CN107077451A - Drug delivery system and method - Google Patents
Drug delivery system and method Download PDFInfo
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- CN107077451A CN107077451A CN201580048532.5A CN201580048532A CN107077451A CN 107077451 A CN107077451 A CN 107077451A CN 201580048532 A CN201580048532 A CN 201580048532A CN 107077451 A CN107077451 A CN 107077451A
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- China
- Prior art keywords
- sensor circuit
- medication device
- transmission center
- application program
- medicine
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Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
Abstract
A kind of drug delivery system includes：Medical server, the medical server is configured to send and receive and processing data；Medication device, the medication device is configured to the medicine using pre-selection；Sensor circuit, the sensor circuit is configured to detect the selected parameter relevant with medicine delivery and transmits information；Transmission center, the transmission center is configured to communicate with the medical server and the sensor circuit.The transmission center is configured to receive the signal from the sensor circuit and exchanges described information.Application program is configured to contribute to the information between the sensor circuit and the medical server to exchange.The application program has the agreement of one group of pre-selection.The application program monitors the use of the medication device and the position of the medication device by being connected to the medication device via the transmission center.
Description
Technical field
Various exemplary embodiments disclosed herein relate generally to configurable drug delivery system, more specifically relate to
And the drug delivery system with intelligence sensor, the sensor is for remote detection and monitoring and medicine and/or medication device
Storage and use relevant design parameter.
Background technology
The regular medication system relevant with medicine delivery is used for monitoring patient couple when patient is located at the health organ specified
The use of medicine.Correspondingly, such medical system monitoring or tracking are administered to the amount of the medicine of patient.This information can be by
Medical practitioner manually or using the equipment of such as scanner and bar code is automatically inputted medical system.Although such system
It is adapted to its desired use：Medicine is tracked and monitored when patient and/or medicine are in medical institutions to use, but is left in user
After medical institutions, most systems are not providing the extensive and accurate remote real time monitoring to user's medicine service condition.
In addition, most of medical systems are unable to tracking user in pharmacy or the medicine for passing through mail reception.
The above object and advantages of the present invention are the illustrations for the objects and advantages that can be realized by various exemplary embodiments, and
It is not intended to exhaustive or limits achievable possible advantage.Therefore, these and other objects of various exemplary embodiments and excellent
Point will from description herein it is clear that or can be by putting into practice various exemplary embodiment acquistions, these objects and advantages
As embodied or obviously any modification may be changed according to for those skilled in the art herein.Therefore, originally
Invention is dependent on the novel method for showing and describing in various exemplary embodiments herein, arrangement, combination and improves.
The content of the invention
The brief overview of various exemplary embodiments is provided below.Can be carried out in the following content of the invention some simplify and
Omit, the content of the invention is intended to protrude and introduces some aspects of various exemplary embodiments, and does not limit the scope of the invention.
The detailed description of exemplary embodiment is enough to allow one of ordinary skill in the art to realize and using will appear from paragraphs below
Inventive concept.
Various exemplary embodiments are related to drug delivery system.Drug delivery system includes：Medical server, it is configured
Into transmission, receive and processing data；Medication device, it is configured to the medicine using pre-selection；Sensor circuit, it is configured to
The detection selected parameter relevant with medicine delivery simultaneously transmits information；Transmission center, it is configured to and medical server and sensing
Device circuit communication.Transmission center be configured to receive the signal from sensor circuit and with server exchange information.Medicine is passed
System is sent also to include application program, the application program is configured to contribute to the letter between sensor circuit and medical server
Breath is exchanged.
In the other various embodiments of drug delivery system, transmission center is mobile device, and it is configured to use
BluetoothTMOr Bluetooth Low Energy technology exchanges information with sensor circuit, and also with server communication.Sensor circuit
It could attach to medication device or on pharmaceutical carrier.
In other various embodiments, sensor circuit includes temperature sensor, and it is configured to detect medication device
The temperature of surrounding environment.The temperature detected is sent to transmission center by sensor circuit, and application program will be detected
Temperature is compared with selected temperature range.
In other various embodiments, sensor circuit includes position detector, and the position detector is configured to, carried
For the information on medication device and the position of the sensor circuit of attachment, and the data relevant with position are sent to apply journey
Sequence.
In other various embodiments, sensor circuit includes contact element, and the contact element is arranged on medication device
On, to contribute to the administration that the medicine from the equipment is detected by application program.Application program can be arranged on transmission center,
So as to provide the interface for entering information into application program for user.
In addition, various exemplary embodiments are related to a kind of side for being used to remotely monitor the medicine delivery at medication device
Method.This method is including the use of being arranged on the element testing communicated in medication device with sensor circuit connecing at medication device
Touch.Next, this method step includes the signal from sensor circuit being sent to application program, to indicate in medication device
Place has come in contact.This method is additionally included in transmission center and receives the signal from sensor circuit and use application program true
The fixed signal includes contact element information.This method also includes sending the signal from transmission center to the medical services of connection
Device, to indicate that medicine has been accessible.
