CN107157480A - A kind of folding microstrip line microwave biological sensor having with reference to characteristic - Google Patents

A kind of folding microstrip line microwave biological sensor having with reference to characteristic Download PDF

Info

Publication number
CN107157480A
CN107157480A CN201710351821.3A CN201710351821A CN107157480A CN 107157480 A CN107157480 A CN 107157480A CN 201710351821 A CN201710351821 A CN 201710351821A CN 107157480 A CN107157480 A CN 107157480A
Authority
CN
China
Prior art keywords
microstrip line
skin
sensor
characteristic
microwave
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710351821.3A
Other languages
Chinese (zh)
Inventor
刘国
张宝
罗勇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Electronic Science and Technology of China
Original Assignee
University of Electronic Science and Technology of China
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Electronic Science and Technology of China filed Critical University of Electronic Science and Technology of China
Priority to CN201710351821.3A priority Critical patent/CN107157480A/en
Publication of CN107157480A publication Critical patent/CN107157480A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  using microwaves or terahertz waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A kind of folding microstrip line microwave biological sensor having with reference to characteristic of the disclosure of the invention, it is related to microwave biological medical sensor technical field, it is specifically a kind of based on surface plasma excimer and with the new microwave biological sensor detected available for malignant melanoma of skin, moisture content of skin with reference to characteristic.The interaction of surface plasma excimer and human skin tissue that the sensor is produced using microwave on metallic conductor distinguishes normal skin and cancerous issue or the water content of heterogeneity skin to detect.Meanwhile, the sensor is using folding microstrip line construction and testing result is had the characteristic referred to.The microwave biological sensor uses microwave frequency band for 5 13GHz, and smaller with reflecting, Insertion Loss is flat, the features such as uniform phase, is adapted to distinguish skin moisture content and malignant mela noma.

