CN107233150A - A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof - Google Patents
A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof Download PDFInfo
- Publication number
- CN107233150A CN107233150A CN201610182388.0A CN201610182388A CN107233150A CN 107233150 A CN107233150 A CN 107233150A CN 201610182388 A CN201610182388 A CN 201610182388A CN 107233150 A CN107233150 A CN 107233150A
- Authority
- CN
- China
- Prior art keywords
- silicon oxide
- mesoporous silicon
- biodegradable stent
- medical
- loaded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
Abstract
The present invention provides a kind of mesoporous silicon oxide biodegradable stent, including biodegradable stent main body and it is loaded with the mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug, it is described to be loaded with medical magnesium metal and the mesoporous silicon oxide of anti-inflammatory drug is dispersed in the biodegradable stent main body.Present invention also offers a kind of preparation method of mesoporous silicon oxide biodegradable stent.The mesoporous silicon oxide biodegradable stent of the present invention is excessive and insert the problem of later stage support force is not enough due to mainly solving current biodegradable stent volume using mesoporous silicon oxide.In addition, the mesoporous silicon oxide biodegradable stent preparation method of the present invention is simple, cost is low.
Description
Technical field
The present invention relates to technical field of medical instruments, more particularly to a kind of degradable branch of mesoporous silicon oxide
Frame.
Background technology
Percutaneous coronary intervention (pci) is the primary treatment hand of unstable angina pectoris and acute myocardial infarction AMI
Section, the short term effect after Metal stent placement significantly, but it is postoperative have that restenosis rate is high, thrombus source is strong and
Support forever retain in vivo, patient's defect such as medication all the life, long-term effect is undesirable.Therefore, Ren Menshi
Figure development of new biodegradability coronary stent, it is desirable to which this support both can temporarily support tube wall, is protected
Vascular patency is held, early stage thrombosis and late neointimal hyperplasia can be suppressed again, and be alternatively arranged as medicine
The local carrier delivered, reaching effectively prevents branch from mounting blood vessel acute occlusion and reduction restenosis rate after people.Mesh
There is the shortcomings of implantation later stage support force is not enough, nerve is big in preceding Wholly-degradable high polymer support, so that
Increase thrombotic risk；In addition, the larger complexity disease small for curing blood vessel diameter of the volume of support
Become also difficult, for contained medicine release can not fully meet clinic the need for, and its development is poor
It is also a distinct issues.
The content of the invention
In order to overcome the problem of prior art is present, the present invention provides a kind of degradable branch of mesoporous silicon oxide
Frame.
The present invention provides a kind of mesoporous silicon oxide biodegradable stent, a kind of meso-porous titanium dioxide in first aspect
Silicon biodegradable stent, including biodegradable stent main body and Jie for being loaded with medical magnesium metal and anti-inflammatory drug
Hole silica, it is described to be loaded with medical magnesium metal and the mesoporous silicon oxide of anti-inflammatory drug is dispersed
In the biodegradable stent main body.
The particle diameter of the mesoporous silicon oxide be 1-100nm (1,10,20,30,40,50,70,80,
100nm etc.).
Mesoporous silicon oxide has Porous materials and the dual-use function of nano material, with good bio-compatible
Property.
Increase the intensity of biodegradable stent using mesoporous silicon oxide, because support intensity is added, therefore
Support can be done is thinner, is close to the mechanical property of metallic support, is easy to by narrower disease
Become.
Mesoporous silicon oxide can be excreted by body metabolism completely with the degraded of support in itself, to human body
Nonhazardous is acted on.
The biodegradable stent main body is medical degradable high polymer,
The medical degradable high polymer is PLLA (PLLA), PLA (dextrorotation PLA), PLGA (gather
Poly lactic coglycolic acid) in one kind or derivatives thereof.
The magnesium metal of loaded medical solves the problem of biodegradable stent developability is poor in mesoporous silicon oxide,
And can be degraded to the magnesium ion of needed by human body after operation terminates.
Loaded in mesoporous silicon oxide anti-inflammatory drug lesion can be carried out lasting insoluble drug release until
Untill whole scaffold degradation terminates.
The anti-inflammatory drug can prevent vessel endothelialisation and inflammation inserting the later stage.
The mesoporous silicon oxide biodegradable stent is tubulose.
The wall thickness of the mesoporous silicon oxide biodegradable stent be 100-140um (be, for example, 100,110,120,
130 or 140um etc.).
The intensity of the mesoporous silicon oxide biodegradable stent is 8-10Gpa (being, for example, 8,9 or 10Gpa etc.).
