CN107073148A - Conduit with antimicrobial treatment - Google Patents

Conduit with antimicrobial treatment Download PDF

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Publication number
CN107073148A
CN107073148A CN201580044480.4A CN201580044480A CN107073148A CN 107073148 A CN107073148 A CN 107073148A CN 201580044480 A CN201580044480 A CN 201580044480A CN 107073148 A CN107073148 A CN 107073148A
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CN
China
Prior art keywords
antimicrobial treatment
conduit
quaternary ammonium
ammonium salt
percents
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Granted
Application number
CN201580044480.4A
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Chinese (zh)
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CN107073148B (en
Inventor
帕特里克·E·埃迪
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Link Medical Ltd
Parasol Medical LLC
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Link Medical Ltd
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Publication of CN107073148B publication Critical patent/CN107073148B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

There is provided a kind of conduit, the conduit has the part with multiple outer surfaces.At least one in the surface is coated with antimicrobial treatment, and wherein antimicrobial material includes silane quaternary ammonium salt.Silane quaternary ammonium salt can include 3 (trimethoxysilyl) propyl-dimethyl octadecyl ammonium chlorides.

Description

Conduit with antimicrobial treatment
Background technology
Present invention relates in general to conduit and the CVC through being the peripherally inserted (is led at the center through being the peripherally inserted Pipe, the centre pipe inserted through peripheral vein, PICC) pipeline.
In the art, it is known that a variety of vascular access products (vascular access product), for example it is intravenous to give Pencil, conduit, and related cap, female Luer, Y-piece (Y site), connector, instillator, PICC pipelines, plug and Similar venous transfusion part, such as the needleless venous transfusion connector with valve system.The reality of such vascular access product Example can be obtained from Utah, USA cent Wei Er vast and boundless bright medicine equipment (Health Line Medical Products of Centerville, Utah) and can see from the www.hlic.net of its website.
A kind of example of valve system for needleless venous transfusion connector is the U.S. for transferring ICU Medical, Inc. The patent No. 5,685, the medical valve described in 866, the said firm is also manufactured in trade markUnder such needleless it is quiet Arteries and veins transfusion connector.One of needleless venous transfusion connector can carry out antimicrobial treatment, and its moderate resistance is micro- Biological treatment includes ionic silver.However, such ionic silver can be leached with the time.
The content of the invention
According to one embodiment of the present invention there is provided a kind of conduit, it includes the part with multiple outer surfaces, wherein At least one in the surface is coated with antimicrobial treatment (antimicrobial treatments, antimicrobial treatment liquid), wherein institute Stating antimicrobial material includes silane quaternary ammonium salt.
According to another embodiment of the present invention there is provided a kind of CVC pipeline through being the peripherally inserted (through periphery The centre pipe pipeline of insertion, the centre pipe pipeline inserted through peripheral vein, peripherally inserted central Catheter line), it includes the part with multiple outer surfaces, wherein at least one in the surface be coated with it is anti-micro- Biological treatment, wherein the antimicrobial material includes silane quaternary ammonium salt.
In in these embodiments one or more, silane quaternary ammonium salt can include 3- (trimethoxysilyl) Propyl-dimethyl octadecyl ammonium chloride.
By reference to following specification, claims and appended accompanying drawing, those skilled in the art can enter one Step understands and understands these and other feature, advantage and the purpose of the present invention.
Brief description of the drawings
In figure：
Figure 1A and 1B show the acute hemodialysis catheter according to a kind of embodiment；
Fig. 1 C show the PICC pipelines according to another embodiment；
Fig. 1 D show the peritoneal dialysis catheters according to another embodiment；
Fig. 1 E and Fig. 1 F show the chronic hemodialysis conduit according to another embodiment；
Fig. 2 is a kind of schematic diagram of monomer, and the monomer can be used as antimicrobial place in implementations described herein Manage material；
Fig. 3 is that multiple shown monomers in fig. 2 apply to the schematic diagram on handled surface；
Fig. 4 A are the schematic diagrames of monomer shown in figs. 2 and 3, and it shows that monomer uses the mode of destruction microorganism First step；
Fig. 4 B are the schematic diagrames of monomer shown in figs. 2 and 3, and it shows that monomer uses the mode of destruction microorganism Second step；And