Description

A kind of folding microstrip line microwave biological sensor having with reference to characteristic
Technical field
It is specifically a kind of to be swashed based on surface plasma the present invention relates to microwave biological medical sensor technical field Member and the new microwave biological sensing detected available for malignant melanoma of skin, moisture content of skin with reference characteristic Device.
Background technology
Sensor originates from bionics fiber.All biologies have the organ or group for perceiving surrounding environment or oneself state Knit.Biomedical sensor refers to the equipment that the analyte comprising biotic component is detected using physical chemistry detector.It is biological Sensor, which is developed so far, mainly includes enzyme sensor, tissus sensor, microbiological sensor, immunosensor, cell sensor And DNA sensor etc..This kind of sensor all has the spies such as simple to operate, rapid, the accurate, response time is short and sensitivity is high Point.Occurs specificity knot using measured molecule and the sensitive material being fixed on biological receptive device more than current biology sensor Close, and occur biochemical reaction, produce the signals such as the change such as heat content change, ionic strength change, color, quality and pH value Biological information is obtained with certain mathematical relationship of tested molecule presence.
Biology sensor is the high-tech sector of a multi-crossed disciplines, and microelectric technique, micro-fabrication technology etc. is biology Sensor lays a solid foundation.With the development of bioscience, electronic information science and material science, people are to biology Sensitivity, cost and the numerous easy degree of operation of sensor etc., which are proposed, higher to be required.Conventional biosensor mainly includes Specific recognition, signal amplification and the signal conversion and processing of biomolecule.In recent years, these traditional thinkings are gradually beaten Broken, some new, highly sensitive biology sensors are appeared in face of people gradually.Especially, with nano-biosensing The proposition of the structure such as device and surface plasma excimer and concept, is achieved very in terms of the development of biology sensor both at home and abroad Big progress.Nano biological sensor is a kind of equipment for analyzing biology, biological derivative or bionic components material.
Surface plasma excimer is that free electron and photon interact a kind of electromagnetism to be formed in metal surface area Surface wave, the field strength at surface location is maximum, is exponential evanescent field on the direction of interface.This effect occurs in vacuum On the contact surface of material, positive dielectric constant or negative permittivity are produced.It can be set using surface plasma excimer concept Count out that simple in construction, sensitivity is high, fast response time biology sensor.Based on surface plasma excimer and with reference to special Property Novel Biosensor be it is a kind of available for malignant melanoma of skin, moisture content of skin detect a kind of novel device. Without mark in detection process, sample can be monitored in real time and the repeatable utilization of sensing chip.
The content of the invention
The present invention proposes that a kind of folding microstrip line microwave biological with reference characteristic is sensed for the deficiency of background technology Device, solves mark the need for existing in the prior art, destruction sample, needs to expend longer time and can not reuse etc. to ask Topic.
There is specific adopt the following technical scheme that to be a kind of of the invention the folding microstrip line microwave biological with reference to characteristic to sense Device, the sensor includes：Medium substrate and the microstrip line on medium substrate, the microstrip line include input, by inputting Hold the detection branch and reference arm that branch out, the detection branch is identical and symmetrical with reference arm structure, detection branch and Reference arm all includes：Gradual change impedance matching unit, periodically folding microstrip line, output end.
Further, the material of the cut-off substrate is Rogers 5880, and thickness is 0.20mm；Microstrip line thickness is 0.10mm, width is 0.53mm；The folding cycle width for periodically folding microstrip line is 3.00mm, and fold height is 5.00mm, Number of cycles is 4 (periodically folding microstrip line overall width 12mm).
Herein gradual change impedance matching unit and periodically fold microstrip line played a part of in the present invention be respectively： Impedance matching is to reduce the Insertion Loss of sensor so that microwave can be transmitted effectively on the microstrip line；Periodically fold micro- The function of surface plasma excimer is formed without with microwave is assembled with line, but also increases test serum and sensor Contact area allows surface plasma excimer preferably to be interacted with human skin tissue.Will inspection in detection process The periodicity surveyed in branch road folds microstrip line and is positioned on skin to be detected, and the periodicity of reference arm folds microstrip line and is positioned over On normal skin, the situation of skin to be detected is judged by periodically folding the Electric Field Distribution situation of microstrip line at analysis two.
A kind of folding microstrip line microwave biological sensor having with reference to characteristic disclosed by the invention；The sensor utilizes micro- The interaction of surface plasma excimer and human skin tissue that ripple is produced on metallic conductor distinguishes normal skin to detect Skin and cancerous issue or the water content of heterogeneity skin.Meanwhile, the sensor is using folding microstrip line construction and makes detection As a result there is the characteristic referred to.The microwave biological sensor uses microwave frequency band for 5-13GHz, with smaller, the Insertion Loss of reflection It is flat, the features such as uniform phase, it is adapted to distinguish skin moisture content and malignant mela noma.
Brief description of the drawings
Fig. 1 has the folding microstrip line microwave biological sensor structure figure with reference to characteristic；
Fig. 2 has the folding microstrip line microwave biological sensor distribution map of the electric field with reference to characteristic；
Under Fig. 3 the same terms, the distribution map of the electric field produced by normal skin and skin with cancer model；
Fig. 4 folds microstrip line construction distribution map of the electric field；
Fig. 5 is under biosensor surface different distance, the damage curve produced by the skin with cancer model；
Fig. 6 normal skins and skin with cancer model are sensed with the folding microstrip line microwave biological with reference to characteristic S under device21Curve distribution figure；
There is Fig. 7 the folding microstrip line microwave biological sensor with reference to characteristic to be located in skin histology to be measured at diverse location Resolution distribution figure.
In figure：1. microstrip structure is periodically folded, 2. gradual change impedance matching units, 3. inputs, 4. outputs, 5. medium bases Plate, 6. skin histology models, 7. cancerous issue models.
Embodiment
The complex dielectric permittivity of human body skin can be provided by Debye relaxation equation：
Wherein, εs、ε∞Respectively static dielectric and optical dielectric constant, ApFor pole amplitude, τpDuring for directric relaxation Between, σ is ionic conductivity, ε0For permittivity of vacuum, the π f of ω=2 represent angular frequency.Especially, table one, which gives, meets debye The skin histology parameter of the cuticula of the different moisture content of equation, skin corium and skin cancer cell.
Table one meets the different moisture content skin histology parameter of Debye equation
Skin histology ε∞ εs Ap τp(ps) σ(S/m)
Cuticula (0.2) 3.24 4.96 1.074 2.14 0.07
Skin corium (0.65) 5 36.55 0.946 6.07 2.60
Skin corium (0.7) 5.12 37.60 1.074 6.20 2.68
Skin cancer cell (0.816) 5.45 56.79 0.908 6.35 2.94
The propagation constant k of surface plasma excimer ripplespIt is able to can be drawn by formula (2)
In formula, εmAnd εrThe respectively dielectric constant of metal and medium；k0For the wave number of free space.Can by formula (1) Know, the dielectric properties of interface media of both sides have a great impact to electromagnetic wave field distribution, and structure is can be designed that using this point Simply, without mark in sensitivity height, the biology sensor of fast response time, detection process, sample can be monitored and passed in real time Sense chip is repeatable to be utilized.
Specifically, as shown in figure 1, two-way folds covering human body skin model (6) on microstrip line construction (1), one of them Fold and contain cutaneous carcinoma tissue (7) on microstrip line construction, another is normal skin tissue and with comparing.Electromagnetic wave by (3) input, during being propagated along microstrip line and be uniformly divided into two-way.Folded in periodicity at microstrip line, surface plasma Body excimer interacts with skin model.Last electromagnetic wave is respectively from (4) two port outputs.Fig. 3, Fig. 4 is during these The top view and left view of electric field intensity map, it can be seen that electromagnetic wave is focused primarily upon around microstrip line, in surfaces of metallic strip electric field most By force, then gradually decay.During surface plasma excimer and human skin tissue interaction, due to human body skin Tissue contains more moisture, the energy of meeting electromagnetic wave absorption, so as to change transmission and the reflecting properties of electromagnetic wave.Shown in Fig. 5 When having microstrip line surface different distance for electromagnetic wave, Absorption of the cutaneous carcinoma tissue to electromagnetic wave.Easily find, apart from micro-strip Line surface is nearer, and the energy of electromagnetic wave loss is more.Skin or cutaneous carcinoma tissue can absorb to surface plasma excimer, and The skin histology and skin of different moisture content are discrepant to the absorption of electromagnetic wave with cutaneous carcinoma tissue.It was found that this Species diversity has very high sensitivity, as shown in Figure 7.We judge both differences by transmission coefficient, pass through contrast two Plant the S of different moisture content tissue21Parameter, as shown in fig. 6, the transmission coefficient of different moisture content tissue or cancer cell has significantly Difference, it was demonstrated that concept feasible.

