CN107076136A - Peristaltic pump and the device analyzed chemical example or biological sample - Google Patents
Peristaltic pump and the device analyzed chemical example or biological sample Download PDFInfo
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- CN107076136A CN107076136A CN201580055239.1A CN201580055239A CN107076136A CN 107076136 A CN107076136 A CN 107076136A CN 201580055239 A CN201580055239 A CN 201580055239A CN 107076136 A CN107076136 A CN 107076136A
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- Prior art keywords
- flexible pipe
- peristaltic pump
- gear
- planetary
- planetary gear
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- 230000002572 peristaltic effect Effects 0.000 title claims abstract description 40
- 239000012472 biological sample Substances 0.000 title description 4
- 239000000126 substance Substances 0.000 title description 3
- 239000012530 fluid Substances 0.000 claims abstract description 18
- 238000012545 processing Methods 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 description 10
- 230000008901 benefit Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 238000005096 rolling process Methods 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000011330 nucleic acid test Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000003869 genetically modified organism Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000012123 point-of-care testing Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1223—Machines, pumps, or pumping installations having flexible working members having peristaltic action the actuating elements, e.g. rollers, moving in a straight line during squeezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Reciprocating Pumps (AREA)
Abstract
A kind of peristaltic pump has the flexible pipe for being used for aspirating fluid to be pumped and has pinion frame, at least two planetary gears that the pinion frame has ring gear, central gear and is placed between ring gear and central gear, wherein, at least one tooth in planetary tooth is engaged at least one times during a circulation of the planetary gear around central gear with flexible pipe, is extruded with the part to flexible pipe.
Description
The present invention relates to peristaltic pump.Related to the invention further relates to the device with this peristaltic pump or system, and especially
And for entering to chemical example or biological sample, particularly biological source sample --- for example, biological sample comprising nucleic acid ---
The device or system of row analysis.In addition, the present invention relates to " the chip reality applied suitable for " scene " and " looking after immediately " (POC)
Test room " technical field.
Pass through WO 2010/003690A1, it is known that for the device analyzed sample, it is known that described device is included extremely
A few storage chamber and at least one processing chamber housing, and processing chamber housing is integrated at least one first supporting member and stored up
Chamber is deposited to be integrated at least one second supporting member, and the supporting member is configured such that processing chamber housing can pass through
The relative motion relative to each other of first supporting member and the second supporting member and be connected with storage chamber.The device, which has, to be used for
Material in device is transferred to the pump element of another chamber from a chamber, the pump element is integrated in supporting member
In one supporting member.
Analysis based on highly complex chemistry, biochemistry or molecular biology, such as, nucleic acid test, NAT with
And particularly all modifications of PCR (PCR), in medicine and health care and including agricultural, biotechnology, chemistry
All become more and more attractive with nearly all industrial circle of environment business.There are following wilderness demands：It disclosure satisfy that pair
Analysis method on the requirement increasingly increased of planning and the control of such as treatment results or industrial manufacturing process and cost.
The analysis system of most prior art is extremely complex and needs to handle unstable reagent, expensive laboratory
Equipment and personnel through professional training carry out and explained test.Therefore, the analysis is generally both without Saving in time costs or not
With cost benefit, because it, which is related to, is sent to sample in special laboratory, result is significantly lingeringly obtained.Therefore, scene and
Immediately looking after detection (POCT) has become special needs, because which significantly shortens the time for being sampled to acquisition result.Facing
In bed diagnosis, some asymptomatic patients may be impatient of to test process and can not participate in and subsequently make an appointment, therefore should be in single
The appropriate treatment of medical period offer is felt at ease.In addition, also existing to other field applications --- for example, legal medical expert detects (" crime
Scene ", the legal medical expert of " arrest and select " detection), food inspection (genetically modified organism detection, the detection of food fake products), defence (biology line
Detection) etc. --- quick and easy to carry out detection the need for.
Up to the present, the nucleic acid test (NAT) of laboratory treatment is generally than being typically based on pathogen immune detection
Quick poc testing has much higher sensitivity.The most of platforms and technology based on NAT being currently being deployed all can not be
Sample preparation, analysis and data assessment provide total solution.Pass through showing for success platform known to the A2 of WO 2005/106040
Example.However, described device needs manual loaded reagent, this is probably inconvenient for user and easily malfunctioned.Separately
Outside, data assessment also needs to the intervention of operating personnel.Therefore, it is not suitable for on-the-spot test.In addition, the complicated box of the device
Formula lab design causes the disposable apparatus of high cost, wherein, the device includes multiple scale injection mould parts and other
Some installing components, such as, and filter, screw and nut etc..
