CN107185027A - A kind of absorbable medical suture and preparation method thereof - Google Patents
A kind of absorbable medical suture and preparation method thereof Download PDFInfo
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- CN107185027A CN107185027A CN201710424733.1A CN201710424733A CN107185027A CN 107185027 A CN107185027 A CN 107185027A CN 201710424733 A CN201710424733 A CN 201710424733A CN 107185027 A CN107185027 A CN 107185027A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a kind of absorbable medical suture and preparation method thereof, belong to medical material preparing technical field.The present invention first will be by balsam pear, Radix Angelicae Sinensis, the mixture that Radix Astragali etc. is made is mixed with ethanol solution, after being extracted through ultrasonic vibration, supercritical carbon dioxide is recycled further to extract, obtain antibacterial analgesic, and the benefit materials of wound healing can be promoted, then by extracting and the high perch roe of human compatibility, colloid and protein inside edible fly maggot and peach gum are mixed with extract, again with PGA basestocks, polyglutamic acid, polycaprolactone etc. is mixed, initiator is used as by the use of potassium peroxydisulfate, in the presence of anisaldehyde and acetic anhydride, promote the mixing crosslinking between polyglutamic acid polymerization and polymer, form high degradability energy material, finally by melt spinning, obtain absorbable medical suture.Suture good biocompatibility produced by the present invention, without obvious individual difference, and high mechanical strength has broad application prospects.
Description
Technical field
The invention discloses a kind of absorbable medical suture and preparation method thereof, belong to medical material technology of preparing neck
Domain.
Background technology
Suture is a kind of thread like material sutured for body operation, is classified according to material, substantially there is silk thread, sheep
Several major classes such as gutstring, chemical synthesis line, pure-natural collagen suture；Classified according to absorbability, as non-absorbing is sutured
Two kinds of line and absorbable suture.Due to the particularity of application field, suture needs to meet following characteristic requirements：1st, exist
Enough intensity can be kept during Wound healing, elongation is should also be able to adapt to wound oedema, and with wound retraction
It is retracted into original length；2nd, its absorption that can voluntarily degrade again after Wound healing, no longer leaves foreign matter；3rd, inflammation is not produced；4th, nothing
Excitant and carcinogenicity；The processing such as the 5th, it is easy to dye, sterilizes, sterilizes；6th, knot securely can be formed；7th, it is easy to make, valency
Lattice are cheap, can largely produce.
Non-absorbing suture can not be absorbed by tissue, and need to take out stitches after suture, easily bring superinfection and the pain of injury；It can inhale
Receive sewing thread and can be degraded with time lengthening by body and absorbed, comparatively, absorbable sewing thread has the advantages that to take out stitches,
So as to alleviate patient's pain, while having the advantages that no antigen and pyrogenicity, wound healing are complete.Particularly with interior internal organs
The suture of official, is particularly important using absorbable suture, and it avoids the secondary pain operated on and caused to patient, reduces
The infection chance of wound, is all used while also accelerating in the operating efficiency of medical worker, therefore all kinds of surgical operations in pursuit
Absorbable suture.
But, existing absorbable suture is generally gutstring and chemical synthesis line, easily because of patient individual difference when using
Property influence absorption process, or even there is non-absorbent phenomenon, organize the reaction to gutstring big, increase the pain of patient, and existing
Absorbable suture tensile strength is low, biocompatibility is not good, these problems limit absorbable suture to a certain extent
The use of line.It would therefore be highly desirable to research and develop a kind of medical sutures that there is high tensile, high-biocompatibility and be easily absorbed by the human body
Line.
The content of the invention
Present invention mainly solves technical problem：For existing absorbable suture tensile strength is low, biocompatibility
It is not good, and there is individual difference, there is provided a kind of absorbable medical suture for defect of the influence human body to suture absorbing state
And preparation method thereof.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
A kind of absorbable medical suture, is counted by weight, including following component：50~55 parts of PGAs, 32~35 parts
Polyglutamic acid, 23~27 parts of extract solutions, 19~22 parts of distilled water, 18~21 parts of polycaprolactones, 11~13 parts of anisaldehydes, 6~9 parts
Mannitol, 5~8 parts of acetic anhydrides and 4~6 parts of potassium peroxydisulfates.
