CN107158580A - A kind of image-guided method and device - Google Patents
A kind of image-guided method and device Download PDFInfo
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Abstract
The invention discloses a kind of image-guided method and device, described device includes：For controlling linear accelerator to produce the linear accelerator console of pulsed X-ray；Ultrasonic probe for receiving the photoacoustic signal that the tissue of tumor locus in Patients During Radiotherapy is produced；The locating support visited for fixed ultrasound；Pre-amplification circuit for amplifying photoacoustic signal；Photoacoustic signal acquisition component for gathering photoacoustic signal；For controlling photoacoustic signal acquisition component in the synchronous trigger circuit of the photoacoustic signal of scheduled time collection pre-amplification circuit；For receiving the data of photoacoustic signal acquisition component collection, and the data of collection are filtered, denoising, obtain reflecting the computer of the photoacoustic image that x-ray dose is distributed in tissue by photoacoustic imaging algorithm.The image-guided device of the present invention can guide equipment as the real-time imaging of radiotherapy, be a kind of economic, noninvasive, radiationless image-guided technology, described device can provide dosage termed image-guided radiotherapy.
Description
Technical field
The present invention relates to image-guided technical field, and in particular to a kind of image-guided method and device.
Background technology
Photoacoustic imaging（Photoacoustic Imaging, PAI）Be a kind of non-invasive developed in recent years and
The new bio medical imaging procedure of unionized formula, when pulsed laser irradiation is arrived（Thermal acoustic imaging is then refered in particular to radio frequency
Pulse laser is irradiated）When in biological tissue, the light absorbs domain of tissue will produce ultrasonic signal, and we claim this to be excited by light
The ultrasonic signal of generation is photoacoustic signal.The photoacoustic signal that biological tissue produces carries the light absorption characteristics information of tissue, leads to
The light absorbs distributed image in tissue can be reconstructed by crossing detection photoacoustic signal.Photoacoustic imaging combines high in pure optical texture imaging
The advantage of deep penetration characteristic, can obtain the organization chart of high-resolution and high-contrast in resolution characteristic and the imaging of pure ultrasonic tissue
Picture, avoids the influence of light scattering from principle, breaches high resolution optical imaging depth " soft limiting "（~1 mm）, can be real
Existing 50 mm deep layer in vivo tissue imaging.
The elementary object of radiotherapy is to greatest extent to focus on X-ray in lesion region, kills tumour cell, and
Make normal surrounding tissue and organ few by or from unnecessary irradiation, that is, destroy malignant tumour and preserve normal structure.Put
Penetrate the success for the treatment of and be unsuccessfully largely determined by the accuracy of target dose.Treatment is designed into from Patient treatment plan
The links of implementation process can all produce certain error；Receive to fill all the time during several all interval procedures by a definite date in patient
Expire parameter, the location and shape of body treatment site may all change, positioned at internal target region shape and it with week
Enclosing the position relationship of organ can also change, and these uncertain factors influence the distribution of the actual exposure dose of tumour, cause
Tumour miss the target or jeopardize organ damage increase.
To improve radiotherapy precision, image-guided radiotherapy image technique arises at the historic moment.Image-guided radiotherapy technology is also known as image
Guided radiation treatment, is to be combined theratron with image documentation equipment, in radiation therapy process, collection area for treatment two dimension
Or 3-D view, using these image informations, this time treatment and follow-up treatment plan are instructed, to reach the mesh of accurate radiotherapy
, the present invention is only a kind of method of imaging, is not belonging to medical diagnosis treatment method.
There is the image-guided technology of kinds of tumors radiotherapy at present, various image-guided modes respectively have its advantage and disadvantage, at first
The radiotherapy apparatus entered referred to as opens up nurse knife when number TomoTherapy systems, and the system is the combination of linear accelerator and spiral CT,
Under CT guiding, malignant tumor patient is carried out efficiently, accurately to treat.Spiral CT is combined with linear accelerator, in machine
The upper difficulty of tool is larger, and manufacture and maintenance cost are very high；This equipment penetrates human body group according to what helical CT device was detected
X-ray dose after knitting is counter to push away target area roentgen dose X, and error is larger；In addition, the reality for the image-guided technology of radiotherapy based on CT of being somebody's turn to do
Shi Xing, resolution ratio have much room for improvement；Finally, the image information of the technical limit spacing is unable to the function information of response organization.Electronics launched field
The image-guided system that image-guided system or X-ray take the photograph piece is difficult to detect that the relative form of soft tissue in Patients During Radiotherapy becomes
Change, navigational figure can not reflect target area x-ray dose distribution, have much room for improvement without real-time, the resolution ratio of image.Electronics
Portal imaging guiding system, X ray image guiding system, the image-guided system based on CT separated with linear accelerator, must
Extra radiation can so be increased to patient, this kind of image guidance mode adds the risk of radiation-sensitive tissue and organ damage.