The present invention provides a kind of mesoporous silicon oxide as described in first aspect present invention in second aspect to drop
The preparation method of support is solved, is comprised the following steps：
1) mesoporous silicon oxide mesoporous middle loaded medical magnesium metal and anti-inflammatory drug, must be loaded with
Medical magnesium metal and the mesoporous silicon oxide of anti-inflammatory drug；；
2) by the mesoporous silicon oxide and degradable branch for being loaded with medical magnesium metal and anti-inflammatory drug
Frame body is uniformly mixed, and obtains mixing pellet；
3) the mixing pellet is put into extruder extruding pipe material, the tubing is cut with laser machine
Engraving, obtains mesoporous silicon oxide biodegradable stent.
The biodegradable stent main body is medical degradable high polymer；Wherein, the medical degradable high polymer
For in PLLA (PLLA), PLA (dextrorotation PLA), PLGA (Poly(D,L-lactide-co-glycolide)
One kind or derivatives thereof.
By the mesoporous silicon oxide for being loaded with medical magnesium metal and anti-inflammatory drug and described degradable
Rack body is 1 according to weight ratio:1000-10000 (is, for example, 1:1000、1:3000、1:5000、1:7000、
1:8000、1:10000 etc.) ratio is uniformly mixed.
It is further noted that, if not otherwise specified, the present invention described in any scope include end value with
And any numerical value between end value and the anyon that is constituted with any number between end value or end value
Scope.
Beneficial effects of the present invention：
1st, the present invention enhances the mechanical strength of biodegradable stent using mesoporous silicon oxide, solves at present
Biodegradable stent volume is excessive and inserts the problem of human body later stage support force is not enough.
2nd, the present invention mesoporous silicon oxide it is mesoporous in be loaded with medical magnesium metal and can make up existing height
The problem of polymers support developability is poor, instead of existing support and can only lean at head and the tail and develop point to develop, and
Because the biodegradable stent of the present invention is loaded with the magnesium metal of medical degradable, so possessing metal branch completely
The characteristic of frame.
3rd, the present invention mesoporous silicon oxide it is mesoporous in be loaded with anti-inflammatory drug and lesion can be held
Continuous insoluble drug release terminates until whole scaffold degradation.
4th, the preparation method of mesoporous silicon oxide biodegradable stent of the invention is simple, and cost is low, it is easy to grasp
Make.
Brief description of the drawings
Fig. 1 is the main body framework figure of mesoporous silicon oxide biodegradable stent.
Fig. 2 is the schematic diagram of mesoporous silicon oxide.
Fig. 3 is the mesoporous silicon oxide schematic diagram for being loaded with medical magnesium metal and anti-inflammatory drug.
Fig. 4 is the schematic diagram of mesoporous silicon oxide biodegradable stent prepared by embodiment 3.
Embodiment
Embodiment of the present invention is described further with reference to embodiment.These embodiments are simply with regard to this
The preferred embodiment of invention is illustrated, and protection scope of the present invention is not read as pertaining only to these
Embodiment.
Embodiment 1
Mesoporous silicon oxide it is mesoporous it is middle first load anti-inflammatory drug, be then reloading with medical magnesium metal, obtain
It is loaded with the mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug；Medical metal is loaded with by described
The mesoporous silicon oxide and PLLA of magnesium and anti-inflammatory drug are 1 according to weight ratio:3000 ratio uniform is mixed
Close, obtain mixing pellet；The mixing pellet is put into extruder extruding pipe material, by the tubing laser machine
Cutting engraving is carried out, mesoporous silicon oxide biodegradable stent is obtained.The mesoporous silicon oxide biodegradable stent
Intensity is 9Gpa, and wall thickness is 120 μm.
Embodiment 2
Mesoporous silicon oxide it is mesoporous it is middle first load anti-inflammatory drug, be then reloading with medical magnesium metal, obtain
It is loaded with the mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug；Medical metal is loaded with by described
The mesoporous silicon oxide and PLA of magnesium and anti-inflammatory drug are 1 according to weight ratio:5000 ratio uniform mixing,
Pellet must be mixed；The mixing pellet is put into extruder extruding pipe material, the tubing is carried out with laser machine
Cutting engraving, obtains mesoporous silicon oxide biodegradable stent.The intensity of the mesoporous silicon oxide biodegradable stent
For 9GPa, wall thickness is 100 μm.
Embodiment 3
Nanoscale mesoporous silicon oxide it is mesoporous it is middle first load anti-inflammatory drug, be then reloading with medical metal
Magnesium, must be loaded with the mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug；By it is described be loaded with it is medical
Magnesium metal and anti-inflammatory drug mesoporous silicon oxide and PLGA according to weight ratio be 1:10000 ratio
Uniform mixing, obtains mixing pellet；The mixing pellet is put into extruder extruding pipe material, the tubing is used
Laser machine carries out cutting engraving, obtains mesoporous silicon oxide biodegradable stent.The mesoporous silicon oxide is degradable
The intensity of support is 9Gpa, and wall thickness is 110 μm.
