CN107149618B - Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof - Google Patents

Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof Download PDF

Info

Publication number
CN107149618B
CN107149618B CN201710337468.3A CN201710337468A CN107149618B CN 107149618 B CN107149618 B CN 107149618B CN 201710337468 A CN201710337468 A CN 201710337468A CN 107149618 B CN107149618 B CN 107149618B
Authority
CN
China
Prior art keywords
vinegar
mulberry leaf
blood sugar
processed
processed mulberry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201710337468.3A
Other languages
Chinese (zh)
Other versions
CN107149618A (en
Inventor
李敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Li Min
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710337468.3A priority Critical patent/CN107149618B/en
Publication of CN107149618A publication Critical patent/CN107149618A/en
Application granted granted Critical
Publication of CN107149618B publication Critical patent/CN107149618B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to the fields of medicines, health products, foods and beverages, in particular to a vinegar-made mulberry leaf blood sugar-reducing tea and a preparation method thereof. The vinegar-processed mulberry leaf blood sugar reducing tea disclosed by the invention comprises vinegar-processed mulberry leaves, and other raw materials are traditional Chinese medicinal materials which can be used as both food and medicine, so that the vinegar-processed mulberry leaf blood sugar reducing tea has no side effect on a human body and is low in production cost; meanwhile, the cavity of the beta-cyclodextrin added during extraction can contain mulberry leaf flavone, which is beneficial to improving the extraction rate of flavone, so that the blood sugar reducing effect of the 1-deoxynojirimycin is enhanced, and the blood sugar reducing effect is obvious.

