CN107073212B - Pellet transport system and pellet transport method using same - Google Patents

Pellet transport system and pellet transport method using same Download PDF

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Publication number
CN107073212B
CN107073212B CN201580038517.2A CN201580038517A CN107073212B CN 107073212 B CN107073212 B CN 107073212B CN 201580038517 A CN201580038517 A CN 201580038517A CN 107073212 B CN107073212 B CN 107073212B
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Prior art keywords
tube
particles
delivery system
split tube
plunger
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CN201580038517.2A
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Chinese (zh)
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CN107073212A (en
Inventor
陈瑾惠
朱建平
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Joy Medical Devices Corp
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Jti Biomed Corpg
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/007—Injectors for solid bodies, e.g. suppositories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8822—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3142—Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/02—Bones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention relates to a particle delivery system comprising a plunger and a divided tube, wherein the divided tube has two or more part-shells adapted to be coupled to each other, so that when said two or more part-shells are coupled to each other, a longitudinal channel is formed in the divided tube, each of said part-shells is longitudinally movable relative to the other, and the plunger is insertable into the longitudinal channel.

Description

Pellet transport system and pellet transport method using same
Technical Field
The present invention relates to techniques for delivering particles, particularly porous particles, into a bone cavity for enhanced bone ingrowth.
Background
Common syringes are designed to deliver a liquid, or sometimes a paste. The conventional syringe is used to deliver granules, particularly fragile porous granules, into the bone cavity to enhance bone ingrowth, and the friction between the surfaces of the granules themselves and between the surfaces of the granules and the inner surface of the syringe barrel and the tubules connecting the barrel to the bone cavity is often too great to successfully accomplish delivery, especially when the granules are porous granules which may be crushed by the friction, as shown in fig. 1. The porous particles initially break up creating more friction and the transport is often interrupted by excessive friction.
Disclosure of Invention
The main object of the present invention is to provide a novel means of solving the aforementioned transport difficulties. As shown in the example of fig. 2, the novel means provided by the present invention utilizes a split tube (divided tube) consisting of two half-shells and a plunger, wherein the particles are held stably by the plunger as the two half-shells of the split tube are withdrawn one at a time, so that the particles originally in the split tube are gradually exposed from the distal end thereof and then fall from the split tube. It is clear that the means provided by the present invention allow to transport these granules with the least possible friction and to transport the porous granules smoothly without crushing them.
A particle delivery system constructed in accordance with the present invention comprises a plunger and a split tube, wherein the split tube comprises two or more part-shells adapted to couple to each other such that when the two or more part-shells are coupled to each other a longitudinal channel is formed in the split tube, each of the part-shells being longitudinally movable relative to the other, and the plunger is adapted to be inserted into the longitudinal channel.
Preferably, the two or more partial shell portions are two half shells.
Preferably, the particle delivery system of the present invention further comprises a holder, wherein the divided tube is adapted to be slidably held by the holder, and a portion of the housing of the divided tube held by the holder is longitudinally movable relative to the holder.
Preferably, the particle delivery system of the present invention further comprises a snap-fit mechanism which only allows longitudinal movement in one direction between the part of the housing and the holder. Preferably, the engaging mechanism includes a resilient clip mounted on each of the partial shells, and a series of parallel latches longitudinally mounted on the holder at regular intervals corresponding to the resilient clip, such that the resilient clip engages with the series of parallel latches ratchetedly.
Preferably, the particle delivery system of the present invention further comprises particles adapted to be introduced into the longitudinal channel.
The present invention additionally provides a method of inputting particles into a space, comprising the steps of: a) preparing the particle delivery system of the present invention; b) introducing particles into a longitudinal channel formed in the split tube; c) inserting the plunger into the channel of the split tube to contact the plunger with the particles; and d) withdrawing said two or more portions of the shell portion simultaneously or one after the other to expose said particles from the segmented tube.
