CN107224603A - A kind of Medical negative pressure drainage composite foam material and preparation method thereof - Google Patents
A kind of Medical negative pressure drainage composite foam material and preparation method thereof Download PDFInfo
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- CN107224603A CN107224603A CN201710397122.2A CN201710397122A CN107224603A CN 107224603 A CN107224603 A CN 107224603A CN 201710397122 A CN201710397122 A CN 201710397122A CN 107224603 A CN107224603 A CN 107224603A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- General Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Medical negative pressure drainage composite foam material and preparation method thereof.The foamed material contains the pore passage structure of three-dimensional insertion, uniform pore diameter and porosity is big, with good water absorbing properties, bacteriostasis property and absorption property.The preparation method of the present invention includes：First, weigh appropriate polyvinyl alcohol and Chitosan powder is placed in three-necked flask, add and be warming up to polyvinyl alcohol under purified water, glacial acetic acid and ethanol, stirring condition and chitosan is completely dissolved, be cooled to certain temperature；Then, the pH of solution is adjusted, appropriate emulsifying agent, formalin, active carbon powder and powdered sodium carbonate is added, injected after stirring in mould in reaction under certain temperature.Finally, foamed material is successively cleaned to pH in neutrality using sodium hydroxide solution and purified water, produced by size section.The inventive method is simple, and easy to operate, the cycle is short, the material prepared, and has important clinical value and social benefit in wound repair field.
Description
Technical field
The present invention relates to technical field of polymer materials, specifically related to a kind of Medical negative pressure drainage composite foam material and its
Preparation method.
Background technology
Polyvinylalcohol formal foam be it is a kind of have three-dimensional pore passage structure, the water resistance being mutually communicated it is excellent,
Elastic recovery rate is controllable, the foamed material of high mechanical properties, stronger water absorbing properties and biocompatibility.Polyvinyl formal
Foamed material is applied to medical material, is the material of main part of negative pressure drainage technology.As people are to surface of a wound Cure, treatment
During the demand such as comfortableness continuous improvement, doctor patient also increases substantially to the understanding degree and demand degree of negative pressure drainage,
For the requirement also more and more higher of closed negative pressure drainage material in surgical procedure, the pore size of closed negative pressure drainage material is to it
Performance has a great impact, uniformity and wound exudates, the downright bad group of negative pressure distribution in pore size influence drainage process
The extraction effect knitted.
The method that is typically prepared of polyvinylalcohol formal foam is to dissolve by heating polyvinyl alcohol, adds pore creating material
（Starch, dextrin etc.）And surfactant（Polyethylene glycol, tween etc.）, adding aldehyde and catalyst（Sulfuric acid, hydrochloric acid etc.）, stirring
After uniform in injection mould under the conditions of certain temperature curing molding.But the foamed material aperture that the method for being typically prepared is prepared is big
Small to differ, closed pore is more, have impact on the uniformity of negative pressure distribution, it is impossible to effectively remove slough, noxious material and bad gas
Taste.
The present invention is also added during polyvinylalcohol formal foam is prepared in addition to polyvinyl alcohol and formalin
Chitosan and active carbon powder, make the foamed material prepared with pore passage structure evenly, enhance the biocidal property of material
Can, the noxious material and bad smell at wound can be effectively removed, the ease for use and peace of closed negative pressure drainage material is greatly improved
Full reliability.Medical negative pressure drainage composite foam material prepared by the present invention has in medical macromolecular materials and wound repair field
There are important clinical value and social benefit.
The content of the invention
It is an object of the invention to provide a kind of Medical negative pressure drainage composite foam material, the material not only possesses three-dimensional and passed through
Logical pore passage structure and with good water absorbing properties, and activated carbon powder in foamed material can effectively adsorb and be organized at wound
Noxious material and bad smell in diffusate.
It is a further object to provide the above-mentioned Medical negative pressure drainage composite foam material with good water absorbing properties
The preparation method of material, the preparation method is not only simple and short preparation period, and production cost is low.