Fig. 4 C are the schematic diagrames of monomer shown in figs. 2 and 3, and it shows that monomer uses the mode of destruction microorganism Third step.
Embodiment
Now with detailed reference to the preferred embodiment of the present invention, the examples of these preferred embodiments has been shown in attached In figure.Refer to same or analogous part using identical reference number as much as possible in whole accompanying drawing.In the accompanying drawings, it is The purpose emphasized and understood, the structural detail described is not in proportion, and some parts are relative to other part quilts Amplification.
As described above, implementations described herein is related to conduit and PICC pipelines.Because conduit and PICC pipelines can be with The path for entering blood stream of patients is provided, it is therefore important that they do not keep bacterium or other microorganisms.
Disclosed herein is new catheter and PICC pipelines, it is not only that such vascular access product provides necessary category Property, also eliminate bacterium during contact.As discussed below, handled or used with the antimicrobial material including silane quaternary ammonium salt It forms the part of conduit and PICC pipelines.The conduit and the example of PICC pipelines that can be processed as are shown in Figure 1A -1F.
Figure 1A and Figure 1B show a kind of example of first embodiment, wherein acute hemodialysis catheter 10a and 10b One or more of outer surface 50 is coated with antimicrobial treatment.
Fig. 1 C show a kind of example of second embodiment, wherein one or many in the outer surface 50 of PICC pipelines 20 It is individual to be coated with antimicrobial treatment.
Fig. 1 D show a kind of example of the 3rd embodiment, wherein one in the outer surface 50 of peritoneal dialysis catheters 30 Or multiple it is coated with antimicrobial treatment.
Fig. 1 E and Fig. 1 F show a kind of example of the 4th embodiment, wherein chronic hemodialysis conduit 40a's and 40b One or more of outer surface 50 is coated with antimicrobial treatment.
In general, antimicrobial treatment can apply to above-mentioned conduit and PICC pipelines (10a, 10b, 20,30,40a, All surface 50 40b).However, these surfaces handled by processing with antimicrobial treatment particularly contact patient Surface at least one, benefit can be obtained.
The surface 50 of conduit and PICC pipelines is coated with antimicrobial treatment, and it can use solution to be ejected on surface And/or the cleaning piece (wipe) being soaked in such solution can be used to apply to surface.Suitable cleaning piece and solution are public It is opened in commonly assigned U.S. Patent number 8,491,922, the complete disclosure of the patent is incorporated herein by reference.At this In the case of kind, antimicrobial material is one of above-mentioned silane quaternary ammonium salt again.
In a kind of preferred form, antimicrobial treatment solution includes the isopropanol and 50- of 30-50 percents by volume The antimicrobial treatment material of 70 percents by volume, the antimicrobial treatment material preferably has unreacted organic functional The silane quaternary ammonium salt of silane.If applying antimicrobial treatment solution by spraying or impregnating, solution is most preferably wrapped Include the isopropanol of 50 percents by volume and the unreacted antimicrobial treatment material of 50 percents by volume.If using wiping Thing applies solution, then solution be preferably 30 percents by volume isopropanol and 70 percents by volume it is unreacted anti-micro- Biological treatment material.
Isopropanol can have the concentration of 70-90 percents by volume.By providing unreacted organic official in isopropanol Can silane, organofunctional silane not with wipe substrate or wipe container internal-response so that its then can freely with The inner surface of vascular access product and outer surface 50 react and with its for good and all covalent bonding (with reference to).Isopropanol is preferred , because once the solution is wiped on the surface through processing, its just quick volatilization, to allow unreacted organic functional silicon Alkane reacts with the surface through processing more quickly.
It is preferred that organofunctional silane quaternary ammonium salt also prevent may be related to microorganism pollution smell, dyeing and product It is rotten.It is preferred that organofunctional silane quaternary ammonium salt be also beneficial because it is for good and all bonded (with reference to) to surface through processing, Cover have no adverse effect or shortcoming broad spectrum of activity, and be easily incorporated to and easily verify.
It is preferred that organofunctional silane quaternary ammonium salt be designed to the reaction of the surface of plastic components and it is formed covalently Key.The material of reaction is maintained on those surfaces, until breaking of covalent bonds.Experiment shows, most of industrial cleaners or disappears Toxic agent will not remove preferred antimicrobial treatment material.The method of removal is by abrasion.