In addition, different soft tissue structures are little to the attenuation by absorption difference of high-energy ray, cause navigational figure contrast low and relatively obscure.
Ultrasonic guidance is a kind of economic, noninvasive, radiationless image-guided technology, but ultrasonic imaging depends on the acoustic impedance of biological tissue
Difference, image resolution ratio is low, and the X-ray absorption distribution that traditional ultrasonic image can not reflect inside biological tissue.
That is, currently without a kind of image processing apparatus and method can obtain it is clear, accurately reflect biological tissue
The image of internal X-ray absorption distribution, the not high phenomenon of the image generally existing resolution ratio that obtains in the prior art.
Therefore, prior art has yet to be improved and developed.
The content of the invention
The technical problem to be solved in the present invention is, for the drawbacks described above of prior art, there is provided a kind of image-guided side
Method and device, it is intended to the photoacoustic signal that inspires of pulse Formula X ray when gathering radiotherapy by image-guided device, using optoacoustic into
As algorithm obtains the photoacoustic image that x-ray dose is distributed in reflection tissue so that the image that x-ray dose is distributed in tissue is more
And image resolution ratio is high clearly, accurately,.The image-guided device can guide equipment as the real-time imaging of radiotherapy, be
A kind of economic, noninvasive, radiationless image-guided technology, described device can provide dosage termed image-guided radiotherapy, be conducive to reality
Existing accurate radiotherapy.
The technical proposal for solving the technical problem of the invention is as follows：
A kind of image-guided device, wherein, described device includes：
Linear accelerator console, for controlling linear accelerator to produce pulsed X-ray；
Linear accelerator, produces the tissue of pulsed x-ray irradiation tumor locus under linear accelerator console control,
Radiation exposed tissue produces photoacoustic signal simultaneously；
Ultrasonic probe, for receiving the photoacoustic signal that the tissue of tumor locus in Patients During Radiotherapy is produced；
Locating support, for fixing ultrasonic probe, and makes ultrasonic probe be contacted with tissue surface to be detected；
Pre-amplification circuit, the photoacoustic signal that tumor locus is produced is received for amplifying ultrasonic probe；
Photoacoustic signal acquisition component, for gathering the photoacoustic signal of tumor locus generation and being saved in computer；
Synchronous trigger circuit, for controlling photoacoustic signal acquisition component to gather the optoacoustic letter of pre-amplification circuit in the scheduled time
Number；
Computer, for receiving the data of photoacoustic signal acquisition component collection, and the data of collection is filtered, at denoising
Reason, obtains reflecting the photoacoustic image that x-ray dose is distributed in tissue by photoacoustic imaging algorithm；
The locating support is connected with ultrasonic probe, for fixing ultrasonic probe；The linear accelerator console controls straight line
Accelerator is produced after the pulsed X-ray of the tissue of irradiation tumor locus, what the tissue that ultrasonic probe receives tumor locus was produced
Photoacoustic signal；The pre-amplification circuit is connected with ultrasonic probe, the optoacoustic letter that pre-amplification circuit amplification ultrasonic probe is received
Number；The photoacoustic signal acquisition component is connected with pre-amplification circuit, and the input of the synchronous trigger circuit is connected by straight line
The irradiance pulse signal that Accelerator control platform is drawn, output end is connected with photoacoustic signal acquisition component, and the photoacoustic signal is adopted
Collection component is connected with computer, and synchronous trigger circuit controls photoacoustic signal acquisition component to gather pre-amplification circuit in the scheduled time
Photoacoustic signal, and be sent to computer, computer is received after the data of photoacoustic signal acquisition component collection, by the data of collection
Be filtered, denoising, using photoacoustic imaging algorithm generate reflection tissue in x-ray dose be distributed photoacoustic image.
