CN107084942A - A kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα- - Google Patents
A kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα- Download PDFInfo
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- CN107084942A CN107084942A CN201710350340.0A CN201710350340A CN107084942A CN 107084942 A CN107084942 A CN 107084942A CN 201710350340 A CN201710350340 A CN 201710350340A CN 107084942 A CN107084942 A CN 107084942A
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- 238000001228 spectrum Methods 0.000 title claims abstract description 39
- 238000001514 detection method Methods 0.000 title claims abstract description 25
- 239000013078 crystal Substances 0.000 claims abstract description 63
- 230000003287 optical effect Effects 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 238000004458 analytical method Methods 0.000 claims abstract description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 47
- 239000003814 drug Substances 0.000 claims description 25
- 229940079593 drug Drugs 0.000 claims description 20
- 239000007787 solid Substances 0.000 claims description 20
- 238000001704 evaporation Methods 0.000 claims description 16
- 230000008020 evaporation Effects 0.000 claims description 16
- 238000005259 measurement Methods 0.000 claims description 15
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 230000036571 hydration Effects 0.000 claims description 9
- 238000006703 hydration reaction Methods 0.000 claims description 9
- 230000004044 response Effects 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001328 terahertz time-domain spectroscopy Methods 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 6
- 239000002904 solvent Substances 0.000 abstract description 3
- 238000012546 transfer Methods 0.000 abstract description 3
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 230000003595 spectral effect Effects 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000004611 spectroscopical analysis Methods 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- 238000004467 single crystal X-ray diffraction Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003874 central nervous system depressant Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
- G01N21/3586—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4022—Concentrating samples by thermal techniques; Phase changes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4022—Concentrating samples by thermal techniques; Phase changes
- G01N2001/4027—Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample
Abstract
The invention provides the polymorphous terahertz light spectrum detection method of thiobarbituricacidα-.The present invention's solves the problem of sample preparation present in existing detection method is cumbersome, analysis is complicated, photon energy height may cause crystal transfer.This patent obtains thiobarbituricacidα- polymorphic using solvent recrystallization legal system, recycles terahertz time-domain spectroscopic technology to measure thiobarbituricacidα- polymorphic, obtain they terahertz wave band optical parametric.The present invention is simple, quick, lossless with terahertz time-domain spectroscopic technology determination sample method.
Description
Technical field
The invention belongs to medicinal chemistry art and spectrum analysis field.More particularly to a kind of thiobarbituricacidα- is polymorphous
Terahertz light spectrum detection method
Background technology
Thiobarbituricacidα-, as a kind of central nervous system depressant, can be used for calm and hypnosis.Current thio bar
6 kinds of polymorphics and a kind of hydration crystal formation are had than appropriate acid.There are some researches show prepared by thiobarbituricacidα- polymorphic have solvent weight
Crystallisation and polishing.But there are tautomeric transformations in itself in thiobarbituricacidα-, upon grinding between and frequency occur it is trickle become
During change, crystal transfer easily occurs for thiobarbituricacidα-.
The premise of reasonable selection drug crystal forms is the detection and resolution of active constituents of medicine in medicine, clinical treatment.And it is many
Crystal formation is easier to change under other change of external conditions such as temperature, humidity.Therefore, polymorphous crystal formation is detected and confirmed just
An important link into the fields such as medicament research and development, production and storage.Current detection method mainly has Single Crystal X-ray
Diffraction approach, solid state nmr spectrum, but two kinds of detection methods have that sample preparation is cumbersome, analysis is complicated, photon energy height can
The defect of crystal transfer can be caused, therefore it is critical to explore a kind of quick, lossless detection method.
The frequency of Terahertz (THz) wave band is located at 0.1~10THz (1THz=1012Hz), its photon energy has with most of
The energy of transition is roughly the same between the vibration of machine molecule and micel and rotational energy level, thus material THz spectrum contain it is rich
Rich physics and chemical information, important application is suffered from fields such as medicine, chemistry and materials.In addition, the photon energy of THz ripples
Very little (only milli electron-volt magnitude) is measured, can avoid causing sample in test process harmful ionization, nothing is carried out to material
Damage detection.Terahertz time-domain spectroscopic technology (terahertz time-domain spectroscopy, THz-TDS) is using same
Coherent detection is walked, the information in terms of obtained signal contains amplitude and phase is measured, is that can obtain THz by Fourier transformation
The optical parametrics such as spectrogram, sample refractive index, absorption coefficient.And measurement can be carried out at room temperature, measurement process is quick, operation letter
It is single, it is widely applied at present.