The method of the present invention preferably further comprises repeating the withdrawing step in step d) to expose more of the particles in the segmented tube from the segmented tube.
Preferably, the method of the present invention further comprises the step of e) removing the split tube to separate the split tube from the exposed particles.
Drawings
Fig. 1 is a schematic sectional view showing the result of delivering porous granules using a conventional syringe from right to left, in which the arrow indicates the advancement of the plunger.
Fig. 2 is a schematic sectional view from right to left showing the result of conveying porous pellets using the novel mechanism provided by the present invention, in which the arrows indicate that the two half shells of the divided tube are alternately removed.
Fig. 3a and 3b are perspective views showing a pellet delivery system (hereinafter abbreviated GDS) constructed in accordance with a first preferred embodiment of the present invention.
Fig. 4a to 4d are plan and perspective views illustrating a GDS constructed according to a second preferred embodiment of the present invention.
Fig. 5a and 5d show a GDS constructed according to a third preferred embodiment of the present invention, wherein fig. 5a and 5b are viewed from opposite sides, fig. 5c is a perspective view of the GDS when assembled, and fig. 5d is a sectional view of the assembled GDS.
Fig. 6a to 6d are perspective and plan views showing a GDS constructed according to a fourth preferred embodiment of the present invention.
Fig. 7a to 7c are perspective views of a GDS constructed according to a fifth preferred embodiment of the present invention.
Fig. 8a to 8d are perspective views of a GDS constructed according to a sixth preferred embodiment of the present invention.
Fig. 9a and 9b are perspective and plan views showing a GDS constructed according to a seventh preferred embodiment of the present invention.
Detailed Description
A particle delivery system according to a first preferred embodiment of the invention (hereinafter abbreviated GDS) is shown in fig. 3a and 3b, wherein the GDS comprises a split tube 10 consisting of two half shells 11, a plunger 5 and a perforated cap 3. The half shells have enlarged proximal ends to facilitate their coupling and sliding relative to each other after coupling. The perforated cap 3 serves to retain porous particles (not shown in fig. 3a and 3 b) located in longitudinal channels formed in the split tube 10 after coupling and to enable the porous particles to be wetted by a liquid (e.g. blood) passing through the perforations formed on the perforated cap 3. The plunger 5 is not inserted deep into the divided tube 10 but to such an extent that its front end touches the porous granules filled in the longitudinal channel of the divided tube 10, so that when the two half shells 11 of the divided tube 10 are withdrawn one at a time, the filled granules are held against the plunger 5, thereby gradually exposing the porous granules originally in the divided tube from its distal end and falling down from the divided tube. The alternate withdrawal of the two half shells 11 of the divided tube 10 is repeated until all the particles filled in the divided tube fall down.
A GDS constructed according to a second preferred embodiment of the present invention is shown in fig. 4a to 4d, which includes an optional component for drawing a liquid (e.g., blood) into the divided tube 10 to wet porous particles (not shown in fig. 4a to 4 d) filled therein, a suction plunger 4. In this embodiment, the split tube 10 has a female half-shell 11 and a male half-shell 12, wherein the former is provided with a ring structure 13 and two grooves 14, and the latter is provided with two pins 15 corresponding to the two grooves 14 to facilitate the coupling thereof and the sliding thereof relative to each other after the coupling. The perforated cover part 3 and the plunger 5 are similar to those described in connection with the first preferred embodiment shown in fig. 3a and 3 b. When the two half shells 11 and 12 of the divided pipe 10 are alternately withdrawn, the particles filled in the longitudinal channel of the divided pipe 10 will be pressed against by the plunger 5, the filled particles gradually emerge from the divided pipe 10, falling from the divided pipe 10 due to gravity and/or the movement of the divided pipe 10. The alternate withdrawal is continued until all the particles filled in the divided tube 10 have been delivered, at which time the front end of the plunger 5 may emerge from the longitudinal channel of the divided tube, as shown in fig. 4 c.
A GDS constructed according to a third preferred embodiment of the present invention is shown in fig. 5a to 5d and comprises a plunger 5, a perforated cover (not shown) and a split tube 10 consisting of a female half-shell 11 and a male half-shell 12, similar to the second preferred embodiment shown in fig. 4a to 4d, wherein the former is provided with a ring structure 13 and two pins 15, and the latter is provided with two grooves 14 corresponding to the two pins 15. However, in this embodiment, the split tube 10 has a rectangular channel formed by the coupling of the female half shell 11 and the male half shell 12, and the front end of the plunger has a rectangular cross section corresponding to the rectangular channel. The female half-shell 11 and the male half-shell 12 are also provided on their outer surfaces with oval recesses sized and spaced to facilitate gripping by the human finger tips. The plunger 5 is further provided with two opposing arms 51 having an arc-shaped cross-section matching the cylindrical split tube 10, whereby the coupling of the female half-shell 11 and the male half-shell 12 can be improved and the plunger 5 can be held more easily by an operator.
