CN107200798A - A kind of antiseptic with broad-spectrum antiseptic - Google Patents
A kind of antiseptic with broad-spectrum antiseptic Download PDFInfo
- Publication number
- CN107200798A CN107200798A CN201710439620.9A CN201710439620A CN107200798A CN 107200798 A CN107200798 A CN 107200798A CN 201710439620 A CN201710439620 A CN 201710439620A CN 107200798 A CN107200798 A CN 107200798A
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- Prior art keywords
- broad
- antiseptic
- spectrum
- preparation
- antibacterial agent
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of antiseptic with broad-spectrum antiseptic, and its structural formula is：.Invention additionally discloses a kind of Antibacterial agent preparation method with broad-spectrum antiseptic.Antibacterial antiplaque agent effect prepared by the present invention preferably, effectively prevents breed bacteria during active carbon filter core use, while effectively killing the bacterium that water body grows, and does not influence health.
Description
Technical field
The present invention relates to water-treatment technology field, a kind of antiseptic with broad-spectrum antiseptic is referred in particular to.
Background technology
In the prior art, the larger filter core of Household water purifier usage amount is activated carbon or Active carbon fiber filter core, and it is adsorbed
Heterochromatic peculiar smell excellent performance, but easy breed bacteria during use, and secondary pollution is caused to drinking water.
To prevent drinking water secondary pollution, prepare antibacterial active carbon filter core and necessitate, but current antibacterial activity on the market
What carbon filter core was added mostly is all Inorganic Ag System Antimicrobial Agents, and Inorganic Ag System Antimicrobial Agents can be more or less without specially treated because of it
Discharge, health is impacted.
In view of this, the present invention develops a kind of antiseptic with broad-spectrum antiseptic for overcoming the defect, and this case is thus
Produce.
The content of the invention
It is an object of the invention to provide a kind of antiseptic with broad-spectrum antiseptic, its antibacterial effect preferably, is effectively prevented
Breed bacteria during active carbon filter core use, while effectively killing the bacterium that water body grows, and does not influence health.
In order to reach above-mentioned purpose, solution of the invention is：
A kind of antiseptic with broad-spectrum antiseptic, its structural formula is：
。
A kind of Antibacterial agent preparation method with broad-spectrum antiseptic, comprises the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by guanidine compound and Isosorbide-5-Nitrae-dibromobutane:1-1:
1.5 add in the reactor with magnetic stir bar, and stirring reaction 8-12h at 50-70 DEG C after reaction terminates, uses ethyl acetate
Washing, is placed at 50-60 DEG C of vacuum drying chamber and dries 3-6h；
Two, it is 1 in molar ratio by intermediate and 1- (3- aminopropyls) imidazoles functional polies divinylbenzene:5-1:8 add ethanol
12-24h is reacted at middle 30-60 DEG C, after reaction terminates, room temperature is cooled to, then ethanol is washed, and is placed in vacuum drying chamber 50-60
3-6h is dried at DEG C, broad spectrum antimicrobial agent is produced.
Further, the functionalization content of 1- (3- aminopropyls) imidazoles functional poly divinylbenzene is 2-3mmol/g.
Further, guanidine compound is guanidine or TMG.
After such scheme, containing two center of positive charge in antibacterial moleucles structure of the present invention, can there is more
Site is gone to be combined with electronegative bacterium, and just carries positive charge under normal conditions, so antibacterial can be played quickly
Effect.The antiseptic is applied in household active carbon filter, effectively prevents breed bacteria during active carbon filter core use, together
Shi Youxiao kills the bacterium that water body grows, and does not influence health.
The preparation process of the present invention is as follows：
。
The beneficial effect of Antibacterial agent preparation method of the present invention is：One, green antibacterial agent is supported on polymer surfaces, risen
It will not be separated out again to effective broad-spectrum antiseptic free；Two, the preparation method is easy, fixed less investment, with short production cycle；Three, the system
Preparation Method technique is simple, and environmental protection, consumed energy is low.
Brief description of the drawings
Fig. 1 is antibacterial test comparison diagram of the present invention；
Fig. 2 is that the present invention separates out test chart.
Embodiment
The present invention is described in detail below in conjunction with drawings and the specific embodiments.
Embodiment one
A kind of Antibacterial agent preparation method with broad-spectrum antiseptic, comprises the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by TMG and Isosorbide-5-Nitrae-dibromobutane:1.1 add
In reactor with magnetic stir bar, stirring reaction 12h at 50 DEG C after reaction terminates, is washed with ethyl acetate, is placed in vacuum
3h is dried at 60 DEG C of drying box, white solid is obtained.