The extract solution is by the component of following parts by weight, 45~50 parts of distilled water, 32~36 parts of plant extracts, 22
~25 parts of perch roes, 21~23 parts of edible fly maggots and 8~11 parts of peach gums, are put into bruisher and smash to pieces, filtering, collect filtered fluid
And obtain.
The plant extract is by the component of following parts by weight, 50~55 parts of balsam pears, 40~45 parts of Radix Angelicae Sinensis, 33~36
Part Radix Astragali, 22~24 portions of pseudo-ginseng, 18~21 portions of Rabdosia rubescens and 12~16 parts of radix paeoniae rubrathe, are obtained by supercritical carbon dioxide extracting.
The supercritical carbon dioxide extracting condition is：45~50 DEG C of temperature, 20~22MPa of extracting pressure, carbon dioxide
21~23kg/h of flow, 1~2h of extraction time.
The preparation method of absorbable medical suture, comprises the following steps：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are well mixed, are put into container, nitrogen is used
Protection, 1~2h of stirring preheating at 70~75 DEG C；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate, rise temperature to 105~110 are added
DEG C, 7~9h is reacted, room temperature is cooled to, is freeze-dried, freeze-drying thing is collected；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 190~230 DEG C, carries out melting deaeration, then through 8~
10mm SPINNERETS FOR MELT SPINNING spinnerets, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is gone out through ultraviolet
Bacterium lamp carries out sterilizing, you can obtain absorbable medical suture.
The beneficial effects of the invention are as follows：
（1）The present invention first mixes the mixture being made up of balsam pear, Radix Angelicae Sinensis, Radix Astragali etc. with ethanol solution, is extracted through ultrasonic vibration
Afterwards, recycle supercritical carbon dioxide further to extract, obtain antibacterial and relieve pain and the benefit materials of wound healing can be promoted, then
Carried out by extracting with the colloid and protein and extract inside the high perch roe of human compatibility, edible fly maggot and peach gum
Mixing, then mixed with PGA basestocks, polyglutamic acid, polycaprolactone etc., by the use of potassium peroxydisulfate as initiator, in fennel
Under the catalytic action of aldehyde and acetic anhydride, promote the mixing crosslinking between polyglutamic acid polymerization and polymer, raising tensile strength is low, shape
Into high degradability energy material；
（2）Absorbable medical suture intensity produced by the present invention is higher, can form knot securely, while suture length
Can voluntarily it be stretched according to wound healing situation, practicality is preferable；
（3）Absorbable medical suture produced by the present invention has non-toxic, non-stimulated, good biocompatibility, pliability good
It is not required to take out stitches after feature, use, no rejection reflection and any toxic side effect eliminate the secondary pain after corrective surgery.
Embodiment
The preparation of plant extract：
（1）Count by weight, take 50~55 portions of balsam pears, 40~45 parts of Radix Angelicae Sinensis, 33~36 parts of Radixs Astragali, 22~24 parts of pseudo-ginseng, 18
~21 portions of Rabdosia rubescens and 12~16 parts of radix paeoniae rubrathe, are put into 60 DEG C of drying boxes and dry 9~12h, drying composite is put into ball mill
In, a diameter of 60mm steel balls of 4~6 times of dry mixed amount of substance are added, with 300r/min 2~3h of ball milling, are terminated in ball milling
Afterwards, the ball-milled mixtures in ball mill are collected；
（2）In mass ratio 1:4, it is that 35% ethanol solution is put into container by ball-milled mixtures and mass fraction, and container is placed in
In ultrasonic oscillation device, 40~50min is shaken with 1.9~2.3MHz；
（3）After earthquake terminates, the fumaric acid of ball milling mixing amount of substance 5~10% is added into container, is well mixed, by container
In mixture be put into supercritical carbon dioxide extraction apparatus, design temperature be 45~50 DEG C, extracting pressure be 20~
22MPa, carbon dioxide flow is 21~23kg/h, extracts 1~2h, after extraction terminates, and collects extract, you can obtain plant extraction
Take thing.
