CN107226769A - A kind of deuterated methoxy containing difluoro（Sulphur）The synthetic method of the aromatic compounds of base functional group - Google Patents
A kind of deuterated methoxy containing difluoro（Sulphur）The synthetic method of the aromatic compounds of base functional group Download PDFInfo
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Abstract
The invention belongs to synthesis technical field containing deuteride, a kind of synthetic method of the aromatic compounds containing the deuterated methoxy functional group of difluoro or the deuterated methyl mercapto functional group of difluoro is specifically disclosed.Under alkali existence condition, difluorocarbene's donor withWith heavy water reaction, deuterated product is madeDifluorocarbene's donor is BrCF2PO(OR)2Or (chlorodifluoramethyl-) trimethyl silane or (bromine difluoro methyl) trimethyl silane, alkali is optionally from Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4, KOD, NaOD, NaOMe, NaOEt, NaOBu, sodium carbonate, potassium carbonate, cesium carbonate.This method has raw material cheap and easily-available, and reaction is simple gentle, and yield is high, and deuterated rate is high, it is easy to the advantages of producing amplification.
Description
Technical field
The present invention relates to synthesis technical field containing deuteride, more particularly to a kind of deuterated methoxy functional group containing difluoro
Or the synthetic method of the aromatic compounds of the deuterated methyl mercapto functional group of difluoro.
Background technology
In April, 2017, U.S. FDA have approved first deuterated medicine, the deuterated tetrabenazine (trade name of Ti Wa companies
Austedo), it is mainly used in treating Huntington's chorea, this indicates the arrival in deuterated medicine epoch.Change containing difluoro-methoxy
Compound especially aromatic compounds have extensive purposes in field of medicaments.On having introduced the synthetic method of difluoro-methoxy
Through there are many reports, but it is rarely reported so far on the synthesis of deuterated difluoro-methoxy aromatic compounds.
My company discloses anti-through free radical with phenol sodium, Bromodifluoroacetic acid ethyl ester and heavy water in patent CN 106083736
The deuterated difluoro-methoxy aromatic compound containing nitro should be synthesized.This method reacts temperature by verifying that applicability is poor
Degree is higher, and deuterated rate is difficult to control to.
Document (Huaxue Xuebao1986,1,92-96) reports and makees solvent with deuterated ethanol, utilizes fluorosulfonyl two
Fluoride compound produces difluorocarbene, prepares deuterated difluoromethoxy phenyl.Have the disadvantage that deuterated ethanol cost is higher, be not suitable for amplification
Production.
Document (Tetrahedron 2009,65,5278-5283) is reported with bromine difluoro methyl diethyl phosphonate as card
The source of guest, with the potassium hydroxide of 20 equivalents, acetonitrile and water make solvent and prepare difluoromethoxy (sulphur) base aromatic compound, this method
Yield is high, and applicability is good, mild condition.Heavy water is replaced with reference to the document, and by water used in solvent, compound experiment is carried out, as a result
It can only obtain the deuterated methoxyl group aromatic compound of difluoro of relatively low deuterated rate (being less than 80%), it is impossible to meet deuterated pharmaceutical purity
It is required that.Analysis reason, which is mainly the potassium hydroxide used in reaction system and acetonitrile, can all have a strong impact on deuterium isotope in product
Abundance, therefore it is not suitable for the synthesis of difluoro deuterated methoxy (sulphur) base functional group aromatic compounds.
For these reasons, it is necessary to which the aromatic compounds suitable for the functional group Han difluoro deuterated methoxy (sulphur) base are provided
Synthetic method, to improve the deuterated rate of synthetic product.
The content of the invention
It is a kind of containing the deuterated methoxy functional group of difluoro or the deuterated first of difluoro the present invention solves the technical problem of providing
The synthetic method of the aromatic compounds of sulfenyl functional group, has the advantages that deuterated rate is high.