Described image-guided method, wherein, the ultrasonic probe is that multiple linear array probe or annular array are visited
Head；Bandwidth 20KHz~10MHz of the ultrasonic probe.
Described image-guided method, wherein, the locating support on radiotherapy localization support by opening one and ultrasound
Ultrasonic probe is fixed in the hole for form fit of popping one's head in, and probe is close to tissue surface to be detected.
Described image-guided method, wherein, the input of the synchronous trigger circuit is connected by linear accelerator control
The irradiance pulse signal that platform is drawn, the output end connection photoacoustic signal acquisition component of synchronous trigger circuit, triggering photoacoustic signal is adopted
Collect the synchronous acquisition that component carries out photoacoustic signal.
A kind of image-guided method, wherein, comprise the following steps：
Step A, the group by linear accelerator console control linear accelerator generation pulsed x-ray irradiation tumor locus
Knit, the tissue resorption pulsed X-ray produces photoacoustic signal；
Step B, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, and optoacoustic letter is input to after amplifying through pre-amplification circuit
Number acquisition component, synchronous trigger circuit triggering photoacoustic signal collection, the photoacoustic signal acquisition component is by the data storage of collection
Into computer；
The data of collection are filtered by step C, computer, denoising, and X in reflection tissue is obtained by photoacoustic imaging algorithm
The photoacoustic image of roentgen dose X distribution.
Described image-guided method, wherein, also include before the step A：
Ultrasonic probe, is fixed on locating support by step S in advance, and is closely connect by couplant with tumor locus skin
Touch.
Described image-guided method, wherein, the couplant is the ultrasonic coupling agent of Clinical practice.
Described image-guided method, wherein, the step A is specifically included：
Step A1, linear accelerator console produce certain ray agent according to the radiotherapy planning control linear accelerator pre-established
Amount irradiates the tissue of tumor locus with field size pulsed X-ray；
Photoacoustic signal is produced after step A2, the tissue resorption pulsed X-ray of tumor locus.
Described image-guided method, wherein, the step B is specifically included：
Step B1, pre-set the irradiance pulse that the input connection of synchronous trigger circuit drawn by linear accelerator console and believe
Number, the output end connection photoacoustic signal acquisition component of synchronous trigger circuit；
Step B2, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, meanwhile, optoacoustic is triggered by synchronous trigger circuit and believed
Number acquisition component carries out the synchronous acquisition of photoacoustic signal；
Step B3, the photoacoustic signal are input to photoacoustic signal acquisition component, the optoacoustic letter after amplifying through pre-amplification circuit
Number acquisition component is by the data Cun Chudao computers of collection.
Described image-guided method, wherein, the step C is specifically included：
Step C1, self-editing data acquisition control program and photoacoustic image reconstruction algorithm are set in computer in advance；
Step C2, when computer receive photoacoustic signal acquisition component collection data after, the data of collection are filtered, gone
Make an uproar processing；
Step C3, by the data after processing by photoacoustic imaging algorithm obtain reflect tissue in x-ray dose be distributed optoacoustic figure
Picture.
Beneficial effects of the present invention：A kind of image-guided method and device that the present invention is provided, described device includes：For
Linear accelerator is controlled to produce the linear accelerator console of pulsed X-ray；For receiving tumor locus in Patients During Radiotherapy
Organize the ultrasonic probe of photoacoustic signal produced；The locating support visited for fixed ultrasound；For amplifying the preposition of photoacoustic signal
Amplifying circuit；Photoacoustic signal acquisition component for gathering photoacoustic signal；For controlling photoacoustic signal acquisition component in pre- timing
Between collection pre-amplification circuit photoacoustic signal synchronous trigger circuit；Number for receiving the collection of photoacoustic signal acquisition component
According to, and the data of collection are filtered, denoising, x-ray dose point in reflection tissue is obtained by photoacoustic imaging algorithm
The computer of the photoacoustic image of cloth.