Embodiment 4
Mesoporous silicon oxide it is mesoporous it is middle first load anti-inflammatory drug, be then reloading with medical magnesium metal, obtain
It is loaded with the mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug；Medical metal is loaded with by described
The mesoporous silicon oxide and PLLA of magnesium and anti-inflammatory drug are 1 according to weight ratio:10000 ratio uniform is mixed
Close, obtain mixing pellet；The mixing pellet is put into extruder extruding pipe material, by the tubing laser machine
Cutting engraving is carried out, mesoporous silicon oxide biodegradable stent is obtained.The mesoporous silicon oxide biodegradable stent
Intensity is 10Gpa, and wall thickness is 130 μm.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and
It is not the restriction to embodiments of the present invention, for those of ordinary skill in the field,
It can also be made other changes in different forms on the basis of described above, here can not be to all
Embodiment be exhaustive, it is every to belong to the obvious change that technical scheme is extended out
Change or change the row still in protection scope of the present invention.
Claims (10)
1. a kind of mesoporous silicon oxide biodegradable stent, it is characterised in that including biodegradable stent main body and
The mesoporous silicon oxide of medical magnesium metal and anti-inflammatory drug is loaded with, it is described to be loaded with medical magnesium metal
And the mesoporous silicon oxide of anti-inflammatory drug is dispersed in the biodegradable stent main body.
2. a kind of mesoporous silicon oxide biodegradable stent according to claim 1, it is characterised in that
The particle diameter of the mesoporous silicon oxide is 1-100nm.
3. a kind of mesoporous silicon oxide biodegradable stent according to claim 1, it is characterised in that
The biodegradable stent main body is medical degradable high polymer.
4. a kind of mesoporous silicon oxide biodegradable stent according to claim 1, it is characterised in that
The medical degradable high polymer is one kind in PLLA, PLA, PLGA or derivatives thereof.
5. according to any described a kind of mesoporous silicon oxide biodegradable stent in Claims 1-4, its
It is characterised by, the mesoporous silicon oxide biodegradable stent is tubulose.
6. a kind of mesoporous silicon oxide biodegradable stent according to claim 5, it is characterised in that
The wall thickness of the mesoporous silicon oxide biodegradable stent is 100-140um.
7. a kind of mesoporous silicon oxide biodegradable stent according to claim 6, it is characterised in that
The intensity of the mesoporous silicon oxide biodegradable stent is 8-10Gpa.
8. a kind of preparation method of mesoporous silicon oxide biodegradable stent as claimed in claim 1, it is special
Levy and be, comprise the following steps：
1) mesoporous silicon oxide mesoporous middle loaded medical magnesium metal and anti-inflammatory drug, must be loaded with
Medical magnesium metal and the mesoporous silicon oxide of anti-inflammatory drug；
2) by the mesoporous silicon oxide and degradable branch for being loaded with medical magnesium metal and anti-inflammatory drug
Frame body is uniformly mixed, and obtains mixing pellet；
3) the mixing pellet is put into extruder extruding pipe material, the tubing is cut with laser machine
Engraving, obtains mesoporous silicon oxide biodegradable stent.
9. preparation method according to claim 8, it is characterised in that the biodegradable stent main body
For medical degradable high polymer；Wherein, the medical degradable high polymer is PLLA, PLA, PLGA
Middle one kind or derivatives thereof.
