CN107049299A - A kind of anti-interference cardiac electricity detecting system, detection method, Special flexible Graphene electrodes and preparation method thereof and purposes - Google Patents
A kind of anti-interference cardiac electricity detecting system, detection method, Special flexible Graphene electrodes and preparation method thereof and purposes Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6804—Garments; Clothes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6823—Trunk, e.g., chest, back, abdomen, hip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6831—Straps, bands or harnesses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
- A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
Abstract
The invention provides a kind of anti-interference cardiac electricity detecting system, detection method, Special flexible Graphene electrodes and preparation method thereof and purposes, anti-interference cardiac electricity detecting system includes Flexible graphene electrode, electrocardiogram signal acquiring processing module, impedance measurement module, cardiac diagnosis lead-line and signal processing module, it can measure electrocardiosignal and motion artifactses signal simultaneously, remove the motion artifactses in electrocardiosignal.Flexible graphene electrode is to be attached to grapheme material on spongy layer through negative pressure deposition, obtains graphene sponge electrically conductive composite, fastener is added thereon, cardiac diagnosis lead-line is fixedly connected on graphene sponge electrically conductive composite by fastener.The anti-interference cardiac electricity detecting system and detection method of the present invention can effectively overcome interference of the motion artifactses to electrocardiosignal, ensure the real-time, accuracy and reliability of electrocardiographic examination result；Flexible graphene electrode preparation flow is simple, and bio-compatibility is good, and service life is long, available for anti-interference cardiac electricity detecting system.
Description
Technical field
The present invention relates to a kind of monitoring of personal health and medical treatment electronic equipment, a kind of anti-interference electrocardio is concretely related to
Detecting system, detection method, Special flexible Graphene electrodes and preparation method thereof and purposes.
Background technology
Electrocardiosignal directly reacts the working condition of heart, and abnormal electrocardiosignal occurs at random, and the time is not fixed, and holds
The continuous time is shorter.Existing electrocardiogram machine checks only last for several minutes every time, and information content is very limited, it is difficult to effective to catch
Abnormal electrocardiogram signal.Holter can continue record heart, be the important evidence for finding heart abnormality activity.In day
Often in life, using wearable cardiac monitoring equipment, in the case of without prejudice to routine work and life, wearer can be in
In, in work position and outdoor travel detect electrocardiosignal whenever and wherever possible, the heart state of oneself is paid close attention in time, is contributed to the greatest extent
Early to find heart abnormality situation, the diagnosis to doctor provides important data.This is the inexorable trend of modern medicine detection development,
Aging simultaneously for society and community medicine level is limited etc. that social concern also gives effective solution, has
Practicality.
There is bio-toxicity in existing commercial Ag/AgCl electrocardioelectrodes, be not suitable for wearing for a long time, and electrode surface and skin
Skin is bonded using Signa Gel, and fastness is poor, easily comes off, human motion can produce larger interference to electrocardiosignal；In addition, with
Use time growth, Signa Gel can be dehydrated dry, electric conductivity variation, and signal amplitude decay is seriously.Accordingly, it would be desirable to develop life
Thing compatibility is good, electric conductivity is stable electrocardioelectrode and heart real time monitoring system.
Patent CN104452309A discloses a kind of preparation method of the conductive fabric of chemical silvering, and it is utilized on fabric
Polyaniline through generation triggers the generation of argent, so that conductive fabric is obtained, but the preparation method can discharge a large amount of waste water, no
Beneficial to environmental protection.Patent CN105286855A discloses a kind of preparation method of dryness electrocardioelectrode, utilizes elastic PDMS bases
Bottom prepares the good electrocardioelectrode of bio-compatibility, but comfortableness and gas permeability need further raising.Patent
CN104739403A discloses flexible electrocardioelectrode of a kind of graphene nano wall and preparation method thereof, and this method is heavy in metal surface
Product graphene, it is not easy to which graphene is transferred in flexible substrate.Patent CN105088749A discloses a kind of using dipping-baking
Dry method covers graphene oxide on cotton-textile fibres surface, then graphene oxide is reduced into graphene, so as to obtain stone
Black alkene/cotton compliant conductive fabric, but dipping-drying course in this method needs to repeat tens times, and preparation method is complicated, and
Graphene is only covered in the surface of cotton-textile fibres, if electrode is made, and after wearing cleaning, electric conductivity is reduced rapidly, is used
Life-span is shorter.
