CN107049352A - PET data acquisition method, PET image reconstruction method and PET system - Google Patents
PET data acquisition method, PET image reconstruction method and PET system Download PDFInfo
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T11/00—2D [Two Dimensional] image generation
- G06T11/003—Reconstruction from projections, e.g. tomography
- G06T11/005—Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/04—Positioning of patients; Tiltable beds or the like
- A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/58—Testing, adjusting or calibrating apparatus or devices for radiation diagnosis
- A61B6/582—Calibration
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T11/00—2D [Two Dimensional] image generation
- G06T11/003—Reconstruction from projections, e.g. tomography
- G06T11/006—Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2211/00—Image generation
- G06T2211/40—Computed tomography
- G06T2211/421—Filtered back projection [FBP]
Abstract
The invention provides a kind of PET data acquisition method, PET image reconstruction method and PET system, including：While event is met using probe unit detection, control scanning bed motion, so as to drive axial movement of the die body along the detector, makes predetermined probe unit to be irradiated to by the die body.And then, for the PET system for growing axial direction, even if can still realize that all predetermined probe units can carry out the purpose of data acquisition to die body using the shorter die body of length；Also, the data acquisition for making all predetermined probe units be all based on same die body and carry out, it can be ensured that radiation uniformity of the die body in the whole axial scan visual field.
Description
Technical field
The present invention relates to medical imaging field, more particularly to a kind of PET data acquisition method, PET image reconstruction method and
PET system.
Background technology
Positron emission tomography (Positron Emission Tomography, PET) is clinically to be widely used
A kind of noninvasive nucleus medical image diagnostic techniques, its by inject live body radioactive tracer be imaged, so as to provide live body
The function information such as metabolism, play important in clinical diagnosis, therapeutic evaluation, basic medical research and new drug development
Effect.
PET is a kind of using positron radionuclide as tracer, passes through intake of the lesions position to tracer and understands focus function
Metabolism state, and then the technology of diagnosis is made to disease.Specifically, the radioactive tracer medicine of positron radionuclide will be marked with
It is injected into detected body, positron radionuclide occurs decay emission and goes out positive electron, occurs with the negatron in detected object body
Annihilation reaction, produces the γ photons that both direction is opposite, energy is 511KeV, so as to be placed on around detected object
Probe unit is detected.Meet the processing of detection by electronics, satisfactory γ photons pair are recorded, wherein once burying in oblivion
Reaction is referred to as one and meets event.It is multiple to meet the image that event is used to rebuilding or creating scanned object, that is to say, that weight
Build the information that image provides scanned object inner radiation Nuclear analysis.
Wherein, PET system generally includes have thousands of probe units in a detector, the detector, passes through
The probe unit detection meets event.PET system is the large-scale medical diagnostic device of complex precise, it usually needs the regular property done
Can test and demarcate, for example, detector normalization and system QC check etc..By constantly updating correction parameter so that
PET system is at good working order, reduces the deviation in detection process, it is ensured that the accuracy of detection structure.With PET
In system exemplified by the normalization of probe unit efficiency, in trimming process, a die body need to be positioned over to the detection of PET system
In device, the die body is usually a radioactive source, after ensuring that all probe units can be irradiated to by die body, and then can be passed through
The probe unit detection meets event.Because the event that meets that all probe units are detected is statistically identical, that
Corresponding counting response can serve as measuring for probe unit efficiency, and normalization factor can be calculated based on this.
From the above, during die body is scanned using PET system to rebuild the normalization factor, it is necessary to assure visit
Surveying probe units all in device can be irradiated to by die body, i.e. need to ensure the length of die body can cover the whole of detector
The individual axial scan visual field (Field Of Vision, FOV).However, for long axial PET system (for example, PET system
When the length in the axial visual field is more than or equal to 2m), so long die body can not be generally provided.Therefore, current way is, will be several
Short die body forms the long die body with sufficient length by way of splicing.Although this method can compensate the length of short die body
Degree, however, this method also needs further exist for ensuring activity and placement location between each short die body for splicing etc.
The deviation of factor is sufficiently small, can so form a uniform long die body.It can be seen that, the operability of this solution is not
It is high.
