inventive method is obtained is 95nm, particle diameter deviation
In ± 5nm or so).
Further, the Electrowetting device is made up of electrically-conductive backing plate, drain insulating layer, conductive pixel wall, pixel walled
Into the pixel compartments of fixed dimension.
Electrically-conductive backing plate has silver, ITO, graphene etc..
Electrowetting is under electric field action, by controlling the switch of electric field, so as to change the close and distant of drain insulating layer surface
It is aqueous.By regulating and controlling the hydrophobe property on drain insulating layer surface, amphipathic nature polyalcohol segment can be controlled in drain insulating layer
The arrangement on surface.When electric field is closed, drain insulating layer surface is in hydrophobicity.Now, amphipathic nature polyalcohol molecule
Hydrophobic side can auto arrangement on drain insulating layer surface.When electric field is in open mode, drain insulating layer surface can be automatic
Assemble a large amount of electric charges, drain insulating layer surface can be transformed into hydrophilic from hydrophobic, be arranged in the hydrophobic section meeting on drain insulating layer surface
Depart from moment, micro-nano granules are self-assembly of in aqueous phase system.Therefore, can quickly it be prepared in a short time using electrowetting
The a large amount of and single micro-nano granules of size.
Its principle as shown in figure 1, amphipathic nature polyalcohol organic solution is coated on the drain insulating layer surface of Electrowetting device,
After the solvent is volatilized, a small amount of water for being used to induce segment to reset is added toward polymeric film surface.Because drain insulating layer surface is in
Hydrophobicity, now the hydrophobic side of amphipathic nature polyalcohol spontaneous can be arranged in drain insulating layer surface, and hydrophilic one end then can be spontaneous
Towards aqueous phase, form that the surface contacted with water is partially hydrophilic, surface that is being contacted with drain insulating layer hydrophobic amphipathic self assembly partially
Thin polymer film.When the added electric field between aqueous phase system and bottom conductive substrate, due to electrowetting effect, drain insulating layer table
The face meeting a large amount of electric charges of self-assemble, its surface can cause the spontaneous disengaging in hydrophobic side of polymer hydrophobic from hydrophobic to hydrophilic transformation
Surface of insulating layer enters aqueous phase.And then, hydrophobe interaction is by induced polymer segment self assembly, so as to form micro-nano
Particle.
The beneficial effects of the invention are as follows：
The present invention can quickly prepare the polymer micro-nano rice grain of single particle size by electrowetting, and particle diameter deviation is in ± 5nm.
The hydrophilic and hydrophobic on drain insulating layer surface can effectively be controlled by the switch of simple and quick control electric field.Opened when electric field is in
During state, the hydrophobic side of di-block copolymer can depart from the surface of drain insulating layer, enter among aqueous phase system, can quickly certainly
Assembling forms polymer micro-nano rice grain.And described Electrowetting device can be repeatedly coated with, apply electric field repeatedly and prepare polymer
Micro-nano granules.Therefore, compared to the method for preparing polymer micro-nano rice grain conventional at present, due in self assembling process
Extra electric field driven power is applied with, it is more efficient and quick to prepare polymer micro-nano particle using electrowetting technology.
The pixel compartments being additionally, since in Electrowetting device all have a fixed dimension, can be formed after organic solvent volatilization with
Pixel compartments size it is consistent, the uniform amphipathic nature polyalcohol film of thin and thick.In the case of device performance and driving electric field identical,
I.e. in the case of self assembly outside force identical, the amphipathic nature polyalcohol film of formed objects and thickness is determined completely in pixel compartments
The granular size of generation, therefore particle diameter, pattern very unified micro-nano granules can be generated, so as to efficiently solve conventional side
The problem of legal system obtains granule-morphology, structure snd size difference is larger.
In addition, as described above, pixel compartments size, drain insulating layer characteristic, driving voltage, on-off mode and number of times can
Effectively the size and speed of regulation and control particles self assemble generation, have obvious advantage in controllability.
The inventive method can generate polymer beads in 1min, and open by design is easy to collect product, can be used for flowing water
Line mode is largely prepared.