In addition, there is contact resistance between electrocardioelectrode and skin, human heartbeat, breathing and limb motion can all cause inspection
The change of contact impedance between electrode and skin is surveyed, electrocardiosignal is detected and produces serious interference, electrocardiosignal base can be caused
Line drifts about, and have impact on the stability and reliability of electrocardiosignal, is unfavorable for accurate evaluation of the doctor to patient health situation.Patent
CN104490387A and CN101422362A disclose the cardiac electricity detecting system for suppressing motion artifact, but above-mentioned patent is required to
Exciting circuit realizes the measurement of contact impedance, system complex and measures band limiting.
The content of the invention
An object of the present invention is to provide a kind of anti-interference cardiac electricity detecting system, to solve the existing portable acquisition terminal heart
Electro-detection is easily disturbed by motion artifactses, and electrocardiosignal drift is serious, suppresses the system complex of interference, the problems such as being difficult to realize.
The second object of the present invention is to provide a kind of anti-interference ECG detecting method, to provide a kind of removable motion artifactses
ECG detecting method, obtain steady electrocardiosignal.
The third object of the present invention is to provide a kind of anti-interference cardiac electricity detecting system Special flexible Graphene electrodes, to solve
Different types of signal could be gathered by needing polytype sensor, and existing Wearable flexible electrode bio-compatibility is poor, easypro
Adaptive and poor air permeability, the problems such as service life is short.
The fourth object of the present invention is to provide a kind of preparation method of Flexible graphene electrode, with using easy method system
Standby bio-compatibility is good, service life length Flexible graphene electrode.
The fifth object of the present invention is to provide a kind of purposes of Flexible graphene electrode, for anti-interference cardiac electricity detecting system
The detection of middle motion artifactses signal, the motion artifactses signal in electrocardiosignal is removed by algorithm process, is obtained stably, reliably
Electrocardiosignal.
What an object of the present invention was realized in：
A kind of anti-interference cardiac electricity detecting system, including：
Flexible graphene electrode, it is deposited through negative pressure is attached with the spongy layer of grapheme material and leads installing fastener additional and connect electrocardio
It is made after on line, is divided into first electrode and second electrode, the first electrode is used to detect human ecg signal, second electricity
Pole is used to detect its contact resistance between human body skin, and first electrode and second electrode fixed position are adjacent；
Electrocardiogram signal acquiring processing module, it connects with the first electrode, for gathering human ecg signal；
Impedance measurement module, it connects with the second electrode, is sent out for measuring the second electrode in suffered external pressure
The corresponding situation of change of its intrinsic impedance during changing, and calculating obtains motion artifactses signal accordingly；And
Signal processing module, connects with the electrocardiogram signal acquiring processing module and the impedance measurement module respectively, for inciting somebody to action
The electrocardiosignal cooperates with processing with motion artifactses signal, to remove the motion artifactses in electrocardiosignal, and by the heart after processing
Electric signal is stored or transmitted.
The electrocardiogram signal acquiring processing module includes：
Electrocardiogram signal acquisition circuit, connects with the first electrode and signal amplification circuit respectively, for being adopted by first electrode
Collect human ecg signal；
Signal amplification circuit, connects with the electrocardiogram signal acquisition circuit and filtering process circuit respectively, for the people to collection
Body-centered electric signal is amplified processing；
Filtering process circuit, connects with the signal amplification circuit and analog to digital conversion circuit respectively, after to amplified processing
Human ecg signal be filtered processing；And
Analog to digital conversion circuit, connects with the filtering process circuit and the signal processing module respectively, for by filtering process
Human ecg signal afterwards is converted into after data signal being output to signal processing module.
The impedance measurement module includes：
Contact impedance measuring circuit, connects with the second electrode and curve matching circuit respectively, exists for measuring second electrode
The situation of change of intrinsic impedance when being changed by external pressure；And
Curve matching circuit, connects with the impedance measuring circuit and the signal processing module, for measured respectively
The nonlinear change signal of intrinsic impedance carries out computing, to obtain motion artifactses signal.