The content of the invention
It is an object of the invention to provide a kind of PET data acquisition method, PET image reconstruction method and PET system, to solve
Certainly existing PET system is when ensuring that all probe units are both needed to be irradiated to by die body, and the die body length used need to be more than
Equal to the axial length in the axial scan visual field of detector, the problem of adding scanning difficulty.
In order to solve the above technical problems, the present invention provides a kind of PET data acquisition method, the PET system includes detection
Device and scanning bed, the detector includes multiple probe units, and the scan method includes：
By die body be positioned over it is described it is scanning bed on, the axial length of the die body is less than the scan vision of the detector
Axial length；
The axial movement of scan vision of the scanning bed drive die body along the detector is controlled, while utilizing institute
State detector cells collection and meet event from the die body.
Optionally, the axial movement of scan vision of the control scanning bed drive die body along the detector
Including：
The scanning bed motion is controlled according to the sweep parameter of the detector, the sweep parameter of the detector includes
The axial length of the scan vision of sweep time and/or the detector.
Optionally, interval the sweeping more than or equal to the detector of motion of the die body in the axial direction of the detector
Retouch the axial length in the visual field.
Optionally, the control scanning bed axial movement for driving the die body along the detector includes：
Scan vision of the scanning bed drive die body along the detector is controlled according to the information of the die body
It is axially moved, the information of the die body includes one or more in position, the weight of die body and the length of die body of die body.
Optionally, the information of the die body is obtained by the CT images of the die body.
It is a further object of the present invention to provide a kind of method of PET image reconstruction, including：
The collection of data is scanned to die body using PET data acquisition method as described above, wherein, it is described in control
When scanning bed motion, scanning bed positional information is also generated；
The positional information of the die body is obtained according to the scanning bed positional information；
Corresponding scan data is extracted from the scan data gathered according to the positional information of the die body and carries out PET figures
As rebuilding.
Optionally, the method for above-mentioned PET image reconstruction also includes：
According to the dampening information of the die body and the scanning bed positional information, mould of the holoaxial into scan vision is obtained
The dampening information of body；
PET image reconstruction is performed with reference to the dampening information of die body of the holoaxial into scan vision, to generate PET reconstructions
Image.
Optionally, the method for above-mentioned PET image reconstruction also includes：
Scanning bed position in the axial scan visual field of the detector and nucleic decay are normalized respectively, obtained
Take scanning bed position statistical information and nucleic decay statistical information；
According to the scanning bed position statistical information in the axial scan visual field and nucleic decay statistical information, and with reference to described
PET reconstruction images, which are performed, axially counts correction, to obtain the PET reconstruction images after correction of the die body in the axial scan visual field.
Another object of the present invention is to there is provided a kind of PET system, including：
Detector, the detector includes multiple probe units, and the probe unit is used for the scan vision in detector
Interior detection meets event；
It is scanning bed, it is described scanning bed for placing die body, and drive the die body to move；
Scanning bed motion control unit, for when probe unit detection meets event, while the control scanning
Bed drives the axial movement of scan vision of the die body along the detector.
Optionally, the PET system also includes：
Image reconstruction unit, the event that meets for being detected according to the detector cells carries out PET image reconstruction.
In the scan method for the PET system that the present invention is provided, while detector carries out data acquisition to die body, make
Scan bed motion and then drive die body movement, can be irradiated to the even all probe units for ensuring predetermined by die body.
Therefore, for the PET system for growing axial direction, even if can still realize all predetermined detection lists using the shorter die body of length
Member can carry out the purpose of data acquisition to die body.Also, all predetermined probe units are all based on same die body and entered
Capable data acquisition, and, the scanning bed motion is controlled always according to logical operation in the present invention, makes die body along detection
During the axial movement of device, it is held on sustained height position, so as to can reach relative to all predetermined probe units
Say the data acquisition for being all based on a uniform die body and carrying out.In addition, by acquired in the scan method of the invention provided
Data are applied also among PET image reconstruction, are analyzed with the performance further to PET system.Or, it will can also scan
Acquired data application is in the generation of the detector efficiency normalization factor to PET system.
Brief description of the drawings
Fig. 1 be one embodiment of the invention in PET data acquisition method schematic flow sheet；
Step schematic diagrames of the Fig. 2 for the PET data acquisition method in one embodiment of the invention in its data acquisition；
Fig. 3 be one embodiment of the invention in PET system structural representation；
Fig. 4 be one embodiment of the invention in PET image reconstruction method schematic flow sheet；
Fig. 5 be another embodiment of the present invention in PET system structural representation.