In order to solve the above technical problems, one aspect of the present invention is：A kind of deuterated methoxy containing difluoro (sulphur)
The synthetic method of the aromatic compounds of base functional group, reaction equation is as follows：
Under alkali existence condition, difluorocarbene's donor withWith heavy water reaction, deuterated product is made
Wherein：
N is 1~3 integer；
Ar is aryl or heteroaryl, or, Ar is any substituted aryl or heteroaryl, contains 1-4 in the heteroaryl
The individual optional hetero atom from O, S, N, P；
X is O atom or S atom；
Difluorocarbene's donor is BrCF2PO(OR)2Or (chlorodifluoramethyl-) trimethyl silane or (bromine difluoro methyl) trimethyl
Silane, BrCF2PO(OR)2In R be C1~5Alkyl；
Alkali base is optionally from Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4、KOD、NaOD、NaOMe、NaOEt、
NaOBu, sodium carbonate, potassium carbonate, cesium carbonate；
Organic solvent solvent is optionally from tetrahydrofuran, 2- methyltetrahydrofurans, 1,4- dioxane, ether, methyl- tert
Butyl ether, glycol dimethyl ether, diethylene glycol dimethyl ether, diethylene glycol dimethyl ether.
Preferably, the synthetic method of the aromatic compounds of the functional group containing difluoro deuterated methoxy (sulphur) base, including step：
WillIt is dissolved into organic solvent, it is 0.05~1.0mol/L's that concentration, which is made,Solution；
, will under inert gas shieldingSolution is cooled to -78 DEG C~30 DEG C, then to describedSolution
In add alkali in batches, the consumption of alkali is 1.0~30.0 equivalents, plus temperature is less than 25 DEG C in control reaction during alkali, afterwards instead
Answer 0.5~18h；
Then heavy water is added dropwise into reaction system again, the consumption of heavy water is 5.0~200.0 equivalents, is added dropwise during heavy water
Keep reaction temperature to be less than 40 DEG C, after completion of dropping, react 0.1~18h；
Then difluorocarbene's donor is added again, and the consumption of difluorocarbene's donor is 1.0~5.0 equivalents, adds difluorocarbene
Controlling reaction temperature is less than 30 DEG C during donor, and 10min~18h is reacted afterwards, and reaction terminates, and deuterated product Ar- is made
XCF2D)n.Again after further treatment, deuterated product Ar-XCF can be obtained2D)nSterling.
The consumption of above-described alkali is that 1.0~30.0 equivalents, the consumption of heavy water are 5.0~200.0 equivalents, difluorocarbene
The consumption of donor is 1.0~5.0 equivalents, is relative toAmount adjusted.
Alternatively, Ar is phenyl, naphthyl, binaphthyl, anthryl, phenanthryl, pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, quinoline
Quinoline base, 1,10- ferrosins base, indyl, indazolyl, pyrrole radicals, thienyl, furyl, imidazole radicals,It is oxazolyl, differentAzoles
Base, thiazolyl, isothiazolyl,Di azoly, thiadiazolyl group, pyranose, pyrazolyl, isoquinolyl, benzofuranyl, benzo thiophene
Fen base, benzothiopyran derivative base, benzimidazolyl, benzoOxazolyl, benzoDi azoly, benzothiazolyl, diazosulfide base,
Benzopyranyl, isoindolyl, triazolyl, triazine radical, quinoxalinyl, purine radicals, quinazolyl, quinolizine base, naphthyridines base, pteridine
Base, carbazyl, azepineBase, diazaBase, acridinyl, steroidal base；Or phenyl, naphthyl, binaphthyl, anthryl, the phenanthrene of substitution
Base, pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, quinolyl, 1,10- ferrosins base, indyl, indazolyl, pyrrole radicals, thiophene
Base, furyl, imidazole radicals,It is oxazolyl, differentOxazolyl, thiazolyl, isothiazolyl,Di azoly, thiadiazolyl group, pyranose, pyrrole
Oxazolyl, isoquinolyl, benzofuranyl, benzothienyl, benzothiopyran derivative base, benzimidazolyl, benzoOxazolyl, benzo
It is di azoly, benzothiazolyl, diazosulfide base, benzopyranyl, isoindolyl, triazolyl, triazine radical, quinoxalinyl, fast
Purine base, quinazolyl, quinolizine base, naphthyridines base, pteridyl, carbazyl, azepineBase, diazaBase, acridinyl, steroidal base,
Described to be substituted by a substitution, two substitutions, three substitutions, four substitutions or five substitutions, substituent is halogen, cyano group, nitro, ester group, C1-6
Alkyl, C3-6Cycloalkyl, C1-6Alkoxy, C3-6Cycloalkyloxy, C1-6Alkylthio group, C1-6Haloalkyl, C1-6Acyl group, C1-6Alkylamino,
Phenyl or C3-6Naphthene amino.
Unless stated otherwise, otherwise in the case where the following term used in the application (including specification and claims) has
Face given a definition that.