What the second object of the present invention was realized in：
A kind of anti-interference ECG detecting method, comprises the following steps：
（a）Flexible graphene electrode is fixed on elastic tight or pectoral girdle, makes person under inspection put on the elastic tight or beam
The upper pectoral girdle, makes Flexible graphene electrode be contacted with human body surface skin well, to reduce contact resistance；
（b）First electrode and second electrode in Flexible graphene electrode is adjusted to the electrocardiosignal measurement position of human body respectively
Place, the intrinsic impedance by measuring Flexible graphene electrode during human motion changes with time situation, sets up pressure-resistance
Anti- characteristic curve, calculates the contact force change waveform for obtaining human body and Flexible graphene electrode, so as to obtain human motion state
Waveform；
（c）The electrocardiosignal of human body surface, the heart gathered are gathered by Flexible graphene electrode and electrocardiogram signal acquisition circuit
After the filtering process of amplification and filtering process circuit of the electric signal through signal amplification circuit, then through analog to digital conversion circuit it is converted into number
Word signal is simultaneously cached；
（d）The impedance of Flexible graphene electrode is measured by Flexible graphene electrode and contact impedance measuring circuit；Utilize flexibility
The characteristic that the intrinsic impedance of Graphene electrodes changes with applied ambient pressure, human motion is extracted by electrode impedance measurement
Status signal；Impedance signal measured by contact impedance measuring circuit is carried out by computing by curve matching circuit, moved
The curve of artefact signal；
（e）The electrocardiosignal gathered is cooperateed with motion artifactses signal by processing by signal processing module, electrocardiosignal is removed
In motion artifactses signal, and by the steady electrocardiosignal obtained after processing stored or uploaded to remote server carry out
The intellectual analysis such as the anomaly analysis of electrocardiosignal.
What the third object of the present invention was realized in：
A kind of anti-interference cardiac electricity detecting system Special flexible Graphene electrodes, by the way that grapheme material is attached to through negative pressure deposition
On spongy layer, graphene-sponge electrically conductive composite is obtained, fastener, the heart are added on the graphene-sponge electrically conductive composite
Conductance on line is fixedly connected on the graphene-sponge electrically conductive composite by the fastener.
The fastener includes the first buckle being made from an insulative material and the second buckle being made of metal material, described the
One buckle is mutually fastened through graphene-sponge electrically conductive composite with second buckle, also, first buckle is used to incite somebody to action
Graphene-sponge electrically conductive composite is fixed on elastic tight or pectoral girdle, and second buckle is used to realize graphene-sponge
Electrically conductive composite is fixedly connected with cardiac diagnosis lead-line.
What the fourth object of the present invention was realized in：
A kind of preparation method of Flexible graphene electrode, comprises the following steps：
（a）It is using vacuum filtration method that the graphene oxide in graphene oxide water solution is attached using spongy layer as filter medium
Inside the surface and duct of flexible spongy layer, graphene oxide-flexibility sponge compound is obtained after drying；
（b）Under agitation, obtained graphene oxide-flexibility sponge compound is impregnated in electronation agent solution,
Graphene-flexibility sponge electrically conductive composite is obtained after washing, drying；
（c）Using step（b）The flexible stone that can be fixed on personal clothing is made in gained graphene-flexibility sponge electrically conductive composite
Black alkene electrode.
Step（a）In, the concentration of graphene oxide water solution is 4 ~ 6 mg/L；Drying mode is by adsorption and oxidation graphene
Flexible sponge be placed in vacuum drying oven, at 40 ~ 80 DEG C dry 3 ~ 10 h.
Step（b）In, the reducing agent is the NaBH that concentration is 0.15 ~ 0.20 mol/L4The aqueous solution；Stirring condition be
10 h are slowly stirred at room temperature；Drying mode is that the graphene oxide after washing-sponge compound is positioned in vacuum drying oven,
In 40 DEG C ~ 80 DEG C 3 ~ 10 h of drying.
What the fifth object of the present invention was realized in：
A kind of application of Flexible graphene electrode in anti-interference cardiac electricity detecting system, it is pseudo- to gather human ecg signal and motion
Mark signal, and the removal motion artifactses signal in same period electrocardiosignal.