Embodiment
As stated in the Background Art, generally need to be to the die body of a radioactive source when carrying out performance test and demarcation to PET system
Data acquisition is carried out, and all probe units that die body can be uniformly irradiated in detector need to be ensured.However, applicant
It was found that, in the PET system for long axial direction, because the whole of detector can not be generally completely covered in the length of existing die body
The axial visual field, causes PET system can not realize that all probe units can carry out data acquisition to die body.
Therefore, the invention provides a kind of PET data acquisition method, die body is scanned by PET system and obtained, the PET
System includes a detector and one scan bed, and the detector includes multiple probe units.Fig. 1 is in one embodiment of the invention
The schematic flow sheet of PET data acquisition method, as shown in figure 1, the scan method of the PET system includes：
Step S110, by die body be positioned over it is described it is scanning bed on, the axial length of the die body is less than the detector
The axial length of scan vision；
Step S120, controls the axial movement of scan vision of the scanning bed drive die body along the detector,
Meet event from the die body using detector cells collection simultaneously.
In the PET data acquisition method that the present invention is provided, existing die body can be based on, by being controlled during collection
Bed motion is scanned, predetermined probe unit is irradiated to by die body, it is ensured that predetermined probe unit can enter to die body
Row data acquisition.When predetermined probe unit is all probe units, that is, all probe units can be right
Die body carries out data acquisition, so that, using data acquisition normalization factor and PET image reconstruction collected etc..
That is, coordinate scanning bed motion in the collecting method that the present invention is provided, so that, even if using shorter die body,
The most axial scan visual field in covering detector still is able to, or even covers the whole axial scan visual field of detector.
Below in conjunction with the drawings and specific embodiments to PET data acquisition method proposed by the present invention, PET image reconstruction method
It is described in further detail with PET system.According to following explanation and claims, advantages and features of the invention will be more clear
Chu.It should be noted that, accompanying drawing is using very simplified form and uses non-accurately ratio, only to conveniently, lucidly
Aid in illustrating the purpose of the embodiment of the present invention.
Fig. 2 is that the PET data acquisition method in one embodiment of the invention is illustrated the step of during its data acquisition
Figure, Fig. 3 be one embodiment of the invention in PET system structural representation.Below in conjunction with shown in Fig. 1-Fig. 3, in embodiment
The scan method of PET system further illustrate.
First, in step s 110, by die body be positioned over it is described it is scanning bed on, the axial length of the die body is less than described
The axial length of the scan vision of detector.
Specifically it refer to shown in Fig. 3, the PET system includes a detector 110 and one scan bed 120.In the PET systems
In the scanning process of system, die body is placed on described scanning bed 120, and with scanning bed 120 movement, makes the mould
Body can be moved into the scan vision of the detector 110, so as to be scanned using detector 110 to die body, entered
And can gather and meet event from the die body.Further, the detector 110 includes multiple probe units 111, many
In annular shape arrangement, the scan vision of detector 110 is for example detected by the probe unit 111 for the individual probe unit 111
Interior meets event.
Then, in the step s 120, scan vision of the scanning bed drive die body along the detector is controlled
It is axially moved, while meeting event from the die body using detector cells collection.That is, data acquisition is being performed
During, while making the die body axially movable, thus, you can ensure that predetermined probe unit can be by the die body
It is irradiated to.
With reference to shown in Fig. 3, in the present embodiment, the axial length of the die body is less than the axle of the scan vision of detector 110
To length, therefore, when the predetermined probe unit 111 is all probe units 111 in detector 110, then in data
During collection, control described scanning bed 120 can be made to drive the motion in axial direction of the die body along the detector interval
More than or equal to the axial length of the scan vision of the detector, so as to make all probe units 111 to gather
Meet event to from die body.