The photoacoustic signal that pulse Formula X ray is inspired when the present invention gathers radiotherapy by image-guided device, using optoacoustic
Imaging algorithm obtains the photoacoustic image that x-ray dose is distributed in reflection tissue so that the image that x-ray dose is distributed in tissue is more
Plus it is clear, accurate, image resolution ratio is high.The image-guided device can guide equipment as the real-time imaging of radiotherapy, be one
Economic, noninvasive, radiationless image-guided technology is planted, described device can provide dosage termed image-guided radiotherapy, be advantageously implemented
Accurate radiotherapy..
Brief description of the drawings
Fig. 1 is the functional schematic block diagram of the preferred embodiment of image-guided device of the invention.
Fig. 2 is the flow chart of the preferred embodiment of image-guided method of the invention.
Fig. 3 is the schematic diagram of the photoacoustic signal of collection lead in image-guided method of the invention.
Embodiment
To make the objects, technical solutions and advantages of the present invention clearer, clear and definite, develop simultaneously embodiment pair referring to the drawings
The present invention is further described.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and without
It is of the invention in limiting.
Fig. 1 described in present pre-ferred embodiments is the principle of work and power frame of the preferred embodiment of image-guided device of the invention
Figure, as shown in figure 1, described device includes：
Linear accelerator console 10, for controlling linear accelerator 20 to produce pulsed X-ray；
Linear accelerator 20, pulsed x-ray irradiation tumor locus is produced under the linear accelerator console 10 control
Tissue, while radiation exposed tissue produces photoacoustic signal；
Ultrasonic probe 30, for receiving the photoacoustic signal that the tissue of tumor locus in Patients During Radiotherapy is produced；
Locating support 40, for fixing ultrasonic probe 30, and makes ultrasonic probe 30 be contacted with tissue surface to be detected；
Pre-amplification circuit 50, the photoacoustic signal that tumor locus is produced is received for amplifying ultrasonic probe 30；
Photoacoustic signal acquisition component 60, for gathering the photoacoustic signal of tumor locus generation and being saved in computer 80；
Synchronous trigger circuit 70, for controlling photoacoustic signal acquisition component 60 to gather the light of pre-amplification circuit 50 in the scheduled time
Acoustical signal；
Computer 80, for receiving the data of the collection of photoacoustic signal acquisition component 60, and the data of collection are filtered, denoising
Processing, obtains reflecting the photoacoustic image that x-ray dose is distributed in tissue by photoacoustic imaging algorithm；
The locating support 40 is connected with ultrasonic probe 30, for fixing ultrasonic probe 30；The linear accelerator console 10
Linear accelerator 20 is controlled to produce after the pulsed X-ray of the tissue of irradiation tumor locus, ultrasonic probe 30 receives tumor locus
Tissue produce photoacoustic signal；The pre-amplification circuit 50 is connected with ultrasonic probe 30, and the amplification of pre-amplification circuit 50 is super
The photoacoustic signal that sonic probe 30 is received；The photoacoustic signal acquisition component 60 is connected with pre-amplification circuit 50, and the synchronization is touched
The irradiance pulse signal that the input connection of Power Generation Road 70 is drawn by linear accelerator console 10, output end is adopted with photoacoustic signal
Collection component 60 is connected, and the photoacoustic signal acquisition component 60 is connected with computer 80, the control optoacoustic letter of synchronous trigger circuit 70
Number acquisition component 60 gathers the photoacoustic signal of pre-amplification circuit 50 in the scheduled time, and is sent to computer 80, computer 80
After the data for receiving the collection of photoacoustic signal acquisition component 60, the data of collection are filtered, denoising, using photoacoustic imaging
The photoacoustic image that x-ray dose is distributed in algorithm generation reflection tissue.
Described image-guided device, wherein, the ultrasonic probe 30 is multiple linear array probe or annular array
Probe；Bandwidth 20KHz~10MHz of the ultrasonic probe 30.
Described image-guided device, wherein, the locating support 40 on radiotherapy localization support by opening one with surpassing
Ultrasonic probe 30 is fixed in the hole of the form fit of sonic probe 30, and ultrasonic probe 30 is close to tissue surface to be detected.
Described image-guided device, wherein, the input of the synchronous trigger circuit 70 is connected by linear accelerator control
The irradiance pulse signal that platform 10 processed is drawn, the output end connection photoacoustic signal acquisition component 60 of synchronous trigger circuit 70, triggers light
Acoustical signal acquisition component 60 carries out the synchronous acquisition of photoacoustic signal.