10. preparation method according to claim 8, it is characterised in that described to be loaded with medical gold
Belong to the mesoporous silicon oxide and the biodegradable stent main body of magnesium and anti-inflammatory drug according to weight ratio
1:1000-10000 ratio is uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610182388.0A CN107233150A (en) | 2016-03-28 | 2016-03-28 | A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610182388.0A CN107233150A (en) | 2016-03-28 | 2016-03-28 | A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107233150A true CN107233150A (en) | 2017-10-10 |
Family
ID=59983203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610182388.0A Pending CN107233150A (en) | 2016-03-28 | 2016-03-28 | A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107233150A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279709A (en) * | 2019-07-22 | 2019-09-27 | 上海交通大学医学院附属第九人民医院 | MSN nanosphere inhibits the application in myocardial infarction region inflammatory reaction drug in preparation |
| CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947333A (en) * | 2010-08-27 | 2011-01-19 | 安泰科技股份有限公司 | Biodegradable medicament-loaded polymer scaffold and preparation method thereof |
| CN102397590A (en) * | 2010-09-07 | 2012-04-04 | 微创医疗器械(上海)有限公司 | Biodegradable bracket |
| CN102786061A (en) * | 2012-07-20 | 2012-11-21 | 东华大学 | Preparation method of hollow mesoporous silica nanoparticle |
| CN103405809A (en) * | 2013-07-23 | 2013-11-27 | 东华大学 | Method used for preparing microcarrier/polymer composite scaffold by electro-deposition |
| CN103656758A (en) * | 2012-09-26 | 2014-03-26 | 中国科学院化学研究所 | Tissue engineering bracket imitating intima-media structure and function of natural blood vessels and preparation method thereof |
| CN103709386A (en) * | 2012-10-09 | 2014-04-09 | 上海微创医疗器械（集团）有限公司 | Modified polylactic acid degradable stent and preparation method thereof |
| CN103705986A (en) * | 2012-10-09 | 2014-04-09 | 上海微创医疗器械（集团）有限公司 | Degradable vascular stent, and manufacturing method thereof |
-
2016
- 2016-03-28 CN CN201610182388.0A patent/CN107233150A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947333A (en) * | 2010-08-27 | 2011-01-19 | 安泰科技股份有限公司 | Biodegradable medicament-loaded polymer scaffold and preparation method thereof |
| CN102397590A (en) * | 2010-09-07 | 2012-04-04 | 微创医疗器械(上海)有限公司 | Biodegradable bracket |
| CN102786061A (en) * | 2012-07-20 | 2012-11-21 | 东华大学 | Preparation method of hollow mesoporous silica nanoparticle |
| CN103656758A (en) * | 2012-09-26 | 2014-03-26 | 中国科学院化学研究所 | Tissue engineering bracket imitating intima-media structure and function of natural blood vessels and preparation method thereof |
| CN103709386A (en) * | 2012-10-09 | 2014-04-09 | 上海微创医疗器械（集团）有限公司 | Modified polylactic acid degradable stent and preparation method thereof |
| CN103705986A (en) * | 2012-10-09 | 2014-04-09 | 上海微创医疗器械（集团）有限公司 | Degradable vascular stent, and manufacturing method thereof |
| CN103405809A (en) * | 2013-07-23 | 2013-11-27 | 东华大学 | Method used for preparing microcarrier/polymer composite scaffold by electro-deposition |
Non-Patent Citations (4)
| Title |
|---|
| 张佳: "镁合金在生物医用材料领域的应用及发展前景", 《中国组织工程研究与临床康复》 * |
| 毛琳: "生物可降解血管支架的研究进展", 《材料导报》 * |
| 王勇平: "镁合金材料在医学临床领域的应用", 《中华临床医师杂志》 * |
| 袁广银: "新型可降解生物医用镁合金JDBM的研究进展", 《中国有色金属学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279709A (en) * | 2019-07-22 | 2019-09-27 | 上海交通大学医学院附属第九人民医院 | MSN nanosphere inhibits the application in myocardial infarction region inflammatory reaction drug in preparation |
| CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
| CN111544170B (en) * | 2020-05-13 | 2021-12-10 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11051958B2 (en) | Biodegradable supporting device | |
| US11173058B2 (en) | Stent | |
| US6491720B1 (en) | Angioplasty stent adapted to counter restenosis respective kit and components | |
| Zilberman et al. | Drug-eluting bioresorbable stents for various applications | |
| US20090149947A1 (en) | Implantable device for drug delivery and improved visibility | |
| CN103169556B (en) | Completely-biodegradable support capable of developing and preparation method thereof | |
| TWI612977B (en) | Drug-containing bioabsorbable fibers and implants | |
| CN105457105B (en) | One kind can develop magnesium alloy blood vessel rack | |
| WO2010127584A1 (en) | Drug-eluting stent with carrying groove and degradable coating | |
| CN104739478B (en) | Spring coil and production method thereof | |
| CN102151185A (en) | Biodegradable stent with laminated coatings | |
| CN105833358B (en) | Intracranial drug eluting stent system and preparation method thereof | |
| Jeong et al. | Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide | |
| CN107233150A (en) | A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof | |
| Chavda et al. | Biodegradable and removable implants for controlled drug delivery and release application | |
| US20140142686A1 (en) | Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same | |
| US20120150282A1 (en) | Implant having a paclitaxel-releasing coating | |
| CN102727331A (en) | Biodegradable magnesium alloy bile duct litholysis knitted bracket and preparation method thereof | |
| CN106668952B (en) | Multi-coating biodegradable metal stent and preparation method thereof | |
| Lee et al. | Promoting vascular healing using nanofibrous ticagrelor-eluting stents | |
| WO2020236174A1 (en) | Biodegradable supporting device with a radio-opaque marker | |
| EP3463128B1 (en) | Stent | |
| US20190269532A1 (en) | Biodegradable supporting device with a radio-opaque marker | |
| CN111067679A (en) | Intracranial degradable polyester stent with high support strength | |
| CN107865983B (en) | Medicine stent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171010 |