Further, when controlling axial movement that described scanning bed 120 drive the die body along the detector 110,
Scanning bed 120 motion can be controlled with specific reference to the sweep parameter of the detector 110.Wherein, the detector 110
Sweep parameter is, for example, the axial length (that is, the Z-direction shown in Fig. 3) of the scan vision of sweep time and/or the detector
Deng.Further, when controlling axial movement that described scanning bed 120 drive the die body along the detector 110, may be used also
The die body motion is driven according to the information of die body control described scanning bed 120.Wherein, the information of the die body is, for example,
Weight of the length of die body, the position of die body and die body etc., specifically, the information of the die body can be broken by the computer of die body
Layer scanning (Conputed Tomography, CT) image is obtained, and the CT images of die body can be obtained by carrying out CT scan to die body
.
In addition, the die body is located on scanning bed 120, and it is the motion and then drive by scanning bed 120
Die body motion, therefore, when controlling axial movement that described scanning bed 120 drive the die body along the detector 110,
Also, consequently, it is possible to not only can control the movement of die body in the axial direction, can may be used also further combined with scanning bed 120 information
Realize position adjustment of the die body on axial direction (that is, the Y-direction shown in Fig. 3).In the present embodiment, the scanning bed letter
Breath can be scanning bed deformation factor, and the scanning bed deformation factor can be calculated by scanning bed deformation curve and obtained,
Specifically, scanning bed deformation factor include the scanning bed deformation in short transverse (that is, the Y-direction shown in Fig. 3) because
Son.So as to by the way that with reference to scanning bed 120 deformation factor in the height direction, scanning bed 120 height can be adjusted in real time
Position is spent, the height for the die body being arranged on scanning bed 120 is consistent in its motion process, it is ensured that die body can be along
Axial direction (that is, the Z-direction shown in Fig. 3) motion of detector 110.
Then with reference to shown in Fig. 2 and Fig. 3, in the present embodiment, described sweep is controlled using one scan bed motion control unit 130
Retouch bed and drive axial movement of the die body along the detector.The scanning bed motion control unit 130 can be visited according to described
Sweep parameter, the information of die body and scanning bed 120 information of device are surveyed, scanning bed 120 motion is controlled, and in real time
Regulate and control scanning bed 120 position.
Specifically, the scanning bed motion control unit 130 can be to the detector 110 got sweep parameter, die body
Information and scanning bed 120 information carry out logical operation, to obtain scanning bed 120 motion control logic.The scanning
Bed motion control logic be, for example,：Moving region on the scanning bed axial direction (Z-direction) in detector, scanning bed motion speed
Degree and scanning bed acceleration and deceleration position etc..In addition, to further ensure that it is enough that detector 110 can be collected
Die body data, can increase sweep time of the PET system to die body, while scanning bed 120 can also be made to move back and forth, its
In, the scanning bed fortune that scanning bed 120 reciprocating number of times can also be obtained by the scanning bed computing of motion control unit 130
Dynamic control logic is regulated and controled.It should be noted that, the scanning bed motion control unit 130 control it is scanning bed 120 motion when,
Scanning bed 120 persistent movement or uniform motion can be made；Obviously, can also make the scanning bed 120 non-standing motion or it is non-at the uniform velocity
Motion, as long as within the period of scanning process, by controlling scanning bed 120 motion to ensure that predetermined probe unit can
Die body is detected, then within this paper intention.
That is, during detector is scanned to die body, while scanning bed motion is controlled, therefore, in pin
For the PET system of long axial direction, even if (axial scan that the length of die body is less than detector is regarded using the shorter die body of length
Wild length), it can also ensure that predetermined probe unit can be irradiated to by die body.That is, utilize the shorter mould of length
When body is scanned, also ensures that most of probe unit in detector can be irradiated to, die body is completely covered
The most axial scan visual field (being, for example, 80%), or even the whole axial scan visual field can be covered.
As described above, the motion interval when die body in the axial direction along the detector is more than or equal to the detector
The axial scan visual field axial length when, you can ensure that the whole axial scan visual field can be completely covered in die body, so that institute
Some probe units can perform data acquisition to the die body.On this basis, all detection lists can further be utilized
Correction or PET image reconstruction etc. is normalized in the data that member is gathered.Further, since to be based on one equal for all probe units
Even die body rather than the data acquisition carried out by the die body being spliced to form, what all probe units were detected meets thing
Part is statistically identical, therefore, when generating the normalization factor and PET image reconstruction, results in and is more defined
The true normalization factor and PET reconstruction images, so as to the more accurate performance to PET system judge and
Correction etc..