For the device as known to from the A1 of WO 2010/003690, particularly it will be used as disposable tubular at it
In the case of part, the peristaltic pump that can be manufactured in cost-benefit mode, and particularly operated in a reliable fashion it is soft
Tube pump is beneficial.
In view of this background, the problem to be solved in the present invention is the flexible pipe for proposing to produce in cost-benefit mode
Pump, and the peristaltic pump particularly operated in a reliable fashion is beneficial.
The problem be by peristaltic pump according to claim 1, device according to claim 8 and/or
System according to claim 9 is solved.Preferred embodiment form dependent claims and following description
A part.
The present invention is based on following general plottings：The planetary gear of pinion frame is used as to the rolling member of peristaltic pump.Planet
Planetary gear in tooth rest occupies what can accurately be limited during turnover of the planetary gear around central gear in ring gear
Position.This allows to accurately control the Fluid Volume pumped by peristaltic pump.In addition, pinion frame can be imitated with cost
The mode of benefit is produced, so that peristaltic pump can be produced in cost-benefit mode.
The passive type rolling member used in planetary gear using pinion frame rather than the peristaltic pump such as prior art
With advantages below：If flexible pipe is arranged in planetary circumferential position, planetary peripheral speed is with it along soft
The speed that pipe is advanced is identical.This causes planetary gear not produce the positive effect of pulling force on flexible pipe.This causes more smart
True pump action.
In a preferred embodiment, a part for flexible pipe is arranged to the form of section in a ring.In a preferred embodiment,
Planetary tooth engages flexible pipe in the hose segment.In particularly preferred embodiments so that planetary some
Tooth is in a moment engagement flexible pipe.In a preferred embodiment, planetary gear is rolled along hose segment.In the following side of being preferable to carry out
In formula：After first tooth and flexible pipe are engaged for the first time in the circulation planetary tooth engaged with flexible pipe it is every other
Time makes planetary gear be rolled along hose segment untill the circulation last tooth departs from flexible pipe, it is planetary at least
One tooth is engaged in synchronization with flexible pipe.
Although planetary gear has the circumferential shapes limited by tooth, planetary gear will act on soft as rolling member
Guan Shang, the gap between the top end of tooth is crossed over by flexible pipe.In a preferred embodiment, the top end of planetary tooth is whole
It is flat.This aspect reduces the gap between tooth, so that flexible pipe needs the gap crossed over to reduce.On the other hand, it is leveled
Tooth or tooth including the top ridge with larger interior ridge angle reduce the abrasion on flexible pipe.Moreover, the top end of tooth can be with
With skidproof effect, to prevent planetary gear from being slided when it is rolled along flexible pipe.
In a preferred embodiment, pinion frame have more than three planetary gears, particularly preferably have be more than
The planetary gear of four, particularly preferably have be more than five or the planetary gear equal to five.
In a preferred embodiment, under all operating conditions of peristaltic pump, at least one planet tooth of pinion frame
At least one tooth of wheel is engaged with flexible pipe to be extruded with the part to flexible pipe.This can prevent the past backflow of the fluid in flexible pipe
It is dynamic.Alternatively, valve can be provided with the downstream of the hose segment of planetary indented joint.The valve is in planet
The tooth of gear engages with flexible pipe and makes to open during the fluid displacement in flexible pipe by squeezing tube.Valve, which is opened, will allow one
Shunting body flows through valve, and a part of fluid is proportional to the segment fluid flow for being engaged and being shifted with flexible pipe by planetary gear.Valve
The backflow of fluid will be turned off to prevent in planetary tooth and flexible pipe disengagement.If however, as described above, flexible pipe
At least one at least one planetary tooth that pump is designed such that in the planetary gear of pinion frame is engaged with flexible pipe
Extruded with the part to flexible pipe, then under all operating conditions, this valve can be removed, because entering to hose segment
The tooth of row extruding can be used for preventing or reducing the backflow of fluid.