In addition, various exemplary embodiments are related to a kind of method for being used to detect the position of medication device.This method includes
Transmit the bluetooth (Bluetooth from the sensor circuit being arranged on medication device or medication device carrierTM) signal.The party
Method also includes：If signal is in the range of, Bluetooth is received in transmission centerTMSignal.This method also includes：If
BluetoothTMSignal is received, then triggers the signal from transmission center to the server remotely connected, to provide transmission center
Position.In the case where signal is not in the range of transmission center, this method includes triggering from transmission center to long-range connection
Server signal, with indication sensor circuit not in the range of transmission center.
This method also includes：Transmission center is detected by sensing the signal intensity of the bluetooth transmission from sensor circuit
Approximate distance and/or position away from sensor circuit.When user moves closer or far from equipment, by showing the strong of signal
Degree, can carry out the positioning in the direction of medication device.
This method also includes：By starting button or signal at transmission center or application program so that sensor circuit
Send sound, vibration and LED, the distance or position of detection sensor circuit and medication device.This method is also using the whole world
Alignment system application program is to determine the location of transmission center, to detect the position of medication device.
Brief description of the drawings
In order to be best understood from various exemplary embodiments, refer to the attached drawing, wherein：
Fig. 1 shows the embodiment of drug delivery system, and the system is configured to remotely monitor medicine use and position, tool
There are the transmission center communicated with medication device and intelligent sensor circuit；
Fig. 2 is the stereogram of illustrative drug equipment, and the equipment includes the intelligent sensor circuit being arranged on housing, with
Help to monitor the position of medication device and use；
Fig. 3 is flow chart, show monitoring Fig. 1 drug delivery system in medication device position method implementation
Example；
Fig. 4 is flow chart, shows the embodiment for the method that detection medicine is used.
Understand for convenience, identical reference be used for indicating with substantially the same or similar structure and/or
The element of substantially the same or similar function.
Embodiment
In order to simplify and illustration purpose, using described system and method to be illustrated principle.In the following description,
Many details are elaborated, to provide the comprehensive understanding to example.However, one of ordinary skill in the art should manage
Solution, example can be put into practice in the case where being not limited to these details.In other situations, well known side is not described in detail
Method and structure, in order to avoid unnecessarily obscure the understanding to example.
The ability that the medicine that health care provider monitored and tracked in real time patient is used contributes to the medical services to provide
Direction patient provides instant proficient service.Health care provider real-time tracking or the medicine of monitoring patient are used can also
There is provided benefit of safety for patient, for example, prevent patient forget to take he/or her medicine, prevent patient's excessive use prescription medicine
Thing, and provide help on-line during medicament administration for patient.Real time drug tracking also allows patient or medical services to provide
The medicine that Fang Dingwei is mislayed, and contribute to contact emergency service mechanism or personnel when using medicine.
Electronic equipment, such as smart mobile phone or similar transmission center, it is allowed to which user and/or health care provider are logical
Cross BluetoothTMWith medication device telecommunication, while passing through internet, Wi-Fi or Cellular Networks and remote date transmission
Device and associated network communication.Accordingly, it is desirable to provide a kind of drug delivery system, the system provides configurable intelligence sensor electricity
Road and the transmission center communicated with remote data server, to monitor and track the use of selected medicine and/or medication device, and
And also help specialized medical service enhanced to patient's offer.
Referring now to accompanying drawing, wherein diagram is to describe one or more embodiments rather than in order to limit one or many
Individual embodiment, Fig. 1 shows the embodiment of the drug delivery system generally indicated by reference 100.With intelligence sensor
102 or the drug delivery system 100 of intelligent sensor circuit communication contribute to the monitoring and tracking of key parameter, the crucial ginseng
Number is associated to the use and storage of selected medicine and/or medication device 104 with patient.Such Medical Devices may include for example
Automatic injectorOr automatic injectorCap 112, novopen, transdermal patch, metered dose inhaler, dry powder
Inhalator, sprayer, acetic acid copaxone pen.It should be noted that it is contemplated that not departing from the situation of the scope of the present invention
Under, intelligence sensor 102 can combine any medical equipment operation for distribute medicine.
Drug delivery system 100 includes intelligent sensor circuit 102.Intelligence sensor 102 may be configured to detection and
Help to be sent to and the information (medication-specific different because of medicine from medication device 104
Information) exchange, to be sent to remote medical server 150 and associated network.Intelligence sensor 102 can be set
Put in medication device 104, in the cap portion 112 of medication device 104 or on associated pharmaceutical carrier 110, the medicine
Carrier can be packaging or container.
As indicated, drug delivery system 100 generally includes medical server 150, and also includes and intelligent sensing
The transmission center 106 of device 102 and the telecommunication of medical server 150.Transmission center 106 contributes to by the institute of intelligence sensor 102
Transmission and friendship of the information different because of medicine detected between remote medical server 150 and intelligent sensor circuit 102
Change.Drug delivery system 100 also includes software application 108.Application program 108 coordinates with the platform of drug delivery system 100
Operation, and be configured to perform various functions, the various functions be related to collect, store, monitoring and in user and/or
The remote transmission information different because of medicine between health care provider, transmission center 106 and medical server 150.
Drug delivery system 100 may also include one or more biometric apparatus 120, different because of patient for measuring
Healthy related data and by the information transmission to transmitting center 106 and/or application program 108.It is contemplated that bio-identification is set
Standby 120 are configured to transmit the information by wireless and/or bluetooth.