The anti-interference cardiac electricity detecting system and detection method of the present invention can detect the heart of the wearer under motion state in real time
Electric signal and electrode-skin contact impedance, obtain motion artifactses signal, and stable signal transmission, noise is small；At signal operation
Reason, overcomes interference of the motion artifactses for electrocardiosignal, obtains stable electrocardiosignal, ensured the reality of electrocardiographic examination result
Shi Xing, accuracy and reliability；The signal gather, handled can be automatically saved to portable terminal device or upload to remote server,
Reasonable data is provided for follow-up intelligent diagnosis and treatment.
Graphene is attached to inside the surface of spongy layer and duct by the Flexible graphene electrode of the present invention via negative pressure, shape
Into 3 D stereo conductive network, electrode contact is improved, then friction and contact force are produced to Graphene electrodes during human motion
Change Flexible graphene electrode intrinsic impedance can be caused to change, detect its impedance variations i.e. can be achieved motion state inspection
Survey；Meanwhile, the electrode has stable impedance in wider frequency band, and electrocardiosignal frequency response is good.
The present invention uses graphene oxide for raw material, and being prepared for graphene oxide-flexibility sponge by vacuum filtration method leads
Reply compound by cable, by graphene oxide evenly, be firmly adhered in the surface and duct of flexible sponge, reduce friction loss,
Then graphene-flexibility sponge electrically conductive composite is obtained using reducing process, using connectors such as buckles by graphene-flexibility sponge
Electrically conductive composite, which is made, can be fixed to the Flexible graphene electrode of personal clothing.Preparation flow of the present invention is simple, graphene-based bottom
Material softness, non-stimulated to skin, bio-compatibility is good, overcomes the bio-toxicity of traditional Ag/AgCl electrodes, is easy to use the head of a household
Phase dresses, and repeated multiple times can clean, and service life is long.
Brief description of the drawings
Fig. 1 is the structural representation of anti-interference cardiac electricity detecting system.
Fig. 2 is the intrinsic impedance figure of prepared Flexible graphene electrode.
Fig. 3 is electrode pressure-impedance diagram of prepared Flexible graphene electrode.
Fig. 4 is the structural representation of prepared Flexible graphene electrode.
Fig. 5 is the structural representation of the anti-interference ECG detecting tight of Wearable.
Fig. 6 is the structural representation that wearable ECG detects pectoral girdle.
Fig. 7 is the electro-cardiologic signal waveforms by motion artifacts that Flexible graphene electrode is collected.
Fig. 8 is the motion artifactses signal that Flexible graphene electrode is collected.
Fig. 9 is the ambulatory ecg signal oscillogram obtained by the anti-interference cardiac electricity detecting system using the present invention.
In figure, 1, Flexible graphene electrode, the 11, first buckle, 12, graphene-flexibility sponge electrically conductive composite, 13,
Two buckles, 14, first electrode, 15, second electrode, 2, cardiac diagnosis lead-line, 3, electrocardiogram signal acquiring processing module, 31, electrocardio letter
Number Acquisition Circuit, 32, signal amplification circuit, 33, filtering process circuit, 34, analog to digital conversion circuit, 4, impedance measurement module, 41,
Contact impedance measuring circuit, 42, curve matching circuit, 5, signal processing module, 6, ecg signal acquiring processing terminal.
Embodiment
The present invention is further described with reference to embodiment, but the invention is not limited in any way.
Agents useful for same is to analyze pure or chemical pure and commercially available or pass through ordinary skill in following embodiments
It is prepared by method known to personnel.Following embodiments realize the goal of the invention of the present invention.
As shown in figure 1, the anti-interference cardiac electricity detecting system of the present invention includes Flexible graphene electrode 1, ecg signal acquiring
Processing module 3, impedance measurement module 4 and signal processing module 5.
Flexible graphene electrode 1 is that the spongy layer for being attached with grapheme material through negative pressure deposition is installing fastener additional and connecting the heart
It is made after conductance on line 2, is divided into first electrode 14 and second electrode 15, first electrode 14 is used to detect human ecg signal, the
Two electrodes 15 are used to detect its contact resistance between human body skin, and first electrode is adjacent with the fixed position of second electrode.