The purpose of the present invention can be achieved through the following technical solutions：
The present invention uses polyvinyl alcohol, formalin, chitosan and active carbon powder to be prepared from for raw material, its preparation process bag
Include three below step：（1）Weigh appropriate polyvinyl alcohol and Chitosan powder is placed in three-necked flask, add purified water, ice
Polyvinyl alcohol is warming up under acetic acid and ethanol, stirring condition and chitosan is completely dissolved, specified temp is cooled to；（2）Regulation is molten
PH≤2.0 of liquid, add appropriate emulsifying agent, formalin, active carbon powder and powdered sodium carbonate, mould are injected after stirring
In tool and be put into air dry oven react.（3）The foamed material of shaping is taken out, successively using sodium hydroxide solution and purified water
Cleaning, in neutrality, is produced to pH by size section.
The concrete scheme of implementation is as follows：
Step one：Weigh appropriate polyvinyl alcohol and chitosan is placed in 2000mL three-necked flask, add purified water, appropriate
Temperature is increased to certain temperature under glacial acetic acid and 95% ethanol, stirring condition, constant temperature stirs complete to polyvinyl alcohol and chitosan
Dissolving, is cooled to preference temperature；
Step 2：Appropriate hydrochloric acid solution is added to pH≤2.0 of solution, stirring adds appropriate emulsification after after temperature recovery
Agent, appropriate formalin（37%）, appropriate active carbon powder and powdered sodium carbonate, solution is poured into advance after stirring
In the mould of wash clean, it is put into 55 DEG C of air dry ovens and reacts some hours；
Step 3：The foamed material of shaping is removed from the molds, 30min is soaked in the sodium hydroxide solution for being placed in dilute concentration, is used
Purified water cleaning produces Medical negative pressure drainage by given size excision upper and lower surface using slicer and is combined for several times to pH in neutrality
Foamed material.
The addition of chitosan described in the materials synthesis step one is the 5% ~ 10% of polyvinyl alcohol quality, and described is pure
Change water, the additional proportion of glacial acetic acid and 95% ethanol is respectively by radix of polyvinyl alcohol：750 ~ 1000%, 5 ~ 10% and 10 ~ 20%.
Certain temperature described in the materials synthesis step one is 60 ~ 150 DEG C, and preference temperature is 20 ~ 55 DEG C.
Formalin described in the materials synthesis step 2（37%）Addition be the 5 ~ 75% of polyvinyl alcohol quality, it is living
5 ~ 10%, the 0.1 ~ 5% of the addition polyvinyl alcohol quality of powdered sodium carbonate of the addition polyvinyl alcohol quality of property carbon powder；
Emulsifying agent described in the materials synthesis step 2 is polyol fatty acid ester class emulsifying agent, preferably xylitol monostearate
One kind in ester and sorbitan stearate and two kinds, the addition of emulsifying agent is the 0.1 ~ 30% of polyvinyl alcohol quality
Reaction time described in the materials synthesis step 2 is 0.5 ~ 24h.
Beneficial effects of the present invention are as follows：（1）Medical negative pressure drainage composite foam material has the duct knot of three-dimensional insertion
Structure and good water absorbing properties；（2）Appropriate chitosan is with the addition of in Medical negative pressure drainage composite foam material so that compound vacuole
Foam material possesses pore passage structure evenly, enhances the bacteriostasis property of material；（3）In Medical negative pressure drainage composite foam material
The activated carbon composition of addition can effectively adsorb the noxious material and bad smell in tissue exudates at wound；(4) it is of the invention
Preparation technology is simple, and production cost is low, workable, and the cycle is short, is a kind of economically viable preparation method.
Embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1
Step one：Weigh 100g polyvinyl alcohol（1750±50）With 10g chitosans（DD=90%）It is placed in 2000mL three-necked flask
In, add under 1000mL purified waters, 10mL glacial acetic acid and the ethanol of 20mL 95%, stirring condition and temperature is increased to 90 DEG C, constant temperature
Stirring is completely dissolved to polyvinyl alcohol and chitosan, is cooled to 55 DEG C；
Step 2：Appropriate hydrochloric acid solution is added to pH≤2.0 of solution, stirring sequentially adds 10g wood after after temperature recovery
Sugar alcohol monostearate, 50g formalins（37%）, 5g active carbon powders and 2.5g powdered sodium carbonates, will be molten after stirring
Liquid is poured into the mould of prior wash clean, is put into 55 DEG C of air dry ovens and is reacted 8 hours；
Step 3：The foamed material of shaping is removed from the molds, the acid solution contained by foamed material is thrown away, is placed in 0.1mol/L
Sodium hydroxide solution in soak 30min, cleaned with purified water for several times to pH in neutrality, using slicer by given size excision
Upper and lower surface produces Medical negative pressure drainage composite foam material.
The Medical negative pressure drainage composite foam material with three-dimensional insertion pore passage structure obtained by embodiment 1 is carried out
The test of pore-size distribution test, porosity and maximum water absorbent rate, it is as a result as follows：Pore-size distribution is 220 ~ 500 μm, and porosity is
89.2%, maximum water absorbent rate is 8.35.
Embodiment 2
Step one：Weigh 100g polyvinyl alcohol（1750±50）With 10g chitosans（DD=90%）It is placed in 2000mL three-necked flask
In, add under 800mL purified waters, 10mL glacial acetic acid and the ethanol of 20mL 95%, stirring condition and temperature is increased to 90 DEG C, constant temperature is stirred
Mix to polyvinyl alcohol and chitosan and be completely dissolved, be cooled to 55 DEG C；
Step 2：Appropriate hydrochloric acid solution is added to pH≤2.0 of solution, stirring sequentially adds 10g wood after after temperature recovery
Sugar alcohol monostearate, 50g formalins（37%）, 5g active carbon powders and 2.5g powdered sodium carbonates, will be molten after stirring
Liquid is poured into the mould of prior wash clean, is put into 55 DEG C of air dry ovens and is reacted 8 hours；
Step 3：The foamed material of shaping is removed from the molds, the acid solution contained by foamed material is thrown away, is placed in 0.1mol/L
Sodium hydroxide solution in soak 30min, cleaned with purified water for several times to pH in neutrality, using slicer by given size excision
Upper and lower surface produces Medical negative pressure drainage composite foam material.
Embodiment 3
Step one：Weigh 100g polyvinyl alcohol（1750±50）With 10g chitosans（DD=90%）It is placed in 2000mL three-necked flask
In, add under 1000mL purified waters, 10mL glacial acetic acid and the ethanol of 20mL 95%, stirring condition and temperature is increased to 90 DEG C, constant temperature
Stirring is completely dissolved to polyvinyl alcohol and chitosan, is cooled to 55 DEG C；
Step 2：Appropriate hydrochloric acid solution is added to pH≤2.0 of solution, stirring sequentially adds 10g wood after after temperature recovery
Sugar alcohol monostearate, 75g formalins（37%）, 5g active carbon powders and 2.5g powdered sodium carbonates, will be molten after stirring
Liquid is poured into the mould of prior wash clean, is put into 55 DEG C of air dry ovens and is reacted 8 hours；
Step 3：The foamed material of shaping is removed from the molds, the acid solution contained by foamed material is thrown away, is placed in 0.1mol/L
Sodium hydroxide solution in soak 30min, cleaned with purified water for several times to pH in neutrality, using slicer by given size excision
Upper and lower surface produces Medical negative pressure drainage composite foam material.
