CN107159901A - A kind of magnetic alloy nanosphere body and the method for cube controllable preparation - Google Patents
A kind of magnetic alloy nanosphere body and the method for cube controllable preparation Download PDFInfo
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- CN107159901A CN107159901A CN201710327267.5A CN201710327267A CN107159901A CN 107159901 A CN107159901 A CN 107159901A CN 201710327267 A CN201710327267 A CN 201710327267A CN 107159901 A CN107159901 A CN 107159901A
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- magnetic alloy
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- acac
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- B22F9/00—Making metallic powder or suspensions thereof
- B22F9/16—Making metallic powder or suspensions thereof using chemical processes
- B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
- B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
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- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
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- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
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- B22F1/0553—Complex form nanoparticles, e.g. prism, pyramid, octahedron
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B22F2201/00—Treatment under specific atmosphere
- B22F2201/02—Nitrogen
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
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Abstract
The invention discloses a kind of magnetic alloy nanosphere body and the method for cube controllable preparation.The present invention is by first by Fe (acac)3、Mn(acac)2With Zn (acac)2Be dissolved in organic stabilizer, then under inert gas shielding pass through weak reductant heating means synthesis containing iron, manganese, zinc and oxygen element magnetic alloy nanometer son；In heating process, particle morphology develops into alloy cube with extending heating time from alloy spheroid.The beneficial effects of the present invention are：Application with magnetic alloy material in fields such as bio-separation, drug deliveries is more and more wider, and particle size, composition, the controllability synthetic method of pattern provide feasibility preferably to expand its application in more many body system.
Description
Technical field
The present invention relates to technical field of nanometer material preparation, specifically, be a kind of magnetic alloy nanosphere body with cube
The method of body controllable preparation.
Background technology
Development functional nanoparticles are used to realize that the research of biomolecule intervention and detection is more and more.Such as, some light
It is both that make use of nano material so as to the important tool as biochemical research to learn probe, and it, which is optimized, it is possessed Gao Ling
Sensitivity and very strong spectral fingerprint characteristic.Such instrument can Molecular Detection, bacterium and cell imaging, organizational diagnosis and
Applied in the multi-level chemistry and biology field such as bio-imaging.But, how optical probe is improving detection signal
Reappearance, how to develop in terms of the biocompatibility of multi-functional combined probe and also there are many problems.
In recent years, biomolecule conjugation has been carried out to nano-particle or magnetic nano-particle, become with uniqueness
The Nanoparticle labeling thing of biocompatibility, and it is used as the probe in field of bioanalysis and carrier is subject to the people's attention.
And the magnetic nano-particle synthetic method continued to develop can realize magnet tuning, and volume can be controlled at several nanometers to tens
In individual nanometer range, this is closely sized to or isometric less than virus, protein molecule and gene；In addition, with superparamagnetism
Magnetic nano-particle, can be regulated and controled by external magnetic field, so formation and separation to immune structure and to tumor tissues
Site-specific delivery of drugs provides possibility.
Although however, existing many research workers were carried out to the synthesis of metal magnetic nano-particle, sign and application
Research, but the size for particle, shape, the understanding of the accurate control of composition and surface property also lack very much, and chi
Very little and morphology controllable, the preparation method of the adjustable magnetic alloy nano-particle of magnetic are not set up.
The content of the invention
For above technical problem, it can control it is an object of the invention to provide a kind of magnetic alloy nanosphere body and cube
Standby method, this method is simply controllable, and obtained nano-particles size is between 1~20 nanometer.
To achieve these goals, the technical solution adopted by the present invention is as follows.
The present invention provides a kind of magnetic alloy nanosphere body and the method for cube controllable preparation, first by Fe (acac)3、Mn
(acac)2With Zn (acac)2It is dissolved in organic stabilizer, then closed under inert gas shielding by weak reductant heating means
Into the magnetic alloy nano-particle containing iron, manganese, zinc and oxygen element；In weak reductant heating process, extending heating time, particle
Pattern develops into cube from spheroid；Wherein：The organic stabilizer is the benzyl ethereal solution of oleic acid and oleyl amine；Weak reductant is
Oleyl amine in organic stabilizer.
In the present invention, in organic stabilizer, oleic acid and oleyl amine mol ratio are 1：1；Heating-up temperature is 280 ± 2 DEG C, during heating
Between be 20~80 minutes.
In the present invention, when the heat time is 20~35 minutes, magnetic alloy nano-particle is spherical in shape；Heat time be 35~
At 80 minutes, magnetic alloy nano-particle is in cubic type.
In the present invention, inert gas is nitrogen or argon gas.
In the present invention, weak reductant is simultaneously as the oleyl amine of component in stabilizer.