" alkyl " refers to the monovalent straight chain containing 1 to 12 carbon atom or the side chain saturation being only made up of carbon and hydrogen atom
Hydrocarbyl group." alkyl " is preferably the alkyl group of 1 to 6 carbon atom, i.e. C1-C6Alkyl, more preferably C1-C4Alkyl.Alkyl base
The example of group includes but is not limited to methyl, ethyl, propyl group, isopropyl, isobutyl group, sec-butyl, the tert-butyl group, amyl group, n-hexyl, pungent
Base, dodecyl etc..
" alkoxy " refers to formula-OR groups, and wherein R is alkyl group defined herein.The example of alkoxy base
Including but not limited to methoxyl group, ethyoxyl, isopropoxy, tert-butoxy etc..
" halogen (halo) " refers to fluorine, chlorine, bromine or iodine substituent.
" haloalkyl " refers to wherein one or more hydrogen by the defined herein of identical or different halogen replacement
Alkyl.The example of haloalkyl includes-CH2Cl、-CH2CF3、-CH2CCl3, perfluoroalkyl is (for example ,-CF3) etc..
" halogenated alkoxy " refers to formula-OR groups, and wherein R is halogenated alkyl group defined herein.Haloalkoxy
The example of base group includes but is not limited to trifluoromethoxy, difluoro-methoxy, 2,2,2- trifluoro ethoxies etc..
" cycloalkyl " refer to by it is single-or two ring groups into monovalent saturated carbon ring group, it has 3-12, preferably 3-10
Individual, more preferably 3-6 annular atom.Cycloalkyl optionally can be replaced by one or more substituents, wherein each substituent is only
It is on the spot hydroxyl, alkyl, alkoxy, halogen, haloalkyl, amino, alkyl monosubstituted amino or dialkyl amido.Group of naphthene base
Example includes but is not limited to cyclopropyl, cyclobutyl, cyclopenta, cyclohexyl, suberyl etc..
" cycloalkyloxy " refers to formula-OR groups, and wherein R is cycloalkyl as herein defined.Exemplary cycloalkyl
Epoxide includes cyclopropyl epoxide, cyclobutyl epoxide, cyclopentyloxy, cyclohexyl epoxide etc..
" acyl group " refers to formula-C (O) R group, and wherein R is alkyl as herein defined.Exemplary acyl group includes second
Acyl group, positive propiono, iso-propionyl, positive bytyry, isobutyryl, tertiary bytyry etc..
Ester group refers to formula-C (O) OR group, and wherein R is alkyl as herein defined.Exemplary ester group includes-C
(O) OMe ,-C (O) OEt etc..
" alkylthio group " refers to formula-SRaGroup, wherein RaFor H or as herein defined alkyl.
" alkylamino " refers to formula-NRaRbGroup, wherein RaFor H or as herein defined alkyl, RbFor such as this paper institutes
The alkyl of definition.
" naphthene amino " refers to formula-NRaRbGroup, wherein RaBy H, alkyl as herein defined or as determined herein
The cycloalkyl of justice, RbFor cycloalkyl as herein defined.
Still optionally further, Ar be phenyl, it is naphthyl, binaphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, phonetic
Piperidinyl, pyridazinyl, quinolyl；Or substitution phenyl, naphthyl, binaphthyl, benzothienyl, indyl, pyridine radicals, steroidal base,
Pyrimidine radicals, pyridazinyl, quinolyl, described to be substituted by a substitution or two substitutions, substituent is halogen, cyano group, phenyl, nitro, C1-6
Alkyl, C3-6Cycloalkyl, C1-6Alkylamino, C1-6Alkoxy.
Preferably, whenWhen middle n takes 1, Ar is phenyl, naphthyl, benzothienyl, indyl, pyridine radicals, steroidal
Base, pyrimidine radicals, pyridazinyl, quinolyl；Or it is the phenyl of substitution, naphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, phonetic
Piperidinyl, pyridazinyl, quinolyl, described to be substituted by a substitution or two substitutions, substituent is halogen, cyano group, phenyl, nitro, C1-6Alkane
Base, C3-6Cycloalkyl, C1-6Alkylamino, C1-6Alkoxy.
Preferably, whenWhen middle n takes 2, Ar is binaphthyl or substituted binaphthyl.
Preferably, difluorocarbene's donor BrCF2PO(OR)2In R be methyl or ethyl.
