CN107102538A - A kind of flow correction method matched somebody with somebody in liquid layer analysis system - Google Patents
A kind of flow correction method matched somebody with somebody in liquid layer analysis system Download PDFInfo
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- CN107102538A CN107102538A CN201710473751.9A CN201710473751A CN107102538A CN 107102538 A CN107102538 A CN 107102538A CN 201710473751 A CN201710473751 A CN 201710473751A CN 107102538 A CN107102538 A CN 107102538A
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- 238000000034 method Methods 0.000 title claims abstract description 21
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B11/00—Automatic controllers
- G05B11/01—Automatic controllers electric
- G05B11/36—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential
- G05B11/42—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential for obtaining a characteristic which is both proportional and time-dependent, e.g. P. I., P. I. D.
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Abstract
The present invention relates to technical field of bioengineering, specifically, it is a kind of flow correction method matched somebody with somebody in liquid layer analysis system, using 5 points of differences and algorithm, a flow value is extracted every time T in systems using analog module, five flow values are extracted altogether and are respectively set to X1、X2、X3、X4、X5, then calculate former and later two numerical differences and be set as Y1、Y2、Y3、Y4, then to Y1、Y2、Y3、Y4Progress, which is summed, obtains Z, when 5 points of differences and result Z are in the range of ± 3 σ, start intervention stability correction, when in the range of ± 1 σ, stability and accuracy reach goal-setting requirement, and correction terminates, and automatic correcting controlling signal is fed next time for wait, using the bearing calibration of present disclosure have that single adjusts time is short, the parameter of single adjustment setting is once adjusted, it is permanent effectively and the benefit such as the stability that adjusts of single is good.
Description
Technical field
It is a kind of flux modification side matched somebody with somebody in liquid layer analysis system specifically the present invention relates to technical field of bioengineering
Method.
Background technology
Chromatography (chromatography) is the abbreviation of " chromatographic analysis ".To be many using the difference of each component physical property
Component mixture is separated and method for measuring.There is two kinds of adsorption chromatography, Partition Chromatography.It is generally used for organic compound, gold
Belong to the analysis of ion, amino acid etc..Chromatography reaches separation using material allocation proportion different between stationary phase and mobile phase
The technology of purpose.Chromatographing the separation analysis to the mixture of the complicated organic matter such as large biological molecule such as protein and nucleic acid has pole
High resolving power.
Traditional pid algorithm is not once to adjust permanent stabilization in liquid layer analysis system flux modification, can be by physical environment
Influence and body operating mode change and change.
The content of the invention
Based on above-mentioned technical problem, the present invention discloses a kind of flow correction method matched somebody with somebody in liquid layer analysis system, using five
Point difference and control algolithm, it is possible to achieve permanent stabilization adjusts flow.
The concrete technical scheme that the present invention is used is as follows：
A kind of flow correction method matched somebody with somebody in liquid layer analysis system, using 5 points of differences and algorithm, be using analog module
A flow value is extracted every time T in system, five flow values are extracted altogether and are respectively set to X1, X2, X3, X4, X5, using following
Formula：Y1=X2-X1, Y2=X3-X2, Y3=X4-X3, Y4=X5-X4, calculate former and later two numerical differences and are set as
Y1, Y2, Y3, Y4 carry out summation Z=Y1+Y2+Y3+Y4, setting σ=target flow (Fo)/100, when five to Y1, Y2, Y3, Y4 again
Point difference and result Z start intervention stability correction, when in the range of ± 1 σ, stability and accuracy reach in the range of ± 3 σ
Goal-setting requirement, correction terminates, and automatic correcting controlling signal is fed next time for wait.
Of the invention further to improve, above-mentioned intervention stability correction uses PID control some algorithm concept, and specific algorithm is such as
Under：
Or
Wherein, uiRepresent the output of ith controller；kpRepresent proportionality coefficient；kIRepresent integral coefficient；kDRepresent differential
Coefficient；eiRepresent value of feedback when ith is sampled and the error e of set-pointi=ci-ri；TsRepresent the sampling period；TIRepresent integration
Time constant；TDRepresent derivative time constant.
It is of the invention further to improve, above-mentioned interval time T=0.01S.
Beneficial effects of the present invention：Using the bearing calibration of present disclosure have that single adjusts time is short, single is adjusted
The parameter of whole setting is once adjusted, it is permanent effectively and the benefit such as the stability that adjusts of single is good.
Brief description of the drawings
Fig. 1 is the 5 points of differences and algorithm schematic diagram of the present invention.
Fig. 2 is the PID control block diagram of the present invention.
Embodiment
In order to deepen the understanding of the present invention, the present invention is done below in conjunction with drawings and examples and further retouched in detail
State, the embodiment is only used for explaining the present invention, protection scope of the present invention is not constituted and limited.