Based on above-described PET data acquisition method, present invention also offers a kind of method of PET image reconstruction.Fig. 4
For the schematic flow sheet of the method for the PET image reconstruction in one embodiment of the invention,
As shown in figure 4, the method for the PET image reconstruction comprises the following steps.
Step S210, the collection of data is scanned using PET data acquisition method as described above to die body.That is, exist
During detector carries out data acquisition to die body, while controlling scanning bed motion, make predetermined probe unit can be by
It is irradiated to.PET data acquisition method based on die body can be with specific reference to as described above, here is omitted.In the present embodiment, make
The length of the interval scan vision for being more than or equal to detector of motion of the die body in axial direction in its axial direction, so that all spies
Survey unit can carry out data acquisition based on the die body.
Further, when controlling scanning bed motion, the positional information of one scan bed can also be generated；And, detector
When detection meets event, one scan data can be generated.The scan data is, for example,：What detector was detected multiple meets thing
Part and multiple meet corresponding line of response of event (Line of Response, LOR) etc..Wherein, detect one and meet thing
Line between the probe unit of two γ photons of part is referred to as line of response.
In addition, when generating scan data of the scanning bed positional information and acquisition based on die body, can also be further right
Data above is stored, thus after execution continuous PET image reconstruction when, be easy to extract corresponding data.
Step S220, the positional information of the die body is obtained according to the scanning bed positional information.
During data acquisition is carried out to die body, because the scanning that the axial length of die body is less than the detector is regarded
Wild axial length, therefore, at sometime node, part detection unit can gather the scan data of correspondence die body, and
Another part probe unit can not be irradiated to and then made by die body its scan data collected to be not correspondence die body
's.When performing image reconstruction, it may be that the scan data collected based on die body, therefore, having for correspondence die body need to be extracted
Scan data is imitated, and cannot not give up correspondingly the invalid scan data of die body, so that the PET reconstruction images generated are more accurate.
Specifically, the effective scanning data of correspondence die body, can be according at corresponding timing node, scanning bed positional information is sentenced
It is disconnected, in the present embodiment, the positional information of the die body is obtained using scanning bed positional information, correspondence die body is extracted with further
Effective scanning data.
Step S230, corresponding scan data is extracted according to the positional information of the die body from the scan data gathered
Carry out PET image reconstruction.
From the above, after the positional information of die body is obtained, you can extract the effective scanning data of correspondence die body.This implementation
In example, the scan data based on die body is stored using PET scan data unit, therefore, can be according to the positional information of die body from PET
Corresponding scan data is extracted in scan data unit.Certainly, it can also determine to sweep accordingly further combined with length of die body etc.
Retouch data.
Specifically, as shown in figure 4, when obtaining the effective scanning data of correspondence die body to perform PET image reconstruction, can join
Examine following steps：
Step S231, according to the dampening information of the die body and the scanning bed positional information, obtains full axial scan
The dampening information of die body in the visual field.Wherein, the dampening information of the die body can for example be obtained by CT scan, i.e. pass through CT
The CT scan data for the die body for scanning and obtaining, and according to the decay pattern of the CT scan data of die body acquisition die body, that is, obtain mould
The dampening information of body.
As noted previously, as the axial length of die body is less than the axial length of the scan vision of the detector, therefore, when
During by carrying out dampening information of the CT scan to obtain die body to die body, the die body in the whole axial scan visual field can not be obtained
Dampening information.Therefore, by the scanning bed positional information in the present invention, and the dampening information of die body known to combination,
So as in axial scan region, corresponding die body dampening information can be filled to corresponding position, and then can obtain holoaxial to sweeping
Retouch the dampening information of the die body in the visual field.
Step S232, performs PET image reconstruction with reference to the dampening information of die body of the holoaxial into scan vision, generates holoaxial
PET reconstruction images into scan vision.
Certainly, during PET image reconstruction is performed, in addition to according to the effective scanning of the positional information of die body extraction
Data, so as to combine the dampening information and corresponding scan data generation PET reconstruction images of die body.
Wherein, the method for performing PET image reconstruction can for example use filtered back-projection (Filtered Back
Projection, FBP) or order subset maximum likelihood method (Ordered Subset Expectation-
Maximization, OSEM).