The content of the invention
It is an object of the invention to provide a kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα-, including it is as follows
Step：
Prepare sample step：
Prepare crystal formation II：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, obtain yellowish after natural evaporation at room temperature
Color solid；
Prepare crystal formation III：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, dry air, obtained after natural evaporation
Yellow solid；
Prepare crystal formation VI：Take thiobarbituricacidα- bulk drug to be dissolved in anhydrous acetonitrile, obtain white after natural evaporation at room temperature
Solid；
Prepare hydration crystal formation：Take thiobarbituricacidα- bulk drug to be dissolved in distilled water, obtain white after natural evaporation at room temperature
Chip solid；
Wherein, the thiobarbituricacidα- bulk drug is crystal formation I, pale yellow powder solid.
Sample test step：The different crystal forms sample of thiobarbituricacidα- is carried out using terahertz time-domain spectroscopy system saturating
Penetrate measurement；
Data processing step：Optical parametric of the different crystal forms sample in terahertz wave band is extracted, different crystal forms sample is obtained
The terahertz wave band characteristic frequency spectrum response and feature spectrum of refractive index.
It is preferred that, crystal formation II is prepared in described sample preparation steps, crystal formation III is prepared, prepares crystal formation VI, prepares hydration
The temperature of solution is 50 DEG C in any one of crystal formation.
It is preferred that, described to prepare in crystal formation III, the air humidity of the dry air is less than 30%.
It is preferred that, it is described that the different crystal forms sample of thiobarbituricacidα- is transmitted using terahertz time-domain spectroscopy system
Measurement includes：At least 2 times measurements, and the number used using the average value of measurement data as detection and analysis are carried out to different crystal forms sample
According to.
It is preferred that, the scanning range of the spectrum of the terahertz wave band is 0.20-1.60THz.
The polymorphous terahertz light spectrum detection method of a kind of thiobarbituricacidα- that the present invention is provided, and overcome traditional inspection
The deficiency of survey method, selects tera-hertz spectra, is because the tera-hertz spectra of sample refers to common to certain material, with spy
The component colony (certain class or several constituents) of levying property determines obtained Terahertz collection of illustrative plates or image through the method such as chromatogram or spectrum.
Utilize analyzing and identifying that tera-hertz spectra can be integrated to it.
What the technical scheme of solution goal of the invention was realized in：
(1) in the case of control organic solvent temperature, air humidity, mixing time, taking thiobarbituricacidα- to be dissolved in has
Machine solvent, at room temperature or under dry air, natural evaporation obtains corresponding crystal formation I, crystal formation II, crystal formation III, crystal formation IV and water
Synthetic type.
(2) recycle terahertz time-domain spectroscopy system to carry out transmission measurement to above-mentioned sample, sample is extracted according to time domain waveform
The optical parametric of product, spectroscopic data chooses absorption coefficient and refractive index.Measured using THz-TDS technologies, sample preparation is simple,
It can avoid to the pretreatment in the technologies such as single crystal X-ray diffraction to sample complexity.And the signal to noise ratio height of THz-TDS systems,
It is simple to operate.
(3) according to obtained crystal formation I, crystal formation II, crystal formation III, crystal formation IV and hydration crystal formation in the different suction of terahertz wave band
Spectrum and spectrum of refractive index are received, qualitative analysis can be carried out to the polymorphous sample of thiobarbituricacidα- inhomogeneity, is final set up
The THz fingerprint spectrum libraries of all kinds of samples lay the foundation.
The polymorphous terahertz light spectrum detection method of a kind of thiobarbituricacidα- that the present invention is provided, it, which has, prepares and surveys
Amount method is simple, quick and easy, the advantages of detection technique is lossless, it is adaptable to all to have characteristic absorption peak in terahertz wave band
Polymorph medicine.
Brief description of the drawings
Fig. 1 is spectral response and the spectrum of refractive index of thiobarbituricacidα- crystal formation I (TBA form I) in embodiment 1；
Fig. 2 is spectral response and the spectrum of refractive index of thiobarbituricacidα- crystal formation II (TBA form II) in embodiment 1；
Fig. 3 is spectral response and the spectrum of refractive index of thiobarbituricacidα- crystal formation III (TBA form III) in embodiment 1；
Fig. 4 is spectral response and the spectrum of refractive index of thiobarbituricacidα- crystal formation IV (TBA form IV) in embodiment 1；
Fig. 5 is spectral response and the spectrum of refractive index of thiobarbituricacidα- hydration crystal formation (TBA hydrate) in embodiment 1.