Electrocardiogram signal acquiring processing module 3 is used to gather human ecg signal, and it includes electrocardiogram signal acquisition circuit 31, letter
Number amplifying circuit 32, filtering process circuit 33 and analog to digital conversion circuit 34.The one end of electrocardiogram signal acquisition circuit 31 and first electrode
14 connect, and the other end connects with signal amplification circuit 32, for gathering human ecg signal by first electrode 31.Signal amplifies
The other end of circuit 32 connects with filtering process circuit 33, and processing is amplified for the human ecg signal to collection.At filtering
The reason other end of circuit 33 connects with analog to digital conversion circuit 34, for being filtered place to the human ecg signal after amplified processing
Reason.The other end of analog to digital conversion circuit 34 connects with signal processing module 4, for the human ecg signal after filtering process to be changed
Signal processing module 5 is output to after into data signal.
Impedance measurement module 4 is used to measure its intrinsic impedance pair when suffered external pressure changes of second electrode 15
The situation of change answered, and calculating obtains motion artifactses signal accordingly, it includes contact impedance measuring circuit 41 and curve matching electricity
Road 42.One end of contact impedance measuring circuit 41 connects with second electrode 15, and the other end connects with curve matching circuit 42, is used for
Measure the situation of change of intrinsic impedance of the second electrode when being changed by external pressure.The other end of curve matching circuit 42 with
Signal processing module 5 connects, and computing is carried out with the nonlinear change signal to measured intrinsic impedance, pseudo- to obtain motion
Mark signal.
Signal processing module 5 connects with electrocardiogram signal acquiring processing module 3 and impedance measurement module 4 respectively, for by institute
State electrocardiosignal and cooperate with processing with motion artifactses signal, to remove the motion artifactses in electrocardiosignal, and by the electrocardio after processing
Signal stores or is transferred to server and carries out further intellectual analysis processing, and atrial fibrillation, the premature beat for such as carrying out electrocardiosignal are abnormal
Analysis.
Embodiment 1
Configuration concentration is 5 mg/ml graphene oxide water solution, and Buchner funnel is arranged on bottle,suction, is then by thickness
5 mm, are shaped as circle, a diameter of 20 mm, and density is 25 kg/m3Flexible sponge be covered in Buchner funnel bottom, open true
Empty pump carries out suction filtration, makes to keep negative pressure to be 2.0 × 10 in Buchner funnel4Pa, afterwards by graphite oxide of the concentration for 5 mg/ml
Aqueous solution is slowly poured on flexible sponge, until completing suction filtration.The shape of flexible sponge may be arranged as circular, oval
Shape, polygon or other patterns attractive in appearance.The flexible sponge of adsorption and oxidation graphene is placed in vacuum drying oven, at 50 DEG C
3 h are dried, graphene oxide-flexibility sponge compound is obtained.Graphene oxide-flexibility sponge compound is impregnated in 0.17
mol/L NaBH4The aqueous solution in, be slowly stirred at a room temperature 10 h, then will impregnate NaBH4Graphene oxide-flexibility afterwards
Sponge compound takes out washing, in drying 3 h at 50 DEG C in vacuum drying oven, obtains graphene-flexibility sponge conduction compound
Thing.Graphene-flexibility sponge electrically conductive composite is pasted on buckle, you can Flexible graphene electrode is obtained, in order to flexibility
The fixation of Graphene electrodes and personal clothing.
Fig. 2 compares Flexible graphene electrode and the tradition Ag/AgCl electrode intrinsic impedances of the present invention, can from figure
Go out, Graphene electrodes have flat impedance curve in whole measurement frequency, purely resistive impedance, and Ag/AgCl electrodes is presented
Capacitive reactances is presented with frequency shift in intrinsic impedance, different to the frequency response of different frequency electrocardiosignal.
Fig. 3 shows the Flexible graphene electrode intrinsic impedance of the present invention with ambient pressure variation characteristic.Can be with from Fig. 3
Find out, the pressure of application is bigger, the hole of graphene-flexibility sponge electrode is smaller, and electrical conductivity is higher, and intrinsic impedance is lower.It is logical
The data that over-fitting is gathered can obtain pressure-impedance relationship curve of Flexible graphene electrode.