Embodiment 4
Step one：Weigh 100g polyvinyl alcohol（1750±50）With 10g chitosans（DD=90%）It is placed in 2000mL three-necked flask
In, add under 1000mL purified waters, 10mL glacial acetic acid and the ethanol of 20mL 95%, stirring condition and temperature is increased to 90 DEG C, constant temperature
Stirring is completely dissolved to polyvinyl alcohol and chitosan, is cooled to 55 DEG C；
Step 2：Appropriate hydrochloric acid solution is added to pH≤2.0 of solution, stirring sequentially adds 5g xyloses after after temperature recovery
Alcohol monostearate, 50g formalins（37%）, 5g active carbon powders and 2.5g powdered sodium carbonates, by solution after stirring
In the mould for pouring into prior wash clean, it is put into 55 DEG C of air dry ovens and reacts 8 hours；
Step 3：The foamed material of shaping is removed from the molds, the acid solution contained by foamed material is thrown away, is placed in 0.1mol/L
Sodium hydroxide solution in soak 30min, cleaned with purified water for several times to pH in neutrality, using slicer by given size excision
Upper and lower surface produces Medical negative pressure drainage composite foam material.
Above-described embodiment is the optimal embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention and the change made under principle, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.The term occurred in the present invention is used for this
The elaboration and understanding of inventive technique scheme, are not construed as limiting the invention.
Claims (7)
1. a kind of Medical negative pressure drainage composite foam material, it is characterised in that the material mainly comprising polyvinyl formal,
Chitosan and active carbon powder, the pore passage structure being mutually communicated with three-dimensional, aperture is 220 ~ 500 μm, and porosity is 70 ~ 90%,
And with bacteriostasis property.
2. the preparation method of Medical negative pressure drainage composite foam material according to claim 1, it is characterised in that prepared
Journey includes three below step：
Step one：Weigh appropriate polyvinyl alcohol and Chitosan powder is placed in three-necked flask, add purified water, glacial acetic acid and second
Preference temperature is warming up under alcohol, stirring condition, certain temperature is cooled to after polyvinyl alcohol and chitosan are completely dissolved；
Step 2：The pH of solution is adjusted, appropriate emulsifying agent, formalin, active carbon powder and powdered sodium carbonate, stirring is added
In reaction under certain temperature in injection mould after uniform；
Step 3：Foamed material is successively cleaned to pH in neutrality using sodium hydroxide solution and purified water, is by size section
.
3. the preparation method of Medical negative pressure drainage composite foam material according to claim 2, it is characterised in that step one
The addition of described chitosan is the 5% ~ 10% of polyvinyl alcohol quality, the addition of described purified water, glacial acetic acid and 95% ethanol
Ratio is respectively by radix of polyvinyl alcohol：750 ~ 1000%, 5 ~ 10% and 10 ~ 20%.
4. the preparation method of Medical negative pressure drainage composite foam material according to claim 2, it is characterised in that step one
Described preference temperature is 60 ~ 150 DEG C, and certain temperature is 20 ~ 55 DEG C.
5. the preparation method of Medical negative pressure drainage composite foam material according to claim 2, it is characterised in that step 2
Described formalin（37%）Addition be polyvinyl alcohol quality 5 ~ 75%, the addition polyvinyl alcohol matter of active carbon powder
5 ~ 10%, the 0.1 ~ 5% of the addition polyvinyl alcohol quality of powdered sodium carbonate of amount.
6. the preparation method of Medical negative pressure drainage composite foam material according to claim 2, it is characterised in that step 2
Described emulsifying agent is polyol fatty acid ester class emulsifying agent, preferably in xylitol monostearate and sorbitan stearate
A kind of and two kinds, the addition of emulsifying agent is the 0.1 ~ 30% of polyvinyl alcohol quality.
7. the preparation method of Medical negative pressure drainage composite foam material according to claim 2, it is characterised in that step 2
The described reaction time is 0.5 ~ 24h.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710397122.2A CN107224603A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical negative pressure drainage composite foam material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710397122.2A CN107224603A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical negative pressure drainage composite foam material and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693821A (en) * | 2021-08-26 | 2021-11-26 | 北京中杰瑞康科技有限公司 | Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693821A (en) * | 2021-08-26 | 2021-11-26 | 北京中杰瑞康科技有限公司 | Self-expansion super-water-absorption water-locking micro-negative pressure dressing and preparation method thereof |
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Application publication date: 20171003 |