CN107088259A - A kind of medicinal balloon and preparation method thereof - Google Patents
A kind of medicinal balloon and preparation method thereof Download PDFInfo
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- CN107088259A CN107088259A CN201710434178.0A CN201710434178A CN107088259A CN 107088259 A CN107088259 A CN 107088259A CN 201710434178 A CN201710434178 A CN 201710434178A CN 107088259 A CN107088259 A CN 107088259A
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- balloon
- medicine
- balloon body
- medicinal
- folded
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- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 51
- 229940079593 drug Drugs 0.000 claims abstract description 14
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960002603 iopromide Drugs 0.000 claims abstract description 10
- 238000005507 spraying Methods 0.000 claims abstract description 10
- 230000002792 vascular Effects 0.000 claims abstract description 10
- 238000002604 ultrasonography Methods 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 10
- 230000001070 adhesive effect Effects 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 229930012538 Paclitaxel Natural products 0.000 claims description 7
- 229960001592 paclitaxel Drugs 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 5
- 229920002614 Polyether block amide Polymers 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229920001778 nylon Polymers 0.000 claims description 5
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 claims description 4
- 206010013786 Dry skin Diseases 0.000 claims description 3
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 3
- 229960002930 sirolimus Drugs 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- 125000002456 taxol group Chemical group 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000010422 painting Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000013146 percutaneous coronary intervention Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 230000001772 anti-angiogenic effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241001563035 Clinopodium polycephalum Species 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 201000006828 endometrial hyperplasia Diseases 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M2025/0025—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter having a collapsible lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
- A61M2025/1004—Balloons with folds, e.g. folded or multifolded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of medicinal balloon, including balloon body, whole body is all covered with 360 ° of the surface of medicine, i.e. balloon body covered with medicine on the balloon body；Balloon body has folded state and expanded state；In a folded configuration, a part of medicine be folded in do not contacted with vascular wall；Under expanded state, be folded in medicine emerge and contacted with vascular wall.The invention also discloses the preparation method of said medicine sacculus, it is related to and is covered medicine on balloon body by Iopromide by the way of extraction and/or ultrasound spraying.Medicinal balloon involved in the present invention, 360 ° of covering medicines cause blood vessel is all-round can receive medicine, and therapeutic effect more preferably, and produces more convenient.
Description
Technical field
The invention belongs to medical instruments field, more particularly, to a kind of medicinal balloon and preparation method thereof.
Background technology
Narrow angiocarpy is the one of the main reasons for causing coronary heart disease.PCI (Percutaneous Coronary
Intervention, PCI) it is the cardiovascular narrow important means for the treatment of.And with the increase of support usage quantity, in support again
Narrow (in-stent restenosis, ISR) problem is increasingly serious.Patient 5~60% by treatment can send out in short, mid-term
Angiogenic ISR, seriously limits PCI development.
In recent years, new technology --- the medicinal balloon of reangiostenosis after prevention interventional therapy operation is occurred in that.It is by
The medicine of anti-angiogenic endometrial hyperplasia applies and is placed in balloon surface, when sacculus reaches lesion vesselses wall and is softened, fills, with vascular wall
Inner membrance is contacted, and the technology in quick release of pressurizeing, diversion medicaments to local vessel wall.Medicine is locally playing anti-angiogenic inner membrance
The effect of hyperplasia, so as to prevent ISR after vascular procedure.Research in terms of its clinical practice shows that medicinal balloon handles ISR
Good curative effect is shown during lesion, and available for treatment Small vessel, bifurcated lesions, part tubular arteries protopathy
Become, and be not resistant to or be not suitable for Long-term Oral duplex antiplatelet drug patient (《In medicine-coated balloon clinical practice
State's Consensus of experts》Expert group, medicine-coated balloon clinical practice China Consensus of experts, Chinese Interventional cardiology magazine,
Volume 2016,24, the 2nd phase, 61-67 pages).
Because when medicinal balloon is in the state for being softened, filling, medicinal balloon understands blocking blood flow, therefore it persistently fills
Otherwise the time being full of at most can only may cause myocardial ischemia at 40 seconds or so.This requires medicine rapid in a short time
Release reaches the dosage for meeting needs.