Intelligent sensor circuit 102 may include one or more various types of sensors, for detecting by applying journey
The pre-selection parameter that sequence 108 is provided.Intelligence sensor 102 may include physical location sensor 122, and it is arranged to detection and medicine
The relevant situation of the physical location of thing equipment 104.Physical location sensor can be incorporated to such as global position system GPS 190
Feature, to provide the information (location-specific different because of position on the present position of medication device 104
information)).Position or health care provider are misplaced it needs to be determined that the position of the patient with the medicine in medicine
In the case of, this feature is probably favourable.
Intelligent sensor circuit 102 can be integrated circuit, and it includes additional sensor, for detection such as temperature
(utilizing temperature sensor 124), pressure (by pressure sensor 126), MAF (by sensor 128), magnetic field
(Hall effect) (conductivity detector 130), electrical impedance (utilizing sensor 132), strain and sound (pass through voice detector
134) and many other parameters parameter, and including colorimetric sensor 136 for detect medicine color.
Temperature sensor 124 provided with sensor circuit 102 may be configured to, and continuously measure the real time temperature of medicine
And/or the storage location of medicine.When temperature sensor 124 provides temperature reading to application program via sensor circuit 102
When 108, the information can be relayed to medical server 150 and by its processing.Can be by application program 108 and/or server
Such temperature information is compared with the approved storage temperature for the medicine, and when the medicine is in undesirable
Patient can be sent to during state via transmission center 106 by warning.So, with temperature sensor 124 and sensor circuit 102
The also measurable medication device 104 of the application program 108 of communication and medicine are in the period of unlicensed temperature, what this was not agreed to
Temperature indicates possible medicine deterioration.
For example, for such as adrenergic medicine, the temperature range of license is about 15-30 DEG C.Therefore, exist
Temperature sensor 124 detects the temperature reading of medicine in the case of the tolerance band of pre-selection, is aroused by application program 108
Indicator 170 by the interface that is arranged on transmission center 106 or can be arranged on medication device 104 or carrier 110
External equipment sends alarm, warning or message.
Intelligent sensor circuit 102 may also include microcontroller 142, and it can be minicom, the minicom
Including processor core 144, memory 146 and programmable input/output ancillary equipment 148.Analog sensed is needed in order to detect
The parameter of device, it is contemplated that, intelligent sensor circuit 102 may include analog-digital converter 140 (" ADC "), for that will be received from
The signal of analog sensor is changed to data signal, for example, Texas Instruments (company) (Texas Instruments) 8/
16/32 MCU.Memory 146 can be arranged on microcontroller 142.Memory 146 can with NOR flash memory or OTP ROM with
And RAM form is provided.In addition, microcontroller 142 may be configured to receive embedded application program so that drug surveillance should
It can be stored on intelligent sensor circuit 102 with program 108.
Intelligent sensor circuit 102 may also include such as BluetoothTMLow-consumption wireless electricity (BluetoothTM Low
Energy Radio, " BTLE ") or infrared transmitter transmitter 116, for will be by intelligent sensor circuit 102 and other
The data and/or information transmission that the sensor is detected are to transmission center 106.It is contemplated that instead of (" Bluetooth Low Energy ")
BTLE transmitting sets 116 and microcontroller 142, can provide module 118, and the module is incorporated to BTLE radio 116 and micro-
Controller 122 and ADC 140 institute are functional.Microcontroller 122 can be analogous to by the micro- of such as Microchip manufactures
Controller.It is further contemplated that sensor circuit 102 can be incorporated to the communication of other forms, such as RFID, NFC or other forms
Radio communication, with transmission center 106 or directly to be communicated with medical server 150.Each sensor circuit 102 can have only
One radio number, the number can be sent to transmission center 106 and application program 108 in communication period.This is uniquely marked
Application program 108 and user can be allowed while tracking multiple medication devices 104, and also allow transmission center 106 by knowing symbol
Automatically matched with circuit 102.
The position of sensor circuit 102 and medication device 104 can be utilized by sensing the signal intensity of Bluetooth transmission
It is directly perceived to instruct to determine.When user moves closer or far from medication device 104, by being shown at transmission center 106
The intensity of signal, it is possible to achieve the positioning to the direction of medication device 104.It is further contemplated that by starting at transmission center 106
Or button or signal at application program 108 so that sensor circuit 102 sends sound, vibration and LED so that user's energy
The position of detection sensor circuit 102, it is possible to achieve distance and/or position to the sensor circuit 102 in medication device 104
The detection put.Furthermore, it is possible to conceive, if transmission center 106 or sensor circuit 102 and medication device 104 are moved to
Outside scope or pairing be disconnected, with transmission center 106 coordinate application program 108 can for user generate notify, refer to
Show that sensor circuit 102 and equipment 104 are no longer in the range of pairing.It can be sent out the finally detected position of equipment 104
Deliver to application program 108 and server 150.
It is contemplated that the transmission center 106 in the range of sensor circuit 102 can be real-time automatically by positional information
Upload to application program 108 and server 150.It is further contemplated that whenever when user it is " fixed using application program launching
During the order of position ", server 150 and/or application program 108 all will provide finally detected position for medication device 104.Cause
This, application program 108 can be used the signal intensity of GPS and/or bluetooth to indicate the position of medication device 104.In addition, reaching
During the position of equipment 104, as previously discussed, sensor circuit 102 sends sound, vibration and LED so that user can detect
To the position of sensor circuit 102.