According to the present invention peristaltic pump in the case of, at least one tooth in the tooth of pinion frame engaged with flexible pipe with
A part to flexible pipe is extruded.In a preferred embodiment, term " extruding " should be understood to mean that hose segment quilt
It is squeezed into so that the passage in flexible pipe is closed in the part that it extends.Channel enclosed in flexible pipe be entirely prevented into stream
Body flows through the part being extruded.If however, in alternative embodiment, term " extruding " is understood to connecing for tooth and flexible pipe
The passage in only partially closed hose is closed, then can also realize advantages of the present invention (may be in lesser degree).Remaining
Gap allows fluid reflux by the part being extruded of flexible pipe in theory.It is contemplated, however, that the flowing in the part of flexible pipe
Resistance is significantly increased, and this make it that the Fluid Volume to the dynamic part being extruded by flexible pipe of backflow reduces.
In a preferred embodiment, peristaltic pump has supporting surface；The part of flexible pipe is in planetary tooth and institute
State and be extruded between supporting surface.In a preferred embodiment, supporting surface has curved shape.In a preferred embodiment,
Flexible pipe and the bearing surface contact of bending cause the shape of the part presentation circular segments with bearing surface contact of flexible pipe.This is carried
A part for flexible pipe is pressed against supporting while having supplied to allow the planetary gear of pinion frame to be rolled along the flexible pipe section
Good design in the part on surface.
In a preferred embodiment, the ring gear of pinion frame is circular segments, thus, and the ring gear does not have
Ring gear will be made to become completely with the other circular segments as ring-shaped article, but with opening, a part of cloth of flexible pipe
Put in the opening.This design allows in a straightforward manner engage the planetary gear of pinion frame with right with flexible pipe
A part for flexible pipe is extruded.
In a preferred embodiment, the circular segments of ring gear, which are crossed over, is more than 180 °.It is contemplated that planetary gear
The motion engaged with hose segment stability and accuracy also kept planetary retainer by pinion frame
The influence of stability.The stability increase of the retainer of pinion frame can be made in following embodiments, in the embodiment party
In formula, at least two planetary gears are configured to a part for pinion frame, and at least one planet in planetary gear
Gear is engaged with ring gear.This can be realized by making ring gear cross over more than 180 °.
In a preferred embodiment, the opening of ring gear, which is crossed over, is more than fenced angle, and the fenced angle passes through following public affairs
Formula is calculated：
The planetary number of fenced angle=360 °/pinion frame.
For two planetary gears, therefore fenced angle will be 180 °, and the circular segments of ring gear are opened
Mouth, which will be crossed over, is more than 180 °.For three planetary gears of pinion frame, fenced angle will be 120 °, and this reality
Apply the opening of the ring gear of mode and will preferably cross over and be more than 120 °.Including the embodiment of the ring gear with opening
Preferred embodiment in, a part for flexible pipe is arranged in the open interior of the shape with circular segments, the portion of flexible pipe
Point across ring gear have opening rather than circular segments angle at least 40%, be preferably at least 50%, particularly preferably
Ground is 75%.The part of flexible pipe occupy opening it is bigger, planetary gear just can be by more around the rotary motion of central gear
Ground is used to promote the fluid in hose passages along passage.
In a preferred embodiment, in ring gear has the embodiment of opening, the size and planetary gear of opening
The planetary number of frame is associated so that in the only one planetary gear and flexible pipe of most of time inner planet gear frame
Part engagement.Preferably, only in a planetary gear and flexible pipe disengagement, next planetary gear just connects with flexible pipe
Close, to prevent or reduce the backflow of fluid.This angle that can be crossed in the part of the shape of the section in a ring of flexible pipe etc.
In or slightly larger than realizing in the case of fenced angle.In this embodiment, circular segments will be needed across less than (360 ° subtract
Fenced angle).
In a preferred embodiment, planetary gear extends across ring gear along planetary rotation axis direction, by
This, the planetary part for extending across ring gear is joined in flexible pipe to be extruded with the part to flexible pipe.At this
Plant in embodiment, flexible pipe can be with adjacent rings arrangement of gears, and ring gear is designed to complete ring-shaped article.This will
The planetary gear while planetary gear of pinion frame is engaged with a part for flexible pipe is allowed to be engaged simultaneously with ring gear.
This can be such that positioning of the planetary gear when it is engaged with flexible pipe further stablizes.
In a preferred embodiment, the part of the shape for being arranged to circular segments of flexible pipe has and ring gear identical
Radius, and the part adjacent rings arrangement of gears is into causing the planetary part for extending beyond ring gear and flexible pipe
The part contact.