Flexible graphene electrode is fixed near electrocardiosignal measurement position, human motion can cause the change of contact
Change, the generation deformation so that graphene-flexibility sponge electrically conductive composite is stressed, sponge grid gap reduces, contact area increases
Plus, electric conductivity increase, and then cause intrinsic impedance to reduce.Therefore, the impedance variations information of Flexible graphene electrode can reflect
The contact force size of human body and electrode, the intrinsic impedance of Graphene electrodes changes with time during measurement human motion, i.e.,
The contact force change waveform for obtaining human body and electrode can be calculated according to Fig. 2 pressure-impedance curve, so as to obtain human motion shape
State waveform.
Embodiment 2
Fig. 4 shows the structural representation of Flexible graphene electrode 1, including the first buckle 11, graphene-flexibility sponge conduction are again
The buckle 13 of compound 12 and second.First buckle 11 is prepared from by insulating materials polyvinyl chloride, and the second buckle 13 is by metal material
Copper is prepared from, and the first buckle 11 passes through graphene-flexibility sponge electrically conductive composite 12.And be engaged with the second buckle 13, altogether
Elastic tight is fixed to by graphene-flexibility sponge electrically conductive composite 12（As shown in Figure 5）Or pectoral girdle（As shown in Figure 6）
On, Flexible graphene electrode 1 is contacted well with human body surface skin.In addition, the second buckle 13 can be with current electrode conducting wire
Connection, facilitates the replacing of Flexible graphene electrode.Cardiac diagnosis lead-line 2 uses button conducting wire, in order to electric with Flexible graphene
The connection of pole is with separating.Cardiac diagnosis lead-line 2 is fixedly connected on graphene-flexibility sponge electrically conductive composite 12 by the second buckle 13
On.
Flexible graphene electrode in the anti-interference cardiac electricity detecting system of the present invention includes first electrode 14 and second electrode 15,
With multiple data channel, the change that the intrinsic impedance of electrocardiosignal and electrode changes with applied ambient pressure can be gathered simultaneously
Change.
Electrocardiogram signal acquisition circuit 31 in electrocardiogram signal acquiring processing module 3 is using 12 sampling precision single-chip microcomputers
MSP430F149；Signal amplification circuit 32 uses low noise integrated amplifier, it is preferable that using AD8232 integrated signals conditioning mould
Block；Filtering process circuit 33 uses low pass and 50 Hz notch filters；Analog to digital conversion circuit 34 is using 12 sampling precision monolithics
Machine MSP430F149 realizes the analog-digital conversion and storage of electrocardiosignal.
The characteristic that impedance measurement module 4 is changed using the intrinsic impedance of Flexible graphene electrode with applied ambient pressure,
Human motion state signal is extracted by electrode impedance measurement.Contact impedance measuring circuit 41 uses AD5933 impedance measurement cores
Piece, curve matching circuit 42 obtains motion artifactses the impedance signal measured by contact impedance measuring circuit is carried out into computing
The curve of signal.
Signal processing module 5 is microprocessor, and the electrocardiosignal gathered is cooperateed with processing with motion artifactses signal by it, right
The electrocardiosignal being disturbed is reconstructed, and removes the motion artifactses signal in electrocardiosignal, and by the electrocardiosignal after processing certainly
It is dynamic to be saved in portable terminal device or upload to remote server, to carry out intellectual analysis.