The preparation of extract solution：Count by weight, take 45~50 parts of distilled water, 32~36 parts of plant extracts, 22~25
Part perch roe, 21~23 parts of edible fly maggots and 8~11 parts of peach gums, are put into bruisher, 10 are smashed to pieces with 11000r/min~
15min, carries out suction filtration to smashing mixture to pieces, collects smoke filtrate, you can obtain extract solution.
Absorbable medical suture：Count by weight, including following component：50~55 parts of PGAs, 32~35 parts
Polyglutamic acid, 23~27 parts of extract solutions, 19~22 parts of distilled water, 18~21 parts of polycaprolactones, 11~13 parts of anisaldehydes, 6~9 parts
Mannitol, 5~8 parts of acetic anhydrides and 4~6 parts of potassium peroxydisulfates.
The preparation of absorbable medical suture：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are put into agitator, thermometer and returned cold
In the four-hole boiling flask of condenser, and four-hole boiling flask is placed in oil bath pan, protected using nitrogen, design temperature is 70~75 DEG C, with
1~2h of 180r/min stirring preheatings；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate, rise temperature to 105~110 are added
DEG C, with 200r/min 7~9h of stirring reaction, room temperature is cooled to, the mixture in four-hole boiling flask is put into cold in freeze drier
It is lyophilized dry, collect freeze-drying thing；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 190~230 DEG C, carries out melting deaeration, then through 8~
10mm SPINNERETS FOR MELT SPINNING spinnerets, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is gone out through ultraviolet
Bacterium lamp carries out sterilizing, you can obtain absorbable medical suture.
Example 1
The preparation of plant extract：
（1）Count by weight, take 50 portions of balsam pears, 40 parts of Radix Angelicae Sinensis, 33 parts of Radixs Astragali, 22 portions of pseudo-ginseng, 18 portions of Rabdosia rubescens and 12 parts red
Chinese herbaceous peony, is put into 60 DEG C of drying boxes and dries 9h, drying composite is put into ball mill, 4 times of dry mixed amount of substance is added
A diameter of 60mm steel balls, with 300r/min ball milling 2h, after ball milling terminates, collect the ball-milled mixtures in ball mill；
（2）In mass ratio 1:4, it is that 35% ethanol solution is put into container by ball-milled mixtures and mass fraction, and container is placed in
In ultrasonic oscillation device, 40min is shaken with 1.9MHz；
（3）After earthquake terminates, the fumaric acid of ball milling mixing amount of substance 5% is added into container, is well mixed, by container
Mixture is put into supercritical carbon dioxide extraction apparatus, and design temperature is 45 DEG C, and extracting pressure is 20MPa, carbon dioxide stream
Measure as 21kg/h, extraction 1h, after extraction terminates, collection extract, you can obtain plant extract.
The preparation of extract solution：Count by weight, take 45 parts of distilled water, 32 parts of plant extracts, 22 parts of perch roes, 21
The edible fly maggot of part and 8 parts of peach gums, are put into bruisher, 10min are smashed to pieces with 11000r/min, and suction filtration is carried out to smashing mixture to pieces,
Collect smoke filtrate, you can obtain extract solution.
Absorbable medical suture：Count by weight, including following component：50 parts of PGAs, 32 parts of polyglutamic acids,
23 parts of extract solutions, 19 parts of distilled water, 18 parts of polycaprolactones, 11 parts of anisaldehydes, 6 portions of mannitol, 5 parts of acetic anhydrides and 4 parts of persulfuric acid
Potassium.