It is preferred that silane quaternary ammonium salt include active component 3- (trimethoxysilyl) propyl-dimethyl octadecyl chloride Change ammonium and other inert fractions.Silane quaternary ammonium salt preferably includes 3- (the trimethoxy first silicon of about 0.1-50 percentage by weights Alkyl) propyl-dimethyl octadecyl ammonium chloride, and most preferably include 3- (the trimethoxy first silicon of about 5 percentage by weights Alkyl) propyl-dimethyl octadecyl ammonium chloride.Such silane quaternary ammonium salt can be obtained from available city Yi Jiesi Envirolution, INC. (Aegis Environments of Midland, Michigan), it is identified as " AEM 5772- 5Antimicrobial ", and the Piedmont chemical industry I Co., Ltds derived from the special city of North Carolina state hypo (Piedmont Chemical Industries I, LLC of High Point, North Carolina), it is identified as “PROMOFRESH X 105”.It is MICROBECARE that antimicrobial treatment solution with isopropanol, which can be obtained from trade mark,TMPosition In state of Michigan Allendale MicrobeCare Co., Ltds (Piedmont Chemical Industries I, LLC of High Point,North Carolina)。
Above-mentioned silane quaternary ammonium salt is preferred, because it is substantially free of arsenic, silver, tin, heavy metal and many chlorine The organofunctional silane antimicrobial treatment material of phenol；Copper；Or silver ion emitter (silver ion emitter).Separately Outside, bacterium when it not only eliminates contact, is also retained on the surface 50 through processing and kills and then contact these surfaces Any bacterium.Such processing preferably continues at least one week, more preferably persistently some months, and most preferably infinitely holding It is continuous.
Fig. 2 shows the signal of the monomeric form 130 of the preferred organofunctional silane as antimicrobial treatment material Figure.As shown, monomer 130 includes the silane matrix (silylation, silane base) for being used to be bonded (with reference to) to surface 50 131, positively charged nitrogen molecular 134, and long chain 132.As shown in Figure 3, the silane matrix of these monomers is total to Valency and for good and all bond together (with reference to), and be bonded to pending surface 50 as follows：Long chain is lined up Straight line and outwards refer to from surface 50.This close bonding provides the micro- polymerization for the protective coating being used as on the outside of surface 50 Thing network, protective coating destruction enters any microorganism of contact.
It is preferred that organofunctional silane use destruction microorganism mode show in figs. 4 a-4 c.Such microorganism can With including bacterium, mould, mould, algae etc..As shown by Figure 4 A, the cell membrane 120 of microorganism is attracted to blood vessel and led to The surface 50 through processing of road product, and then pierced through by the long chain 132 of monomer 130.When microorganism due to it is positive and negative from When son is exchanged and pulled closer, monomer 130 further penetrates cell membrane 120, as illustrated in fig. 4b.Once dearly Penetrate, cell membrane 120 will act on physical damage by sword sample, then be shocked by electricity cause by the positively charged nitrogen molecular 134 of monomer 130 Extremely, microorganism is thus destroyed, as shown in FIG. 4 C.Therefore, eliminate microorganism, without " using up " any antimicrobial acivity into Point, antimicrobial acivity composition is remained on surface 50, gets out continue to protect the article through processing from further micro- Biological pollution.
It is preferred that organofunctional silane be designed to react and formed common with the surface 50 of conduit and PICC pipelines Valence link.The material of reaction is maintained on those surfaces 50, until breaking of covalent bonds.Experiment is it has been shown that most of industrial cleaners Or disinfectant can't remove preferred antimicrobial treatment material.The method of removal is by abrasion.In vascular access production At least a portion of product or vascular access product is by the case that silicone is made, antimicrobial material can be integrally formed In silicone.In general, silicone is formed by the slurry handled at relatively low temperatures.These low temperature allow antimicrobial material Mix and therefore be incorporated into the foam of gained or silicone portions with slurry.The percentage of antimicrobial material in the slurry can be with Change between by weight 0.001% to 20%.
Although the special construction on the conduit shown in Figure 1A -1F and PICC pipelines describes the present invention, its Construction can still change.
The description described above being to be considered only as preferred embodiment.Those skilled in the art and manufacture or The modification of the present invention is will recognize that using the personnel of the present invention.It will thus be appreciated that being shown in the drawings and being described above Embodiment be intended solely for illustrative purposes, and be not intended to limit the basis that is defined by the claims and include doctrine of equivalents Patent Law principle explain the scope of the present invention.