Preferably, alkali base is NaH, and organic solvent solvent is tetrahydrofuran and/or Isosorbide-5-Nitrae-dioxane.
Preferably,The concentration of solution is 0.25mol/L, under inert gas shielding, willSolution drops
Temperature is to 0 DEG C~25 DEG C.
Preferably, the consumption of alkali is 10.0 equivalents.
The consumption of heavy water is 50.0 equivalents.
The consumption of difluorocarbene's donor is 2.0 equivalents.
The beneficial effects of the invention are as follows：The synthetic method that the present invention is provided, using non-protonic solvent, in alkali existence condition
Under, such as, will in the presence of metal or metal hydrideHydrogen in phenolic hydroxyl group or sulfydryl is converted into hydrogen removing,
Then using cheap heavy water as deuterium source, commercialized difluorocarbene's donor as difluorocarbene source, gentle anti-
Under the conditions of answering, the deuterated methoxy of difluoro (sulphur) base aromatic compounds of high deuterated rate are can be obtained by by single step reactionThis method has raw material cheap and easily-available, and reaction is simple gentle, and yield is high, and deuterated rate is high, it is easy to production amplification
The advantages of.
Embodiment
Technical scheme is described in detail below by specific embodiment.
Embodiment 1
Compound beta naphthal (144mg, 1mmol) is dissolved in Isosorbide-5-Nitrae-dioxy that 4.0ml dries (metallic sodium water removal drying)
In six rings, under argon gas protection, ice-water bath is cooled to 15 DEG C, and NaH (60%, 400mg, 10mmol), adding procedure are added in batches
It is middle guarantee temperature of reaction system be less than 25 DEG C, then react 0.5h, after heavy water 1ml (50mmol) is slowly added dropwise, during dropwise addition
Ensure that temperature of reaction system is less than 40 DEG C, react 0.5h after completion of dropping, be added dropwise bromine difluoro methyl diethyl phosphate (534mg,
2mmol), ensure that temperature of reaction system is less than 30 DEG C during dropwise addition, be warmed to room temperature reaction 0.5h.After reaction terminates, second is added
Ether 20ml, by organic phase and aqueous phase separation, organic phase is washed (20ml × 3) with saturated ammonium chloride solution, the anhydrous sulphur of organic phase
After sour sodium is dried, concentrated at 30 DEG C, silica gel column chromatography is carried out afterwards, eluant, eluent is petroleum ether, colorless oil is obtained, after low temperature is placed
For white solid (156mg, yield 80%, deuterated rate 98.7%).The analyze data information of gained compound is：
1H NMR(400MHz,CDCl3,ppm):δ=7.85-7.42 (m, 3H), 7.50-7.42 (m, 3H), 7.25 (dd, J
=2.4Hz, 8.9Hz, 1H)；
19F NMR(376MHz,CDCl3,ppm):δ=- 81.32 (t, J=11.6Hz)；
13C NMR(100MHz,CDCl3,ppm):δ=149.0 (t, JC-F=2.6Hz), 133.8,131.1,130.1,
127.8,127.5,127.0,125.7,119.7,115.9(tt,JC-D=33.7Hz, JC-F=256.6Hz), 115.4.
To data above information analysis, it is defined as target compound.
Embodiment 2- embodiments 9
It is embodiment 2-9 below, the other conditions of reaction are same as Example 1, differ only in the use that have adjusted alkali NaH
Amount, has been investigated under conditions of different base amounts, the influence to target compound yield and deuterated rate.
The consumption that can be seen that alkali from upper table data influences larger to yield, and in 8-15 equivalents, yield is higher；But
The consumption of alkali influences little to deuterated rate, and with the adjustment of base amount, deuterated rate fluctuation is minimum, and deuterated rate is >=98.5%.
Embodiment 10- embodiments 16
It is embodiment 10-16 below, the other conditions of reaction are same as Example 1, differ only in and have adjusted heavy water
Consumption, has been investigated under conditions of different heavy water consumptions, the influence to target compound yield and deuterated rate.
The consumption that can be seen that heavy water from upper table data influences larger to yield, and in 40 equivalent, yield reaches 65%,
More than 80% is reached when more than 100 equivalents, it is considered to Cost Problems, can select 50 equivalents or so；Equally, the consumption of heavy water is to deuterium
Little for rate influence, with the increase of heavy water consumption, deuterated rate increases to 98.7% from 95%, more than 30 equivalents, and deuterated rate is equal
>=98.5%.