The preparation of absorbable medical suture：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are put into agitator, thermometer and returned cold
In the four-hole boiling flask of condenser, and four-hole boiling flask is placed in oil bath pan, protected using nitrogen, design temperature is 70 DEG C, with 180r/
Min stirring preheatings 1h；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate are added, temperature is raised to 105 DEG C, with
200r/min stirring reaction 7h, are cooled to room temperature, and the mixture in four-hole boiling flask is put into freeze drier and is freeze-dried, and receive
Collection freeze-drying thing；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 190 DEG C, carries out melting deaeration, then through 8mm melt-spuns
Spinneret spinneret, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is carried out through ultraviolet sterilizing lamp
Sterilizing, you can obtain absorbable medical suture.
Example 2
The preparation of plant extract：
（1）Count by weight, take 53 portions of balsam pears, 43 parts of Radix Angelicae Sinensis, 35 parts of Radixs Astragali, 23 portions of pseudo-ginseng, 20 portions of Rabdosia rubescens and 14 parts red
Chinese herbaceous peony, is put into 60 DEG C of drying boxes and dries 11h, drying composite is put into ball mill, 5 times of dry mixed amount of substance is added
A diameter of 60mm steel balls, with 300r/min ball milling 2h, after ball milling terminates, collect the ball-milled mixtures in ball mill；
（2）In mass ratio 1:4, it is that 35% ethanol solution is put into container by ball-milled mixtures and mass fraction, and container is placed in
In ultrasonic oscillation device, 45min is shaken with 2.1MHz；
（3）After earthquake terminates, the fumaric acid of ball milling mixing amount of substance 8% is added into container, is well mixed, by container
Mixture is put into supercritical carbon dioxide extraction apparatus, and design temperature is 48 DEG C, and extracting pressure is 21MPa, carbon dioxide stream
Measure as 22kg/h, extraction 1h, after extraction terminates, collection extract, you can obtain plant extract.
The preparation of extract solution：Count by weight, take 48 parts of distilled water, 34 parts of plant extracts, 24 parts of perch roes, 22
The edible fly maggot of part and 10 parts of peach gums, are put into bruisher, 13min are smashed to pieces with 11000r/min, and suction filtration is carried out to smashing mixture to pieces,
Collect smoke filtrate, you can obtain extract solution.
Absorbable medical suture：Count by weight, including following component：53 parts of PGAs, 34 parts of polyglutamic acids,
25 parts of extract solutions, 21 parts of distilled water, 20 parts of polycaprolactones, 12 parts of anisaldehydes, 8 portions of mannitol, 7 parts of acetic anhydrides and 5 parts of persulfuric acid
Potassium.
The preparation of absorbable medical suture：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are put into agitator, thermometer and returned cold
In the four-hole boiling flask of condenser, and four-hole boiling flask is placed in oil bath pan, protected using nitrogen, design temperature is 73 DEG C, with 180r/
Min stirring preheatings 1h；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate are added, temperature is raised to 108 DEG C, with
200r/min stirring reaction 8h, are cooled to room temperature, and the mixture in four-hole boiling flask is put into freeze drier and is freeze-dried, and receive
Collection freeze-drying thing；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 210 DEG C, carries out melting deaeration, then through 9mm melt-spuns
Spinneret spinneret, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is carried out through ultraviolet sterilizing lamp
Sterilizing, you can obtain absorbable medical suture.
Example 3
The preparation of plant extract：
（1）Count by weight, take 55 portions of balsam pears, 45 parts of Radix Angelicae Sinensis, 36 parts of Radixs Astragali, 24 portions of pseudo-ginseng, 21 portions of Rabdosia rubescens and 16 parts red
Chinese herbaceous peony, is put into 60 DEG C of drying boxes and dries 12h, drying composite is put into ball mill, 6 times of dry mixed amount of substance is added
A diameter of 60mm steel balls, with 300r/min ball milling 3h, after ball milling terminates, collect the ball-milled mixtures in ball mill；
（2）In mass ratio 1:4, it is that 35% ethanol solution is put into container by ball-milled mixtures and mass fraction, and container is placed in
In ultrasonic oscillation device, 50min is shaken with 2.3MHz；
（3）After earthquake terminates, the fumaric acid of ball milling mixing amount of substance 10% is added into container, is well mixed, by container
Mixture is put into supercritical carbon dioxide extraction apparatus, and design temperature is 50 DEG C, and extracting pressure is 22MPa, carbon dioxide stream
Measure as 23kg/h, extraction 2h, after extraction terminates, collection extract, you can obtain plant extract.