It should be noted that, the extraction of the acquisition process of the dampening information of die body and effective scan data in step S231
The sequencing of journey can be exchanged mutually or while carry out, and be only to be shown with example herein, be not limited thereto, as long as performing
Possess the dampening information and effective scan data of die body during PET image reconstruction.
It is preferred that scheme in, still further comprise following steps in the method for PET image reconstruction：
Step S233, is normalized to the scanning bed position in the axial scan visual field of the detector and nucleic decay,
To obtain scanning bed position statistical information and nucleic decay statistical information.
Wherein, what the scanning bed position statistical information can be stored by extracting in PET scan data unit is scanning bed
Positional information and die body position or length information, and acquisition is normalized.During data acquisition is performed, institute
Scanning bed motion is stated while driving the die body to move, and, it is described it is scanning bed moving when, it is understood that there may be acceleration or deceleration
The problems such as, it is corresponding to drive die body to perform accelerated motion or retarded motion.Therefore, it is corresponding to sweep at according to each timing node
Retouch the positional information of bed, and combine position (positional information of the die body on scanning bed) and/or the length of die body of die body, carry out
After normalization, you can correct scan bed in motion process due to image difference caused by the factors such as scanning bed acceleration and deceleration, after making
The PET reconstruction images of continuous generated corresponding die body are more accurate.
Similar, the nucleic decay statistical information also can extract PET scan number according to the scanning bed positional information
According to the nucleic decay information in unit at corresponding timing node, the nucleic in the axial scan visual field of the detector is decayed
Acquisition is normalized.That is, because radioactive decay can occur for nucleic, therefore, according to scanning bed positional information and extract each
Nucleic decay information at individual timing node performs normalization, can avoid being decayed by nucleic and causing generated reconstruction image to be deposited
The problem of deviation.
Step S234, according to the scanning bed position statistical information in the axial scan visual field and nucleic decay statistical information,
And performed with reference to the PET reconstruction images and axially count correction, to obtain die body after correction of the holoaxial into scan vision
PET reconstruction images.
That is, after execution step S232 obtains PET reconstruction images, by further combined with sweeping in the axial scan visual field
The position statistical information and nucleic decay statistical information of bed are retouched, so as to carry out axial correction to PET reconstruction images, to exclude
Image difference caused by the factors such as scanning bed acceleration and deceleration, and the influence for avoiding nucleic decay from causing reconstruction image, are obtained
PET reconstruction image of the more accurate die body after correction of the holoaxial into scan vision.Thus, you can by PET
Reconstruction image is analyzed, to further infer that the performance and situation of PET system, for example, according to the PET reconstruction images pair
The isotypy of PET system axial direction is verified.
In the present embodiment, the die body data collected using all probe units carry out PET image reconstruction, so as to logical
Cross generated PET reconstruction images and carry out quality analysis etc..In addition, in other embodiments, also using above-described PET
Collecting method and the die body data obtained, carry out the generation of the normalization factor of detector efficiency.
Due to having thousands of probe units in the detector of PET system, by its each geometric position and poor performance
Different influence, such as crystal bar luminous efficiency, the coupling of crystal bar and photomultiplier, crystal bar are different to the subtended angle for meeting line
Deng making its detection efficient not the same, each probe unit is exported result of detection heterogeneous, this is inevitably resulted in reality
In the application process of border, artifact is introduced during PET image reconstruction, and then influences the degree of accuracy of image, therefore, in order to accurately to visiting
Examining system is modeled, and obtains satisfied picture quality, generally needs the detection efficient in advance to detector to be corrected, i.e. normalizing
Change correction.
Specifically, the normalization method of the detector efficiency is：Based on a uniform die body, each detection of measurement
Unit counting response Di (i=1,2,, m), wherein, m be probe unit quantity；So as to can be according to normalizing be obtained as below
Change the factor：
These factors are stored in computer in the way of file, when carrying out PET detections to patient, by normalization factor
Directly act on measured value, you can realize the normalization of detector efficiency.