Description

Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof
Technical Field
The invention relates to the fields of medicines, health products, foods and beverages, in particular to a vinegar-made mulberry leaf blood sugar-reducing tea and a preparation method thereof.
Background
Folium mori is recorded in traditional Chinese medicine books all over the past to treat diabetes, and recent doctors often use folium mori to treat diabetes and obtain satisfactory curative effects. Modern pharmacological research shows that mulberry leaves contain a plurality of polyhydroxy alkaloids, wherein the polyhydroxy alkaloids represented by 1-Deoxynojirimycin (DNJ) are important blood sugar reducing components in the mulberry leaves, and are highly concerned by scholars at home and abroad. However, as DNJ is poor in water solubility, active ingredients of the mulberry leaf beverage taking mulberry leaves as main raw materials are difficult to fully utilize, and the effect of reducing blood sugar is not obvious; researches show that the combination of the mulberry leaf flavone and the DNJ can effectively inhibit the rise of blood sugar, and the mulberry leaf flavone and the mulberry leaf DNJ have a certain synergistic effect.
Disclosure of Invention
The invention aims to provide a novel mulberry leaf tea and a preparation method thereof, and aims to solve the problem that the mulberry leaf tea in the prior art has an unobvious blood sugar reduction effect.
The technical purpose is realized by the following technical scheme:
the invention provides vinegar-processed mulberry leaf hypoglycemic tea which is characterized by being prepared from the following materials: 35-40 parts of vinegar-processed mulberry leaves, 35-40 parts of hawthorn and 20-30 parts of medlar.
Preferably, the vinegar-processed mulberry leaf blood sugar-reducing tea is a capsule, a tablet or a granule.
The preparation method of the vinegar-processed mulberry leaf hypoglycemic tea is characterized by comprising the following preparation steps:
(1) taking fresh mulberry leaves, removing impurities, drying, cutting, moistening the dried mulberry leaves for 2-24 hours by using 3-5% of edible rice vinegar with the material-liquid ratio of 1:0.1-0.5, steaming for 2-10 hours, and drying until the water content is 8-12% to obtain vinegar-processed mulberry leaves;
(2) extracting the vinegar-processed mulberry leaves, the hawthorn and the medlar in the step (1) by deionized water containing beta-cyclodextrin with the mass of 1-5% of the raw materials at 90-100 ℃, concentrating in vacuum until the density is 1.15-1.3, and adding 0.5-3% of natural sweetening agent into the thick paste.
Preferably, the vinegar-processed mulberry leaves, hawthorn and Chinese wolfberry in the step (2) are extracted twice by deionized water, wherein the ratio of the first liquid to the material is 6:1, and the ratio of the second liquid to the material is 5: 1.
Preferably, after the vinegar-processed mulberry leaves, hawthorn and Chinese wolfberry in the step (2) are extracted, vacuum concentration is carried out twice, the first vacuum concentration is carried out until the density is 1.08-1.12, 95% ethanol is added according to the volume ratio of the feed liquid to the 95% ethanol of 1:1.5, and the vacuum concentration is carried out again until the density is 1.15-1.3.
Preferably, the temperature at the time of vacuum concentration is 60 to 80 ℃.
Preferably, the sweetener is stevioside or mogroside.
The vinegar-prepared mulberry leaf blood sugar-reducing tea provided by the invention is safe and reliable, the raw materials are traditional Chinese medicinal materials which can be used as both food and medicine, no side effect is caused to human bodies, and the production cost is low; the mulberry flavone can enhance the blood sugar reducing effect of the 1-deoxynojirimycin, and the cavity of the beta-cyclodextrin added during extraction can contain the mulberry flavone, so that the extraction rate of the flavone is improved, and the blood sugar reducing effect is obvious.
Detailed Description
Example 1
Removing impurities from fresh folium Mori, and drying. Taking 100g of dried mulberry leaves, cutting up the dried mulberry leaves, putting the cut mulberry leaves into a tray, adding 10g of rice vinegar with the concentration of 3% into the mulberry leaves, uniformly stirring, covering the tray, moistening the tray for 4 hours, steaming the tray for 2 hours in a water-proof way, taking the tray out, and drying the tray for 4 hours by hot air at the temperature of 80 ℃ to obtain the vinegar-processed mulberry leaves with the water content of 11.2%.
Example 2
Removing impurities from fresh folium Mori, and drying. Taking 100g of dried mulberry leaves, cutting up the dried mulberry leaves, putting the cut dried mulberry leaves into a tray, adding 20g of rice vinegar with the concentration of 3% into the mulberry leaves, uniformly stirring, covering the tray, moistening the tray for 6 hours, steaming the tray for 6 hours in a water-proof way, taking the tray out, and drying the tray for 8 hours by hot air at the temperature of 60 ℃ to obtain the vinegar-processed mulberry leaves with the water content of 8.8%.
Example 3
Removing impurities from fresh folium Mori, and drying. Taking 100g of dried mulberry leaves, cutting up the dried mulberry leaves, putting the cut mulberry leaves into a tray, adding 20g of rice vinegar with the concentration of 5% into the mulberry leaves, uniformly stirring, covering the tray, moistening the tray for 6 hours, steaming the tray for 8 hours in a water-proof way, taking out the tray and drying the tray for 4 hours by hot air at the temperature of 90 ℃ to obtain the vinegar-processed mulberry leaves with the water content of 10.0%.
Example 4
Removing impurities from fresh folium Mori, and drying. Taking 100g of dried mulberry leaves, cutting up the dried mulberry leaves, putting the cut mulberry leaves into a tray, adding 30g of rice vinegar with the concentration of 5% into the mulberry leaves, uniformly stirring, covering the tray, moistening the tray for 4 hours, steaming the tray for 6 hours in a water-proof way, taking the tray out, and drying the tray for 6 hours by hot air at the temperature of 80 ℃ to obtain the vinegar-processed mulberry leaves with the water content of 10.2%.
Example 5
Removing impurities from fresh folium Mori, and drying. Taking 100g of dried mulberry leaves, cutting up the dried mulberry leaves, putting the cut mulberry leaves into a tray, adding 50g of rice vinegar with the concentration of 3% into the mulberry leaves, uniformly stirring, covering the tray, moistening the tray for 8 hours, steaming the tray for 10 hours in a waterproof way, taking the tray out, and drying the tray for 7 hours by hot air at the temperature of 70 ℃ to obtain the vinegar-processed mulberry leaves with the water content of 11.3%.
Example 6
Comparison of 1-Deoxynojirimycin (DNJ) content in different vinegar preparation methods of mulberry leaves:
the method for detecting the content of the sanguinarine comprises the following steps: weighing 0.5g of vinegar-processed mulberry leaf powder, and mixing the raw materials according to a material-liquid ratio of 1: 20 adding deionized water, extracting for 2 hours at 80 ℃, extracting twice, combining extracting solutions, filtering, and fixing the volume to 50ml by using the deionized water. Taking 2.5mg of 1-deoxynojirimycin standard substance, dissolving with a small amount of water, transferring to a 25ml volumetric flask, adding water to a constant volume to obtain 100ul of 0.1mg/ml 1-deoxynojirimycin standard solution (or extract) in a 1.5ml centrifuge tube, adding 100ul of 0.4mol/L boric acid buffer solution (pH = 8.5), adding 200ul of 5nmol/L FMOC-Cl (dissolved in 50% acetonitrile), mixing uniformly, and carrying out water bath at 25 ℃ for 20 min. Adding 100uL of 1mol/L glycine to neutralize the residual FMOC-Cl (9-fluorenylmethyl chloroformate) to terminate the reaction, adding 100uL of 1% (V/V) acetic acid solution and 400uL of ultrapure water to dilute, centrifuging at 10000r/min for 5min, filtering by a 0.45um microporous membrane filter, and collecting the filtrate for testing. The detection wavelength is 254nm, the mobile phase is acetonitrile-0.1% acetic acid (55: 45, V/V), the flow rate is 1.0mL/min, the sample injection amount is 20uL, and the content is detected by an external standard method. The results are shown in the table I:
TABLE-percentage content of water-soluble total alkaloids in mulberry leaves
Sample (I) Not processed with vinegar Example 1 Example 2 Example 3 Example 4 Example 5
DNJ 0.021% 0.123% 0.156% 0.170% 0.172% 0.164%
Example 7
Taking vinegar-processed mulberry leaves 40g, hawthorn 40g and medlar 20g, adding 5g of beta-cyclodextrin into deionized water, stirring uniformly, extracting twice at 100 ℃, adding 95% ethanol according to the volume ratio of the material liquid to 95% ethanol of 1:1.5, taking supernatant, concentrating at 70 ℃ to 1.3, adding 0.4g of stevioside into the thick paste, mixing uniformly, and granulating by a wet method.
Example 8
Taking 35g of vinegar-processed mulberry leaves, 35g of hawthorn and 30g of medlar, adding 3g of beta-cyclodextrin into deionized water, stirring uniformly, extracting twice at 100 ℃, wherein the ratio of liquid to material in the first time is 6:1, the ratio of liquid to material in the second time is 5:1, vacuum concentrating at 70 ℃ until the density is 1.12, adding 95% ethanol according to the volume ratio of the material liquid to 95% ethanol of 1:1.5, taking supernatant, vacuum concentrating at 70 ℃ to the density of 1.15, adding 0.3g of mogroside into thick paste, mixing uniformly, spray drying and granulating.
The usage and dosage of the invention are as follows: the preparation is taken 3 times a day with 5g per bag before meal.
The beneficial effects of the vinegar-processed mulberry leaf blood sugar-reducing tea are further illustrated by the following relevant experimental cases, and the clinical effect test is carried out on the product obtained by the preparation method in the example 7:
the rat model is a diabetes model when the blood sugar and the blood fat are high, the blood sugar level is tested by combining one-time intraperitoneal injection of 60mg/Kg streptozotocin, the fasting blood sugar is more than 13mmol/L, and the patient with polydipsia, polyphagia and polyuria appears. 10 healthy rats and 30 diabetic model rats, each half of male and female, are divided into 4 groups, namely a normal rat group (A), a diabetic model rat group (B), a vinegar-processed mulberry leaf beverage group (C), a kazaipin positive drug group (D) and an A, B group, are fed with common feed, are fed with free drinking water, and are irrigated with distilled water (2 ml/day) every day, a solid beverage 50mg/Kg is irrigated with the group C, a kazaipin 20mg/Kg is irrigated with the group D, the periphery of the irrigated stomach is irrigated with the group D, the blood sugar level is measured, the blood sugar change is shown in table two, the blood sugar level of the group C, D is obviously reduced, and the symptoms of polydipsia, polyphagia and polyuria of the rats.
TABLE 4 blood sugar changes after gavage (unit: mmol/L)
Group of n Pre-molding/pre-administration After administration
A 10 4.01±1.03 3.98±2.77
B 10 19.18±2.13 19.12±2.42
C 10 18.98±4.09 10.78±3.13*
D 10 18.94±2.43 11.75±3.59*
P < 0.05 compared to B.