Embodiment：As shown in figure 1, a kind of flow correction method matched somebody with somebody in liquid layer analysis system, using 5 points of differences and algorithm, makes
With analog module in systems every time T extract a flow value, altogether extract five flow values be respectively set to X1, X2,
X3, X4, X5, use following equation：Y1=X2-X1, Y2=X3-X2, Y3=X4-X3, Y4=X5-X4, before and after calculating
Two values difference is set as that Y1, Y2, Y3, Y4 carry out summation Z=Y1+Y2+Y3+Y4 to Y1, Y2, Y3, Y4 again, sets σ=target
Flow (Fo)/100, when 5 points of differences and result Z are in the range of ± 3 σ, starts intervention stability correction, when in the range of ± 1 σ, surely
Qualitative and accuracy reaches goal-setting requirement, and correction terminates, and automatic correcting controlling signal is fed next time for wait.
As shown in Fig. 2 PID control is by ratio (Proportional), integration (Integral), differential
(Differential) linear controller constituted, wherein kp, kI, kD is respectively PID controller parameter.The PID of discrete system
The expression formula is controlled to be：
Also it is often expressed as following form：
Wherein, uiRepresent the output of ith controller；kpRepresent proportionality coefficient；kIRepresent integral coefficient；kDRepresent differential
Coefficient；eiRepresent value of feedback when ith is sampled and the error e of set-pointi=ci-ri；TsRepresent the sampling period；TIRepresent integration
Time constant；TDRepresent derivative time constant.
Steady-state error, response speed and the overshoot of proportional component main influence systems.Scaling up coefficient can be accelerated
Response speed, reduces the steady-state error of system, improves control accuracy.But larger overshoot is produced as crossed conference, causes system
It is unstable；It is too small, reduce overshoot so that system stability margin increases, reduce system fading margin precision.
The effect of integration is to eliminate steady-state error.In closed-loop control system, increase integration control can increase system
Stable state accuracy.The continuous add up error of integral element, can be such that error eliminates rapidly, but integration makes system add one positioned at origin
Open loop pole, therefore 90 ° of phase delay makes overshoot quantitative change big, causes system to produce vibration.
The differential action is increase system damping, improves the stationarity of response, the change of differentiation element energy stock dividends signal
Trend, before deviation signal becomes too big, introduces an effective revise signal, rapidity is improved, so as to improve system
Dynamic characteristic, but poor anti jamming capability also easily makes system produce vibration.
The quality of the parameter tuning of PID controller be weigh PID controller can reliably working important foundation.Though because
Right PID controller can control effectively to most control systems, and setting method is also fairly simple, and robustness is good, but
Pid parameter, which does not conform to reed time controll effect, to be greatly affected, and cause system to be unable to asymptotically stability.
Practical tuning method is the most practical in practice, because the method adjusted often through theoretical calculation is mainly according to system
The mathematical modeling of system, is got by theoretical calculation, and the data obtained by these methods be able to may not be used directly, in addition it is also necessary to pass through work
Journey practice is adjusted and changed.The response condition of the necessary observing system of practical tuning method, is determined according to the response condition of system
The parameter of adjustment, by gathering examination pid parameter repeatedly, observing system response effect, until there is satisfied response curve, so that really
Determine pid control parameter.The order of adjusting of practical tuning method is generally：First ratio, then integrate, last differential.
5 points of differences and the practical application Integrated comparative corrected with application traffic of the pid algorithm in liquid layer analysis system, PID
There is notable difference in control algolithm and 5 points of differences and control algolithm.Specific difference is as follows：
Pid control algorithm is compared to 5 points of differences and control algolithm, it may appear that adjustment flow overshoot；
Pid control algorithm is compared to 5 points of differences and control algolithm, and adjustment time is long, and pid control algorithm be 5 points of differences and
10 times even more than 40 times of relation of control algolithm adjustment time；
Pid control algorithm is compared to 5 points of differences and control algolithm, and flowed fluctuation is big, and pid control algorithm be 5 points of differences and
2 times of control algolithm flowed fluctuation；
Pid control algorithm is compared to 5 points of differences and control algolithm, and long-term stability is poor, and regulation process is cumbersome, by physical rings
Border and the influence of body operating mode are big.
Application scenario is chromatographed in biology, overshoot occur absolutely not allows.Overshoot can be such that sample is eluted out in advance,
The sample inconvenience analysis being collected into, it is zero that may finally cause yield；Overshoot can cause the error increase of configuration solution proportion；PID
Control algolithm there is this risk.The problem of 5 points of differences and control algolithm are just not present such；Pid control algorithm adjustment time
It is long, substantial amounts of solvent loss can be caused, increase single experiment cost.Compare and pid control algorithm, 5 points of differences and control algolithm are just
Outstanding is more, and quantity of solvent is lost in experimentation and be can be neglected；Pid control algorithm is compared and 5 points of differences and control algolithm, tune
Whole pulsation is big, if now entering pillar, the phenomenon of pit will occurs in filler in post, causes post effect reduction, collection of illustrative plates hangover etc..And
5 points of differences and control algolithm then in this respect, remote excellent and pid control algorithm；Pid control algorithm is calculated compared to 5 points of differences and control
Method in liquid layer analysis system the practical application comparative result of flux modification be 5 points difference and control algolithm better than PID controls
Algorithm.