Described image-guided device, wherein, there is self-editing data acquisition control software and optoacoustic in the computer 80
Image reconstruction program.
In addition, the present invention also provides a kind of image-guided method, as shown in Fig. 2 the image-guided method is including following
Step：
Step S100, pass through linear accelerator console and control linear accelerator to produce pulsed x-ray irradiation tumor locus
Tissue, the tissue resorption pulsed X-ray produces photoacoustic signal.
It is preferred that the step S100 comprises the following steps：
Step S101, linear accelerator console produce certain ray according to the radiotherapy planning control linear accelerator pre-established
Dosage irradiates the tissue of tumor locus with field size pulsed X-ray；
Photoacoustic signal is produced after step S102, the tissue resorption pulsed X-ray of tumor locus.
When it is implemented, also including before the step S100：Ultrasonic probe is fixed on locating support in advance, and
It is in close contact with tumor locus skin by couplant；The ultrasonic probe is multiple linear array probe or ring-type battle array
Row probe, is easy to ultrasonic probe to receive the photoacoustic signal of multiple positions, and the ultrasonic probe is only responsible for receiving group in Patients During Radiotherapy
The photoacoustic signal of generation is knitted, transmission signal use, a width of 20KHz~10MHz of band of probe are not done；The locating support can pass through
One is opened on the radiotherapy localization support that Hospitals at Present makes to patient with the hole for form fit of popping one's head in fix ultrasonic probe, and
Probe is set to be close to test serum surface, it is convenient and practical.
Couplant is a kind of water soluble polymer colloid, and it is for excluding the air between probe and testee, making
Ultrasonic wave energy effectively penetrates measured object and reaches effective detection purpose, and heretofore described couplant is the ultrasonic coupling of Clinical practice
Mixture, is a kind of curable product being made up of aqueous high molecular gel of new generation, pH value is neutrality, nontoxic to human body, no
Easily dry, be difficult to become sour, ultrasonoscopy is clear, toughness is suitable, without greasy, pop one's head in and be easy to slide, wettable skin is eliminated
Skin surface air, greasy property is good, it is easy to deploy；, not damaged corrosion-free to ultrasonic probe；Occur in that on the market with sterilization
The ultrasonic coupling agent of sterilizing function, relative to traditional plain edition couplant, for more strict, the applicable model of production environment
Enclose also more extensive.
Step S200, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, and are inputted after amplifying through pre-amplification circuit
To photoacoustic signal acquisition component, synchronous trigger circuit triggering photoacoustic signal collection, the photoacoustic signal acquisition component is by collection
In data Cun Chudao computers.
It is preferred that the step S200 comprises the following steps：
Step S201, the irradiance pulse drawn by linear accelerator console of input connection for pre-setting synchronous trigger circuit
Signal, the output end connection photoacoustic signal acquisition component of synchronous trigger circuit；
Step S202, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, meanwhile, optoacoustic is triggered by synchronous trigger circuit
Signal acquisition component carries out the synchronous acquisition of photoacoustic signal；
Step S203, the photoacoustic signal are input to photoacoustic signal acquisition component, the optoacoustic after amplifying through pre-amplification circuit
Signal acquisition component is by the data Cun Chudao computers of collection.
When it is implemented, linear accelerator console control linear accelerator produces pulsed X-ray, roentgen dose X, penetrate
Wild size etc. is carried out according to radiotherapy planning, and the input of synchronous trigger circuit connects the irradiation drawn by linear accelerator console
Pulse signal, the output end connection photoacoustic signal acquisition component of synchronous trigger circuit, triggering photoacoustic signal acquisition component carries out light
The synchronous acquisition of acoustical signal.The effect of synchronous trigger circuit is when control photoacoustic signal acquisition component is carrying out photoacoustic signal and adopt
Collection.Due to linear accelerator console produce be pulsed X-ray signal, therefore, to unify determination is in respective pulses
Rising edge start collection photoacoustic signal still the trailing edge of pulse start collection, in addition, which X-ray pulse irradiate
When be acquired, will be controlled by setting synchronous trigger circuit.