Medication device 104 may include one or more medicines and/or delivery of drugs product, for processing emergency
And/or other medical conditions, for example, adrenaline (Automatic injector), acetic acid copaxone (From
Dynamic syringe), adalimumab (Automatic injector), insulin (automatic injector), naloxone (automatic injection
Device) and various respiratory medications delivery devices (quantitative and Diskus).In various exemplary embodiments, medication device 104
Can be for applying the adrenergic automatic injector of doses, quantitative and Diskus or miscellaneous equipment.Properly
Automatic injector and associated device and method U.S. Patent No. 4,031,893, No. 4,226,235, the 4th,
No. 329,988, No. 4,394,863, No. 4,484,910, No. 4,640,686, No. 4,678,461, the 4,795,433rd
Number, No. 4,832,682, No. 5,085,641, No. 5,092,843, No. 5,102,393, No. 5,295,965, the 5th,
Be described in 354, No. 286, the 7th, 449, No. 012, the 7th, 794, No. 432 and the 8th, 048, No. 035, these patents all with
Way of reference is incorporated by herein for various purposes.
Intelligent sensor circuit 102 is configured to ginseng that detection is specified by application program 108, relevant with medicine delivery
Number, for example when medication device 104 is being used or started.Correspondingly, intelligence sensor 102 may also include contact or frangible
Element 114.Contact element 114 is configured to that signal or instruction are detected and generated when surface is touched, opened or closed.Work as medicine
When thing equipment 104 is activated or packaging 110 is opened, contact element 114 can close or disconnect electronic circuit, and signal is sent out
Deliver to intelligent sensor circuit 102.
For example, the intelligent sensor circuit 102 coordinated with contact element 114 is configured to, detection automatic injector packaging
Time and the therefore such as injection of the medicine of adrenaline, insulin, naloxone or another medicine that capping 110 is opened
The time that will be disposed, further to indicate the time of user's injection progress.In addition, with being arranged in medication device 104
Contact element 114 coordinate intelligent sensor circuit 102 be configured to detectionPin when bounce back or be covered with
And when injection completes.Such detection can use one or more contact elements 114 and become convenient.Other medicines are set
The use of sensor 102 and contact element 114 is exercisable for standby 104 embodiments.For optional drug delivery device
104, such as Diskus, intelligent sensor circuit 102 may be configured to detect the various events relevant with delivering.With regard to all
For such as medication device 104 of inhalator 104, the envelope of medication device 104 is detected with the sensor circuit 102 that element 114 coordinates
When lid is removed from Diskus, metered dose inhaler, sprayer.
In addition, intelligent sensor circuit 102 can detect when drug delivery device 104 is captured by people.In addition, and pressure
Sensor 126 coordinates, and sensor circuit 102 can detect when the pressure inside or around suction or nose spraying equipment 104 increases,
Or when power is applied to pressurized equipment.In such a case, it usually needs pressure, so as to from such as pharmaceutical tank
The distribute medicine of medication device 104, therefore, sensor circuit 102 detect the power being applied on pressurized equipment and show that medicine is in
During being delivered.This information can then teletransmission to application program 108 and medical server 150.
For the drug delivery device 104 of such as transdermal delivery patch, the sensor circuit coordinated with contact element 114
102 are configured to detect when the packaging of transdermal delivery patch 104 is opened, and when patch is placed on skin, with
Indicate that medicine is delivered.
Medication device 104 can be arranged in carrier 110 or packaging, and packaging can be printed on a variety of selected drug informations.
Such drug information can also be arranged on sensor circuit 102, in medicinal application program 108, or be remotely stored in medical clothes
It is engaged in device 150.For example, drug information may include the title of medicine, active component, dosage, Expiration Date, lot number, license storage
Temperature and product ID and other relevant informations different because of medicine.Drug information can print in machine readable manner.
For example, drug information can be printed for quick response (Quick Response, QR) code.Drug information can also be printed for text
This, the text is easily identified using optical character identification (OCR).These codes are stored entirely in as by the drug information
One of in alternative, code can be transferred into be stored in application program 108 or server 150 in look-up table.Should
Code can be used to the long-range information searched and distribute to particular code.Code distribution can be completed in manufacture or packaging by manufacturer.
Because the information can be stored remotely, drug information can also be accessed or modified.
Carrier 110 may also comprise the plug-in unit or card being included therein.Any information being included in medication device 104 also may be used
With in packaging 110.It will beadiscussedain further detail below, drug information can also be encoded in medication device in a digital manner
In 104 memory 146 or intelligence sensor 102, so as to allow shared with medicinal application program 108 and medical server 150
The information.
Transmission center 106 may be configured to contribute in intelligent sensor circuit 102, medicinal application program 108 and remote
Communicated between journey medical server 150.The information detected by smart circuit 102 is transmitted at transmission center 106, and the information is passed
Deliver to medical server 150 or processor.Transmission center 106 may include such as iPhoneTMSmart mobile phone, personal digital assistant
(" PDA "), such as computer, iPadTMTablet personal computer or be capable of such as Bluetooth of teletransmission informationTMHub
Hub, for example, the 2net hubs (2net Hub) manufactured by Qualcomm.