Claims (2)

1. a kind of folding microstrip line microwave biological sensor having with reference to characteristic, the sensor includes：Medium substrate and it is located at Microstrip line on medium substrate, detection branch and reference arm that the microstrip line includes input, branched out by input, institute State detection branch identical and symmetrical with reference arm structure, detection branch and reference arm all include：Gradual change impedance matching unit, Periodically fold microstrip line, output end.
2. a kind of folding microstrip line microwave biological sensor having with reference to characteristic as claimed in claim 1, it is characterised in that The material of the medium substrate is Rogers 5880, and thickness is 0.20mm；Microstrip line thickness is 0.10mm, and width is 0.53mm； The folding cycle width for periodically folding microstrip line is 3.00mm, and fold height is 5.00mm, and number of cycles is 4.
CN201710351821.3A 2017-05-18 2017-05-18 A kind of folding microstrip line microwave biological sensor having with reference to characteristic Pending CN107157480A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710351821.3A CN107157480A (en) 2017-05-18 2017-05-18 A kind of folding microstrip line microwave biological sensor having with reference to characteristic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710351821.3A CN107157480A (en) 2017-05-18 2017-05-18 A kind of folding microstrip line microwave biological sensor having with reference to characteristic

Publications (1)

Publication Number Publication Date
CN107157480A true CN107157480A (en) 2017-09-15

Family

ID=59815214

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710351821.3A Pending CN107157480A (en) 2017-05-18 2017-05-18 A kind of folding microstrip line microwave biological sensor having with reference to characteristic

Country Status (1)

Country Link
CN (1) CN107157480A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111565639A (en) * 2017-11-15 2020-08-21 新加坡科技设计大学 Apparatus and method for non-invasive monitoring of blood glucose