The data of collection are filtered by step S300, computer, denoising, are reflected by photoacoustic imaging algorithm
The photoacoustic image that x-ray dose is distributed in tissue.
It is preferred that the step S300 is specifically included：
Step S301, self-editing data acquisition control program and photoacoustic image reconstruction algorithm are set in computer in advance；
Step S302, when computer receive photoacoustic signal acquisition component collection data after, the data of collection are filtered,
Denoising；
Step S303, by the data after processing by photoacoustic imaging algorithm obtain reflect tissue in x-ray dose be distributed optoacoustic
Image
Specifically, when the tissue using the irradiation tumor locus such as pulsed X-ray, high energy electron, neutron and other charged particles
When, tissue resorption light energy and the expansion that heats up, and due to the tissue of the light irradiation tumor locus that uses pulsed, tissue by
To the alternating action process of similar heating cooling, and different tissues are had differences to light absorbs, and photic heat will be produced in tissue
Play ultrasonic signal（Also referred to as photoacoustic signal）, coupled dose of coupling of ultrasonic signal received by ultrasonic probe, and the signal of reception is through preposition
After amplifying circuit amplification, then gathered by multi-channel parallel high-speed data photoacoustic signal acquisition component and store computer, by
Photoacoustic image algorithm for reconstructing（Photoacoustic image algorithm for reconstructing is calculated for the existing photoacoustic imaging based on pulsed laser irradiation in the present invention
Method）The photoacoustic image of organization internal is reconstructed, the image reflects the dosage distributed intelligence of radioactive ray in tissue.
The imaging method and device of the present invention can provide the x-ray dose distributed image in being organized in Patients During Radiotherapy, institute
State that image is pure and fresh, accurate, high resolution.
Methods and apparatus of the present invention has the following advantages that and effect compared with prior art：
1. the X-ray of radiotherapy as the excitation source of photoacoustic imaging, is utilized absorption difference of the different tissues to X-ray by the present invention
The change of tissue characteristics in different and Patients During Radiotherapy, can obtain the photoacoustic image of high-resolution high-contrast, the figure rebuild
Structural information as not only having reacted tissue, also reflects the change of tissue optical property, can provide more tissue letters
Breath.
2. the present invention dexterously using the X-ray of radiotherapy as photoacoustic imaging excitation source, therefore, image of the invention
Bootstrap technique need not introduce extra excitation source, will not give patient's increase ray radiation.
3. what is collected is to be organized in the acoustical signal for receiving and being produced in Patients During Radiotherapy, the image rebuild is that radiotherapy is supervised in real time
Altimetric image, specially utilizes the image-guided process of apparatus of the present invention.
4. the image-guided device in the present invention is gathered in real time by ultrasonic probe, pre-amplification circuit, multi-channel parallel is
The composition such as system and computer, the more existing image-guided system of cost of whole imaging device is low.
5. application photoacoustic image is as the navigational figure of radiotherapy in the treatment, can not only be sensitive detect the small of tumor locus
Change, the imaging that reflection function of organization can also be realized, such as viscoplasticity change, change of cell metabolism function for organizing etc..Cause
This, the photoacoustic image that each radiotherapy is obtained can be for evaluation radiotherapeutic effect.
6. using excitation source of the radiotherapy X-ray as photoacoustic imaging, deeper imaging of tissue, obtained image can be achieved
Information is clearer, accurate.
To cause the image-guided method of the present invention clearer, the present invention is illustrated with a specific embodiment, this
The photoacoustic signal for the lead that embodiment passes through collection illustrate the present invention feasibility and effect.
The present invention provides one and simulates embodiment, as shown in figure 3, the photoacoustic signal image detected under being irradiated for radiotherapy X-ray,
Lead is placed and is loaded with water in the sink, in tank as couplant, immersion type probe（Olympus, V301-SU）It is placed in
In water.
The preamplifier being connected with popping one's head in（Olympus 5662）Multiplication factor is set to 34dB, uses oscillograph
（Tektronix DPO5054）For acquisition system, sample frequency is set to 5MHz.
Linear accelerator model Siemens primus, from this shelves of low energy 6MV, dosage is set to 200MU/min,
The hot spot of X-ray is 10cm*10cm on sample.
Using linear accelerator X-ray pulse signal as synchronous trigger circuit input signal, using trailing edge triggering collection.