The content of the invention
The problem of in order to solve to discharge enough drug doses in a short time, the present invention provides a kind of medicinal balloon, bag
Balloon body is included, whole body is all covered with 360 ° of the surface of medicine, i.e. balloon body covered with medicine on the balloon body；Sacculus sheet
Body has folded state and expanded state；In a folded configuration, a part of medicine be folded in do not contacted with vascular wall；Filling
Be full of under state, be folded in medicine emerge and contacted with vascular wall.
Further, balloon body has at least one flap, and flap has inside and outside two surfaces；In a folded configuration,
In medicine on the inner surface of flap is folded in.
Preferably, flap is 3 to 5.
In a kind of embodiment, under expanded state, the circular in cross-section of balloon body.
In another embodiment, under expanded state, the cross section of balloon body shows as setting between flap
It is equipped with depression.
Further, axis of the folding line of flap parallel to balloon body.The axis of balloon body is generally through sacculus
The conduit of body.
Further, it is provided with developing element on balloon body.
Further, developing element is ring-type.
Further, balloon body is proximally and distally provided with developing element.Distally refer in the present invention away from behaviour
That one end of author (such as doctor)；Near-end refers to close to that one end of operator (such as doctor).
In another embodiment, under expanded state, the surface of the cross section of balloon body is provided with depression.
Further, the material of balloon body is Pebax or nylon.Pebax scientific name is block polyether acidamide resin,
It is the nylon elastomer of French ARKEMA companies production.
Further, medicine is selected from taxol and rapamycin, or its combination.
Further, medicine is covered on balloon body by adhesive by the way of extraction and/or ultrasound spraying,
Adhesive is Iopromide.
The present invention also provides a kind of preparation method of medicinal balloon as described above, is sprayed using extraction and/or ultrasound
Mode covers medicine on balloon body by adhesive, and adhesive is Iopromide.
Further, it is specially by the operation of ultrasonic spraying method：
Step 1: configuration mixed solution：In mass ratio 1:2 to 2:1 takes taxol and Iopromide, is configured to mix with solvent
Solution is closed, wherein the solvent is selected from ethanol, methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, ethyl acetate and formic acid first
Ester, or its combination；
Step 2: the mixed solution to be coated to the surface of balloon body by the way of ultrasound spraying；
Step 3: dry naturally, or less than 60 DEG C heating, dryings.
Further, natural flash-off time is 5-30 minutes.Heating, drying in less than 60 DEG C of baking oven, the time is 3-20 points
Clock.
Beneficial effect：
1st, 360 ° of covering medicines are carried out to balloon body so that blood vessel is all-round can to receive medicine, therapeutic effect more preferably,
And produce more convenient.
2nd, flap is conducive to protecting the medicine in being folded in be not washed away by the blood flow, so as to avoid drug loss.
3rd, the circular in cross-section of balloon body is conducive to fitting with blood vessel.
4th, under expanded state, the cross section of balloon body shows as being provided with depression between flap, is conducive to blood flow to pass through,
So as to suitably extend the persistently full time, drug effectiveness is lifted.
5th, material is Pebax, and semi-compliant, adherent performance is good.Suitable for being blocked for cardiac stent, sacculus can be stretched
Enter, block part is supportted big, the medicine of balloon surface can coat the medicine for putting endothelial cell growth.
6th, material is nylon, and harder, non-compliance is more suitable for being expanded before stenter to implant.
Brief description of the drawings
Fig. 1 is a kind of structural representation of medicinal balloon involved in the present invention in a folded configuration.
Fig. 2 is the partially unfolded structural representation of medicinal balloon in Fig. 1.
Fig. 3 is structural representation of the medicinal balloon under expanded state in embodiment 1.
Fig. 4 is structural representation of the medicinal balloon under expanded state in embodiment 2.
Embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings, and of the invention protects content not limit to
In following examples.Under the spirit and scope without departing substantially from inventive concept, those skilled in the art it is conceivable that change and excellent
Point is all included in the present invention, and using appended claims as protection domain.