Multiple transmission centers 106 or electronic equipment can be for each medication device 104 of tracking and its sensor circuits
102.This can use the manufacturer of radio (bluetooth, Bluetooth Low Energy, RFID, NFC etc.) to distribute in the fabrication process often
Unique digital code of individual specific radio/chip or sensor circuit 102 is realized.Therefore, distribute to each corresponding
Unique digital code of radio/chip or sensor 102 can also distribute to medicine or medication device 104, so as to be each
Corresponding medication device 104 provides single identity.
Identification to medication device 104 can realize that the transmission center, which has, to be arranged in transmission using center 106 is transmitted
On the heart 106 or the application program 108 that is remotely located on server 150.Therefore, equipment identification can utilize multiple transmission centers
106 (phone, tablet personal computer, electronic equipments) are realized, because code can be assigned to device sensor 102 and slave unit sensor
102 transmission.
Medicinal application program 108 can be configured to reception, processing and transmit relevant with the delivering of a kind of and a variety of selected medicines
Information.Application program 108 can be stored or be arranged in the framework of medical delivery system, in transmission center 106 or sensor
On circuit 102, or remotely on medical server 150 or connected network.Medicinal application program 108 be configured to monitoring with
The relevant many kinds of parameters and/or attribute of delivering of medicine.Be arranged on transmission center 106, such as mobile phone, on application program
Preselected information can be supplied to user/patient in real time and access any other authorized of mobile device 106 by 108
Body.
The application program 108 communicated with sensor circuit 102 is configured to detection such asMedication device 104
Physical location, and when equipment 104 be in transmission center 106 in the range of when and additionally when equipment transmitting center 106
Scope outside when provide state warning and other information.Therefore, system 100 can detect equipment 104 and patient, such as children,
The degree of approach, and the information is relayed to doctor or father and mother.
Application program 108 also communicates with one or more biometric apparatus 120.Biometric apparatus 120, which provides to work as, to be made
User uses the data different because of patient for detecting and/or being collected into during biometric apparatus 120.The information is sent in real time
Transmission center 106, and further it is sent to application program 108 and medical server 150.So, the doctor of such as doctor or nurse
The biometric data of patient can remotely be monitored by treating professional, and according to the biometric information adjust drug dose and
Prescription.In addition, health care provider can remotely design dosage release.
Application program 108 is further configured to provide a variety of configurable users' settings, for example, the detection used medicine.
Application program 108 is further configured to receive the signal from sensor circuit 102, and therefore the capping of detection packaging 110 is opened and
Medicine (for example, adrenaline, insulin, naloxone or another medicine) will start the time of injection.Application program 108 by with
It is set to the processing information and exchanges the information with medical server 150.Application program 108 may be configured to monitor other things
Part, for example, when automatic injector capping is opened, when automatic injector pin is disposed and is bounced back, and/or when complete injects
Into.Such information different because of delivering can be stored by application program 108, and be sent to medical server 150.With regard to other
For said medicine equipment, application program 108 is configured to monitoring and teletransmission use information is to medicine server 150.
Because medication related malpractice can store and/or be sent to server 150 by application program 108, so handle
It can be provided in real time to mobile device or transmission center 106 using data.Such as map can be supplied to doctor by application program 108
Service provider or user are treated, to indicate when and where user's past application of medication device 104.In addition, using journey
Sequence 108 can also provide real-time warning including positional information, when being used on medicine 104.Application program 108 can also
Historical data and analysis of the medication device 104 using event are provided, for example, list of thing and curve map.
Application program 108 is configured to exchange information with remote medical server 150.Application program 108 provide one or
Multiple promptings or input, to allow user or health care provider to provide selected information, for example, demographic information,
The resource-user cost method for managing information and such as taking exercise and feeding.Application program 108 can also be connected with other Medical Devices interfaces
To exchange medical treatment and the biometric information of user, for example, blood pressure monitor, blood glucose meter, pulse oximetry, scale, the heart
Electrograph instrument (EKG) and any other Medical Devices for being configured to transmit the information relevant with medical treatment.
Drug delivery system 100 may include cloud computing foundation structure, its can receive from intelligent sensor circuit and/or
The signal of application program 108, and information remote is sent to processor or cloud computer server 150.Transmission center 106 with
Server or one group of server communication, these servers can pass through such as internet, Intranet, LAN (LAN), wide area network
(WAN), Cellular Networks 196, Wi-Fi communication network 198 are connected.Connected transmission center 106 or be arranged on transmission center 106 or
Application program 108 on server 150 includes license and the agreement of pre-selection, to allow transmission center 106 to medical server 150
Communication and remote access.
Medical server 150 can be the clothes operated by care provider, medical insurance provider or Government Health mechanism
Business device.In addition to storing the information different because of medicine, medical server 150 can store or access the letter different because of patient
Breath.Therefore, the information different because of patient can be provided setting to mandate by the medical server 150 communicated with transmission center 106
It is standby, for example, transmission center 106, associated medication device control centre 180 and emergency service provider 180.