Claims (5)

1. The vinegar-processed mulberry leaf blood sugar reducing tea is characterized by comprising vinegar-processed mulberry leaves, the vinegar-processed mulberry leaf blood sugar reducing tea is a capsule, a tablet or a granule, and the vinegar-processed mulberry leaf blood sugar reducing tea is prepared from the following materials in parts by weight: 35-40 parts of vinegar-processed mulberry leaves, 35-40 parts of hawthorn and 20-30 parts of medlar, and the preparation method of the vinegar-processed mulberry leaf blood sugar-reducing tea comprises the following preparation steps:
(1) taking fresh mulberry leaves, removing impurities, drying, cutting, moistening the dried mulberry leaves for 2-24 hours by using 3-5% of edible rice vinegar with the material-liquid ratio of 1:0.1-0.5, steaming for 2-10 hours, and drying until the water content is 8-12% to obtain vinegar-processed mulberry leaves;
(2) extracting the vinegar-processed mulberry leaves, the hawthorn and the medlar in the step (1) by deionized water containing beta-cyclodextrin with the mass of 1-5% of the raw materials at 90-100 ℃, concentrating in vacuum until the density is 1.15-1.3, and adding 0.5-3% of natural sweetening agent into the thick paste.
2. The method for preparing vinegar-processed mulberry leaf hypoglycemic tea according to claim 1, wherein the vinegar-processed mulberry leaf, hawthorn and medlar in the step (2) are extracted twice with deionized water, the ratio of the first liquid to the material is 6:1, and the ratio of the second liquid to the material is 5: 1.
3. The preparation method of the vinegar-processed mulberry leaf blood sugar-reducing tea as claimed in claim 1, wherein the vinegar-processed mulberry leaf, hawthorn and medlar in the step (2) are extracted and then subjected to vacuum concentration twice, the first vacuum concentration is carried out until the density is 1.08-1.12, 95% ethanol is added according to the volume ratio of the material liquid to the 95% ethanol being 1:1.5, and the vacuum concentration is carried out again until the density is 1.15-1.3.
4. The method for preparing the vinegar-processed mulberry leaf hypoglycemic tea as claimed in claim 1, wherein the temperature during vacuum concentration is 60-80 ℃.
5. The preparation method of the vinegar-processed mulberry leaf hypoglycemic tea according to claim 1, wherein the sweetener is stevioside or mogroside.
CN201710337468.3A 2017-05-15 2017-05-15 Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof Expired - Fee Related CN107149618B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710337468.3A CN107149618B (en) 2017-05-15 2017-05-15 Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710337468.3A CN107149618B (en) 2017-05-15 2017-05-15 Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof

Publications (2)

Publication Number Publication Date
CN107149618A CN107149618A (en) 2017-09-12
CN107149618B true CN107149618B (en) 2021-01-05

Family

ID=59792757

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710337468.3A Expired - Fee Related CN107149618B (en) 2017-05-15 2017-05-15 Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof

Country Status (1)

Country Link
CN (1) CN107149618B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394966A (en) * 2018-11-08 2019-03-01 沈阳衡天然生物科技有限公司 A kind of mulberry leaf compound and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
环糊精对黄酮的包合作用及其在银杏黄酮提取中的应用;徐志红等;《精细化工》;20051031;第22卷(第10期);第762-765页 *
糖尿病患者怎么吃山楂;罗春燕等;《糖尿病天地》;20081231(第1期);第46-48页 *

Also Published As

Publication number Publication date
CN107149618A (en) 2017-09-12

Similar Documents

Publication Publication Date Title
EP2829275B1 (en) Total flavone extract of abelmoschus manihot and preparation method thereof
CN113150867B (en) Preparation method of ganoderma lucidum extract oil rich in ganoderma lucidum triterpenes
EP4023239A1 (en) Plant extraction method
CN103768152B (en) Flos Osmanthi Fragrantis phenethyl alcohol glycoside extract and its production and use
WO2008147141A1 (en) A method for preparing novel black-red ginseng and the extract therefrom and the composition comprising the extract isolated therefrom
EP2502629A1 (en) Liver function enhancer composition
CN100502833C (en) Novel preparing method for Tibetan medicine Qingpeng ointment
CN111568948A (en) Application of mulberry extract in preparing medicine for improving pancreatic islet function
WO2007007993A1 (en) Pharmaceutical composition for the prevention and treatment of liver disease comprising a lonicera caerulea l. var. edulis extract
CN107149618B (en) Vinegar-processed mulberry leaf blood sugar reducing tea and preparation method thereof
CN111388602B (en) Lucid ganoderma and dendrobium officinale suspension and preparation method thereof
EP3626246A1 (en) Agent for suppressing carbohydrate breakdown and absorption
CN101444599B (en) Corn silk extract and preparation method thereof and application thereof in preparing drugs for treating gout
CN112007133A (en) Selenium-rich loquat syrup
EP2486808B1 (en) Polyphenol compound absorption promoter and utilization of same
EP3025721B1 (en) Pharmaceutical composition for preventing or treating asthma comprising pistacia weinmannifolia j. poiss. ex franch extract or fraction thereof
US20100074975A1 (en) Pharmaceutical composition for the prevention and treatment of liver disease comprising a lonicera caerulea L. Var. Edulis extract
CN106421741A (en) Water-soluble olive leaf extract health-care product and preparation method thereof
KR101321203B1 (en) Anti-diabetic composition comprising Angelica Keiskei Koid. extracts
CN102258578A (en) Novel lotus leaf total alkaloid extract and preparation method as well as application thereof
CN105031033B (en) Blood sugar reducing pharmaceutical composition containing boxthorn leaves and preparation method and application thereof
CN104940428B (en) Hypoglycemic composition containing wolfberry fruits and application thereof
CN102488742A (en) Preparation method of astragaloside
CN103800389A (en) Hypoglycemic active ingredient in Sarcodon leucopus and preparation method and application thereof
KR102421081B1 (en) A composition for anti-smoke comprising niacin

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20201215

Address after: Group 2, Tiantang village, shitouzui Town, Yingshan County, Huanggang City, Hubei Province 438700

Applicant after: Li Min

Address before: Hongshan Zhen Zhang Fan Cun San San Lu, Yingshan County, Huanggang City, Hubei Province 438700

Applicant before: YINGSHAN SANGHE FLAT COCOON PROFESSIONAL COOPERATIVE

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20210105