In gatherer process, two panels Flexible graphene electrode 1 is fixed on elastic tight or pectoral girdle, makes person under inspection put on
The pectoral girdle on the elastic tight or beam, makes Flexible graphene electrode be contacted well with human body surface skin.By Flexible graphene
First electrode 14 and second electrode 15 in electrode 1 are adjusted to the electrocardiosignal measurement position of human body respectively, by measuring people
The intrinsic impedance of Flexible graphene electrode changes with time situation in body motion process, sets up pressure-impedance characteristic, counts
The contact force change waveform for obtaining human body and Flexible graphene electrode is calculated, so as to obtain human motion state waveform.Pass through flexibility
Graphene electrodes 1 and electrocardiogram signal acquisition circuit 31 gather the electrocardiosignal of human body surface, and the electrocardiosignal gathered is through high-precision
Close amplifier AD8232 carries out amplification and the LPF of faint electrocardiosignal, to reduce noise jamming, then passes through notch filter
Device reduces the interference of 50 Hz power frequency components, and the electrocardiosignal after filtered processing is by 12 precision modulus conversion chips
MSP430F149 is converted into data signal and cached.Measure soft by Flexible graphene electrode 1 and contact impedance measuring circuit 41
The impedance of property Graphene electrodes；Pass through AD5933 impedance measurement cores using the contact resistance between Flexible graphene electrode and skin
Piece is sampled, and obtains human motion state signal；By curve matching circuit 42 by measured by contact impedance measuring circuit
Impedance signal carries out computing, obtains the curve of motion artifactses signal.By signal processing module 5 by the electrocardiosignal gathered with
The collaboration of motion artifactses signal is handled, and removes the motion artifactses signal in electrocardiosignal, and the steady electrocardio obtained after processing is believed
Number stored or uploaded to remote server and carry out intellectual analysis.
Fig. 7 is shown under human locomotion state, when not using anti-interference cardiac electricity detecting system herein, utilizes graphite
The ambulatory ecg signal waveform that alkene electrode and electrocardiogram signal acquiring processing module are collected, electrocardiosignal QRS complex, it is apparent that
But there is larger baseline drift, the judgement of severe jamming signal P-wave amplitude.Fig. 8 is to be become by measuring Graphene electrodes impedance
Change obtained motion artifactses signal, motion artifactses interference signal is approached with the electro-cardiologic signal waveforms in Fig. 7 from figure also.
Using echo state network algorithm, electrocardiosignal is disturbed to Fig. 7 according to the feature of motion disturbance signals in Fig. 7 and handled,
The motion artifactses interference in electro-cardiologic signal waveforms is removed, steady electrocardiosignal as shown in Figure 9 is obtained.
Claims (10)
1. a kind of anti-interference cardiac electricity detecting system, it is characterised in that including：
Flexible graphene electrode, it is deposited through negative pressure is attached with the spongy layer of grapheme material and leads installing fastener additional and connect electrocardio
It is made after on line, is divided into first electrode and second electrode, the first electrode is used to detect human ecg signal, second electricity
Pole is used to detect its contact resistance between human body skin；
Electrocardiogram signal acquiring processing module, it connects with the first electrode, for gathering human ecg signal；
Impedance measurement module, it connects with the second electrode, is sent out for measuring the second electrode in suffered external pressure
Its intrinsic impedance corresponding situation of change during changing, and calculating obtains motion artifactses signal accordingly；And
Signal processing module, connects with the electrocardiogram signal acquiring processing module and the impedance measurement module respectively, for inciting somebody to action
The electrocardiosignal cooperates with processing with motion artifactses signal, to remove the motion artifactses in electrocardiosignal, and by the heart after processing
Electric signal is stored or transmitted.
2. anti-interference cardiac electricity detecting system according to claim 1, it is characterised in that the ecg signal acquiring handles mould
Block includes：
Electrocardiogram signal acquisition circuit, connects with the first electrode and signal amplification circuit respectively, for being adopted by first electrode
Collect human ecg signal；
Signal amplification circuit, connects with the electrocardiogram signal acquisition circuit and filtering process circuit respectively, for the people to collection
Body-centered electric signal is amplified processing；
Filtering process circuit, connects with the signal amplification circuit and analog to digital conversion circuit respectively, after to amplified processing
Human ecg signal be filtered processing；And
Analog to digital conversion circuit, connects with the filtering process circuit and the signal processing module respectively, for by filtering process
Human ecg signal afterwards is converted into after data signal being output to signal processing module.
3. anti-interference cardiac electricity detecting system according to claim 1, it is characterised in that the impedance measurement module includes：
Contact impedance measuring circuit, connects with the second electrode and curve matching circuit respectively, exists for measuring second electrode
The situation of change of intrinsic impedance when being changed by external pressure；And
Curve matching circuit, connects with the impedance measuring circuit and the signal processing module, for measured respectively
The nonlinear change signal of intrinsic impedance carries out computing, to obtain motion artifactses signal.