A GDS constructed according to a fourth preferred embodiment of the present invention is shown in fig. 6a to 6d, which, like the third preferred embodiment shown in fig. 5a to 5d, comprises a plunger 5, a perforated cap (not shown in the drawings) and a split tube 10 consisting of a female half-shell 11 and a male half-shell 12. However, in this embodiment, the split tube 10 has a circular channel formed by the coupling of the female half shell 11 and the male half shell 12, and the front end of the plunger has a circular cross-section corresponding to the circular channel. The female and male half shells 11 and 12 are provided with wedge-shaped grooves 14 and wedge-shaped pins 15, respectively, so that the female and male half shells 11 and 12 are coupled by sliding the wedge-shaped pins 15 into the wedge-shaped grooves 14, and thus the ring structure mounted on the female half shell of the third preferred embodiment shown in fig. 5a to 5d is omitted in the fourth embodiment of the present invention. Furthermore, the plunger 5 is provided with two opposing arms 51 having a rectangular cross-section, and the split tube 10 after coupling forms two opposing notches 52 on its flange to slidably receive the two opposing arms 51.
A GDS constructed according to a fifth preferred embodiment of the present invention is shown in fig. 7a to 7c, which comprises a split tube 10 of three 1/3 shell portions 11, a plunger 5 and a perforated cap portion (not shown in the drawings). In this embodiment, each of the 1/3 shell portions is provided with a T-shaped projection 16 and a longitudinal slit 17 so that they can be engaged with each other to form a split tube 10, wherein the third 1/3 shell portion 11 shown in FIG. 7a is coupled to the two 1/3 shell portions 11 that have been engaged with each other, which are envisioned as being transparent in FIG. 7 c. The plunger 5 in this embodiment is similar to that shown in fig. 5a to 5d, except that the opposing arms 51 shown in fig. 5a to 5d are replaced by three arms 51 separated by an angle of 120 degrees between any two adjacent arms 51.
A GDS constructed according to a sixth preferred embodiment of the present invention is shown in fig. 8a to 8d, comprising two half shells 11, a plunger 5, a perforated cover 3 and a holder 20. As shown in fig. 8b and 8c, the outer surface of the half shell 11 near the proximal end is provided with resilient clips 18. The holder 20 has an upper portion 21 and a lower portion 22. The upper portion is provided with a series of parallel detents 23 corresponding to the spring clips 18. The proximal end of the half-shell 11 is slidably received in the central hole of the upper portion 21, and the spring clip 18 is capable of releasably engaging with the detent 23 one after the other, and the two half-shells 11 are coupled to form a split tube 10. The lower portion 22 of the retainer 20 is then attached to the split tube 10 from the distal end of the split tube 10. The lower portion 22 of the retainer 20 will contact the upper portion 21 of the retainer 20 and the plunger 5 is then inserted into the longitudinal channel formed in the split tube 10 to complete the assembly of the GDS shown in fig. 8 d.
A GDS constructed according to a seventh preferred embodiment of the present invention is shown in fig. 9a and 9b, which comprises a plunger 5, a perforated cap portion (not shown), a split tube 10 and a holder 20 having an upper portion 21 and a lower portion 22, which embodiment is similar to the sixth preferred embodiment of the present invention shown in fig. 8a to 8d, but the split tube 10 has a different cross-sectional shape. In this embodiment, the split-tube 10 is formed by coupling a flat bottom shell 12 with a semi-circular top shell 11, so that a longitudinal channel with a semi-circular cross-section is formed in the split-tube 10, so that the split-tube 10 can be inserted into a semi-circular cavity, and the split-tube 10 can be used for a sinus lift (sinus lift) operation.
It will be appreciated from the above description of the particular embodiment of the invention that particles transported through a tube and in particular a tubule are not pushed through the tube but are held substantially immobile as the tube is slid. It is clear that the design of the GDS of the present invention is particularly suited for transporting low strength, highly porous particles (e.g., 80% porosity) through thin tubes into small cavities. The main difference between the GDS of the present invention and a regular injector is that the GDS of the present invention does not "push" the particles forward in the tube. The plungers in the GDS of the present invention are primarily used to "hold" these particles in place. The GDS of the present invention "slips" the particles into the cavity, while the regular syringe "pushes" the particles into the cavity. For solid particles, the normal syringe may be able to accomplish this delivery. However, for fragile highly porous pellets, the "pushing" action of the normal syringe will easily crush the pellets into a powder before they reach the outlet of the syringe.