Brief description of the drawings
Fig. 1 is the principle schematic that the present invention prepares single particle size polymer micro-nano rice grain using electrowetting；
Fig. 2 is the hydrogen nuclear magnetic resonance spectrogram of MPEG-PLA before the self assembly of embodiment 1；
Fig. 3 is the hydrogen nuclear magnetic resonance spectrogram of MPEG-PLA after the self assembly of embodiment 1；
Fig. 4 is the scanning electron microscope (SEM) photograph of the polymer micro-nano rice grain obtained by prepared by embodiment 1；
Fig. 5 is the scanning electron microscope (SEM) photograph of the polymer micro-nano rice grain obtained by prepared by embodiment 2；
Fig. 6 is the scanning electron microscope (SEM) photograph of the polymer micro-nano rice grain obtained by prepared by embodiment 4.
Embodiment
With reference to specific embodiment, the present invention is described further.
Embodiment 1
In Study Polymer Melts self assembly, polyethylene glycol-polylactic acid block copolymer is most typical, because main chain is soft
It is soft, be easily assembled to.
Take 1.000g CH3O-PEG1000- OH is in the neck reaction bulbs of 50mL tri-.The lower vacuum drying 2h of 60 DEG C of heating.It is cooled to
After room temperature, a small amount of stannous octoate is added dropwise under Ar protections, continues to be dried in vacuo 30min, 2.5g D- third is added under Ar protections
Lactide, 5mL are super, and dry toluene makees solvent, in 120 DEG C of oil bath heating backflow 12h.After reaction terminates, by the poly- second two of product methoxyl group
The toluene solution of alcohol-PLA instills in frost absolute ether and carries out reprecipitation, is collected into 50mL centrifuge tubes, with 10000rpm
Rotating speed centrifuges 2min, removes supernatant liquid, retains bottom solid.Dissolved again with dichloromethane, nothing of the secondary reprecipitation in frost
In water ether, through centrifuging, being dried in vacuo and obtaining final sample.Product is dissolved in deuterochloroform to be characterized by nuclear-magnetism.
As shown in Fig. 2 positioned at solvent peak of the 7.26ppm peak for deuterochloroform, the peak at 3.62-3.73ppm is
The peak of ethyl in hydrophilic segment polyethylene glycol backbone, the peak at 1.55ppm is pending methyl group on hydrophobic segment PLA main chain
Peak, the chemical constitution of provable products therefrom, while calculating the molecular weight about 5000g/ for obtaining polymer poly lactic acid section
Mol, the block ratio with hydrophilic polyglycol is 1：5.
MPEG-PLA is dissolved in tetrahydrofuran, the polymer that concentration is 50mg/mL is obtained molten
Liquid.Using the method for blade coating, polymer solution is coated on the electrowetting drain insulating layer surface with pixel compartments, each pixel
The size of lattice is 150 μm of 150 μ m.Stand at room temperature, one layer of polymeric film is obtained after the solvent is volatilized, dredged in electrowetting
Stick ito glass and be prepared into circumferential closed container in the four sides of water insulating barrier.Just covered in polymeric film surface plus one layer
The moisture film of thin polymer film, for inducing molecule in drain insulating layer surface alignment.After after water film evaporation, toward the appearance that four sides is closed
2mL deionized waters are added in device, 40V voltage 1min are persistently added between deionized water and bottom conductive substrate, are obtained containing poly-
The deionized water of polymer beads is simultaneously collected into 50mL centrifuge tubes, then removes water, and freeze-drying obtains polymer beads.
Fig. 3 is located at 4.65ppm in the hydrogen nuclear magnetic resonance spectrogram of MPEG-PLA after self assembly, figure
Peak be D2O solvent peak, peak at 3.53ppm is the peak of ethyl in polyethylene glycol backbone, can by comparison diagram 2, Fig. 3
To show, in the presence of electric field, MPEG-PLA is successfully self-assembled into polymer beads.
Fig. 4 is that (word is except representing multiplication factor, the necessity such as length in figure for the scanning electron microscope (SEM) photograph of polymer micro-nano rice grain
Outside information, without other implications), after 200,000 times of amplification, particle diameter, the pattern that polymer can be observed are very unified, and particle diameter is about
For 45~60nm, it is 15nm to illustrate particle diameter line width, and deviation is ± 7.5nm.
Because in embodiment is the amphipathic copolymer of oneself synthesis, molecular weight distribution is wider, have impact on indirectly certainly
Assemble the particle diameter of particle.If molecular weight distribution is enough narrow, its particle diameter deviation should be able to be smaller.