The preparation of extract solution：Count by weight, take 50 parts of distilled water, 36 parts of plant extracts, 25 parts of perch roes, 23
The edible fly maggot of part and 11 parts of peach gums, are put into bruisher, 15min are smashed to pieces with 11000r/min, and suction filtration is carried out to smashing mixture to pieces,
Collect smoke filtrate, you can obtain extract solution.
Absorbable medical suture：Count by weight, including following component：55 parts of PGAs, 35 parts of polyglutamic acids,
27 parts of extract solutions, 22 parts of distilled water, 21 parts of polycaprolactones, 13 parts of anisaldehydes, 9 portions of mannitol, 8 parts of acetic anhydrides and 6 parts of persulfuric acid
Potassium.
The preparation of absorbable medical suture：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are put into agitator, thermometer and returned cold
In the four-hole boiling flask of condenser, and four-hole boiling flask is placed in oil bath pan, protected using nitrogen, design temperature is 75 DEG C, with 180r/
Min stirring preheatings 2h；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate are added, temperature is raised to 110 DEG C, with
200r/min stirring reaction 9h, are cooled to room temperature, and the mixture in four-hole boiling flask is put into freeze drier and is freeze-dried, and receive
Collection freeze-drying thing；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 230 DEG C, carries out melting deaeration, then through 10mm melt-spuns
Spinneret spinneret, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is carried out through ultraviolet sterilizing lamp
Sterilizing, you can obtain absorbable medical suture.
To absorbable medical suture made from example 1~3 and commercially available collagen sutures（Comparative example）Carry out performance
Detection, its testing result such as following table：
In summary, absorbable medical suture produced by the present invention has preferable mechanical performance and biological tissue's compatibility,
It need not take out stitches, can be fully absorbed by human body, with preferable prospect of the application after carrying out wound suture.
Claims (5)
1. a kind of absorbable medical suture, it is characterised in that count by weight, including following component：50~55 parts of poly- second
Lactide, 32~35 parts of polyglutamic acids, 23~27 parts of extract solutions, 19~22 parts of distilled water, 18~21 parts of polycaprolactones, 11~13 parts
Anisaldehyde, 6~9 portions of mannitol, 5~8 parts of acetic anhydrides and 4~6 parts of potassium peroxydisulfates.
2. absorbable medical suture according to claim 1, it is characterised in that the extract solution is by following parts by weight
Several components, 45~50 parts of distilled water, 32~36 parts of plant extracts, 22~25 parts of perch roes, 21~23 parts of edible fly maggots
And 8~11 parts of peach gums, it is put into bruisher and smashs to pieces, filter, collects filtered fluid and obtain.
3. absorbable medical suture according to claim 2, it is characterised in that the plant extract is by weighing as follows
The component of number is measured, 50~55 parts of balsam pears, 40~45 parts of Radix Angelicae Sinensis, 33~36 parts of Radixs Astragali, 22~24 parts of pseudo-ginseng, 18~21 parts of winters insult
Grass and 12~16 parts of radix paeoniae rubrathe, are obtained by ultrasonic vibration, supercritical carbon dioxide extracting.
4. absorbable medical suture according to claim 3, it is characterised in that the supercritical carbon dioxide extracting bar
Part is：45~50 DEG C of temperature, 20~22MPa of extracting pressure, 21~23kg/h of carbon dioxide flow, 1~2h of extraction time.