In a preferred embodiment, position sensor is set at planetary gear or retainer, to determine planetary gear
Rotation position in pinion frame.Understand rotation position of the planetary gear in pinion frame to allow to peristaltic pump
Pump action be better controlled.
The apparatus according to the invention has at least one storage chamber and at least one processing chamber housing, and processing chamber housing is integrated in
In at least one first supporting member, and storage chamber is integrated at least one second supporting member, the supporting member
Be arranged so that processing chamber housing can by the relative motion of the first supporting member and the second supporting member relative to each other with
Storage chamber is connected, and the device also includes being used for the pump member that the material in the device is transferred to another chamber from a chamber
Part.The device has such as according to the pump element of the peristaltic pump of the present invention.
A system in accordance with the present invention has the peristaltic pump or the apparatus according to the invention and base station according to the present invention,
The base station at least includes acting on peristaltic pump for example to drive planetary gear around central gear by driving central gear
The pump drive of rotation.Alternatively, the planetary retainer of holding can be driven.
In a preferred embodiment, in system according to the present invention, peristaltic pump or described device are with dismountable
Mode is connected to base station.This allows the part that planetary drive device is for example made to base station.This means according to this
It is also to be related to the embodiment for being not provided with planetary drive device that the term " peristaltic pump " of invention, which should be understood to it,.
In a preferred embodiment, pinion frame has more than two planetary gear.Preferably, pinion frame has
There are the planetary gear of six or less than six.
The device analyzed sample is used for there is provided simple and uncomplicated design according to the present invention, and especially
Ground provides the design that can be produced with inexpensive way.Therefore, the present invention also provide it is a kind of can suitably disposable dress
Put, i.e., the chip lab for " using rear disposable type ".Therefore, apparatus of the invention particularly useful for scene and immediately placement is looked after.
In addition, in by the way that pump element is integrated into the device in itself, all elements contacted with material are combined in during analyzing
Preferably with the unit of rear disposable type, this allows to the fluid system to form closing, and it helps to prevent material or set
Any pollution of standby therein.This pollution will be produced when " outside " pump may will be had to connect in equipment.
Advantageously, the chamber of the device can be pre-filled with being adapted for the reagent of different analyses.Therefore, the device can be with
" instant " form as chip lab.
The sample analyzed in the apparatus of the present can be any source or any property, for example, biological source, natural
Source, synthetic source or semi-synthetic source.Therefore, the invention is not restricted to any specific sample source.
Preferably, elastic hose can be configured to a part for pump element.Elastic hose can be by being integrated into branch
Corresponding conduit in bearing member and be connected to chamber.Can be for example, by the rolling moved by means of the length along elastic hose
Dynamic element makes elastic hose local deformation and thus reversibly it is sealed to form pumping pressure in elastic hose.This
The side towards moving direction for being located at rolling element in elastic hose produces malleation.Therefore, the phase in elastic hose
Anti- side produces negative pressure.
Following all elements can be covered according to the term " elastic hose " of the present invention, the element limits inner space
And with the elastic housing around the inner space and also with least one entrance and one outlet.According to the present invention's
Elastic hose not necessarily has elongated tubular form, although the shape is preferred.
Advantage using planetary gear as the rolling member of pinion frame is, it is only necessary in planetary gear and supporting table
The advantage extruded between face flexible pipe.Flexible pipe need not be walked between other elements.Therefore, when flexible pipe is placed in
When in peristaltic pump, in the absence of open fluid boundary.Therefore, the risk of pollution is minimized.
In another preferred embodiment of the present invention, it is in supporting member and causes chamber to be connected to mutual relative position
In the case of putting, chamber is connected to pump element to produce closed loop.On the one hand closed-loop fluid circuit avoids thing in chamber
Any pollution of matter, and further allow to make the flow direction of the material reverse in a straightforward manner.
In order to allow that test or analysis result progress vision, optics or the related to image of any other form are commented
Estimate, device of the invention can be made up of transparent material such as transparent polymer at least in part, so as to allow to reaction chamber
Or the miscellaneous part (including conduit) of the device is observed.
The apparatus according to the invention advantageously can be used together with base station, and the base station can include being used to make supporting member
At least one drive device being moved relative to each other.The base station can also include pump drive.At least include base station and list
Only analytical equipment Such a system provides the advantage that can be integrated into complicated and therefore expensive technique device in base station,
And analytical equipment can be designed as cheap disposable apparatus.This causes using analytical equipment or corresponding according to the present invention's
Cost reduction involved by system.