Embodiment
To make those skilled in the art more fully understand technical scheme, below in conjunction with the accompanying drawings and specific embodiment party
Formula is described in further detail to the present invention.
Experiment is measured with THz-TDS systems to sample, and the signal to noise ratio of system is up to 50dB, the spectroscopic data of sample
Extraction is the physical model (formula 1,2) proposed using T.D.Dorney et al..It is logical respectively with reference to the time-domain signal with sample
Three average gained of measurement nitrogen and sample are crossed, the time window width of time-domain signal is about 20ps, corresponding spectral resolution
About 0.05THz.
Wherein n (ω) is the real part of the complex refractivity index of sample, and abbreviation refractive index, (ω) is the absorption coefficient of sample, and d is sample
Product thickness, ω is frequency, and φ (ω) and ρ (ω) are sample and the phase difference and quotient of amplitudes of reference signal respectively.
Above description is only used for realizing embodiments of the present invention, do not depart from any modification in the scope of the invention or
It is local to replace, it should belong to the scope of the claim of the present invention.
Embodiment 1
The present embodiment provides a kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα-, comprises the following steps：
Prepare sample step：
Prepare crystal formation II (sample 2)：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, obtained at room temperature after natural evaporation
To faint yellow solid；
Specifically, take thiobarbituricacidα- bulk drug to be dissolved in the absolute ethyl alcohol that temperature is 50 DEG C, in course of dissolution fully
Stir about puts it at room temperature in 20 minutes after being completely dissolved, natural cooling, waits for evaporation, 15 quietly under condition of natural ventilation
Crystallization forms faint yellow solid crystal formation II after it.
Prepare crystal formation III (sample 3)：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, dry air, steam naturally
Yellow solid is obtained after hair；
Specifically, take thiobarbituricacidα- bulk drug to be dissolved in the absolute ethyl alcohol that temperature is 50 DEG C, in course of dissolution fully
Stirring is placed at room temperature, natural cooling for 20 minutes afterwards up to being completely dissolved, and is less than in air humidity under 30% closed environment
Wait for evaporation quietly, after 15 days, crystalline yellowly solid, yellow solid is crystal formation III.
Prepare crystal formation VI (sample 4)：Take thiobarbituricacidα- bulk drug to be dissolved in anhydrous acetonitrile, obtained at room temperature after natural evaporation
To white solid；
Specifically, take thiobarbituricacidα- bulk drug to be dissolved in the anhydrous acetonitrile that temperature is 50 DEG C, in course of dissolution fully
Stirring is placed at room temperature, natural cooling for 20 minutes after being completely dissolved, and waits for evaporation, 15 quietly under condition of natural ventilation
White solid crystal formation IV is obtained after it.
Prepare hydration crystal formation (sample 5)：Take thiobarbituricacidα- bulk drug to be dissolved in distilled water, obtained at room temperature after natural evaporation
To white flaky solid；
Specifically, take thiobarbituricacidα- bulk drug to be dissolved in the distilled water that solution temperature is 50 DEG C, filled in course of dissolution
Divide stirring 20 minutes until being completely dissolved, be placed in natural cooling at room temperature, wait for evaporation quietly under condition of natural ventilation, after 15 days
The white flaky solid arrived is hydration crystal formation.
Wherein, the thiobarbituricacidα- bulk drug is crystal formation I (sample 1), pale yellow powder solid.Can be by direct
Purchase is obtained.
Sample test step：The different crystal forms sample of thiobarbituricacidα- is carried out using terahertz time-domain spectroscopy system saturating
Penetrate measurement；
Fine particle is obtained specifically, the above-mentioned 5 kinds of samples prepared are ground with mortar respectively, is weighed about
260mg, the experiment test sample that a diameter of 13mm, thickness are 1.2-1.6mm or so, sample knot are pressed into 4Mpa pressure
Structure is uniform, both ends of the surface are parallel.THz time domain spectrum (THz Time-Domain Spectroscopy, THz-TDS) is using (beautiful
Zomega companies of state) Z2 measuring systems.Excitation source swashs for the titanium sapphire femtosecond mode locking pulse of Spectra Physics companies
Light device, laser repetition rate 80MHz, pulsewidth 100fs, centre wavelength 800nm.Measuring environment be room temperature, the nitrogen environment of drying,
Relative humidity is less than 4%.The scanning range of the spectrum of the terahertz wave band is 0.20-1.60THz.