Two, the preparation of broad spectrum antimicrobial agent：Intermediate and function in step one is turned to 2mmol/g 1- (3- aminopropyls)
Imidazoles functional poly divinylbenzene is 1 in molar ratio:24h is reacted at 40 DEG C in 5 addition absolute ethyl alcohols, it is cold after reaction terminates
But to room temperature, then washed with ethanol, be finally placed at 60 DEG C of vacuum drying chamber and dry 6h, produce broad spectrum antimicrobial agent.
The above method prepare green antibacterial agent can be applied to broad-spectrum antiseptic field, antibacterial effect up to more than 99.9%,
It also is adapted for being applied to water purification field, any harmful material will not be separated out.
Embodiment two
A kind of Antibacterial agent preparation method with broad-spectrum antiseptic, comprises the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by guanidine and Isosorbide-5-Nitrae-dibromobutane:1.1 add with magnetic
In the reactor of power stirrer, the h of stirring reaction 12 at 50 DEG C after reaction terminates, is washed with ethyl acetate, is finally placed in vacuum
3 h are dried at 60 DEG C of drying box, white solid is obtained.
Two, the preparation of broad spectrum antimicrobial agent：Intermediate and function in step one is turned to 2mmol/g 1- (3- aminopropyls)
Imidazoles functional poly divinylbenzene is 1 in molar ratio:24h is reacted at 40 DEG C in 5 addition absolute ethyl alcohols, it is cold after reaction terminates
But to room temperature, then washed with ethanol, be finally placed at 60 DEG C of vacuum drying chamber and dry 6 h, produce broad spectrum antimicrobial agent.
The above method prepare green antibacterial agent can be applied to broad-spectrum antiseptic field, antibacterial effect up to more than 99.9%,
It also is adapted for being applied to water purification field, any harmful material will not be separated out.
Embodiment three
A kind of Antibacterial agent preparation method with broad-spectrum antiseptic, comprises the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by TMG and Isosorbide-5-Nitrae-dibromobutane:1.5 add
In reactor with magnetic stir bar, stirring reaction 8h at 60 DEG C after reaction terminates, is washed with ethyl acetate, is finally placed in
5h is dried at 50 DEG C of vacuum drying chamber, white solid is obtained.
Two, the preparation of broad spectrum antimicrobial agent：Intermediate and function in step one is turned to 3mmol/g 1- (3- aminopropyls)
Imidazoles functional poly divinylbenzene is 1 in molar ratio:24h is reacted at 30 DEG C in 8 addition absolute ethyl alcohols, it is cold after reaction terminates
But to room temperature, then washed with ethanol, be finally placed at 60 DEG C of vacuum drying chamber and dry 6 h, produce broad spectrum antimicrobial agent.
The above method prepare green antibacterial agent can be applied to broad-spectrum antiseptic field, antibacterial effect up to more than 99.9%,
It also is adapted for being applied to water purification field, any harmful material will not be separated out.
Example IV
A kind of Antibacterial agent preparation method with broad-spectrum antiseptic, comprises the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by guanidine and Isosorbide-5-Nitrae-dibromobutane:1.2 add with magnetic
In the reactor of power stirrer, the h of stirring reaction 8 at 60 DEG C after reaction terminates, is washed with ethyl acetate, is finally placed in vacuum and is done
Dry case 50o5 h are dried under C, white solid is obtained.
Two, the preparation of broad spectrum antimicrobial agent：Intermediate and function in step one is turned to 3mmol/g 1- (3- aminopropyls)
Imidazoles functional poly divinylbenzene is 1 in molar ratio:24h is reacted at 40 DEG C in 6 addition absolute ethyl alcohols, it is cold after reaction terminates
But to room temperature, then washed with ethanol, be finally placed in vacuum drying chamber 50o6 h are dried under C, broad spectrum antimicrobial agent is produced.
The above method prepare green antibacterial agent can be applied to broad-spectrum antiseptic field, antibacterial effect up to more than 99.9%,
It also is adapted for being applied to water purification field, any harmful material will not be separated out.
Antibacterial test
Green antibacterial agent anti-bacteria test result
| Strain | Blank sample bacterial number after 24 h/ | After 24h through antimicrobial treatment bacterial number/ | Antimicrobial efficiency |
| Escherichia coli | 4.2*10^5 | 0 | 99.99 |
Test process：Two parts of same amount of Escherichia coli liquid are taken, portion adds the green antibacterial agent stirring of a certain amount of preparation
Uniformly, another is used as blank（Do not add antiseptic）, stand 1min after it is separately sampled tested, antibacterial test is to such as
Shown in Fig. 1, test result shows：Green New-type wide-spectrum antibacterial antiplaque agent effect is up to more than 99.99% and will not separate out any to people
The harmful material of body, can effectively be applied in family's water purification catridge as a kind of antiseptic of green safety.
Separate out test
Test process：A certain amount of green antibacterial agent is soaked in pure water, respectively at 1h, 2h, 6h, 24h, 36h, 48h takes
Sample tests COD value（COD value is the important indicator that water body contains content of organics）, as shown in Figure 2.Test result shows：
Material precipitation is not had again while green antibacterial agent effective broad-spectrum antiseptic, is a kind of safely and effectively antiseptic.