Claims (18)

1. a kind of conduit, including：
Part with multiple outer surfaces, wherein at least one in the surface is coated with antimicrobial treatment,
Wherein described antimicrobial treatment includes silane quaternary ammonium salt.
2. conduit according to claim 1, wherein, the silane quaternary ammonium salt includes the organofunctional silane of reaction, to promote Enter and be bonded with the surface of shell.
3. the conduit according to any one of claim 1 and 2, wherein, the silane quaternary ammonium salt includes 3- (trimethoxy first Silylation) propyl-dimethyl octadecyl ammonium chloride.
4. conduit according to any one of claim 1 to 3, wherein, the antimicrobial treatment includes antimicrobial place Solution is managed, the antimicrobial treatment solution includes the silane quaternary ammonium salt and isopropanol.
5. conduit according to claim 4, wherein, the antimicrobial treatment solution includes about 30 percents by volume to about The isopropanol of 50 percents by volume.
6. conduit according to claim 4, wherein, the antimicrobial treatment solution includes about 50 percents by volume to about The antimicrobial treatment material of 70 percents by volume.
7. conduit according to any one of claim 1 to 6, wherein, the conduit be selected from by acute hemodialysis catheter, The group of chronic hemodialysis conduit and peritoneal dialysis catheters composition.
8. conduit according to any one of claim 1 to 7, wherein, the antimicrobial treatment substantially free of arsenic, Silver, tin, heavy metal and polystream phenol.
9. conduit according to any one of claim 1 to 8, wherein, the antimicrobial treatment is covalently bonded to institute State at least one in surface and the ion for helping to destroy microorganism can be launched.
10. a kind of CVC pipeline through being the peripherally inserted, including：
Part with multiple outer surfaces, wherein at least one in the surface is coated with antimicrobial treatment,
Wherein described antimicrobial treatment includes silane quaternary ammonium salt.
11. the CVC pipeline according to claim 10 through being the peripherally inserted, wherein, the silane quaternary ammonium salt bag The organofunctional silane of reaction is included, to promote to be bonded with the surface of shell.
12. the CVC pipeline through being the peripherally inserted according to any one of claim 10 and 11, wherein, it is described Silane quaternary ammonium salt includes 3- (trimethoxysilyl) propyl-dimethyl octadecyl ammonium chloride.
13. the CVC pipeline through being the peripherally inserted according to any one of claim 10 to 12, wherein, it is described Antimicrobial treatment includes antimicrobial treatment solution, and the antimicrobial treatment solution includes the silane quaternary ammonium salt and isopropyl Alcohol.
14. the CVC pipeline according to claim 13 through being the peripherally inserted, wherein, the antimicrobial treatment Solution includes the isopropanol of about 30 percents by volume to about 50 percents by volume.
15. the CVC pipeline according to claim 13 through being the peripherally inserted, wherein, the antimicrobial treatment Solution includes the antimicrobial treatment material of about 50 percents by volume to about 70 percents by volume.
16. the CVC pipeline through being the peripherally inserted according to any one of claim 10 to 15, wherein, it is described Antimicrobial treatment is substantially free of arsenic, silver, tin, heavy metal and polystream phenol.
17. the CVC pipeline through being the peripherally inserted according to any one of claim 10 to 16, wherein, it is described Antimicrobial treatment be covalently bonded in the surface at least one and can launch and help to destroy the ion of microorganism.
18. the CVC pipeline through being the peripherally inserted according to any one of claim 10 to 17, wherein, it is described Vascular access product is selected from the group being made up of conduit and PICC pipelines.
CN201580044480.4A 2014-08-20 2015-08-20 Catheter with antimicrobial treatment Active CN107073148B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462039539P 2014-08-20 2014-08-20
US62/039,539 2014-08-20
PCT/US2015/046100 WO2016029010A1 (en) 2014-08-20 2015-08-20 Catheters having an antimicrobial treatment

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112479656A (en) * 2020-12-15 2021-03-12 湖北工业大学 Preparation method of biological corrosion resistant concrete with surface conditioning function
CN112772673A (en) * 2019-11-11 2021-05-11 阳伞医药有限公司 Disinfecting and antimicrobial solutions containing hypochlorous acid and silane quats

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005104845A1 (en) * 2004-04-30 2005-11-10 Coloplast A/S A hydrophilic coating of a water-swellable hydrophilic matrix and an anti-microbial polymer
US20120052106A1 (en) * 2010-08-24 2012-03-01 Eddy Patrick E Antimicrobial wipes and solution
US20120157567A1 (en) * 2010-12-16 2012-06-21 Saint-Gobain Performance Plastics Corporation Silicone composition, an article and method of making an article

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122555A (en) * 1996-05-07 2002-12-01 Bioschield Technologies Inc Water-stabilized organosilane compounds and methods for using the same
US20110208023A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005104845A1 (en) * 2004-04-30 2005-11-10 Coloplast A/S A hydrophilic coating of a water-swellable hydrophilic matrix and an anti-microbial polymer
US20120052106A1 (en) * 2010-08-24 2012-03-01 Eddy Patrick E Antimicrobial wipes and solution
US20120157567A1 (en) * 2010-12-16 2012-06-21 Saint-Gobain Performance Plastics Corporation Silicone composition, an article and method of making an article

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112772673A (en) * 2019-11-11 2021-05-11 阳伞医药有限公司 Disinfecting and antimicrobial solutions containing hypochlorous acid and silane quats
CN112479656A (en) * 2020-12-15 2021-03-12 湖北工业大学 Preparation method of biological corrosion resistant concrete with surface conditioning function
CN112479656B (en) * 2020-12-15 2022-03-15 湖北工业大学 Preparation method of biological corrosion resistant concrete with surface conditioning function

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WO2016029010A1 (en) 2016-02-25

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