Embodiment 17- embodiments 20
It is below embodiment 17-20, the other conditions of reaction are same as Example 1, differs only in have adjusted and drip
Finish the reaction time that reaction is warmed to room temperature after bromine difluoro methyl diethyl phosphate, investigate the reaction time to target compound yield
With the influence of deuterated rate.
Reaction time on yield influence is can be seen that from upper table data less, and it is small that the reaction time extended to 18 from 10 minutes
When, yield improves 10%, and when reacting 10 minutes, yield is 70%, reacts 20 minutes, yield brings up to 78%, reaction time
Extend to again 18 hours, yield is 80%；Reaction time has no significant effect to deuterated rate, and deuterated rate is 98.7%.
Embodiment 21- embodiments 23
It is embodiment 21-23 below, the other conditions of reaction are same as Example 1, differ only in and changed different
Difluorocarbene's donor, has investigated the influence to target compound yield and deuterated rate using different difluorocarbene's donors.
Different difluorocarbene's donors are can be seen that from upper table data and slightly have influence on yield, and little is influenceed on deuterated rate.
Embodiment 24- embodiments 44
It is embodiment 24-44 below, with reference to the synthetic method of embodiment 1, the different initial compounds by changing are made
A series of different target compounds, specific as follows, its deuterated rate is more than 98%.
Embodiment 45
The consumption of difluorocarbene's donor bromine difluoro methyl diethyl phosphate in embodiment 1 is changed to 4mmol, i.e. 4.0 equivalents,
Complete embodiment 45.
The analyze data information of target compound made from embodiment 24-45 is as follows.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention.
Claims (10)
1. a kind of synthetic method of the aromatic compounds of the functional group Han difluoro deuterated methoxy (sulphur) base, it is characterised in that reaction
Formula is as follows：
Under alkali existence condition, difluorocarbene's donor withWith heavy water reaction, deuterated product is made
Wherein：
N is 1~3 integer；
Ar is aryl or heteroaryl, or, Ar is any substituted aryl or heteroaryl, is appointed containing 1-4 in the heteroaryl
Hetero atom selected from O, S, N, P；
X is O atom or S atom；
Difluorocarbene's donor is BrCF2PO(OR)2Or (chlorodifluoramethyl-) trimethyl silane or (bromine difluoro methyl) trimethyl silicane
Alkane, BrCF2PO(OR)2In R be C1~5Alkyl；
Alkali base is optionally from Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4、KOD、NaOD、NaOMe、NaOEt、NaOBu、
Sodium carbonate, potassium carbonate, cesium carbonate；
Organic solvent solvent is optionally from tetrahydrofuran, 2- methyltetrahydrofurans, 1,4- dioxane, ether, methyl tertbutyl
Ether, glycol dimethyl ether, diethylene glycol dimethyl ether, diethylene glycol dimethyl ether.
2. the synthetic method of the aromatic compounds of the functional group according to claim 1 Han difluoro deuterated methoxy (sulphur) base,
It is characterised in that it includes step：
WillIt is dissolved into organic solvent, it is 0.05~1.0mol/L's that concentration, which is made,Solution；
, will under inert gas shieldingSolution is cooled to -78 DEG C~30 DEG C, then to describedDivide in solution
Batch adds alkali, and the consumption of alkali is 1.0~30.0 equivalents, plus temperature is less than 25 DEG C in control reaction during alkali, and 0.5 is reacted afterwards
~18h；
Then heavy water is added dropwise into reaction system again, the consumption of heavy water is 5.0~200.0 equivalents, and holding during heavy water is added dropwise
Reaction temperature is less than 40 DEG C, after completion of dropping, reacts 0.1~18h；
Then difluorocarbene's donor is added again, and the consumption of difluorocarbene's donor is 1.0~5.0 equivalents, adds difluorocarbene's donor
During controlling reaction temperature be less than 30 DEG C, 10min~18h is reacted afterwards, reaction terminates, deuterated product is made
3. the synthetic method of the aromatic compounds of the functional group according to claim 2 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that, Ar be phenyl, naphthyl, binaphthyl, anthryl, phenanthryl, pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, quinolyl,