Embodiment 1
Fig. 1-3 shows a specific embodiment of medicinal balloon involved in the present invention.In the present embodiment, medicine ball
Capsule includes balloon body 1.360 ° of the surface of balloon body 1 is covered with medicine 2.Balloon body 1 has three flaps 3.At this
The quantity of flap 3 is not limited to three in invention.In a folded configuration, in the medicine 2 in the inner surface of flap 3 is folded in, because
This is not contacted with vascular wall, ensures that this some drugs 2 will not be depleted during balloon body 1 passes through blood vessel
Fall.Under expanded state, as shown in Fig. 3, the medicine 2 of the inner surface of flap 3 is emerged together with (including the flap of remaining medicine 2
The medicine 2 of 3 outer surfaces) contacted together with vascular wall, play drug effect.In the present embodiment, the cross section of balloon body 1 is in circle
Shape, to be fitted with blood vessel so that more medicines are acted on angiogenesis.
Axis of the folding line of flap 3 parallel to balloon body 1.The axis of balloon body 1 is leading through balloon body 1
Pipe.The developing element for being proximally and distally provided with ring-type of balloon body 1.
The material of balloon body 1 is Pebax or nylon；Medicine 2 is selected from taxol and rapamycin, or its combination.
Embodiment 2
Fig. 4 shows under another medicinal balloon of the present invention, its expanded state that the cross section of balloon body 1 is shown as
Depression 4 is provided between adjacent flaps.Depression 4 effect be so that medicinal balloon will not also hinder completely under expanded state
Clinopodium polycephalum, so as to extend the persistently full time, provides more times, so as to reach more preferable effect for insoluble drug release
Really.Remaining design is same with embodiment 1, is 360 ° of covering medicines 2, and possess flap 3.The quantity of depression 4 and flap 3
Quantity is identical.
Embodiment 3
Under expanded state, the surface of the cross section of balloon body is provided with depression, is conducive to blood flow to pass through.With embodiment
Unlike 2, the depression is not limited to the depression between flap.Remaining be the same as Example 2.
The medicine covering method of embodiment 4
Medicine is covered on balloon body by adhesive by the way of extraction and/or ultrasound spraying, adhesive is
Iopromide.
It is specially by the operation of ultrasonic spraying method：
Step 1: configuration mixed solution：In mass ratio 1:1 takes taxol and Iopromide, mixing is configured to solvent molten
Liquid, wherein the solvent is ethanol；
Step 2: the mixed solution to be coated to the surface of balloon body by the way of ultrasound spraying；
Step 3: dry naturally, or less than 60 DEG C heating, dryings.
Wherein, the mass ratio of taxol and Iopromide is not limited to the present embodiment, can be 1:2 to 2:1.And solvent is not yet
It is limited to ethanol, can is methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, ethyl acetate and methyl formate, or its combination.
Preferred embodiment of the invention described in detail above, technical concept and spy only for the explanation present invention
Point, its object is to allow those skilled in the art to understand present disclosure and implement according to this, can not limit this with this
The protection domain of invention.It should be appreciated that one of ordinary skill in the art just can be according to the present invention's without creative work
Many modifications and variations are made in design.Therefore, all technical staff in the art are under this invention's idea in prior art
On the basis of by the available technical scheme of logical analysis, reasoning, or a limited experiment, all should be by claims institute
In the protection domain of determination.
Claims (10)
1. a kind of medicinal balloon, including balloon body, it is characterised in that whole body is all covered with medicine on the balloon body, i.e.,
360 ° of the surface of the balloon body is covered with medicine；The balloon body has folded state and expanded state；In the folding
Under overlapping state, a part of medicine be folded in do not contacted with vascular wall；Under the expanded state, it is described be folded in
Medicine is emerged to be contacted with vascular wall.
2. medicinal balloon as claimed in claim 1, it is characterised in that the balloon body has at least one flap, described
Flap has inside and outside two surfaces；Under the folded state, the medicine on the inner surface of the flap is folded in interior.
3. medicinal balloon as claimed in claim 2, it is characterised in that the flap is 3 to 5.
