CN107041877A - A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type - Google Patents
A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type Download PDFInfo
- Publication number
- CN107041877A CN107041877A CN201710015063.8A CN201710015063A CN107041877A CN 107041877 A CN107041877 A CN 107041877A CN 201710015063 A CN201710015063 A CN 201710015063A CN 107041877 A CN107041877 A CN 107041877A
- Authority
- CN
- China
- Prior art keywords
- scar
- silicone
- dispelled
- preparation
- silica hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Dispelled the preparation method pasted repeatedly of scar ultrathin type the present invention relates to a kind of silicone, its step is：4~5g of silicone gel component A, 5~6g of B component are weighed respectively to be mixed evenly, and are placed in vacuumizing and defoaming about 2~4min in vacuum tank；Silica hydrogel is uniformly brushed on pellosil backing after the completion of deaeration, 5~10min is stood, 20~30min of solidification in 50~70 DEG C of drying boxes is placed in after silicate gel film surface is smooth；Cooled down after taking-up, one layer of release liners are covered in gel film surface, be cut into 12cm*6cm or 12cm*3cm specification, obtain this product.Silica hydrogel scar patch prepared by this method is ultra-thin, it is soft, paste performance good, sharpest edges be can Reusability, after 24 hours, can remove and use clear water wash clean, after drying, can reuse, its viscosity when reusing, except scar effect as previously used effect it is good, and without skin irritation.
Description
Technical field
Dispelled the preparation method pasted repeatedly of scar ultrathin type the present invention relates to a kind of silicone, belong to and paste preparing technical field repeatedly.
Background technology
Silicone, also known as polysiloxanes or organosilicon polymer, are the organic compound that a class contains silicon, its chemical constitution
In contain the Si-O keys repeated as main chain, organic group is directly connected on silicon atom, main silicone articles have silicone oil, silicon to coagulate
Glue, silicon rubber, silicones etc..The mechanism of action that many domestic and international researchers prevent and treat silicone scar is explored, when there is silicon
When ketone dressing is covered in scar surface, the water evaporation rate at scar position reduces, and the water transport in scar is to cuticula, at angle
The deposition of matter layer generation moisture accumulation effect, fibroblastic propagation and collagen is suppressed, so as to reach treatment scar
Purpose.Some scholars have found that continuous application and the negative electrostatic field of increase can speed up scar healing, it is taken as that silicone is applied
Expect that the electrostatic of generation of being rubbed between skin be one of the reason for silicone dressing can treat scar.In a word, silicone can promote
Scar healing, good action is played to reducing cicatrization.
The content of the invention
The purpose of the present invention is the effect of the good mitigation cicatrization based on silicone, uses for convenience and reaches that beauty is imitated
Fruit is dispelled the preparation method pasted repeatedly of scar ultrathin type there is provided a kind of silicone.
To achieve the above object, technical scheme is as follows.
A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type, and its step is：Weigh respectively silicone gel component A 4~
5g, 5~6g of B component are mixed evenly, and are placed in vacuumizing and defoaming about 2~4min in vacuum tank；By Silica hydrogel after the completion of deaeration
Uniformly brush on pellosil backing, stand 5~10min, be placed in after silicate gel film surface is smooth in 50~70 DEG C of drying boxes
Solidify 20~30min；Cooled down after taking-up, cover one layer of release liners in gel film surface, be cut into 12cm*6cm or 12cm*3cm
Specification, obtain this product.
Further, 1.5~2.0mm of Silica hydrogel scar patch thickness that the above method is made.
The beneficial effect of the invention is：Silica hydrogel scar patch prepared by this method is ultra-thin, and soft, stickup performance is good, most
Big advantage be can Reusability, after 24 hours, can remove and use clear water wash clean, after drying, can reuse, again
Its viscosity when using, except scar effect as previously used effect it is good, and without skin irritation.
Brief description of the drawings
Fig. 1 is the inventive method implementing procedure figure.
Fig. 2 is measure of merit sample structure schematic diagram of the embodiment of the present invention.