In addition, present invention also offers a kind of PET system, the PET system is above-described based on mould available for realizing
The PET data acquisition method of body.With specific reference to shown in Fig. 3, the PET system includes：
Detector 310, the detector 310 includes multiple probe units 311, and the probe unit 311 is used in detection
Detection meets event in the scan vision of device 310；
Scanning bed 320, described scanning bed 320 are used to place die body (not shown), and drive the die body to move；Tool
Body, the die body be a radioactive source, it is described it is scanning bed can for one scan bed；
Scanning bed motion control unit 330, for when probe unit detection meets event, while being swept described in control
Retouch axial direction (Z-direction i.e. shown in Fig. 3) motion that bed drives scan vision of the die body along the detector 310, it is ensured that institute
The predetermined probe unit 311 stated in detector 310 can be irradiated to by the die body.
Further, the scanning bed motion control unit 330 can be according to die body information (for example, the position of die body, die body
Length and die body weight etc.), scanning bed information (for example, scanning bed deformation curve and deformation factor etc.) and visit
Survey scanning bed 320 motion of sweep parameter (for example, the sweep time of detector and axial scan visual field etc.) control of device.That is,
The scanning bed motion control unit 330 carries out logic according to the sweep parameter of die body information, scanning bed information and detector
After computing, scanning bed 320 motion is controlled, for example, controls scanning bed 320 moving region, movement velocity, acceleration and deceleration
Position etc., and scanning bed height and position (Y-direction shown in Fig. 3) can be also adjusted in real time, it is ensured that die body is in motion process
On the height and position for being held in a fixation.Thus, you can ensure the die body putting in the whole axial scan visual field
Uniformity is penetrated, the die body data acquisition for making all probe units be all based on a uniform die body and carrying out.
In addition, the PET system may also include a PET scan data unit, the PET scan data unit can be used for depositing
The scanning bed positional information of storage and scan data etc..That is, during PET system carries out data acquisition to die body, the scanning
Bed motion control unit 330 can generate the positional information of one scan bed, and detector 310 is generated when detection meets event
One scan data, the scanning bed positional information and scan data can be sent to the PET scan data unit in real time
In 340, to be stored to data above, so that, when need to subsequently perform other operations, be conducive to extracting effective data.
Further, it can also be used to realize above-described PET image reconstruction using above-described PET system.Fig. 5 is
The structural representation of PET system in another embodiment of the present invention, with reference to shown in Fig. 3 and Fig. 5,
The PET system not only includes detector 310, scanning bed 320, scanning bed motion control unit 330.In addition, also
Including：
Image reconstruction unit 340, the event that meets for being detected according to probe unit 311 carries out PET image reconstruction.
Further, described image reconstruction unit 340 includes the axially counting correction module of a PET image reconstruction module, one.
Specifically, the PET image reconstruction module, for extracting effective (or corresponding) scan data according to the position of die body, with
And the dampening information of die body of the holoaxial into scan vision is combined, PET image reconstruction is carried out, to generate PET reconstruction images.It is described
Correction module is axially counted, for according to the scanning bed position statistical information in the axial scan visual field and nucleic decay statistics letter
Breath, and axially counting correction is performed with reference to the PET reconstruction images, to improve the decay due to scanning bed motion and nucleic
And the image deviations produced.
In summary, the PET data acquisition method provided by the present invention, can use existing die body (its axial length
Less than the axial length in the axis scan vision of detector), make probe unit predetermined in detector even all spy
Die body data can be collected by surveying unit.
That is, the scan method provided by the present invention, in the PET system for long axial direction, using arbitrarily long
Predetermined probe unit can be achieved in the die body of degree can carry out the collection of die body data based on a same die body, it is ensured that single
The radiation uniformity of die body.
Further, the data acquired in the scan method of the PET system provided by the present invention, also can operate with PET
In image reconstruction, further PET system is analyzed with the PET reconstruction images for passing through generated.And, carried by the present invention
Data acquired in the scan method of confession also can operate with the normalization factor of generation detector efficiency.
The embodiment of each in this specification is described by the way of progressive, and what each embodiment was stressed is and other
Between the difference of embodiment, each embodiment identical similar portion mutually referring to.For system disclosed in embodiment
For, due to corresponding to the method disclosed in Example, so description is fairly simple, related part is referring to method part illustration
.
Foregoing description is only the description to present pre-ferred embodiments, not to any restriction of the scope of the invention, this hair
Any change, modification that the those of ordinary skill in bright field does according to the disclosure above content, belong to the protection of claims
Scope.