Claims (10)

1. A particle delivery system comprising a plunger and a split tube, wherein the split tube comprises two or more part-shells adapted to couple to each other such that when the two or more part-shells are coupled to each other a longitudinal channel is formed in the split tube, each of the part-shells being longitudinally movable relative to the other, and the plunger is adapted to be inserted into the longitudinal channel.
2. A particle delivery system according to claim 1, further comprising a holder, wherein the split tube is adapted to be slidably held by the holder, and a portion of the shell of the split tube held by the holder is longitudinally movable relative to the holder.
3. The particulate delivery system of claim 1, wherein the two or more partial shell portions are two half shells.
4. The particulate delivery system of claim 2, wherein the two or more partial shell portions are two half shells.
5. The particle delivery system of claim 2 further comprising a snap-fit mechanism that only allows longitudinal movement in a direction between the partial housing portion and the holder.
6. The particulate delivery system of claim 5 wherein the engagement mechanism includes a resilient clip mounted on each of the partial housing portions and a series of parallel detents corresponding to the resilient clip and longitudinally mounted on the retainer at regular intervals such that the resilient clip ratchets with the series of parallel detents.
7. The particle delivery system of claim 1, wherein the particle delivery system further comprises particles adapted to be introduced into the longitudinal channel.
8. A method of inputting particles into a space, comprising the steps of: a) preparing the particle delivery system of claim 1; b) introducing particles into a longitudinal channel formed in the split tube; c) inserting the plunger into the channel of the split tube to contact the plunger with the particles; and d) withdrawing said two or more portions of the shell portion simultaneously or one after the other to expose said particles from the segmented tube.
9. The method of claim 8, further comprising repeating the withdrawing step in step d) to expose more particles in the segmented tube from the segmented tube.
10. The method of claim 8, further comprising the step of e) removing the split tube to separate the split tube from the exposed particles.
CN201580038517.2A 2014-07-16 2015-07-10 Pellet transport system and pellet transport method using same Active CN107073212B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462025140P 2014-07-16 2014-07-16
US62/025140 2014-07-16
PCT/US2015/039852 WO2016010836A1 (en) 2014-07-16 2015-07-10 Granule delivery system and method of delivering granules using the same

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Publication Number Publication Date
CN107073212A CN107073212A (en) 2017-08-18
CN107073212B true CN107073212B (en) 2020-01-10

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US (1) US10500383B2 (en)
CN (1) CN107073212B (en)
TW (1) TWI533901B (en)
WO (1) WO2016010836A1 (en)

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Publication number Priority date Publication date Assignee Title
US10285987B2 (en) 2017-04-28 2019-05-14 Amplipharm Pharmaceuticals, LLC Device and kit for dosing and dispensing non-liquid medicine
TWI679040B (en) 2017-01-30 2019-12-11 喜樂醫療器材股份有限公司 Particulate material delivery system and method
US11559342B2 (en) * 2019-05-24 2023-01-24 Joy Medical Devices Corporation Delivery tool and method for forming a structure having a layer of hardened paste and particles under the layer

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US5910315A (en) * 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
CN1238007A (en) * 1996-09-25 1999-12-08 鲍德杰克特疫苗公司 Gas-driven particle delivery device
WO2011081975A1 (en) * 2009-12-29 2011-07-07 3M Innovative Properties Company Dental auto-mixing methods, devices, and compositions
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CN1238007A (en) * 1996-09-25 1999-12-08 鲍德杰克特疫苗公司 Gas-driven particle delivery device
US5891104A (en) * 1997-01-10 1999-04-06 Univec, Inc. Hypodermic syringe having retractable needle
US5910315A (en) * 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
WO2011081975A1 (en) * 2009-12-29 2011-07-07 3M Innovative Properties Company Dental auto-mixing methods, devices, and compositions
CN103842005A (en) * 2011-10-03 2014-06-04 辉凌公司 Device and method for delivering a dose of medicament comprising activated carbon particles

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Publication number Publication date
CN107073212A (en) 2017-08-18
WO2016010836A1 (en) 2016-01-21
US20170209680A1 (en) 2017-07-27
TWI533901B (en) 2016-05-21
US10500383B2 (en) 2019-12-10
TW201603845A (en) 2016-02-01

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Effective date of registration: 20201015

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Patentee before: JTI BIOMED Corp.

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