In the present invention, described magnetic alloy nano-particles size is between 1~20 nanometer.
In the present invention, Fe (acac)3、Mn(acac)2With Zn (acac)2Mol ratio be 4:1:1.
In the present invention, oleic acid, oleyl amine and Fe (acac)3Three's mol ratio be:8:8:(1~2).
Compared to the prior art, the beneficial effects of the present invention are：The inventive method can realize magnetic alloy nanosphere
Body and cube controllable preparation：Application with magnetic alloy material in fields such as bio-separation, drug deliveries is more and more wider, grain
Sub- size, composition, the controllability synthetic method of pattern provide feasibility preferably to expand its application in more many body system.
Brief description of the drawings
Fig. 1 for embodiment 1~7 nanometers of magnetic alloy nanosphere body electron microscope.
Fig. 2 for embodiment 2~15 nanometers of magnetic alloy nanosphere body electron microscope.
Embodiment
Technical scheme is further described with reference to specific embodiment, but the present invention is not limited to
Following embodiments.
Various raw materials used, are commercially available unless otherwise specified in various embodiments of the present invention.
Embodiment 1
(~7 nanometers) controllable preparation of magnetic alloy nanosphere body and sign：
(1) preparation of reactant, stabilizer
Fe(acac)3、Mn(acac)2、Zn(acac)2Anabolic reaction agent, three's consumption be followed successively by 2.40 mMs, 0.60
MM, 0.60 mM；In addition, the benzyl ether solvents of 12.0 mMs of oleic acid and 12.0 mMs of oleyl amine at 80 milliliters
In be mixed into stabilizer, under inert gas, reactant and stabilizer are stirred mixing in flask.
(2) the heating building-up process of magnetic alloy particle
Above-mentioned mixed liquor is heated using heater, under inert gas, is risen with 3 DEG C per minute of speed and added
Hot temperature is until 280 DEG C.From the point of view of the result of test of many times：Particle morphology is different because of heating duration difference, 20~35 minutes
Alloy spheroid can be obtained；Alloy cube was then obtained higher than 35 minutes；Higher than 80 minutes, then cube pattern tended to be random.Cause
This, reaches after 280 DEG C of target temperature, a length of 32 minutes when maintaining to heat.
(3) the final pattern and size of magnetic alloy particle
Magnetic particle is shape characteristic nanosphere body as obtained by ESEM (Fig. 1) determines synthesis, and average grain diameter is 7.3
± 0.8 nanometer.
(4) composition of magnetic alloy particle
Using x-ray photoelectron power spectrum (XPS) technical Analysis Mn 2p, Zn 2p, Fe 2p and determine magnetic alloy particle
Final composition (%) is Mn：22.1、Zn：16.4、Fe：61.4.
Embodiment 2
(~15 nanometers) controllable preparation of magnetic alloy nanocube and sign：
(1) preparation of reactant, stabilizer
Fe(acac)3、Mn(acac)2、Zn(acac)2Anabolic reaction agent, three's consumption is followed successively by：6.0 mMs, 1.5 millis
Mole, 1.5 mMs；In addition, 30 mMs of oleic acid and 30 mMs of oleyl amine are mixed in 200 milliliters of benzyl ether solvents
Into stabilizer, under inert gas, reactant and stabilizer are stirred mixing in flask.
(2) the heating building-up process of magnetic alloy particle
Above-mentioned mixed liquor is heated using heater, under inert gas, is risen with 4 DEG C per minute of speed and added
Hot temperature is until 281 DEG C.From the point of view of the result of test of many times：Particle morphology is different because of heating duration difference, 20~35 minutes
Alloy spheroid can be obtained；Alloy cube was then obtained higher than 35 minutes；Higher than 80 minutes, then cube pattern tended to be random.Cause
This, reaches after 281 DEG C of target temperature, a length of 65 minutes when maintaining to heat.
(3) the final pattern and size of magnetic alloy particle
Magnetic particle is shape characteristic nanocube as obtained by ESEM (Fig. 2) determines synthesis, and average grain diameter is
15.6 ± 1.1 nanometers.
(4) composition of magnetic alloy particle
Using x-ray photoelectron power spectrum (XPS) technical Analysis Mn 2p, Zn 2p, Fe 2p and determine magnetic alloy particle
Final composition (%) is Mn：20.8、Zn：15.9、Fe：63.2.