The photoacoustic signal collected during to 512 X-ray pulsed irradiation is averaged to improve signal to noise ratio.
In Fig. 3 the signal of this time of 80us ~ 150us be from the photoacoustic signal produced by sample lead, 0 ~ 50us it
Preceding signal is the ambient noises such as electromagnetic interference.
Photoacoustic signal produced by lead is significantly stronger, reflects the distribution of X-ray absorption, is popped one's head according to ring-shaped ultrasonic
It is parallel to receive, the photoacoustic signal under multiple angles will can be detected, and then X-ray pulse spoke can be obtained with light sound algorithm for reconstructing
Photoacoustic image according under.
In summary, the invention provides a kind of image-guided method and device, described device includes：For controlling straight line
Accelerator produces the linear accelerator console of pulsed X-ray；Tissue for receiving tumor locus in Patients During Radiotherapy is produced
Photoacoustic signal ultrasonic probe；The locating support visited for fixed ultrasound；Pre-amplification circuit for amplifying photoacoustic signal；
Photoacoustic signal acquisition component for gathering photoacoustic signal；For controlling photoacoustic signal acquisition component preposition in scheduled time collection
The synchronous trigger circuit of the photoacoustic signal of amplifying circuit；Data for receiving the collection of photoacoustic signal acquisition component, and will collection
Data be filtered, denoising, by photoacoustic imaging algorithm obtain reflect tissue in x-ray dose be distributed photoacoustic image
Computer.The photoacoustic signal that pulse Formula X ray is inspired when the present invention gathers radiotherapy by image-guided device, using optoacoustic
Imaging algorithm obtains the photoacoustic image that x-ray dose is distributed in reflection tissue so that the image that x-ray dose is distributed in tissue is more
Plus it is clear, accurate, image resolution ratio is high.The image-guided device can guide equipment as the real-time imaging of radiotherapy, be one
Economic, noninvasive, radiationless image-guided technology is planted, described device can provide dosage termed image-guided radiotherapy, be advantageously implemented
Accurate radiotherapy.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can
To be improved or converted according to the above description, all these modifications and variations should all belong to the guarantor of appended claims of the present invention
Protect scope.
Claims (10)
1. a kind of image-guided device, it is characterised in that described device includes：
Linear accelerator console, for controlling linear accelerator to produce pulsed X-ray；
Linear accelerator, produces the tissue of pulsed x-ray irradiation tumor locus under linear accelerator console control,
Radiation exposed tissue produces photoacoustic signal simultaneously；
Ultrasonic probe, for receiving the photoacoustic signal that the tissue of tumor locus in Patients During Radiotherapy is produced；
Locating support, for fixing ultrasonic probe, and makes ultrasonic probe be contacted with tissue surface to be detected；
Pre-amplification circuit, the photoacoustic signal that tumor locus is produced is received for amplifying ultrasonic probe；
Photoacoustic signal acquisition component, for gathering the photoacoustic signal of tumor locus generation and being saved in computer；
Synchronous trigger circuit, for controlling photoacoustic signal acquisition component to gather the optoacoustic letter of pre-amplification circuit in the scheduled time
Number；
Computer, for receiving the data of photoacoustic signal acquisition component collection, and the data of collection is filtered, at denoising
Reason, obtains reflecting the photoacoustic image that x-ray dose is distributed in tissue by photoacoustic imaging algorithm；
The locating support is connected with ultrasonic probe, for fixing ultrasonic probe；The linear accelerator console controls straight line
Accelerator is produced after the pulsed X-ray of the tissue of irradiation tumor locus, what the tissue that ultrasonic probe receives tumor locus was produced
Photoacoustic signal；The pre-amplification circuit is connected with ultrasonic probe, the optoacoustic letter that pre-amplification circuit amplification ultrasonic probe is received
Number；The photoacoustic signal acquisition component is connected with pre-amplification circuit, and the input of the synchronous trigger circuit is connected by straight line
The irradiance pulse signal that Accelerator control platform is drawn, output end is connected with photoacoustic signal acquisition component, and the photoacoustic signal is adopted
Collection component is connected with computer, and synchronous trigger circuit controls photoacoustic signal acquisition component to gather pre-amplification circuit in the scheduled time
Photoacoustic signal, and be sent to computer, computer is received after the data of photoacoustic signal acquisition component collection, by the data of collection
Be filtered, denoising, using photoacoustic imaging algorithm generate reflection tissue in x-ray dose be distributed photoacoustic image.