In a preferred embodiment of the invention, the pump element of the device includes elastic hose, and the pump driving of base station
Device includes deformation element, preferably includes and moved along the length of elastic hose so that the rolling of elastic hose local deformation
Element.The advantage of the embodiment is, the complexity of pump (its pump element for including the device and the pump drive of base station) and
Expensive part is located in base station and only elastic hose is (preferably) part for disposable apparatus.Therefore, the device
Production cost can keep relatively low.
In the case of also including control unit and assessment unit in base station, the control of the drive device of base station can be automatic
Change.This make it that the analysis process performed in the device can be with full automation.
The system according to the present invention can also include at least one heater.The heater can be produced in a base station
Raw different temperature province.In addition, the base station can include drive device, by the drive device, the temperature province can be with
Relative to device movement.It therefore, it can temperature adjustment in the different chamber by the device into being best suited in the chamber
The value of the respective handling step of interior progress.This allows the temperature point for producing the continuous processing step for being suitable to be carried out in analytical equipment
Cloth.
Instant photograph is preferably used for according to peristaltic pump, the apparatus according to the invention and the system according to the present invention of the present invention
Protect application field, particularly nucleic acid analysis.
Below, with reference to the accompanying drawing for only showing particular implementation, the present invention will be described.The sole FIGURE is with schematic
Side view shows the tubular elements of the accommodating peristaltic pump according to the present invention.
The peristaltic pump (1) shown in figure, which has, is used to aspirate the flexible pipe (2) for treating pumped fluid.Peristaltic pump (1) also has
Have a pinion frame (3), pinion frame (3) there is ring gear (4), central gear (5) and be placed in ring gear (4) with
Five planetary gears (6) kept between central gear (5) and by retainer.
Six teeth (7) in a planetary tooth in the operation moment shown in figure, planetary gear (6) with it is soft
Manage a part for (2) engagement and squeezing tube.This can be observed from figure；The engagement of tooth (7) and flexible pipe causes in flexible pipe (2)
Passage be completely plugged.The wall of flexible pipe is in point (8) place in the particular moment.
As can be observed from Figure, ring gear is circular segments.Ring gear (4), which does not have, will make ring gear (4)
Become completely with the other circular segments as ring-shaped article, but with opening (9).A part for flexible pipe (2) is arranged on this
It is open in (9).The opening crosses over angle [alpha], is about 115 ° in angle [alpha] embodiment shown in this figure.Therefore, annular tooth
The circular segments of wheel cross over the angle of 245 ° (360 ° of-α).
Peristaltic pump (1) is provided with the supporting surface (10) with curved shape.This allow flexible pipe (2) and supporting surface
(10) shape of circular segments is presented in the part of contact.The circular segments cross over about 90 ° of angle beta.
The fenced angle of angle ratio that the opening of ring gear and the circular segments of flexible pipe are crossed over is big, and the fenced angle is defined
For the planetary number of=360 °/pinion frame.Fenced angle pinion frame shown in this figure has five
It is 72 ° in individual planetary embodiment.Opening span is α=115 °.It is equal to 90 ° due to β and is therefore more than 72 °, institute
The part for ensuring at least one planetary gear in each moment, planetary gear and flexible pipe with the design shown in figure connects
Close, and ensure for angle number (that is, about 18 °) bigger than fenced angle β, two planetary gears and flexible pipe it is described
Part is engaged.This fluid for preventing from back flowing is pumped through the passage of flexible pipe (2).
It is assumed that the opening (9) of ring gear (4) crosses over angle [alpha]=115 °, and assume the shape of the circular segments of flexible pipe (2)
Shape crosses over the embodiment shown in about 90 ° of angle, figure and shows the mode of being implemented as follows：Flexible pipe (2) circularizes section
About 80% (beta/alpha is equal to 90 °/115 °=80%) of angle of the angle occupied by opening (9) occupied by the part of shape.
Claims (11)
1. a kind of peristaltic pump (1), the peristaltic pump (1) has the flexible pipe (2) for being used for aspirating fluid to be pumped and has row
Gear rack (3), the pinion frame (3) has ring gear (4), central gear (5) and is placed in the ring gear
(4) at least two planetary gears (6) between the central gear (5), it is characterised in that
At least one tooth in the tooth (7) of the planetary gear (6) is in the planetary gear (6) around the central gear (5)
Engage at least one times, extruded with the part to the flexible pipe (2) with the flexible pipe (2) during one circulation.