Claims (4)
1. a kind of antiseptic with broad-spectrum antiseptic, it is characterised in that：Its structural formula is：
IMG_256。
2. a kind of Antibacterial agent preparation method with broad-spectrum antiseptic, it is characterised in that：Comprise the following steps：
One, the preparation of intermediate：At ambient temperature, it is 1 in molar ratio by guanidine compound and Isosorbide-5-Nitrae-dibromobutane:1-1:
1.5 add in the reactor with magnetic stir bar, and stirring reaction 8-12h at 50-70 DEG C after reaction terminates, uses ethyl acetate
Washing, is placed at 50-60 DEG C of vacuum drying chamber and dries 3-6h；
Two, it is 1 in molar ratio by intermediate and 1- (3- aminopropyls) imidazoles functional polies divinylbenzene:5-1:8 add ethanol
12-24h is reacted at middle 30-60 DEG C, after reaction terminates, room temperature is cooled to, then ethanol is washed, and is placed in vacuum drying chamber 50-60
3-6h is dried at DEG C, broad spectrum antimicrobial agent is produced.
3. a kind of Antibacterial agent preparation method with broad-spectrum antiseptic as claimed in claim 2, it is characterised in that：1- (3- ammonia third
Base) imidazoles functional poly divinylbenzene functionalization content be 2-3mmol/g.
4. a kind of Antibacterial agent preparation method with broad-spectrum antiseptic as claimed in claim 2, it is characterised in that：Guanidine compound
For guanidine or TMG.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710439620.9A CN107200798A (en) | 2017-06-12 | 2017-06-12 | A kind of antiseptic with broad-spectrum antiseptic |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710439620.9A CN107200798A (en) | 2017-06-12 | 2017-06-12 | A kind of antiseptic with broad-spectrum antiseptic |
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| CN107200798A true CN107200798A (en) | 2017-09-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107141408A (en) * | 2017-06-12 | 2017-09-08 | 厦门建霖健康家居股份有限公司 | A kind of antibacterial polymer and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082968A (en) * | 1990-11-01 | 1992-01-21 | General Electric Company | Method of preparing hexaalkylguanidinium salts |
| CN101374885A (en) * | 2006-01-27 | 2009-02-25 | 西巴控股公司 | Polymeric anti-microbial agents |
| CN103819668A (en) * | 2014-01-16 | 2014-05-28 | 昆山京昆油田化学科技开发公司 | Preparation method of ionic liquid polymer |
| CN104726902A (en) * | 2013-11-21 | 2015-06-24 | 罗门哈斯电子材料有限公司 | Reaction products of guanidine compounds or salts thereof, polyepoxides and polyhalogens |
| TW201710239A (en) * | 2015-06-03 | 2017-03-16 | 日本曹達股份有限公司 | Guanidine compound and fungicidal agent |
-
2017
- 2017-06-12 CN CN201710439620.9A patent/CN107200798A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082968A (en) * | 1990-11-01 | 1992-01-21 | General Electric Company | Method of preparing hexaalkylguanidinium salts |
| CN101374885A (en) * | 2006-01-27 | 2009-02-25 | 西巴控股公司 | Polymeric anti-microbial agents |
| CN104726902A (en) * | 2013-11-21 | 2015-06-24 | 罗门哈斯电子材料有限公司 | Reaction products of guanidine compounds or salts thereof, polyepoxides and polyhalogens |
| CN103819668A (en) * | 2014-01-16 | 2014-05-28 | 昆山京昆油田化学科技开发公司 | Preparation method of ionic liquid polymer |
| TW201710239A (en) * | 2015-06-03 | 2017-03-16 | 日本曹達股份有限公司 | Guanidine compound and fungicidal agent |
Non-Patent Citations (2)
| Title |
|---|
| DAI WEI-LI, ET AL.: "Polymers anchored with carboxyl-functionalized di-cation ionic liquids as efficient catalysts for the fixation of CO2 into cyclic carbonates", 《CATALYSIS SCIENCE & TECHNOLOGY》 * |
| 刘泓 等: "离子液体1,4-二（1-异丙基咪唑）丁烷溴化物的合成研究", 《应用化工》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107141408A (en) * | 2017-06-12 | 2017-09-08 | 厦门建霖健康家居股份有限公司 | A kind of antibacterial polymer and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171220 Address after: 361000 Fujian Province, Xiamen city Tongan Industrial Zone Siming Park No. 305 Applicant after: Xiamen Bailin water purification technology Co. Ltd. Address before: The North Industrial Zone of Jimei Tianfeng road Xiamen City, Fujian province 361021 No. 69 Applicant before: Xiamen Jian Lin health home Limited by Share Ltd |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170926 |