2. image-guided device according to claim 1, it is characterised in that the ultrasonic probe is visited for multiple linear array
Head or annular array probe；Bandwidth 20KHz~10MHz of the ultrasonic probe.
3. image-guided device according to claim 1, it is characterised in that the locating support passes through in radiotherapy localization branch
One is opened on frame with the hole of ultrasonic probe form fit to fix ultrasonic probe, and probe is close to tissue surface to be detected.
4. image-guided device according to claim 1, it is characterised in that the input connection of the synchronous trigger circuit
The irradiance pulse signal drawn by linear accelerator console, the output end connection photoacoustic signal collection group of synchronous trigger circuit
Part, triggering photoacoustic signal acquisition component carries out the synchronous acquisition of photoacoustic signal.
5. a kind of image-guided method as claimed in claim 1, it is characterised in that the described method comprises the following steps：
Step A, the group by linear accelerator console control linear accelerator generation pulsed x-ray irradiation tumor locus
Knit, the tissue resorption pulsed X-ray produces photoacoustic signal；
Step B, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, and optoacoustic letter is input to after amplifying through pre-amplification circuit
Number acquisition component, synchronous trigger circuit triggering photoacoustic signal collection, the photoacoustic signal acquisition component is by the data storage of collection
Into computer；
The data of collection are filtered by step C, computer, denoising, and X in reflection tissue is obtained by photoacoustic imaging algorithm
The photoacoustic image of roentgen dose X distribution.
6. image-guided method according to claim 5, it is characterised in that also include before the step A：
Ultrasonic probe, is fixed on locating support by step S in advance, and is closely connect by couplant with tumor locus skin
Touch.
7. image-guided method according to claim 6, it is characterised in that the couplant is the ultrasonic coupling of Clinical practice
Mixture.
8. image-guided method according to claim 5, it is characterised in that the step A is specifically included：
Step A1, linear accelerator console produce certain ray agent according to the radiotherapy planning control linear accelerator pre-established
Amount irradiates the tissue of tumor locus with field size pulsed X-ray；
Photoacoustic signal is produced after step A2, the tissue resorption pulsed X-ray of tumor locus.
9. image-guided method according to claim 5, it is characterised in that the step B is specifically included：
Step B1, pre-set the irradiance pulse that the input connection of synchronous trigger circuit drawn by linear accelerator console and believe
Number, the output end connection photoacoustic signal acquisition component of synchronous trigger circuit；
Step B2, ultrasonic probe receive the photoacoustic signal that tumor locus is produced, meanwhile, optoacoustic is triggered by synchronous trigger circuit and believed
Number acquisition component carries out the synchronous acquisition of photoacoustic signal；
Step B3, the photoacoustic signal are input to photoacoustic signal acquisition component, the optoacoustic letter after amplifying through pre-amplification circuit
Number acquisition component is by the data Cun Chudao computers of collection.
10. image-guided method according to claim 5, it is characterised in that the step C is specifically included：
Step C1, self-editing data acquisition control program and photoacoustic image reconstruction algorithm are set in computer in advance；
Step C2, when computer receive photoacoustic signal acquisition component collection data after, the data of collection are filtered, gone
Make an uproar processing；
Step C3, by the data after processing by photoacoustic imaging algorithm obtain reflect tissue in x-ray dose be distributed optoacoustic figure
Picture.
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| CN113598719A (en) * | 2021-09-01 | 2021-11-05 | 上海科技大学 | Hardware acceleration method, device and system of photoacoustic reconstruction algorithm |
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| CN110691547A (en) * | 2017-11-28 | 2020-01-14 | 奥里斯医疗有限公司 | Optical coherence tomography system |
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| CN113274654B (en) * | 2021-06-29 | 2024-03-01 | 程明霞 | Tumor and organ position ultrasonic image real-time monitoring system for radiotherapy |
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| CN113598719B (en) * | 2021-09-01 | 2024-06-14 | 上海科技大学 | Hardware acceleration method, device and system of photoacoustic reconstruction algorithm |
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