5. a kind of preparation method of absorbable medical suture as claimed in claim 1, it is characterised in that comprise the following steps：
（1）Each component is weighed according to parts by weight；
（2）PGA, polyglutamic acid, extract solution, distilled water and mannitol are well mixed, are put into container, nitrogen is used
Protection, 1~2h of stirring preheating at 70~75 DEG C；
（3）After preheating terminates, polycaprolactone, anisaldehyde, acetic anhydride and potassium peroxydisulfate, rise temperature to 105~110 are added
DEG C, 7~9h is reacted, room temperature is cooled to, is freeze-dried, freeze-drying thing is collected；
（4）Freeze-drying thing is put into melt spinning machine, design temperature is 190~230 DEG C, carries out melting deaeration, then through 8~
10mm SPINNERETS FOR MELT SPINNING spinnerets, the spinneret fiber water-bath of gained is stretched, finished fiber is obtained, and finished fiber is gone out through ultraviolet
Bacterium lamp carries out sterilizing, you can obtain absorbable multifunctional suture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710424733.1A CN107185027A (en) | 2017-06-07 | 2017-06-07 | A kind of absorbable medical suture and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107903641A (en) * | 2017-10-31 | 2018-04-13 | 常州市顺旭商贸有限公司 | A kind of preparation method of edible fruit-vegetable plastic wrap |
| CN108842479A (en) * | 2018-06-02 | 2018-11-20 | 叶建民 | A kind of preparation method of environmental protection type crucian seed levelling agent |
| CN108853563A (en) * | 2018-06-26 | 2018-11-23 | 常州市蒽盗钟情生物科技有限公司 | A kind of preparation method of absorbable suture |
| CN109735906A (en) * | 2018-12-18 | 2019-05-10 | 仪征威英化纤有限公司 | A kind of production technology of perspiration Regenerated Polyester Staple Fiber dimension |
| CN109770982A (en) * | 2019-02-20 | 2019-05-21 | 东华大学 | A kind of hollow porous part absorbable suture and preparation method |
| CN113796904A (en) * | 2021-10-08 | 2021-12-17 | 西北工业大学 | Drug-loaded high-strength medical suture and using method thereof |
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| EP2567714A1 (en) * | 2011-09-07 | 2013-03-13 | Aesculap AG | Flocked surgical suture and methods for the production thereof |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105963763A (en) * | 2016-04-20 | 2016-09-28 | 苏州蔻美新材料有限公司 | Medical suture and preparation method thereof |
| CN105963764A (en) * | 2016-06-21 | 2016-09-28 | 林春梅 | Anti-infection and high-strength medical absorbable suture and preparation method thereof |
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| EP2567714A1 (en) * | 2011-09-07 | 2013-03-13 | Aesculap AG | Flocked surgical suture and methods for the production thereof |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105963763A (en) * | 2016-04-20 | 2016-09-28 | 苏州蔻美新材料有限公司 | Medical suture and preparation method thereof |
| CN105963764A (en) * | 2016-06-21 | 2016-09-28 | 林春梅 | Anti-infection and high-strength medical absorbable suture and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107903641A (en) * | 2017-10-31 | 2018-04-13 | 常州市顺旭商贸有限公司 | A kind of preparation method of edible fruit-vegetable plastic wrap |
| CN108842479A (en) * | 2018-06-02 | 2018-11-20 | 叶建民 | A kind of preparation method of environmental protection type crucian seed levelling agent |
| CN108853563A (en) * | 2018-06-26 | 2018-11-23 | 常州市蒽盗钟情生物科技有限公司 | A kind of preparation method of absorbable suture |
| CN109735906A (en) * | 2018-12-18 | 2019-05-10 | 仪征威英化纤有限公司 | A kind of production technology of perspiration Regenerated Polyester Staple Fiber dimension |
| CN109770982A (en) * | 2019-02-20 | 2019-05-21 | 东华大学 | A kind of hollow porous part absorbable suture and preparation method |
| CN113796904A (en) * | 2021-10-08 | 2021-12-17 | 西北工业大学 | Drug-loaded high-strength medical suture and using method thereof |
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