Claims (8)
1. a kind of magnetic alloy nanosphere body and the method for cube controllable preparation, it is characterised in that first by Fe (acac)3、Mn
(acac)2With Zn (acac)2It is dissolved in organic stabilizer, then closed under inert gas shielding by weak reductant heating means
Into the magnetic alloy nano-particle containing iron, manganese, zinc and oxygen element；In weak reductant heating process, extending heating time, particle
Pattern develops into cube from spheroid；Wherein：The organic stabilizer is the benzyl ethereal solution of oleic acid and oleyl amine；Weak reductant is
Oleyl amine in organic stabilizer.
2. magnetic alloy nanosphere body according to claim 1 and the method for cube controllable preparation, it is characterised in that have
In machine stabilizer, oleic acid and oleyl amine mol ratio are 1：1；Heating-up temperature is 280 ± 2 DEG C, and the heat time is 20~80 minutes.
3. magnetic alloy nanosphere body according to claim 2 and the method for cube controllable preparation, it is characterised in that plus
When hot, heating rate is 3~6 DEG C per minute.
4. magnetic alloy nanosphere body according to claim 2 and the method for cube controllable preparation, it is characterised in that plus
When the hot time is 20~35 minutes, magnetic alloy nano-particle is spherical in shape；When heat time is 35~80 minutes, magnetic alloy is received
Rice corpuscles is in cubic type.
5. magnetic alloy nanosphere body according to claim 1 and the method for cube controllable preparation, it is characterised in that lazy
Property gas be nitrogen or argon gas.
6. magnetic alloy nanosphere body according to claim 1 and the method for cube controllable preparation, it is characterised in that institute
The magnetic alloy nano-particles size stated is between 1~20 nanometer.
7. magnetic alloy nanosphere body according to claim 1 and the method for cube controllable preparation, it is characterised in that Fe
(acac)3、Mn(acac)2With Zn (acac)2Mol ratio be 4:1:1.
8. magnetic alloy nanosphere body according to claim 1 and the method for cube controllable preparation, it is characterised in that oil
Acid, oleyl amine and Fe (acac)3The mol ratio of three is 8:8:(1~2).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108806960A (en) * | 2018-04-24 | 2018-11-13 | 沈阳工业大学 | A kind of liquid phase chemical combination method preparing Nd-Fe-B permanent magnetic nano-particle |
| CN108856729A (en) * | 2018-07-16 | 2018-11-23 | 东北大学 | The nanometer grain preparation method of the simple substance of Ferrious material or its binary, ternary alloy three-partalloy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101774027A (en) * | 2010-03-15 | 2010-07-14 | 北京化工大学 | Method for preparing nano-magnetic alloy wave-absorbing material |
| CN101817088A (en) * | 2009-02-27 | 2010-09-01 | 天津商业大学 | Preparation method of Pt-Ni alloy nano particle and colloidal dispersion system thereof |
| CN102744419A (en) * | 2012-06-20 | 2012-10-24 | 中国科学院宁波材料技术与工程研究所 | Morphology control method of magnetic nanometer particles |
| CN103192086A (en) * | 2012-01-10 | 2013-07-10 | 中国科学院宁波材料技术与工程研究所 | Preparation method for controllable duplex metal alloy nano particle |
| CN103667887A (en) * | 2013-12-25 | 2014-03-26 | 南京航空航天大学 | Preparation method of FeCo alloy absorbing material |
-
2017
- 2017-05-10 CN CN201710327267.5A patent/CN107159901A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817088A (en) * | 2009-02-27 | 2010-09-01 | 天津商业大学 | Preparation method of Pt-Ni alloy nano particle and colloidal dispersion system thereof |
| CN101774027A (en) * | 2010-03-15 | 2010-07-14 | 北京化工大学 | Method for preparing nano-magnetic alloy wave-absorbing material |
| CN103192086A (en) * | 2012-01-10 | 2013-07-10 | 中国科学院宁波材料技术与工程研究所 | Preparation method for controllable duplex metal alloy nano particle |
| CN102744419A (en) * | 2012-06-20 | 2012-10-24 | 中国科学院宁波材料技术与工程研究所 | Morphology control method of magnetic nanometer particles |
| CN103667887A (en) * | 2013-12-25 | 2014-03-26 | 南京航空航天大学 | Preparation method of FeCo alloy absorbing material |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108806960A (en) * | 2018-04-24 | 2018-11-13 | 沈阳工业大学 | A kind of liquid phase chemical combination method preparing Nd-Fe-B permanent magnetic nano-particle |
| CN108806960B (en) * | 2018-04-24 | 2020-07-17 | 沈阳工业大学 | Liquid phase combination method for preparing neodymium iron boron permanent magnetic nano particles |
| CN108856729A (en) * | 2018-07-16 | 2018-11-23 | 东北大学 | The nanometer grain preparation method of the simple substance of Ferrious material or its binary, ternary alloy three-partalloy |
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Application publication date: 20170915 |