The reason for not detecting particle diameter distribution be：The concentration of gained particle solution is very low, it is necessary to which appropriate concentration can be used
Nano particle size instrument is characterized, but after concentration or lyophilized redisperse, partial particulate can reunite, cause the particle diameter measured bigger than normal, together
When also widened particle size distribution.Therefore finally it still have selected with ESEM to characterize, it is more accurate.
Embodiment 2
Take 1.000g CH3O-PEG1000- OH is in the neck reaction bulbs of 50mL tri-.The lower vacuum drying 2h of 60 DEG C of heating.It is cooled to
After room temperature, a small amount of stannous octoate is added dropwise under Ar protections, continues to be dried in vacuo 30min, the D- third that 5g is added under Ar protections is handed over
Ester, 7.5mL are super, and dry toluene makees solvent, in 120 DEG C of oil bath heating backflow 12h.After reaction terminates, by the poly- second two of product methoxyl group
The toluene solution of alcohol-PLA instills in frost absolute ether and carries out reprecipitation, is collected into 50mL centrifuge tubes, with 10000rpm
Rotating speed centrifuges 2min, removes supernatant liquid, retains bottom solid.Dissolved again with dichloromethane, secondary reprecipitation is in absolute ether
In, through centrifuging, being dried in vacuo and obtaining final sample.
MPEG-PLA is dissolved in tetrahydrofuran, the polymer that concentration is 50mg/mL is obtained molten
Liquid.Using the method for spin coating, polymer solution is coated on the electrowetting drain insulating layer surface with pixel compartments, each pixel
The size of lattice is 150 μm of 150 μ m.Stand at room temperature, one layer of polymeric film is obtained after the solvent is volatilized, dredged in electrowetting
Stick ito glass and be prepared into circumferential closed container in the four sides of water insulating barrier.Just covered in polymeric film surface plus one layer
The moisture film of thin polymer film, for inducing molecule in drain insulating layer surface alignment.After after water film evaporation, toward the appearance that four sides is closed
2mL deionized waters are added in device, 40V voltage 1min are persistently added between deionized water and bottom conductive substrate, are obtained containing poly-
The deionized water of polymer beads is simultaneously collected into 50mL centrifuge tubes, then removes water, and freeze-drying obtains polymer beads.
Fig. 5 is that (word is except representing multiplication factor, the necessity such as length in figure for the scanning electron microscope (SEM) photograph of polymer micro-nano rice grain
Outside information, without other implications).
Embodiment 3
Take 1.000g CH3O-PEG1000- OH is in the neck reaction bulbs of 50mL tri-.The lower vacuum drying 2h of 60 DEG C of heating.It is cooled to
After room temperature, a small amount of stannous octoate is added dropwise under Ar protections, continues to be dried in vacuo 30min, 2.5g D- third is added under Ar protections
Lactide, 5mL are super, and dry toluene makees solvent, in 120 DEG C of oil bath heating backflow 12h.After reaction terminates, by the poly- second two of product methoxyl group
The toluene solution of alcohol-PLA instills in frost absolute ether and carries out reprecipitation, is collected into 50mL centrifuge tubes, with 10000rpm
Rotating speed centrifuges 2min, removes supernatant liquid, retains bottom solid.Dissolved again with dichloromethane, secondary reprecipitation is in absolute ether
In, through centrifuging, being dried in vacuo and obtaining final sample.
MPEG-PLA is dissolved in tetrahydrofuran, the polymer that concentration is 50mg/mL is obtained molten
Liquid.Using the method for spraying, polymer solution is coated on the electrowetting drain insulating layer surface with pixel compartments, each pixel
The size of lattice is 180 μm of 180 μ m.Stand at room temperature, one layer of polymeric film is obtained after the solvent is volatilized, dredged in electrowetting
Stick ito glass and be prepared into circumferential closed container in the four sides of water insulating barrier.Just covered in polymeric film surface plus one layer
The moisture film of thin polymer film, for inducing molecule in drain insulating layer surface alignment.After after water film evaporation, toward the appearance that four sides is closed
2mL deionized waters are added in device, 40V voltage 1min are persistently added between deionized water and bottom conductive substrate, are obtained containing poly-
The deionized water of polymer beads is simultaneously collected into 50mL centrifuge tubes, then removes water, and freeze-drying obtains polymer beads.
