CN107158059A - Application of the cardio-cerebral refreshing composition in Infant Injury in White Matter medicine caused by preparing treatment and/or preventing chronic cerebral ischemia - Google Patents
Application of the cardio-cerebral refreshing composition in Infant Injury in White Matter medicine caused by preparing treatment and/or preventing chronic cerebral ischemia Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
Abstract
The present invention relates to field of medicaments, and in particular to a kind of application of cardio-cerebral refreshing composition in Infant Injury in White Matter medicine caused by preparing treatment and/or preventing chronic cerebral ischemia.The Chinese medicine composition is main by safflower oil, borneol, vitamin E, vitamin B6It is prepared from for raw material；Its consumption proportion is 390 parts of safflower oil, 3 parts of borneol, 17 parts of vitamin E, vitamin B65 parts.Preparation prepared by current cardio-cerebral refreshing composition is Xinnaoqing soft capsules.Xinnaoqing soft capsules record in《National standard for traditional Chinese medicines compilation》Internal medicine brain system channels and collaterals limbs fascicle, major function is promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, inducing resuscitation of having one's ideas straightened out, the applicating history for having the more than ten years, clinic is usually used in the apoplexy caused by stagnation of blood stasis, apoplex involving the channels and collaterals, hemiplegia, facial paralysis, the illnesss such as chest impediment and cardialgia, cerebral infarction, coronary heart disease, angina pectoris and hyperlipidemia.
Description
Technical field
The invention belongs to field of medicaments, and in particular to cardio-cerebral refreshing composition is preparing treatment and/or preventing chronic cerebral ischemia
Application in caused Infant Injury in White Matter medicine.
Background technology
With social senilization's process, the influence of chronic cerebral ischemia and its relevant disease to society is increasing, and brain is white
Matter damage and the relation of chronic cerebral ischemia are very close, and research thinks that Infant Injury in White Matter is the knot of chronic cerebral ischemia effect mostly
Really.Clinically Infant Injury in White Matter is very common, and dull-witted and amyloid angiopathy etc. all may occur in which diffusivity or multifocal white matter of brain
Damage, therefore the research of Infant Injury in White Matter is gradually valued by people.With deepening continuously for studying Infant Injury in White Matter,
People have been fully recognized that the importance of white matter of brain protection, and propose the concept of full brain protection after cerebral ischemia, i.e., in cerebral ischemia
After generation, protected brain as a complete functive, not only to protect neuron pericaryon, also to protect nerve
Spongiocyte and aixs cylinder；Not only grey matter is protected also to protect white matter of brain.Research to Infant Injury in White Matter thinks, not only inflammation,
Nitric oxide and free radical take part in the spongiocyte that is enriched in the process of Infant Injury in White Matter, white matter of brain, and (including astroglia is thin
Born of the same parents and microglia) inflammatory reaction after cerebral ischemia is also assisted in, therefore research spongiocyte and inflammatory reaction lack in chronic cerebral
Effect after blood in Infant Injury in White Matter, seeks to be effectively protected measure and has great importance.In addition, in recent years about Chinese medicine pair
The research of Infant Injury in White Matter treatment also obtains quick development.Toxicity is small, effect mitigation is lasting, curative effect because it has for Chinese medicine
Reliable and stable the features such as, certain superiority is shown in terms of cranial vascular disease is prevented and treated.
Cardio-cerebral refreshing composition is a kind of Chinese and Western medicine complex composition based on Chinese medicine.Medicine in cardio-cerebral refreshing composition is lived
Property composition be safflower oil, borneol, vitamin E, vitamin B6；Its consumption proportion is 390 parts of safflower oil, 3 parts of borneol, vitamin E
17 parts, 5 parts of vitamin B6.In safflower oil in said composition active component containing a variety of human bodies can not itself synthesis it is required
Unrighted acid.It can not only reduce cholesterol but also can be combined with cholesterol, reduce cholesterol in the heavy of vascular wall
Product, effectively prevents and treats hypertension, hyperlipidemia, atherosclerosis, coronary heart diseases and angina pectoris and apoplexy hemiplegia sequela；Borneol has
There are resuscitation with aromatics, inducing resuscitation effect, nervous function can be recovered, treatment cerebral arteriosclerosis, encephalatrophy, apoplexy sequelae cause
It is clouded in mind, forgetful, dull-witted etc.；Vitamin B6 participates in internal three major nutrient sugar, fat, the metabolism of protein, resists dynamic
Arteries and veins angionecrosis, come off, prevent thrombosis, prevention of arterial atherosis, cerebral thrombus, the generation of miocardial infarction；A large amount of dimensions
Raw element E protects vitamin A, vitamin C and aliphatic acid to exempt from destruction in human body, makes cell complete, and can suppress free radical
Formed, strengthen body immunity, reduce disease, anti-aging.
Xinnaoqing soft capsules record in《National standard for traditional Chinese medicines compilation》Internal medicine brain system channels and collaterals limbs fascicle, major function is
Promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, inducing resuscitation of having one's ideas straightened out, the applicating history for having the more than ten years, clinic be usually used in the apoplexy caused by stagnation of blood stasis, in
The illnesss such as channels and collaterals, hemiplegia, facial paralysis, chest impediment and cardialgia, cerebral infarction, coronary heart disease, angina pectoris and hyperlipidemia.Due to heart and brain
Clear soft capsule has the characteristics of covering adverse drug smell, facilitate patients, therefore is favored deeply by clinical patients.The present invention
Find that cardio-cerebral refreshing composition or preparation have the effect of Infant Injury in White Matter caused by treatment and/or preventing chronic cerebral ischemia first.
The content of the invention
It is an object of the invention to provide the new application of cardio-cerebral refreshing composition.
To achieve these goals, present invention employs following technical scheme：
A kind of cardio-cerebral refreshing composition is in the medicine of Infant Injury in White Matter caused by preparing treatment and/or preventing chronic cerebral ischemia
Application.
In some embodiments, the cardio-cerebral refreshing composition is made up of following raw material：Safflower oil, borneol, vitamin
E, vitamin B6。
In some embodiments, the cardio-cerebral refreshing composition is made up of the raw material of following parts by weight：Safflower oil 390
Part, 3 parts of borneol, 17 parts of vitamin E, vitamin B65 parts.
In some embodiments, the preparation method of the cardio-cerebral refreshing composition comprises the following steps：Take refined safflower oil
130 parts, add 3 parts of borneol, vitamin B65 parts, mix, grinding adds 17 parts of vitamin E and refined safflower oil 260
Part, stir evenly.
In some embodiments, the cardio-cerebral refreshing composition can be prepared into oral formulations with appropriate auxiliary material, can adopt
Prepared with conventional preparation method, for example, Fan Biting《Pharmacy of Chinese materia medica》(Shanghai Science Press December the 1st edition in 1997)
The preparation technology of record, is made pharmaceutically acceptable regular dosage form.
In some embodiments, the oral formulations include oral liquid, tablet, capsule, granule.
To enable above-mentioned formulation to realize, pharmaceutically acceptable auxiliary material need to be added when preparing these formulations, for example：Filling
Agent, disintegrant, lubricant, suspending agent, adhesive, sweetener, flavouring, preservative, matrix etc..Filler includes：It is starch, pre-
Gelling starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose etc.；Disintegrant includes：Starch, pregelatinized starch, crystallite
Cellulose, sodium carboxymethyl starch, PVPP, low-substituted hydroxypropyl cellulose, Ac-Di-Sol etc.；
Lubricant includes：Magnesium stearate, lauryl sodium sulfate, talcum powder, silica etc.；Suspending agent includes：Polyvinylpyrrolidine
Ketone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Adhesive includes, starch slurry, polyvinylpyrrolidone,
Hydroxypropyl methyl cellulose etc.；Sweetener includes：Saccharin sodium, aspartame, sucrose, honey element, enoxolone etc.；Flavouring bag
Include：Sweetener and various essence；Preservative includes：Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzene prick bromine
Ammonium, acetic acid chloroethene are fixed, eucalyptus oil etc.；Matrix includes：PEG6000, PEG4000, insect wax etc..To enable above-mentioned formulation to realize
Pharmacy of Chinese materia medica, need to add pharmaceutically acceptable other auxiliary material (Fan Biting when preparing these formulations《Pharmacy of Chinese materia medica》, Shanghai
The auxiliary material that each formulation is recorded in Science Press December the 1st edition in 1997).
In some embodiments, the preferred soft capsule preparation of the capsule.
The beneficial effects of the present invention are：Cardio-cerebral refreshing composition of the present invention, can mitigate oxygen radical after chronic cerebral ischemia
Infringement；Suppress Activation of Astrocytes hyperplasia；Mitigating myelinoclasis and axonal injury, and then mitigate chronic cerebral ischemia causes
Infant Injury in White Matter, but its to normal cerebral tissue without obvious effect.
Specific embodiment
Following is in conjunction with specific embodiments or the present invention is expanded on further in test example.But these embodiments or test example are only limited
It is used to limit the scope of the present invention in illustrating rather than.Unreceipted specific experiment condition in the following example or test example
Experimental method, generally according to normal condition.
Embodiment 1：Cardio-cerebral refreshing composition
Safflower oil 390g, borneol 3g, vitamin E 17g, vitamin B6 5g
The taste of the above four, takes refined safflower oil 130g, adds borneol 3g, vitamin B65g, is mixed, grinding, adds dimension life
Plain E 17g and refined safflower oil 260g, stir evenly, produce.
Embodiment 2：Xinnaoqing soft capsules
Safflower oil 390g, borneol 3g, vitamin E 17g, vitamin B65g, polyethylene glycol 400 400g, ethyl cellulose
70g, beeswax 50g；
By 130g safflower oils and borneol, vitamin B6And vitamin E, it is ground in the lump；By the safflower oil of surplus with
Ethyl cellulose, beeswax grind, mixed in the lump；The two is mixed again, 100 mesh sieves is crossed, capsule 's content is made；Prepare softgel shell：
First 1000g gelatin is melted, 500g polyvinylpyrrolidones are added in gelatin, are stirred evenly；Content is suppressed with above-mentioned softgel shell
Or dripping is soft capsule, sizing washes ball, dries, produce.
Protective effect of the test example cardio-cerebral refreshing composition to brain of chronic cerebral ischemia in rats white matter lesions
1. experimental animal and packet
Healthy SD rat 80,300~400g, male and female are not limited, and are randomly divided into 4 groups, every group 20.A groups：Sham-operation group
(sham-operation+solvent)；B groups：Sham-operation treatment group (sham-operation+cardio-cerebral refreshing composition+solvent)；C groups：(the operation+molten of operation group
Agent)；D groups：Operative treatment group (operation+cardio-cerebral refreshing composition+solvent).Sham-operation and operation group give 0.5% carboxymethyl cellulose
Plain sodium solution 2ml, sham-operation treatment group and operative treatment group give being uniformly dissolved with 0.5% sodium carboxymethylcellulose for equivalent
Cardio-cerebral refreshing composition (30mg/kg) solution gavage, in postoperative 24h, once a day, continuous 60d.
2. the making of model
Reference literature (De la Torre JC, Fortin T, Park GA, et al.Chronic cerebrovascular
insufficiency induces dementia-like deficits in aged rats.Brain Res.1992；582
(2):Method 186-195) makes chronic cerebral ischemia model.SD rats 10% (W/V) chloraldurate (0.35mL/100g) abdominal cavity
Injecting anesthetic, dorsal position is fixed, the sterilization of throat portion unhairing；Along neck midsection skin, careful separation goes out bilateral common carotid arteries；Point
Not Jie Zha bilateral common carotid arteries distal end and proximal part, from centre cutting, with ensure block arteria carotis communis blood flow；Suture skin
Skin.Rat anus temperature is maintained at 36.5~37.5 DEG C in art.Sham-operation group is not cut outside bilateral common carotid arteries except not ligaturing, remaining
Process is identical with operation group.320,000 u/mL penicillin injection liquid 0.lmL of injection, sew up the incision in otch, carry out chelated iodine sterilization,
The penicillin injection liquid 0.3mL of above-mentioned concentration is injected intraperitoneally, puts back in former environment and raises.
3. specimen collection and detection
1. biochemical indicator：Every group takes rat 10, and broken end takes brain after anesthesia, removes brain stem and cerebellum, through being preced with optic chiasma
Shape is cut, and thickness about 5mm coronal brain tissue, plus physiological saline are taken backward, grinding, is made 10% (w/w) brain tissue homogenate, survey MDA,
SOD absorption photometric values.
2. pathological observation and SABC：Every group takes remaining rat 10, and brain is taken after being fixed with the perfusion of 4% paraformaldehyde is interior
It is put into 4% paraformaldehyde to fix, is cut through coronal at optic chiasma, thickness about 3mm coronal brain tissue is taken backward, routine paraffin wax is embedded,
Brain coronal paraffin slides (thickness is about such as 4 μm) are made, HE dyeing, LFB dyeing and SP immunohistochemical stainings, detection is respectively adopted
Histopathology change, capsula interna and corpus callosum GEAP positive cell numbers, corpus callosum myelin staining and aixs cylinder colour developing situation, and carry out
Compare.
4. statistical analysis
Using the processing data of statistic software SPSS 10.0, statistical method with one-way analysis of variance and carries out two with LSD methods
Two compare.It is significance test standard to take p=0.05.
5. result
(1) influence of the cardio-cerebral refreshing composition to rat MDA and SOD
MDA is the metabolite for the biomembrane unrighted acid peroxidization that oxygen radical triggers, and MDA content can
To reflect the degree of body lipid peroxidating and reflect the level for the oxygen radical for causing lipid peroxidation indirectly.Therefore, pass through
The power of tissue oxygen Free Radical Level and peroxidatic reaction of lipid can be evaluated by determining MDA contents in tissue.SOD is organism
Topmost radicals scavenging enzyme, can be catalyzed O2 —Generation disproportionated reaction, removes the oxygen generated in vivo free by disproportionated reaction
Base, blocks free radical pathologic chain reaction, to protecting cell not played an important role by oxygen free radical injury, by determining SOD
Activity can reflect the ability that tissue removes free radical.
Comparison (X ± S) of the cardio-cerebral refreshing composition of table 1 to rat blood serum SOD vigor and MDA contents
Note：* compared with A groups：P ＜ 0.05；#Compared with C groups：P ＜ 0.05
This experimental result finds that difference is not statistically significant (P between the MDA values and SOD values of A, B group>0.05), show
Cardio-cerebral refreshing composition influences little to the changes of free radicals of normal mice；C groups are compared with A, B group, and MDA values are significantly raised, SOD values
It is decreased obviously, difference is respectively provided with statistical significance (P<0.05).Show that oxygen radical generation increases in chronic cerebral ischemia tissues following MCAO in rats
Many, brain tissue is decreased obviously to the Scavenging activity of oxygen radical, the reduced capability of antioxidant radical damage.D groups are compared with C groups,
MDA values are substantially reduced, and SOD values are significantly raised, and difference is respectively provided with statistical significance (P<0.05).Show that cardio-cerebral refreshing composition can
The level of chronic cerebral ischemia brain tissue oxygen free radical is reduced, and the decline of SOD activity after ischemic can be reversed, cerebral ischemia-reperfusion is maintained
The Scavenging activity to oxygen radical is organized, so as to mitigate lipid peroxidation injury.
(2) influence of the cardio-cerebral refreshing composition to rat GFAP immunohistochemical stainings
Astroglia is that intracerebral quantity is most, is distributed a kind of most wide cell, and it is the main of central nervous system
Composition is supported, a variety of physiological reactions are participated in.Its physiological function is to maintain relatively stable, the star of microenvironment in local damage area
Spongiocyte quickly can absorb and prevent the neurotransmitter that synaptic cleft discharges, such as excitatory amino acid；It participates in blood simultaneously
The formation of brain barrier, astroglia is maintaining intracerebral water, also have important effect in terms of electrolyte balance in addition.Colloid
Fibrillary acidic protein (GFAP) is a kind of major protein of colloid intermediate filament, is the specificity marker protein of astroglia,
Under pathological conditions, GFAP expression is significantly changed, its overexpression, it is considered to be astroglia increases under pathological conditions
A raw mark.
Influence (X ± S) of the cardio-cerebral refreshing composition of table 2 to rat GFAP
Note：* compared with A groups：P ＜ 0.05；#Compared with C groups：P ＜ 0.05
In this experiment, comparing difference is not counted between A, B group capsula interna area and callosity body region GFAP positive cell numbers
Learn meaning ((P>0.05), show that cardio-cerebral refreshing composition does not have any effect to astroglia in normal cerebral tissue；C groups two
Position GFAP positive cell number showed increaseds, and cell space increase, the projection thickening of astroglia, with A, B group comparing difference
It is respectively provided with statistical significance (P<0.05), activation proliferation response occurs for astroglia in white matter after prompting chronic cerebral ischemia.D
GFAP positive cell numbers are significantly reduced in group above-mentioned zone, have statistical significance (P with C group comparing differences<0.05) heart, is shown
The clear composition of brain can suppress the overactivity hyperplasia of astroglia in white matter of brain after chronic cerebral ischemia.
(3) influence that cardio-cerebral refreshing composition is scored to rat LFB coloration results
The myelin of central nervous system medullated fibers is by the after birth winding aixs cylinder of oligodendroglia projection and shape
Into, therefore the situation of oligodendroglia can be reflected by the myelin for observing central nervous system.Labor gram fast blue is dyed
The method of classical display myelin, this dyestuff is only combined with the Phospholipids specificity of myelin, colour it is bright-coloured, axon and other
Structure is not colored, clean background, is the high method of a specificity easy to operate compared with the method for other display myelins.
In this experiment, colouring method is before Yihong is redyed plus to have redyed nucleus with haematoxylin, makes structure in brain tissue more
Clearly.Coloration result is that the myelin of medullated fibers is dyed to blueness, and pericaryon is dyed to red, nerve cell core into
Blueness, section background is red.
The cardio-cerebral refreshing composition of table 3 is to rat LFB coloration results score situation (X ± S)
Note：* compared with A groups：P ＜ 0.05；#Compared with C groups：P ＜ 0.05
This experimental result is found, does not find that the white matters such as obvious myelinoclasis change at A, B group corpus callosum, scoring is equal
For 0 point, show cardio-cerebral refreshing composition to normal cerebral tissue without any effect；It is visible at C group corpus callosums to have myelinoclasis and sheet
The loose phenomenon of the white matters such as vacuolization, scoring is substantially increased, and difference has statistical significance (P<0.05).Show chronic cerebral ischemia
Occur myelinoclasis, the impaired phenomenon of oligodendroglia in white matter of brain.The above-mentioned change of D groups substantially mitigates, commenting at corpus callosum
Divide reduction, there is statistical significance (P with C group comparing differences<0.05), show that cardio-cerebral refreshing composition can suppress myelinoclasis, subtract
Light oligodendroglia is impaired so as to mitigate white matter lesions.
(4) influence of the cardio-cerebral refreshing composition to rat β-APP immunohistochemical stainings
β-APP are the precursor substances of amyloid beta, are the single span memebrane proteins with membrane receptor protein spline structure.In life
In the case of reason, it is a kind of neuron normal components transported by aixs cylinder rapid transport mechanism, Deiter's cells (including star
Shape spongiocyte, oligodendroglia and microglia) β-APP can be also expressed on a small quantity.β-APP function is currently not ten
Distinguish one from the other, comprehensive current data thinks, may have and promote cell adherence growth, stimulate neuron axon to grow up to, safeguard cynapse
Membrane stability, suppresses serine protease and participates in the functions such as central nervous system immune response.
The cardio-cerebral refreshing composition of table 4 is to rat β-APP positive axons score situation (X ± S)
Note：* compared with A groups：P ＜ 0.05；#Compared with C groups：P ＜ 0.05
This experiment β-APP SABCs appraisal result finds do not have aixs cylinder coloring at A, B group corpus callosum, scoring is 0
Point, show that cardio-cerebral refreshing composition has no effect to normal white matter of brain；C group β-APP immuno positive aixs cylinder showed increaseds, corpus callosum
Locate the visible substantial amounts of nerve fibre for being dyed to brown color, scoring is substantially increased, and difference has statistical significance (P<0.05), table
There are β-APP aggregation and the damage of aixs cylinder after bright chronic cerebral ischemia.The above-mentioned change of D groups substantially mitigates, the β-APP at corpus callosum
Immuno positive aixs cylinder is significantly reduced, and statistical significance (P is respectively provided with other each group comparing differences<0.05) cardio-cerebral refreshing group, is shown
Compound can mitigate β-APP aggregations, reduce the damage of aixs cylinder after chronic cerebral ischemia.
It should be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can be to present invention work
Various changes or modification, these equivalent form of values equally fall within the application appended claims limited range.
Claims (7)
1. a kind of cardio-cerebral refreshing composition is in the medicine of Infant Injury in White Matter caused by preparing treatment and/or preventing chronic cerebral ischemia
Using.
2. application according to claim 1, the cardio-cerebral refreshing composition is made up of following raw material：Safflower oil, borneol, dimension
Raw element E, vitamin B6。
3. application according to claim 2, the cardio-cerebral refreshing composition is made up of the raw material of following parts by weight：Safflower
390 parts of oil, 3 parts of borneol, 17 parts of vitamin E, vitamin B65 parts.
4. application according to claim 3, the preparation method of the cardio-cerebral refreshing composition comprises the following steps：Take refined red
130 parts of caul-fat, adds 3 parts of borneol, vitamin B65 parts, mix, grinding adds 17 parts of vitamin E and refined safflower oil
260 parts, stir evenly.
5. the application according to claim 3 or 4, the cardio-cerebral refreshing composition can be prepared into oral system with appropriate auxiliary material
Agent.
6. application according to claim 5, the oral formulations include oral liquid, tablet, capsule, granule.
7. application according to claim 6, the preferred soft capsule preparation of capsule.
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| CN116370471A (en) * | 2021-12-22 | 2023-07-04 | 深圳泰乐德中药有限公司 | Composition for cerebral apoplexy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116370471A (en) * | 2021-12-22 | 2023-07-04 | 深圳泰乐德中药有限公司 | Composition for cerebral apoplexy |
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Effective date of registration: 20180524 Address after: 051430 No. 168, Shi Luan street, Luancheng District, Shijiazhuang, Hebei. Applicant after: China Shineway Pharmaceutical Group Co., Ltd. Applicant after: Beijing Tianjin Hebei LIAN pharmaceutical research (Beijing) Co., Ltd. Address before: 051430 No. 168, Shi Luan street, Luancheng District, Shijiazhuang, Hebei. Applicant before: China Shineway Pharmaceutical Group Co., Ltd. |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170915 |
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| WD01 | Invention patent application deemed withdrawn after publication |