Because medical server 150 may be configured to receive and handle from medication device 104, mobile device or transmission
Center 106 and the particular message of control centre 180.For example, medical server 150 may be configured to checking medicine, prescription simultaneously
Order replenishers.Medical server 150 may include processor 160 and/or controller, and it can be any of such as microprocessor
The computer processor of suitable type, the processor is configured to perform calculating, judgement, data transfer or data receiver, transmission
Or receive the control signal through processing or order.As used herein, term " processor " is it will be appreciated that cover plurality of devices, example
Such as, microprocessor, field programmable gate array (FPGA), application specific integrated circuit (ASIC) are set with other similar processing and calculating
It is standby.
Medical server 150 have disposal ability, by run application program 108, data storage or perform it is any other in terms of
Calculation task, to allow user remotely to access and run application program 108, because medical server 150 is also passed through as previously described
Network is connected to from Anywhere accessing by internet or other connecting platforms.
Medical server 150 can also be operated by drug manufacturer or other third parties.It is contemplated that medical server
150 can with can download formats provide application program 108 for being performed on transmission center 106, or can be in memory 152
Store above or remotely application program.Medical server 150 can also be Downloadable application program and/or web application
There is provided and support.Medical server 150 may include the database for registering drug information, and the registration drug information is by selection registration medicine
The patient of thing equipment 104 provides.Medical server 150 can provide the various services that can be accessed by application program.With medicine
The medicine server 150 that application program 108 coordinates can provide text or audio and/or video instructions, and the instruction can be downloaded
Or it is fluidised to transmission center or mobile device 106.
Medical server 150 can provide information to application program 108 and transmission according to the registration information of medication device 104
Center 106.For example, medical server 150 can track Expiration Date, medication device using 104 and provide close to the Expiration Date
Notice.So, when the medicine in equipment 104 will exhaust or be expired, system 100 can be pointed out to order again.In various realities
Apply in example, medical server 150 can provide the tracking system of such as geographical position tracking system, to allow the user of registration
Tracking medication device 104 or communicate with equipment 104 transmit center 106 upper one known to physical location.
With reference to medicine server 150 drug system 100 may also include the storage device that is communicated with medical server 150 or
Memory 152, with data storage and information.Memory can be arranged on medical server 150 or can be by medical server 150
In outside access.Memory 152 can be the computer-readable and programmable memory of any suitable type.It is computer-readable
The example of medium includes the computer-readable storage memory of magnetic recording, non-transitory, CD, magneto-optic disk and/or partly led
Body memory (for example, RAM, ROM etc.).The magnetic recording that can be used as the supplement of memory 152 or instead of memory 152
The example of device includes hard disc apparatus (HDD), floppy disk (FD) and tape (MT).The example of CD include DVD (digital universal disc),
DVD-RAM, CD-ROM (aacompactadisk read onlyamemory) and CD-R (recordable)/RW.
Memory 152 can store the information about medication device 104.The information stored by memory 152 may include system
Make date, Expiration Date, medicine, dosage size, audio instructions, text instruction, other instructions, again prescription information, ordering information
And contact details.
The sensor circuit 102 being arranged on carrier 110 allows health care provider to track carrier to order again
And/or recycle the purpose of carrier 110.When the use of carrier 110 is completed, the sensor circuit on carrier 110 is arranged on
Positional information via transmission center 106 can be sent to system 100 by 102.In order to reduce cost and waste, sensor circuit
102 can track to home position by being arranged on the transmission center at the position of health care provider.So, once carrier
110 in the range of, and health care provider can just detect sensor circuit 102, so that reminding medical service provider is
User orders the medication device 104 of replacement again.
In operation, match somebody with somebody with sensor circuit 102, transmission center 106, application program 108 and remote medical server 150
The drug delivery system 100 of conjunction provides the real-time monitoring to medication device 104, and the monitoring may include the temperature of medicine, medicine
Apparent position (being detected by the position at the center of transmitting 106) and other medicament administration and use information.
As disclosed hereinbefore, sensor circuit 102 is attached or secured to medication device 104, and this may include to be connected toCap 112, automatic injector plastic housing 110 or carrier 110.As shown in figure 3, in step 202., sensor circuit 102
When it is opened using the detection of contact element 114 automatic injector package closure and when medicine use will starts.Sensor
Circuit 102 can also further detect when automatic injecting needle is disposed and injected and when start when to return with further pin
Contracting.
In step 204 and 206, once intelligent sensor circuit 102 detects medicine delivery, application program 108 can
Information is applied to be accessed by application program 108, and delivers the information, the packet, which contains, will be sent with pre-selected sequence to transmission
Sequence of audio, video or the text prompt of center 106 or mobile device 106.It can be passed using information according to relevant agreement
Send, the agreement indicates how how patient or user correctly using medication device 104 and deliver medicine.System 100 is 208
Also detect the position at transmission center 106.
In addition, in step 210, when sensor circuit 102 detects automatic injector or medication device 104 is just being opened
When, and/or when detecting medication device 104 and being disposed, sensor circuit 102 can send a signal to application at step 212
Program 108, to point out user to determine whether they wish the server 150 or associated net of transmission center 106 or connection
Network equipment contact first responder, nursing staff, medical professional or such as 911 crisis phone only.