Embodiment 4
Take 1.000g CH3O-PEG1000- OH is in the neck reaction bulbs of 50mL tri-.The lower vacuum drying 2h of 60 DEG C of heating.It is cooled to
After room temperature, a small amount of stannous octoate is added dropwise under Ar protections, continues to be dried in vacuo 30min, added under Ar protections 0.5g ε-oneself
Lactone, 5mL are super, and dry toluene makees solvent, in 120 DEG C of oil bath heating backflow 12h.After reaction terminates, by the poly- second two of product methoxyl group
The toluene solution of alcohol-poly- (6-caprolactone) instills in frost absolute ether and carries out reprecipitation, is collected into 50mL centrifuge tubes, with
10000rpm rotating speeds centrifuge 2min, remove supernatant liquid, retain bottom solid.Dissolved again with dichloromethane, secondary reprecipitation exists
In absolute ether, through centrifuging, being dried in vacuo and obtaining final sample.
Methoxy poly (ethylene glycol)-poly- (6-caprolactone) is dissolved in tetrahydrofuran, the polymerization that concentration is 50mg/mL is obtained
Thing solution.Using the method for spraying, polymer solution is coated on the electrowetting drain insulating layer surface with pixel compartments, each
The size of pixel compartments is 100 μm of 100 μ m.Stand at room temperature, one layer of polymeric film is obtained after the solvent is volatilized, in electricity profit
Stick ito glass and be prepared into circumferential closed container in the four sides of wet drain insulating layer.In polymeric film surface plus one layer just
The moisture film of cover aggregation thing film, for inducing molecule in drain insulating layer surface alignment.It is closed toward four sides after after water film evaporation
Container in add 2mL deionized waters, contained between deionized water and bottom conductive substrate persistently plus 40V voltage 1min
There is the deionized water of polymer beads and be collected into 50mL centrifuge tubes, then remove water, freeze-drying obtains polymer beads.
Fig. 6 is that (word is except representing multiplication factor, the necessity such as length in figure for the scanning electron microscope (SEM) photograph of polymer micro-nano rice grain
Outside information, without other implications).
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Belong to those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in, all should
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be defined by scope of the claims.
Claims (10)
1. a kind of preparation method of single particle size polymer micro-nano rice grain, it is characterised in that amphipathic copolymer will be contained
Organic solvent is coated on the drain insulating layer of Electrowetting device, is gathered under the electric field action of Electrowetting device by self assembly
Compound micro-nano granules.
2. preparation method according to claim 1, it is characterised in that comprise the following steps：
S1, amphipathic copolymer is dissolved in organic solvent, obtains polymer solution；
S2, the drain insulating layer surface that polymer solution is coated on to Electrowetting device, after the solvent is volatilized, form polymer thin
Film；
S3, polymeric film surface add water induced polymer segment reset, treat water volatilize naturally do；
S4, water is added into Electrowetting device, apply voltage between aqueous phase system and Electrowetting device electrically-conductive backing plate, then remove
Water is removed, single particle size polymer micro-nano rice grain is obtained.
3. preparation method according to claim 2, it is characterised in that the amphipathic copolymer be containing hydrophilic segment or
Group, and hydrophobic chain segment or group polymer.
4. preparation method according to claim 3, it is characterised in that the hydrophilic segment or group be polyacrylic acid,
Polyacrylamide, polyvinyl alcohol, glucan or hyaluronic acid, shown hydrophobic chain segment or group be polyacrylate, polyolefin,
Polyester or makrolon.
5. preparation method according to claim 2, it is characterised in that the organic solvent is volatile organic solvent.
6. preparation method according to claim 2, it is characterised in that the concentration of the polymer solution is 0.01~
10mol/L。
7. preparation method according to claim 2, it is characterised in that in the S2, using blade coating, spin coating, spraying or spray
Ink printing coated polymeric solution.
8. preparation method according to claim 2, it is characterised in that in the S4,20~50V of application voltages 0.5~
5min。
9. preparation method according to claim 2, it is characterised in that the particle diameter of the polymer micro-nano rice grain is 10nm
~5 μm.