1,10- ferrosins base, indyl, indazolyl, pyrrole radicals, thienyl, furyl, imidazole radicals,It is oxazolyl, differentOxazolyl, thiazole
Base, isothiazolyl,Di azoly, thiadiazolyl group, pyranose, pyrazolyl, isoquinolyl, benzofuranyl, benzothienyl, benzene
And thiapyran base, benzimidazolyl, benzoOxazolyl, benzoDi azoly, benzothiazolyl, diazosulfide base, chromene
Base, isoindolyl, triazolyl, triazine radical, quinoxalinyl, purine radicals, quinazolyl, quinolizine base, naphthyridines base, pteridyl, carbazole
Base, azepineBase, diazaBase, acridinyl, steroidal base；Or phenyl, naphthyl, binaphthyl, anthryl, phenanthryl, the pyridine of substitution
Base, pyrimidine radicals, pyridazinyl, pyrazinyl, quinolyl, 1,10- ferrosins base, indyl, indazolyl, pyrrole radicals, thienyl, furans
Base, imidazole radicals,It is oxazolyl, differentOxazolyl, thiazolyl, isothiazolyl,It is di azoly, thiadiazolyl group, pyranose, pyrazolyl, different
Quinolyl, benzofuranyl, benzothienyl, benzothiopyran derivative base, benzimidazolyl, benzoOxazolyl, benzoDi azoly,
Benzothiazolyl, diazosulfide base, benzopyranyl, isoindolyl, triazolyl, triazine radical, quinoxalinyl, purine radicals, quinoline
Oxazoline base, quinolizine base, naphthyridines base, pteridyl, carbazyl, azepineBase, diazaBase, acridinyl, steroidal base, the substitution
For a substitution, two substitutions, three substitutions, four substitutions or five substitutions, substituent is halogen, cyano group, nitro, ester group, C1-6Alkyl, C3-6
Cycloalkyl, C1-6Alkoxy, C3-6Cycloalkyloxy, C1-6Alkylthio group, C1-6Haloalkyl, C1-6Acyl group, C1-6Alkylamino, phenyl or
C3-6Naphthene amino.
4. the synthetic method of the aromatic compounds of the functional group according to claim 3 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that, Ar is phenyl, naphthyl, binaphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, pyrimidine radicals, pyridazine
Base, quinolyl；Or the phenyl of substitution, naphthyl, binaphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, pyrimidine radicals, rattle away
Piperazine base, quinolyl, described to be substituted by a substitution or two substitutions, substituent is halogen, cyano group, phenyl, nitro, C1-6Alkyl, C3-6
Cycloalkyl, C1-6Alkylamino, C1-6Alkoxy.
5. the synthetic method of the aromatic compounds of the functional group according to claim 4 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that,When middle n takes 1, Ar is phenyl, naphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, phonetic
Piperidinyl, pyridazinyl, quinolyl；Or substitution phenyl, naphthyl, benzothienyl, indyl, pyridine radicals, steroidal base, pyrimidine radicals,
Pyridazinyl, quinolyl, described to be substituted by a substitution or two substitutions, substituent is halogen, cyano group, phenyl, nitro, C1-6Alkyl,
C3-6Cycloalkyl, C1-6Alkylamino, C1-6Alkoxy.
6. the synthetic method of the aromatic compounds of the functional group according to claim 4 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that,When middle n takes 2, Ar is binaphthyl or substituted binaphthyl.
7. according to the synthesis of the aromatic compounds of any described functional groups Han difluoro deuterated methoxy (sulphur) base of claim 1-6
Method, it is characterised in that alkali base is NaH, organic solvent solvent is tetrahydrofuran and/or Isosorbide-5-Nitrae-dioxane.
8. the synthetic method of the aromatic compounds of the functional group according to claim 7 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that, the consumption of alkali is 10.0 equivalents.
9. the synthetic method of the aromatic compounds of the functional group according to claim 8 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that, the consumption of heavy water is 50.0 equivalents.
10. the synthetic method of the aromatic compounds of the functional group according to claim 9 Han difluoro deuterated methoxy (sulphur) base,
Characterized in that, the consumption of difluorocarbene's donor is 2.0 equivalents.
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| CN114149354A (en) * | 2021-12-10 | 2022-03-08 | 南京贝塔生物科学有限公司 | Deuterated difluoromethyl substituted thioaryl sulfonate as well as preparation method and application thereof |
| CN116514786A (en) * | 2023-06-26 | 2023-08-01 | 北京科翔中升医药科技有限公司 | Preparation method of deuterated indazole triazine compound |
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