2. peristaltic pump according to claim 1, it is characterised in that the peristaltic pump is provided with supporting surface, the flexible pipe
(2) a part is extruded between the tooth (7) and the supporting surface (10) of the planetary gear (6).
3. peristaltic pump according to claim 1 or 2, it is characterised in that the ring gear (4) is circular segments, and
The ring gear (4) does not have the other circular segments that the ring gear (4) will be made to become complete loop part, but has
There is opening (9), a part for the flexible pipe (2) is arranged in the opening (9).
4. peristaltic pump according to claim 3, it is characterised in that the circular segments of the ring gear (4), which are crossed over, to be more than
180°。
5. the peristaltic pump according to claim 3 or 4, it is characterised in that what the circular segments of the ring gear (4) were crossed over
Angle is less than the angle for being subtracted fenced angle by 360 ° and being calculated, and the fenced angle is calculated by following formula：Fenced angle
The number of the planetary gear (6) of=360 ° of degree/pinion frame (3).
6. the peristaltic pump according to any one of claim 1 to 5, it is characterised in that the planetary gear is in the row
The rotation axis side of star gear extends upwards beyond the ring gear, and described planetary extends across the annular
The part of gear is joined in the flexible pipe, is extruded with the part to the flexible pipe.
7. the peristaltic pump according to any one of claim 1 to 6, it is characterised in that at the planetary gear or institute
Setting position sensor at retainer is stated, to determine rotation position of the planetary gear in the pinion frame.
8. a kind of device for being analyzed sample, described device includes at least one storage chamber and at least one is handled
Chamber, the processing chamber housing is integrated at least one first supporting member, and the storage chamber is integrated at least one
In second supporting member, the supporting member is arranged so that the processing chamber housing can be by first supporting member and institute
State the relative motion relative to each other of the second supporting member and be connected with the storage chamber, described device also includes being used for institute
The pump element that the material in device is transferred to another chamber from a chamber is stated,
Characterized in that, the pump element is the peristaltic pump (1) according to any one of claim 1 to 7.
9. a kind of system, including：
- the peristaltic pump (1) or device according to claim 8 according to any one of claim 1 to 7,
- base station, the base station at least includes acting on the peristaltic pump (1) to drive the planetary gear around the centre tooth
Take turns the pump drive of rotation.
10. system according to claim 9, it is characterised in that soft according to any one of claim 1 to 7
Tube pump or device according to claim 8 are connected releasably to the base station.
11. a kind of peristaltic pump (1) or device according to claim 8 according to any one of claim 1 to 7
Or the system described in one in claim 9 to 10 in application field is looked after immediately, particularly in foranalysis of nucleic acids
Purposes in field.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188850.3A EP3009679A1 (en) | 2014-10-14 | 2014-10-14 | Hose pump and device for analysing a chemical or biological sample |
| EP14188850.3 | 2014-10-14 | ||
| PCT/EP2015/073382 WO2016058926A1 (en) | 2014-10-14 | 2015-10-09 | Hose pump and device for analysing a chemical or biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107076136A true CN107076136A (en) | 2017-08-18 |
Family
ID=51703028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580055239.1A Pending CN107076136A (en) | 2014-10-14 | 2015-10-09 | Peristaltic pump and the device analyzed chemical example or biological sample |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170306942A1 (en) |
| EP (2) | EP3009679A1 (en) |
| JP (1) | JP2017531132A (en) |
| CN (1) | CN107076136A (en) |
| CA (1) | CA2962128A1 (en) |
| ES (1) | ES2704116T3 (en) |