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120078893A (en) * 2011-01-03 2012-07-11 동국대학교 산학협력단 Apparatus for skin cancer diagnosis
CN104993205A (en) * 2015-07-06 2015-10-21 电子科技大学 Microstrip fold line directional coupler
CN105981223A (en) * 2013-12-10 2016-09-28 Iee国际电子工程股份公司 Radar sensor with frequency dependent beam steering

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120078893A (en) * 2011-01-03 2012-07-11 동국대학교 산학협력단 Apparatus for skin cancer diagnosis
CN105981223A (en) * 2013-12-10 2016-09-28 Iee国际电子工程股份公司 Radar sensor with frequency dependent beam steering
CN104993205A (en) * 2015-07-06 2015-10-21 电子科技大学 Microstrip fold line directional coupler

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
张宝: "基于表面等离子体激元的微波/毫米波生物传感器", 《万方学位论文》 *
张长青: "大功率毫米波折叠波导行波管的研究", 《万方学位论文》 *
李庆云: "毫米波检测皮肤癌的技术研究", 《万方学位论文》 *
李锦豪: "生物组织的微波毫米波电特性研究", 《万方学位论文》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111565639A (en) * 2017-11-15 2020-08-21 新加坡科技设计大学 Apparatus and method for non-invasive monitoring of blood glucose
CN111565639B (en) * 2017-11-15 2023-06-06 新加坡科技设计大学 Device and method for non-invasively monitoring blood glucose

Similar Documents

Publication Publication Date Title
Nag et al. Sensing system for salinity testing using laser-induced graphene sensors
Biagi et al. Nanoscale electric permittivity of single bacterial cells at gigahertz frequencies by scanning microwave microscopy
CN103335984B (en) A kind of incorporeity wall micro-array chip based on LSPR and application thereof
JP6243446B2 (en) Method for analyzing a fluid using a resonant sensor
Liu et al. SPR quantitative analysis of direct detection of atrazine traces on Au-nanoparticles: nanoparticles size effect
Sharafadinzadeh et al. Investigation on planar microwave sensors with enhanced sensitivity from microfluidic integration
Zeng et al. Aptamer HB5 modified terahertz metasurface biosensor used for specific detection of HER2
Piekarz et al. Planar single and dual-resonant microwave biosensors for label-free bacteria detection
CN207908584U (en) Microfluid dielectric property detection device based on coplanar waveguide transmission line
Blakey et al. Real-time monitoring of pseudomonas aeruginosa concentration using a novel electromagnetic sensors microfluidic cell structure
Quoc et al. High-frequency interdigitated array electrode-based capacitive biosensor for protein detection
Pandit et al. Towards development of a non–intrusive and label–free THz sensor for rapid detection of aqueous bio–samples using microfluidic approach
CN108169573A (en) Small sample dielectric property detection device based on microchannel electric-field enhancing
Esfandyarpour et al. Nanoelectronic impedance detection of target cells
CN107582054B (en) Skin water content detection sensor based on surface plasmon polariton
Stiharu et al. Single living cell manipulation and identification using microsystems technologies
CN107157480A (en) A kind of folding microstrip line microwave biological sensor having with reference to characteristic
CN108279332A (en) Fluid dielectric constant microwave measuring device based on microchannel
Hou et al. Cancer biomarkers ultrasensitive detection based on terahertz frequency-comb-like
CN108267642B (en) Micro-fluid electric characteristic microwave detection device
CN207908583U (en) A kind of small size samples dielectric constant detection device
Kim et al. Differentiation between normal and cancerous human urothelial cell lines using micro-electrical impedance spectroscopy at multiple frequencies
Guo et al. A novel paper biosensor based on Fe3O4@ SiO2–NH2 and MWCNTs for rapid detection of pseudorabies virus
He et al. Integrated wireless microfluidic liquid sensors based on low temperature co-fired ceramic (LTCC) technology
Liu et al. A transmission line sensor with sensitivity improved for detection of ionic concentration in microfluidic channel

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170915

WD01 Invention patent application deemed withdrawn after publication