Claims (10)
1. a kind of PET data acquisition method, scans die body by PET system and obtains, the PET system includes detector and scanning
Bed, the detector includes multiple probe units, and methods described includes：
By die body be positioned over it is described it is scanning bed on, the axial length of the die body is less than the axial direction of the scan vision of the detector
Length；
The axial movement of scan vision of the scanning bed drive die body along the detector is controlled, while utilizing described visit
Survey the collection of device unit and meet event from the die body.
2. PET data acquisition method as claimed in claim 1, it is characterised in that described in the control scanning bed drive
The axial movement of scan vision of the die body along the detector includes：
The scanning bed motion is controlled according to the sweep parameter of the detector, the sweep parameter of the detector includes scanning
The axial length of the scan vision of time and/or the detector.
3. PET data acquisition method as claimed in claim 1, it is characterised in that the die body is in the axial direction of the detector
On the interval scan vision more than or equal to the detector of motion axial length.
4. PET data acquisition method as claimed in claim 1, it is characterised in that described in the control scanning bed drive
Axial movement of the die body along the detector includes：
The axial direction of scan vision of the scanning bed drive die body along the detector is controlled according to the information of the die body
Motion, the information of the die body includes one or more in position, the weight of die body and the length of die body of die body.
5. PET data acquisition method as claimed in claim 4, it is characterised in that the information of the die body passes through the die body
CT images obtain.
6. a kind of method of PET image reconstruction, including：
The collection of data is scanned to die body using the PET data acquisition method as described in one of claim 1-5,
When controlling the scanning bed motion, scanning bed positional information is also generated；
The positional information of the die body is obtained according to the scanning bed positional information；
Corresponding scan data is extracted from the scan data gathered according to the positional information of the die body and carries out PET image weight
Build.
7. the method for PET image reconstruction as claimed in claim 6, it is characterised in that also include：
According to the dampening information of the die body and the scanning bed positional information, die body of the holoaxial into scan vision is obtained
Dampening information；
PET image reconstruction is performed with reference to the dampening information of die body of the holoaxial into scan vision, to generate PET reconstruction figures
Picture.
8. the method for PET image reconstruction as claimed in claim 6, it is characterised in that also include：
Scanning bed position in the axial scan visual field of the detector and nucleic decay are normalized respectively, acquisition is swept
Retouch the position statistical information and nucleic decay statistical information of bed；
According to the scanning bed position statistical information in the axial scan visual field and nucleic decay statistical information, and with reference to the PET
Reconstruction image, which is performed, axially counts correction, to obtain the PET reconstruction images after correction of the die body in the axial scan visual field.
9. a kind of PET system, including：
Detector, the detector includes multiple probe units, and the probe unit is used to visit in the scan vision of detector
Survey meets event；
It is scanning bed, it is described scanning bed for placing die body and driving the die body to move；
Scanning bed motion control unit, for when probe unit detection meets event, while the control scanning bed band
Move the axial movement of scan vision of the die body along the detector.
10. PET system as claimed in claim 9, it is characterised in that the PET system also includes：
Image reconstruction unit, the event that meets for being detected according to the probe unit carries out PET image reconstruction.
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| CN201710308861.XA CN107049352A (en) | 2017-05-04 | 2017-05-04 | PET data acquisition method, PET image reconstruction method and PET system |
| CN202310166952.XA CN116211332A (en) | 2017-05-04 | 2017-05-04 | PET data acquisition method, PET image reconstruction method and PET system |
| EP17855027.3A EP3503810A4 (en) | 2016-09-30 | 2017-09-30 | Method and system for calibrating an imaging system |
| PCT/CN2017/104779 WO2018059577A1 (en) | 2016-09-30 | 2017-09-30 | Method and system for calibrating an imaging system |
| US16/237,145 US10902646B2 (en) | 2016-09-30 | 2018-12-31 | Method and system for calibrating an imaging system |
| US17/156,708 US11568583B2 (en) | 2016-09-30 | 2021-01-25 | Method and system for calibrating an imaging system |
| US18/161,870 US11935159B2 (en) | 2016-09-30 | 2023-01-30 | Method and system for calibrating an imaging system |
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