Information and position about medication device 104 and carrier 110 can be sent to server by application program 108
150.This can automatically be carried out when medication device 104 is in the range of transmission center 106, or be manually inputted
Application program 108 at transmission center 106.Detect to the real-time continuous of drug delivery system 100 and be arranged close to medication device
When 104 sensor circuit 102 communicates with transmission center 106, whether sends detection sensor 102 at transmission center 106
In the range of signal.Medication device 104 detects the transmission generally relied between sensor circuit 102 and transmission center 106
Scope, the scope is in BluetoothTMIn the case of be about 150 feet.It is contemplated that can also using GPS chip or with biography
The cellular communication of sensor circuit 102 tracks medication device 104.Application program 108 or transmission center 106 can be by equipment 104
The gps coordinate detected is converted to text message or audible voice command.So, once emergency service provider is connected to electricity
Words, audible voice command will warn provider to need detecting for medical treatment and nursing and medication device 104 and user
Position.
As discussed, application program 108 can detect the position of medication device 106.When there are BTLE signals, application
Program 108 may infer that victim has medicine to medication device 104 near transmission center 106, and therefore.The information can be sent out
Cloud/medical server 150 is delivered to, nursing staff (for example, father and mother) is then relayed to, shows the medicine of patient on hand.When
During BTLE blackouts, infer that medicine is likely to not nearby, application program 108 can send to patient or nursing staff and warn.
Fig. 4 shows the monitoring used to medication device 104.In step 405 and 410, multiple position signallings can be with
Exchanged between transmission center 106, sensor circuit 102 and application program 108, to provide on medication device 104 and carry
The real time information of the approximate location of body 110.In step 420 and 425, if sensor circuit 102 leaves transmission center 106
Detection range, then send message, to notify the user to user.In addition, if sensor were returned in the range of this, Huo Zhe
It is restarted in the range of transmission center 106, then sends message to user.
Using positional information and use information, the system 100 of connected applications program 108 can using transmit center 106 or
Position of mobile equipment follow-up service positions patient, and in step 435, in such as naloxone, adrenaline or cortex class
Whenever what the first aid medicine of sterol was delivered sends message (step 445) to 911 and/or nursing staff, and in step
Replenishers can be ordered in 455 again.User can also configure additional contact preference when drug delivery event occurs.
System 100 can also provide about monitoring storage and use and order convenient auxiliary.Once it is contemplated that medicine
Equipment 104 is opened, and application program 108 suggests that user provides and whether used medicine on them, and they whether
It is ready the information placed an order again for replacement/replenishers of medicine.
The medicine service condition of patient can also be sent using timestamp by sensor circuit 102 and transmission center 106
To medical server 150, so as to longitudinal direction plan for such as insulin,Or the maintenance medicine of bronchodilator
Medication dependency.The medicine delivery number of times and dosage that measure or key in are measured with by associated biometric apparatus 120
Biological characteristic combine and allow the medical worker of managing patient remotely to check effect and side effect, for example, the heart rate of patient, exhaling
Change in suction, blood pressure, oxygen saturation and/or body temperature.The biometric apparatus 120 of connection also allows health care provider will
Variable, such as dosage, diet and exercise, the bio-identification change with patient are compared.
Although describe in detail various exemplary embodiments particularly referring to its some illustrative aspect, but it should reason
Solution, the present invention can have other embodiments, and its details can modify at various obvious aspects.Such as this area
What technical staff was readily appreciated that, while keeping within the spirit and scope of the present invention, variants and modifications can be carried out.Cause
This, above disclosure, description and accompanying drawing are merely illustrative purpose, and not limit the present invention in any way, the present invention
Only it is defined by the claims.
Claims (18)
1. a kind of drug delivery system, including：
Medical server, the medical server is configured to send and receive and processing data；
Medication device, the medication device is configured to the medicine using pre-selection；
Sensor circuit, the sensor circuit is configured to detect the selected parameter relevant with medicine delivery and transmits information；
Transmission center, the transmission center is configured to communicate with the medical server and the sensor circuit, described to pass
Send center to be configured to, receive the signal from the sensor circuit and exchange described information with the medical server；With
And
Application program, the application program is configured to the letter contributed between the sensor circuit and the medical server
Breath is exchanged, and the application program has the agreement of one group of pre-selection.
2. drug delivery system according to claim 1, in addition at least one biometric apparatus, it is described at least one
Biometric apparatus and the transmission center to center communications, the transmission center is sent to by the distinctive biometric information of patient.
3. drug delivery system according to claim 1, wherein the transmission center is mobile device, the mobile device
Be configured to, using Bluetooth technology exchanged with the sensor circuit information and with the server communication.
4. drug delivery system according to claim 1, wherein the sensor circuit is attached to the medication device.
5. drug delivery system according to claim 1, wherein the sensor circuit is arranged on pharmaceutical carrier.
6. drug delivery system according to claim 4, wherein the sensor circuit includes temperature sensor, the temperature
Degree sensor is configured to, and detects the temperature of the environment around the medication device so that the sensor circuit will be detected
The temperature be sent to the transmission center, and the application program is by the temperature detected and selected temperature range
It is compared.
7. drug delivery system according to claim 4, wherein the sensor circuit includes position detector, institute's rheme
Detector is put to be configured to there is provided the information on the medication device and the position of the sensor circuit of attachment, and will be with position
The data for being equipped with pass are sent to the application program.
8. drug delivery system according to claim 4, wherein the sensor circuit includes contact element, the contact
Element is arranged in the medication device, to contribute to the application program to detect the administration of the medicine from the equipment.