In a word, the selection of control law will be chosen according to process characteristic and technological requirement, and pid control algorithm is said by no means
All there is preferable control performance under any circumstance, regardless of occasion, it is inappropriate all to be used regardless of application field.If this
Sample is done, and only can increase complexity to other work, and bring difficulty to parameter tuning.Technique is not reached also when using PID control
It is required that, then need to consider other control programs.Such as it is better than in the practical application of the flux modification in liquid layer analysis system
The 5 points of differences and control algolithm of pid control algorithm.
General principle, principal character and the advantage of the present invention has been shown and described above.The technical staff of the industry should
Understand, the present invention is not limited to the above embodiments, the original for simply illustrating the present invention described in above-described embodiment and specification
Reason, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes and improvements
It all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent circle
It is fixed.
Claims (3)
1. a kind of flow correction method matched somebody with somebody in liquid layer analysis system, using 5 points of differences and algorithm, it is characterised in that：Use analog quantity
Module extracts a flow value every time T in systems, and five flow values are extracted altogether and are respectively set to X1、X2、X3、X4、X5, make
Use following equation：Y1=X2—X1、Y2=X3—X2、Y3=X4—X3、Y4=X5—X4, calculate former and later two numerical differences and be set as
Y1、Y2、Y3、Y4Again to Y1、Y2、Y3、Y4Carry out summation Z=Y1+Y2+Y3+Y4, setting σ=target flow (Fo)/100, when 5 points of differences
With result Z in the range of ± 3 σ, start intervention stability correction, when in the range of ± 1 σ, stability and accuracy reach target
Sets requirement, correction terminates, and automatic correcting controlling signal is fed next time for wait.
2. the flow correction method according to claim 1 matched somebody with somebody in liquid layer analysis system, it is characterised in that the intervention is stable
Property correction use PID control some algorithm concept, specific algorithm is as follows：
OrWherein, uiRepresent ith
The output of controller；Kp represents proportionality coefficient；KI represents integral coefficient；KD represents differential coefficient；Ei is represented when ith is sampled
The error e i=ci-ri of value of feedback and set-point；Ts represents the sampling period；TI represents integration time constant；When TD represents differential
Between constant.
3. the flow correction method according to claim 1 or 2 matched somebody with somebody in liquid layer analysis system, it is characterised in that the interval
Time T=0.01S.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09134202A (en) * | 1995-11-09 | 1997-05-20 | Horiba Ltd | Target value control method |
| CN101634862A (en) * | 2009-07-31 | 2010-01-27 | 中南大学 | Control method of opening of large flow throttle valve for water |
| WO2015008896A1 (en) * | 2013-07-19 | 2015-01-22 | 재단법인대구경북과학기술원 | Variable pid gain design device and method for controlling multi-variable nonlinear system |
| CN104730175A (en) * | 2015-04-10 | 2015-06-24 | 大连工业大学 | Automatic vacuum liquid-chromatography separator and control method thereof |
| CN204815785U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Automatic control chromatographic device |
| CN105396327A (en) * | 2015-12-14 | 2016-03-16 | 天津汉德威药业有限公司 | Chromatography device |
| CN106255542A (en) * | 2014-02-17 | 2016-12-21 | 拜耳公司 | For from buffering or the ultra filtration unit of Medium Exchange continuously of protein solution |
| CN205941515U (en) * | 2016-05-06 | 2017-02-08 | 医博科技股份有限公司 | Rapid detection equipment |
-
2017
- 2017-06-21 CN CN201710473751.9A patent/CN107102538A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09134202A (en) * | 1995-11-09 | 1997-05-20 | Horiba Ltd | Target value control method |
| CN101634862A (en) * | 2009-07-31 | 2010-01-27 | 中南大学 | Control method of opening of large flow throttle valve for water |
| WO2015008896A1 (en) * | 2013-07-19 | 2015-01-22 | 재단법인대구경북과학기술원 | Variable pid gain design device and method for controlling multi-variable nonlinear system |
| CN106255542A (en) * | 2014-02-17 | 2016-12-21 | 拜耳公司 | For from buffering or the ultra filtration unit of Medium Exchange continuously of protein solution |
| CN104730175A (en) * | 2015-04-10 | 2015-06-24 | 大连工业大学 | Automatic vacuum liquid-chromatography separator and control method thereof |
| CN204815785U (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Automatic control chromatographic device |
| CN105396327A (en) * | 2015-12-14 | 2016-03-16 | 天津汉德威药业有限公司 | Chromatography device |
| CN205941515U (en) * | 2016-05-06 | 2017-02-08 | 医博科技股份有限公司 | Rapid detection equipment |
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| Title |
|---|
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