10. preparation method according to claim 2, it is characterised in that the Electrowetting device by electrically-conductive backing plate, it is hydrophobic absolutely
Edge layer, conductive pixel wall composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710475057.0A CN107236136B (en) | 2017-06-21 | 2017-06-21 | A kind of preparation method of single particle size polymer micro-nano rice grain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710475057.0A CN107236136B (en) | 2017-06-21 | 2017-06-21 | A kind of preparation method of single particle size polymer micro-nano rice grain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107236136A true CN107236136A (en) | 2017-10-10 |
| CN107236136B CN107236136B (en) | 2019-09-20 |
Family
ID=59987901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710475057.0A Active CN107236136B (en) | 2017-06-21 | 2017-06-21 | A kind of preparation method of single particle size polymer micro-nano rice grain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107236136B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111253596A (en) * | 2019-11-05 | 2020-06-09 | 浙江理工大学 | Preparation method of polyetherimide micro-nano particles with controllable particle sizes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103946148A (en) * | 2011-09-27 | 2014-07-23 | 俄亥俄州立大学研究基金会 | Methods for producing nanoparticles and using the same |
-
2017
- 2017-06-21 CN CN201710475057.0A patent/CN107236136B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103946148A (en) * | 2011-09-27 | 2014-07-23 | 俄亥俄州立大学研究基金会 | Methods for producing nanoparticles and using the same |
Non-Patent Citations (2)
| Title |
|---|
| REYNIER REVILLA ET AL.: ""Nanoscale Electrowetting Effects Observed by Using Friction Force Microscopy"", 《LANGMUIR》 * |
| 唐彪等: ""基于相变操控的电润湿显示油墨填充与封装工艺研究"", 《华南师范大学学报(自然科学版)》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111253596A (en) * | 2019-11-05 | 2020-06-09 | 浙江理工大学 | Preparation method of polyetherimide micro-nano particles with controllable particle sizes |
| CN111253596B (en) * | 2019-11-05 | 2023-03-10 | 浙江理工大学 | Preparation method of polyetherimide micro-nano particles with controllable particle sizes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107236136B (en) | 2019-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jie et al. | Micelle-like nanoparticles of star-branched PEO–PLA copolymers as chemotherapeutic carrier | |
| Walther et al. | Engineering nanostructured polymer blends with controlled nanoparticle location using Janus particles | |
| Liang et al. | Rational design and synthesis of Janus composites | |
| Zhan et al. | A novel multinozzle electrospinning process for preparing superhydrophobic PS films with controllable bead-on-string/microfiber morphology | |
| Dong et al. | Honeycomb-structured microporous films made from hyperbranched polymers by the breath figure method | |
| Al-Mulla et al. | Properties of epoxidized palm oil plasticized polytlactic acid | |
| Park et al. | Highly tunable photoluminescent properties of amphiphilic conjugated block copolymers | |
| Qian et al. | Nanofiber micelles from the self-assembly of block copolymers | |
| Zhu et al. | Ionic liquid assisted electrospinning of quantum dots/elastomer composite nanofibers | |
| Sain et al. | Synthesis and characterization of PMMA‐cellulose nanocomposites by in situ polymerization technique | |
| Stanssens et al. | Creating water-repellent and super-hydrophobic cellulose substrates by deposition of organic nanoparticles | |
| CN103346182B (en) | A kind of back film of solar cell and production technology thereof | |
| JP5997068B2 (en) | Sheet-like laminate and method for producing sheet-like laminate | |
| Theisinger et al. | Encapsulation of a fragrance via miniemulsion polymerization for temperature‐controlled release | |
| Botiz et al. | Minimizing lateral domain collapse in etched poly (3-hexylthiophene)-block-polylactide thin films for improved optoelectronic performance | |
| Maiti et al. | Biodegradation behaviour of PMMA/cellulose nanocomposites prepared by in-situ polymerization and ex-situ dispersion methods | |
| CN107236136A (en) | A kind of preparation method of single particle size polymer micro-nano rice grain | |
| CN106012086A (en) | Graphene/polyaniline composite fiber and preparation method thereof | |
| CN107573655A (en) | A kind of method that polyester material performance is improved using modified graphene oxide | |
| Hao et al. | Electrochemical responsive superhydrophilic surfaces of polythiophene derivatives towards cell capture and release | |
| CN106867467A (en) | The method and phase-change material of polyethylene glycol phase-change material performance are improved using modified silica | |
| CN110284259A (en) | A kind of compound thermoelectric film material and preparation method thereof | |
| Liu et al. | Phase separation and surface morphology of spin-coated films of polyetherimide/polycaprolactone immiscible polymer blends | |
| CN108017049A (en) | Carbon nano-tube dispersant and process for dispersing based on carbazyl conjugated polymer | |
| Jiang et al. | Fabrication and structural characterization of poly (vinylidene fluoride)/polyacrylate composite waterborne coatings with excellent weather resistance and room-temperature curing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |