CN107158010A - A kind of fish medicine - Google Patents
A kind of fish medicine Download PDFInfo
- Publication number
- CN107158010A CN107158010A CN201710455417.0A CN201710455417A CN107158010A CN 107158010 A CN107158010 A CN 107158010A CN 201710455417 A CN201710455417 A CN 201710455417A CN 107158010 A CN107158010 A CN 107158010A
- Authority
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- Prior art keywords
- percentage
- weight
- tetracycline
- amino acid
- fish
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- 241000251468 Actinopterygii Species 0.000 title claims abstract description 37
- 239000003814 drug Substances 0.000 title claims abstract description 30
- 239000004098 Tetracycline Substances 0.000 claims abstract description 30
- 229960002180 tetracycline Drugs 0.000 claims abstract description 30
- 229930101283 tetracycline Natural products 0.000 claims abstract description 30
- 235000019364 tetracycline Nutrition 0.000 claims abstract description 30
- 150000003522 tetracyclines Chemical class 0.000 claims abstract description 30
- 235000001014 amino acid Nutrition 0.000 claims abstract description 20
- -1 compound amino acid Chemical class 0.000 claims abstract description 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000004471 Glycine Substances 0.000 claims abstract description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 5
- 235000004279 alanine Nutrition 0.000 claims abstract description 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims abstract description 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 4
- 229930182817 methionine Natural products 0.000 claims abstract description 4
- 241000252210 Cyprinidae Species 0.000 claims description 5
- 241000252233 Cyprinus carpio Species 0.000 claims description 4
- 239000013505 freshwater Substances 0.000 claims description 4
- 241000252230 Ctenopharyngodon idella Species 0.000 claims description 2
- 241000252234 Hypophthalmichthys nobilis Species 0.000 claims description 2
- 241001275898 Mylopharyngodon piceus Species 0.000 claims description 2
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 claims 1
- 241000755266 Kathetostoma giganteum Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 238000009360 aquaculture Methods 0.000 description 5
- 244000144974 aquaculture Species 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000010824 fish disease Diseases 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
A kind of fish medicine, the tetracycline by bait and as active component is constituted with compound amino acid, and the mass ratio of the tetracycline and compound amino acid is 1：0.5~2, described compound amino acid by percentage by weight 11%~13% methionine, the histidine of percentage by weight 19%~21%, the alanine of percentage by weight 19%~21%, the L-aminobutanedioic acid of percentage by weight 11%~13%, the tyrosine of percentage by weight 1%~1.5% and the glycine composition of surplus.
Description
Technical field
The invention belongs to Medicines in Aquaculture, more particularly to a kind of fish medicine.
Background technology
The antibiotic that tetracycline is determined as a kind of with low cost, curative effect is widely used in aquaculture,
It can be both added in bait again as water body bacteriostatic agent, but can produce " " tetracycline pigmentation teeth after human body intake tetracycline "
In the problem of etc. being difficult to cure, existing aquaculture technology, being generally required in application tetracycline could up to 30d off-drug period
Its residual in aquatic products body is set to be down to below 100 μ g/kg, tetracycline has more serious limit in aquaculture application
System, therefore provide and a kind of can reduce the new fish medicine that tetracycline remains in aquatic products body and turn into urgently to be resolved hurrily in the prior art
The problem of.
The content of the invention
To solve aforementioned technical problem, the invention provides a kind of fish medicine, it is characterized in that the fish medicine is by bait and conduct
The tetracycline of active component is constituted with compound amino acid, and the mass ratio of the tetracycline and compound amino acid is 1：0.5~2, institute
The compound amino acid stated is by the methionine of percentage by weight 11%-~13%, the histidine of percentage by weight 19%~21%,
The alanine of percentage by weight 19%~21%, the L-aminobutanedioic acid of percentage by weight 11%~13%, percentage by weight 1%~
1.5% tyrosine and the glycine composition of surplus.
Described a kind of fish medicine, it is characterized in that the mass ratio of the tetracycline and compound amino acid is 1:0.8~1.2.
Described a kind of fish medicine, it is characterized in that the compound amino acid is by the methionine by percentage by weight 12%, weight
Measure the histidine of percentage 20%, the alanine of percentage by weight 20%, the L-aminobutanedioic acid of percentage by weight 12%, weight percent
The glycine composition of tyrosine and surplus than 1%~1.5%.
Described a kind of fish medicine, it is characterized in that the fish medicine is used for the cultivation of the fresh-water fishes of Cyprinidae.
A kind of described fish medicine, it is characterized in that the preferred black carp of the fresh-water fishes of the Cyprinidae, grass carp, silver carp, bighead, carp,
Crucian, Tilapia mossambica.
By each amino acid ligand ratio in the proportioning and compound amino acid between preferred tetracycline and compound amino acid, I
Be found surprisingly that, system will be mixed with conventional bait again after the compound amino acid of specific preferred prescription and tetracycline composition compound
When treating and preventing into fish medicine and for fish disease, fish only internal tetracycline residue can be significantly reduced, in tetracycline administration
After end individually when giving the bait containing compound amino acid, then tetracycline can be further improved in fish only internal metabolism speed
Degree, so as to which off-drug period of tetracycline medicine when applied to aquaculture is greatly reduced.
Embodiment
A kind of fish medicine that the present invention is provided, is prepared in the following manner,
1) it will be mixed as the tetracycline of active component, amino acid with bait
2) by step 1) mixture in add water mix after suppress into strips dry after produce the present invention fish medicine.
The bait formula used in present embodiment for：
Fish meal 8%, dregs of beans 13%, peanut meal 18.8%, cotton dregs 13%, rapeseed dregs 13%, soya-bean oil 4%, premix 1%,
Flour 13%, rice bran 7%, wheat bran 8%, (above percentage accounts for the weight percent of bait for each component in bait to medical stone 1.2%
Than)
The premix uses the premix of carp 1% that biological feedstuff Co., Ltd of Beijing BDCom produces, and contains per g premixes
There is following nutritional ingredient：
Vitamin A >=400IU, vitamin D3100~300IU, vitamin E >=7mg, vitamin K3>=0.2mg, vitamin
B1>=0.3mg, vitamin B2>=0.5mg, vitamin B6>=0.22mg, niacinamide >=2.5mg, calcium pantothenate >=2mg, folic acid >=
0.2mg, vitamin C >=8mg, inositol >=7mg, 8~75mg of iron, 0.875~2.5mg of copper, 7~20mg of zinc, 2~10mg of manganese, iodine
>=0.03mg, 0.01~0.05mg of selenium, 0.01~0.2mg of cobalt.
The formula of embodiment 1~6 is as follows
Comparative example 1~6, it is identical with the formula of embodiment 1~6 respectively, but it is added without tetracycline.
Pharmacological Examples
Using the childhood carp of health, 13.51 ± 0.67g of original body mass is divided into experimental group 1~6 and control group
Experimental group 1~6 feeds the fish medicine that embodiment 1~6 is obtained respectively, and control group only feeds bait
The experiment pool is 86cm × 56cm × 48cm plastics pond, and 25 tail carps, every group of 1 pond are put in a suitable place to breed per pond.Feeding method is
The fish medicine being made is fed twice daily as bait, the time is respectively 9:00 and 18:00, the amount of feeding is about fish body weight every time
3%, it is 60mh/kg body weight to convert into tetracycline dosage, and Feeding time is 5d, and experiment takes 5 tail test fish at random after terminating per pond,
Internal Tetracycline Residues detection is carried out to it, then experimental group 1~6 is continued to feed the comparative example fish medicine without tetracycline, it is right
Continue only to feed bait according to group, every group takes the experiment of 5 tails to carry out internal Tetracycline Residues detection with fish at random again after lasting 5d, with reality
It is Tetracycline Residues knot in 100, experimental group 1~6 to test the average residual quantity of group internal tetracycline for raising control group fish after 5d
Fruit such as following table.
When as can be seen here, using the fish medicine of the present invention, tetracycline can be substantially reduced in fish only internal residual, Er Qie
When further feeding only has the comparative example of compound amino acid and bait after drug withdrawal, the metabolic rate of tetracycline can be also significantly improved.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Any modifications, equivalent substitutions and improvements made within principle etc., are all contained within protection scope of the present invention.
Claims (5)
1. a kind of fish medicine, it is characterized in that tetracycline of the fish medicine by bait and as active component is constituted with compound amino acid,
The mass ratio of the tetracycline and compound amino acid is 1：0.5~2, described compound amino acid by percentage by weight 11%-~
13% methionine, the histidine of percentage by weight 19%~21%, the alanine of percentage by weight 19%~21%, weight
The L-aminobutanedioic acid of percentage 11%~13%, the tyrosine of percentage by weight 1%~1.5% and the glycine composition of surplus.
2. a kind of fish medicine as claimed in claim 1, it is characterized in that the mass ratio of the tetracycline and compound amino acid is 1:0.8
~1.2.
3. a kind of fish medicine described in claim 1, it is characterized in that the compound amino acid is by the first sulphur by percentage by weight 12%
Propylhomoserin, the histidine of percentage by weight 20%, the alanine of percentage by weight 20%, the L-aminobutanedioic acid of percentage by weight 12%,
The tyrosine of percentage by weight 1%~1.5% and the glycine composition of surplus.
4. a kind of fish medicine as described in claims 1 to 3 is any, it is characterized in that the fish medicine is used for the cultivation of the fresh-water fishes of Cyprinidae.
5. a kind of fish medicine as claimed in claim 4, it is characterized in that the preferred black carp of the fresh-water fishes of the Cyprinidae, grass carp, silver carp, flathead
Fish, carp, crucian, Tilapia mossambica.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455417.0A CN107158010B (en) | 2017-06-16 | 2017-06-16 | Fish medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710455417.0A CN107158010B (en) | 2017-06-16 | 2017-06-16 | Fish medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107158010A true CN107158010A (en) | 2017-09-15 |
| CN107158010B CN107158010B (en) | 2019-12-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
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| GB892083A (en) * | 1959-11-12 | 1962-03-21 | Pfizer & Co C | Resin absorbate and use for purification |
| WO2002024911A2 (en) * | 2000-09-19 | 2002-03-28 | Millennium Pharmaceuticals, Inc. | 63760, a novel human transporter and uses thereof |
| US20050176140A1 (en) * | 2004-02-10 | 2005-08-11 | Benedict Daniel J. | Method and apparatus for cell culture using a two liquid phase bioreactor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
| CN109464435B (en) * | 2018-11-30 | 2021-06-29 | 河南师范大学 | Pharmaceutical composition for preventing and treating fish liver inflammation |
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| Publication number | Publication date |
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| CN107158010B (en) | 2019-12-17 |
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