Measurement is that each product are tested 5 times, and 5 measurement results of data progress are averaged；
Data processing step：Optical parametric of the different crystal forms sample in terahertz wave band is extracted, different crystal forms sample is obtained
The terahertz wave band characteristic frequency spectrum response and feature spectrum of refractive index.
The statistical average of measurement is handled, the spectral response of crystal formation and specific refractivity in five has been respectively obtained
(Fig. 1,2,3,4,5).
A kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα- of the offer of the present embodiment, it, which has, prepares
Simple, quick and easy, the advantages of detection technique is lossless with measuring method.
It is understood that the principle that embodiment of above is intended to be merely illustrative of the present and the exemplary implementation that uses
Mode, but the invention is not limited in this.For those skilled in the art, the essence of the present invention is not being departed from
In the case of refreshing and essence, various changes and modifications can be made therein, and these variations and modifications are also considered as protection scope of the present invention.
Claims (5)
1. a kind of polymorphous terahertz light spectrum detection method of thiobarbituricacidα-, it is characterised in that comprise the following steps：
Prepare sample step：
Prepare crystal formation II：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, obtain pale yellow colored solid after natural evaporation at room temperature
Body；
Prepare crystal formation III：Take thiobarbituricacidα- bulk drug to be dissolved in absolute ethyl alcohol, dry air, yellow is obtained after natural evaporation
Solid；
Prepare crystal formation VI：Take thiobarbituricacidα- bulk drug to be dissolved in anhydrous acetonitrile, obtain white solid after natural evaporation at room temperature；
Prepare hydration crystal formation：Take thiobarbituricacidα- bulk drug to be dissolved in distilled water, obtain white plates after natural evaporation at room temperature
Solid；
Wherein, the thiobarbituricacidα- bulk drug is crystal formation I, pale yellow powder solid.
Sample test step：Transmission survey is carried out to the different crystal forms sample of thiobarbituricacidα- using terahertz time-domain spectroscopy system
Amount；
Data processing step：Extract different crystal forms sample terahertz wave band optical parametric, obtain different crystal forms sample
The characteristic frequency spectrum response of the terahertz wave band and feature spectrum of refractive index.
2. the polymorphous terahertz light spectrum detection method of thiobarbituricacidα- according to claim 1, it is characterised in that institute
Crystal formation II is prepared in the sample preparation steps stated, crystal formation III is prepared, prepares crystal formation VI, prepares solution in any one of hydration crystal formation
Temperature be 50 DEG C.
3. the polymorphous terahertz light spectrum detection method of thiobarbituricacidα- according to claim 1, it is characterised in that institute
State and prepare in crystal formation III, the air humidity of the dry air is less than 30%.
4. the polymorphous terahertz light spectrum detection method of thiobarbituricacidα- according to claim 1, it is characterised in that institute
State is included using terahertz time-domain spectroscopy system to the different crystal forms sample progress transmission measurement of thiobarbituricacidα-：To the not isomorphous
Pattern product carry out at least 2 times measurements, and the data used using the average value of measurement data as detection and analysis.
5. the polymorphous terahertz light spectrum detection method of thiobarbituricacidα- according to claim 1, it is characterised in that institute
The scanning range for stating the spectrum of terahertz wave band is 0.20-1.60THz.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113237847A (en) * | 2021-05-07 | 2021-08-10 | 西南科技大学 | Nondestructive testing method and system for hexanitrohexaazaisowurtzitane crystal form |
-
2017
- 2017-05-18 CN CN201710350340.0A patent/CN107084942A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| MICHELE R. CHIEROTTI ET AL: "The Richest Collection of Tautomeric Polymorphs:The Case of 2-Thiobarbituric Acid", 《CHEM. EUR. J.》 * |
| 方虹霞: "太赫兹技术在沙坦类药物多晶、共晶及定量分析中的应用", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 杨玉平 等: "《太赫兹成像技术》", 31 August 2008, 中央民族大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113237847A (en) * | 2021-05-07 | 2021-08-10 | 西南科技大学 | Nondestructive testing method and system for hexanitrohexaazaisowurtzitane crystal form |
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