4. a kind of anti-interference ECG detecting method, it is characterised in that comprise the following steps：
（a）Flexible graphene electrode is fixed on elastic tight or pectoral girdle, makes person under inspection put on the elastic tight or beam
The upper pectoral girdle, makes Flexible graphene electrode be contacted well with human body surface skin；
（b）First electrode and second electrode in Flexible graphene electrode is adjusted to the electrocardiosignal measurement position of human body respectively
Place, the intrinsic impedance by measuring Flexible graphene electrode during human motion changes with time situation, sets up pressure-resistance
Anti- characteristic curve, calculates the contact force change waveform for obtaining human body and Flexible graphene electrode, so as to obtain human motion state
Waveform；
（c）The electrocardiosignal of human body surface, the heart gathered are gathered by Flexible graphene electrode and electrocardiogram signal acquisition circuit
Electric signal is amplified through signal amplification circuit, and filtering process circuit is filtered after processing, then is converted through analog to digital conversion circuit
For data signal and cache；
（d）The impedance of Flexible graphene electrode is measured by Flexible graphene electrode and contact impedance measuring circuit；Utilize flexibility
The intrinsic impedance of Graphene electrodes extracts people by electrode impedance measurement with the characteristic of applied ambient pressure nonlinear change
Body motion state signal；Impedance signal measured by contact impedance measuring circuit is carried out by computing by curve matching circuit, obtained
To the curve of motion artifactses signal；
（e）The electrocardiosignal gathered is cooperateed with motion artifactses signal by processing by signal processing module, electrocardiosignal is removed
In motion artifactses signal, and by the steady electrocardiosignal obtained after processing stored or be transferred to remote server carry out
Intellectual analysis.
5. a kind of anti-interference cardiac electricity detecting system Special flexible Graphene electrodes, it is characterised in that by the way that grapheme material is passed through
Negative pressure deposition is attached on spongy layer, graphene-sponge electrically conductive composite is obtained, in the graphene-sponge electrically conductive composite
On add fastener, cardiac diagnosis lead-line is fixedly connected on the graphene-sponge electrically conductive composite by the fastener.
6. Special flexible Graphene electrodes according to claim 5, it is characterised in that the fastener includes using insulating materials
The first buckle being made and the second buckle being made of metal material, first buckle are compound through graphene-sponge conduction
Thing is mutually fastened with second buckle, also, first buckle is used to graphene-sponge electrically conductive composite being fixed to bullet
Property tight or pectoral girdle on, second buckle is used to realize the fixation of graphene-sponge electrically conductive composite and cardiac diagnosis lead-line
Connection.
7. a kind of preparation method of Flexible graphene electrode, it is characterised in that comprise the following steps：
（a）It is using vacuum filtration method that the graphene oxide in graphene oxide water solution is attached using spongy layer as filter medium
Inside the surface and duct of flexible spongy layer, graphene oxide-flexibility sponge compound is obtained after drying；
（b）Under agitation, obtained graphene oxide-flexibility sponge compound is impregnated in electronation agent solution,
Graphene-flexibility sponge electrically conductive composite is obtained after washing, drying；
（c）Using step（b）The flexible stone that can be fixed on personal clothing is made in gained graphene-flexibility sponge electrically conductive composite
Black alkene electrode.
8. Flexible graphene electrode according to claim 7, it is characterised in that step（a）In, graphene oxide water solution
Concentration be 4 ~ 6 mg/L；Drying mode is that the flexible sponge of adsorption and oxidation graphene is placed in vacuum drying oven, in 40 ~ 80 DEG C
The lower h of drying 3 ~ 10.
9. Flexible graphene electrode according to claim 7, it is characterised in that step（b）In, the reducing agent is concentration
For 0.15 ~ 0.20 mol/L NaBH4The aqueous solution；Stirring condition is to be slowly stirred at a room temperature 10 h；Drying mode is by water
Graphene oxide-sponge compound after washing is positioned in vacuum drying oven, in 40 DEG C ~ 80 DEG C 3 ~ 10 h of drying.
10. a kind of Flexible graphene electrode as any one of patent requirements 7 ~ 9 is in anti-interference cardiac electricity detecting system
Using.
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