| WO (1) | WO2016058926A1 (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0448937A2 (en) * | 1990-02-23 | 1991-10-02 | Alcatel SEL Aktiengesellschaft | Hose pump |
| DE102005061331A1 (en) * | 2005-12-21 | 2007-06-28 | Vmi-Az Extrusion Gmbh | Extruder pump for transporting viscous fluids, in particular polymer melts and/or rubber compounds, is connected to a peristaltic pump for pulsed volumetric delivery of materials |
| US20080056912A1 (en) * | 2006-08-31 | 2008-03-06 | Pizzichil William P | Pump system and method using planetary gear assembly |
| WO2010003690A1 (en) * | 2008-07-10 | 2010-01-14 | Carpegen Gmbh | Device for analysing a chemical or biological sample |
| DE102010000592B3 (en) * | 2010-03-01 | 2011-06-16 | Ulrich Gmbh & Co. Kg | Peristaltic pump with planetary gear |
| US20130177463A1 (en) * | 2012-01-11 | 2013-07-11 | Cheshire Electric Company, Llc | Precision peristaltic metering pump and device thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56151289A (en) * | 1980-04-25 | 1981-11-24 | Japan Storage Battery Co Ltd | Elastic tube pump |
| JPS6026295U (en) * | 1983-07-28 | 1985-02-22 | 株式会社島津製作所 | Shigo pump device |
| US5871341A (en) * | 1996-12-31 | 1999-02-16 | Melody; Brian J. | Peristaltic pump driven pump roller apparatus and methodology |
| JP2001227476A (en) * | 2000-02-15 | 2001-08-24 | Yutaka Sonoda | Tube type hydraulic pump with double speed mechanism |
| WO2002025112A1 (en) * | 2000-09-22 | 2002-03-28 | Sorenson Technologies, Inc. | Flexible tube positive displacement pump |
| US20050129545A1 (en) * | 2003-12-15 | 2005-06-16 | Prosek Michael E.Jr. | Peristaltic pumping mechanism with geared occlusion rollers |
| US20050244837A1 (en) | 2004-04-28 | 2005-11-03 | Cepheid | Method and device for sample preparation control |
| US7578662B1 (en) * | 2005-11-18 | 2009-08-25 | Araz Ibragimov | Peristaltic pump having pumping and occluding rollers and alternating pumping systems utilizing thereof |
| EP2036585A1 (en) * | 2007-09-13 | 2009-03-18 | Ulrich GmbH & Co. KG | Roller pump |
| US8292604B2 (en) * | 2009-05-01 | 2012-10-23 | Xerox Corporation | Peristaltic pump |
| JP6060337B2 (en) * | 2012-06-25 | 2017-01-18 | 国立大学法人大阪大学 | Tube pump |
| GB2518806B (en) * | 2013-06-26 | 2018-04-11 | Intelligent Energy Ltd | Pump assembly |
-
2014
- 2014-10-14 EP EP14188850.3A patent/EP3009679A1/en not_active Withdrawn
-
2015
- 2015-10-09 WO PCT/EP2015/073382 patent/WO2016058926A1/en active Application Filing
- 2015-10-09 JP JP2017519818A patent/JP2017531132A/en active Pending
- 2015-10-09 ES ES15790845T patent/ES2704116T3/en active Active
- 2015-10-09 CN CN201580055239.1A patent/CN107076136A/en active Pending
- 2015-10-09 US US15/518,152 patent/US20170306942A1/en not_active Abandoned
- 2015-10-09 CA CA2962128A patent/CA2962128A1/en not_active Abandoned
- 2015-10-09 EP EP15790845.0A patent/EP3207252B1/en not_active Not-in-force
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0448937A2 (en) * | 1990-02-23 | 1991-10-02 | Alcatel SEL Aktiengesellschaft | Hose pump |
| DE102005061331A1 (en) * | 2005-12-21 | 2007-06-28 | Vmi-Az Extrusion Gmbh | Extruder pump for transporting viscous fluids, in particular polymer melts and/or rubber compounds, is connected to a peristaltic pump for pulsed volumetric delivery of materials |
| US20080056912A1 (en) * | 2006-08-31 | 2008-03-06 | Pizzichil William P | Pump system and method using planetary gear assembly |
| WO2010003690A1 (en) * | 2008-07-10 | 2010-01-14 | Carpegen Gmbh | Device for analysing a chemical or biological sample |
| DE102010000592B3 (en) * | 2010-03-01 | 2011-06-16 | Ulrich Gmbh & Co. Kg | Peristaltic pump with planetary gear |
| US20130177463A1 (en) * | 2012-01-11 | 2013-07-11 | Cheshire Electric Company, Llc | Precision peristaltic metering pump and device thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3207252A1 (en) | 2017-08-23 |
| JP2017531132A (en) | 2017-10-19 |
| ES2704116T3 (en) | 2019-03-14 |
| US20170306942A1 (en) | 2017-10-26 |
| WO2016058926A1 (en) | 2016-04-21 |
| EP3207252B1 (en) | 2018-12-12 |
| EP3009679A1 (en) | 2016-04-20 |
| CA2962128A1 (en) | 2016-04-21 |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170818 |
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