4. medicinal balloon as claimed in claim 2, it is characterised in that under the expanded state, the horizontal stroke of the balloon body
Section is rounded.
5. medicinal balloon as claimed in claim 2, it is characterised in that under the expanded state, the horizontal stroke of the balloon body
Section shows as being provided with depression between the flap.
6. medicinal balloon as claimed in claim 1, it is characterised in that the material of the balloon body is Pebax or nylon.
7. medicinal balloon as claimed in claim 1, it is characterised in that the medicine is selected from taxol and rapamycin, or
It is combined.
8. medicinal balloon as claimed in claim 1, it is characterised in that will be described by the way of extraction and/or ultrasound spraying
Medicine is covered on the balloon body by adhesive, and the adhesive is Iopromide.
9. a kind of preparation method of medicinal balloon as claimed in claim 1, it is characterised in that using extraction and/or ultrasound spray
The mode of painting covers the medicine on the balloon body by adhesive, and the adhesive is Iopromide.
10. preparation method as claimed in claim 9, it is characterised in that be specially by the operation of ultrasonic spraying method：
Step 1: in mass ratio 1:2 to 2:1 takes taxol and Iopromide, and mixed solution is configured to solvent, wherein described molten
Agent is selected from ethanol, methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, ethyl acetate and methyl formate, or its combination；
Step 2: the mixed solution to be coated to the surface of balloon body by the way of ultrasound spraying；
Step 3: dry naturally, or less than 60 DEG C heating, dryings.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710434178.0A CN107088259A (en) | 2017-06-09 | 2017-06-09 | A kind of medicinal balloon and preparation method thereof |
| PCT/CN2018/083316 WO2018223775A1 (en) | 2017-06-09 | 2018-04-17 | Drug-coated balloon and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710434178.0A CN107088259A (en) | 2017-06-09 | 2017-06-09 | A kind of medicinal balloon and preparation method thereof |
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Cited By (6)
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| CN107519571A (en) * | 2017-07-27 | 2017-12-29 | 上海心至医疗科技有限公司 | Medicinal balloon and preparation method thereof |
| WO2018223775A1 (en) * | 2017-06-09 | 2018-12-13 | 上海心至医疗科技有限公司 | Drug-coated balloon and preparation method therefor |
| CN109481827A (en) * | 2018-11-05 | 2019-03-19 | 南京友德邦医疗科技有限公司 | A kind of medicine eluting balloon catheter and preparation method thereof |
| CN111298272A (en) * | 2020-03-11 | 2020-06-19 | 科塞尔医疗科技（苏州）有限公司 | Drug-coated balloon, preparation method thereof and drug-coated balloon dilatation catheter |
| CN111603664A (en) * | 2020-05-28 | 2020-09-01 | 上海市东方医院（同济大学附属东方医院） | Balloon catheter |
| CN112827055A (en) * | 2019-11-25 | 2021-05-25 | 丁海雁 | Medicine-feeding balloon assembly and medical instrument comprising same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018223775A1 (en) * | 2017-06-09 | 2018-12-13 | 上海心至医疗科技有限公司 | Drug-coated balloon and preparation method therefor |
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| CN109481827A (en) * | 2018-11-05 | 2019-03-19 | 南京友德邦医疗科技有限公司 | A kind of medicine eluting balloon catheter and preparation method thereof |
| CN112827055A (en) * | 2019-11-25 | 2021-05-25 | 丁海雁 | Medicine-feeding balloon assembly and medical instrument comprising same |
| CN112827055B (en) * | 2019-11-25 | 2022-02-18 | 丁海雁 | Medicine-feeding balloon assembly and medical instrument comprising same |
| CN111298272A (en) * | 2020-03-11 | 2020-06-19 | 科塞尔医疗科技（苏州）有限公司 | Drug-coated balloon, preparation method thereof and drug-coated balloon dilatation catheter |
| CN111603664A (en) * | 2020-05-28 | 2020-09-01 | 上海市东方医院（同济大学附属东方医院） | Balloon catheter |
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| WO2018223775A1 (en) | 2018-12-13 |
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