9. drug delivery system according to claim 4, wherein the application program is arranged on the transmission center, from
And the interface for inputting information to the application program for user is provided.
10. drug delivery system according to claim 1, wherein the transmission center is tablet personal computer.
11. a kind of method for being used to remotely monitor the medicine delivery at medication device, including：
Contact of the element testing communicated using being arranged in the medication device with sensor circuit at the medication device；
Signal from the sensor circuit is sent to application program, to indicate to have connect at the medication device
Touch；
The signal from the sensor circuit is received in transmission center；
Determine that the signal includes contact element information using the application program；
Signal from the transmission center is sent to the medical server of connection, to indicate that the medicine has been accessible.
12. the method according to claim 11 for being used to remotely monitor the medicine delivery at medication device, wherein detecting
Contact at the medication device also includes：Using being arranged in the medication device and connecing that the sensor circuit communicates
Touch element.
13. the method according to claim 11 for being used to remotely monitor the medicine delivery at medication device, wherein detecting
Contact at the medication device also includes：Use the magnetic field sensor communicated with the sensor circuit.
14. the method according to claim 11 for being used to remotely monitor the medicine delivery at medication device, wherein detecting
Contact at the medication device also includes：The pressure communicated using being arranged in the medication device with the sensor circuit
Power element.
15. a kind of method for being used to detect the position of medication device, including：
Transmit the Bluetooth signal from the sensor circuit being arranged on medication device or medication device carrier；
If the signal is in the range of, the Bluetooth signal is received in transmission center；
If the Bluetooth signal is received, trigger the signal from the transmission center to the server remotely connected, to carry
For the position at the transmission center；
The signal intensity of the Bluetooth signal between the medication device and transmission center is detected, and the signal is strong
Angle value is compared with preset value；
If the bluetooth signal intensity value is less than preset value, trigger from the transmission center to the server remotely connected
Signal, so as to indicate the medication device not in the preselected distance from user.
16. method according to claim 11, wherein the position of detection medication device includes：Should using global positioning system
The location of described transmission center is determined with program.
17. a kind of drug delivery system, including：
Medical server, the medical server is configured to send and receive and processing data；
Medication device, the medication device is configured to the medicine using pre-selection；
Sensor circuit, the sensor circuit is configured to detect the selected parameter relevant with medicine delivery and transmits information；
Transmission center, the transmission center is configured to communicate with the medical server and the sensor circuit, described to pass
Send center to be configured to, receive the signal from the sensor circuit and exchange described information with the medical server；With
And
Application program, the application program is configured to contribute between the sensor circuit and the medical server
Information is exchanged, and the application program has the agreement of one group of pre-selection, wherein the application program passes through via the transmission center
The medication device is connected to monitor the use of the medication device and the position of the medication device.
18. drug delivery system according to claim 17, in addition at least one biometric apparatus, described at least one
Individual biometric apparatus is with the transmission center to center communications so that the distinctive biometric information of patient is sent into the transmission center.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/483,572 | 2014-09-11 | ||
| US14/483,572 US9692829B2 (en) | 2012-12-03 | 2014-09-11 | Medication delivery system and method |
| PCT/US2015/049232 WO2016040512A1 (en) | 2014-09-11 | 2015-09-09 | Medication delivery system and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107077451A true CN107077451A (en) | 2017-08-18 |
Family
ID=55459534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580048532.5A Pending CN107077451A (en) | 2014-09-11 | 2015-09-09 | Drug delivery system and method |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3191972A4 (en) |
| JP (2) | JP6766034B2 (en) |
| CN (1) | CN107077451A (en) |
| AU (1) | AU2015315181A1 (en) |
| CA (1) | CA2960519A1 (en) |
| RU (1) | RU2017107745A (en) |
| WO (1) | WO2016040512A1 (en) |
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| US10420623B2 (en) | 2012-12-03 | 2019-09-24 | Mylan Inc. | Medicament information system and method |
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| CN114053071A (en) * | 2021-11-16 | 2022-02-18 | 中国医学科学院肿瘤医院深圳医院 | Intelligent nursing workbench |
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| AU2020356529A1 (en) * | 2019-09-25 | 2022-05-19 | Janssen Pharmaceuticals, Inc. | Interconnection of drug administration systems |
| KR20220088703A (en) * | 2019-09-25 | 2022-06-28 | 얀센 파마슈티칼즈, 인코포레이티드 | Coordination of drug delivery |
| CN114746138A (en) * | 2019-09-25 | 2022-07-12 | 杨森制药公司 | Drug administration device measuring parameters associated with drug administration and incorporating parameter measurements |
| MX2022003639A (en) * | 2019-09-25 | 2022-07-05 | Janssen Pharmaceuticals Inc | Drug delivery systems and methods. |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2017529920A (en) | 2017-10-12 |
| RU2017107745A (en) | 2018-10-11 |
| CA2960519A1 (en) | 2016-03-17 |
| WO2016040512A1 (en) | 2016-03-17 |
| JP6766034B2 (en) | 2020-10-07 |
| EP3191972A4 (en) | 2018-03-14 |
| EP3191972A1 (en) | 2017-07-19 |
| JP2020053078A (en) | 2020-04-02 |
| AU2015315181A1 (en) | 2017-03-30 |
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