Fig. 3 is measure of merit sample preparation schematic diagram of the embodiment of the present invention.
Embodiment
The present invention is further described for pin with reference to the accompanying drawings and examples.
Silicone as shown in Figure 1 is dispelled the preparation method pasted repeatedly of scar ultrathin type, and its step is：Silicone gel A is weighed respectively
4~5g of component, 5~6g of B component are mixed evenly, and are placed in vacuumizing and defoaming about 2~4min in vacuum tank；Will after the completion of deaeration
Silica hydrogel is uniformly brushed on pellosil backing, stands 5~10min, and 50~70 DEG C are placed in after silicate gel film surface is smooth and is done
Solidify 20~30min in dry case；After taking-up cool down, gel film surface cover one layer of release liners, be cut into 12cm*6cm or
12cm*3cm specification, obtains this product.
1.5~2.0mm of Silica hydrogel scar patch thickness that the above method is made.Silica hydrogel scar patch prepared by this method is super
Thin, soft, it is good to paste performance, sharpest edges be can Reusability, after 24 hours, can remove and use clear water wash clean, dry in the air
After dry, can reuse, its viscosity when reusing, except scar effect as previously used effect it is good, and without skin
Skin excitant.
Measure of merit is carried out for the said goods：
(1) skin irritation test：
Experimental drug reagent：It is the silicate gel film that is prepared by above-mentioned embodiment, depilatory cream, absorbent gauze, absorbent cotton, medical
Adhesive tape, operating scissors etc..
Experimental animal：Adult rabbit 3, male and female are regardless of, body weight 2.0-2.5kg.
Experimental method：
Rabbit loses hair or feathers：Be in rabbit back backbone both sides about 15cm*10cm region is lost hair or feathers.First hair is subtracted with curved scissors
Go, then uniform smearing depilatory cream, make depilatory cream all covering epilating areas, wait 3-4min, clear water is dipped in absorbent cotton and gently will
Depilatory cream is washed away, and exposes skin.
4 pieces of 3cm*3cm region is drawn as experiment and look-out station in baring skin with marking pen.As shown in figure 3, its
In, 1,4 regions are covered as sample application site, 2,3 regions as control application site, control position with gauze.
1st, single contact test：
4-24h is tested after depilation, and silicate gel film and gauze are cut into 2.5cm*2.5cm specification sizes respectively, is applied
A rabbit back respective regions is labelled to, silicate gel film is without fixing, and gauze is fixed with medical adhesive tape.Removed after application 4h, use clear water
Remove residual Silica hydrogel.Observed respectively under available light or full spectrum light and record removing paster after 1h, 24h, 48h,
72h dermoreaction situation, according to circumstances scores by the score system of table 1.Single contact test calculates primary stimulus index
(PII), calculated using only 24h, 48h, 72h data.
The primary sexual stimulus of PII=silicone scar plasters primary sexual stimulus of scoring-compare is scored；
Wherein, by the primary sexual stimulus sum of every animal erythema caused by silicone scar plaster and oedema at the appointed time
Divided by the total sum of observation, it is that the primary sexual stimulus of silicone scar plaster is scored；Calculated according to same method and compare primary sexual stimulus note
Point.
2nd, multiple contact test：
Skin contact method is with single contact test, 1h and observed and recorded contact site feelings before contacting again after contact every time
Condition, contacts 4h every time, contacts 4 times altogether.After last contact, the skin for removing 1h, 24h, 48h, 72h after paster is observed and recorded
Response situation, according to circumstances scores by the score system of table 1.Multiple contact test calculates accumulation stimulus index.Every animal exists
In stipulated time erythema and oedema stimulate score is added after again divided by the total sum of observation, be that every animal stimulation is scored；All
Animal, which stimulates, scores addition divided by animal number is that accumulation stimulation is scored, and will accumulate stimulates the stimulate the reaction scored according to table 2, report
Accuse corresponding reaction type.
The dermoreaction score system of table 1
Result of the test：
Single contact test the results are shown in Table 3.
The single contact test result of table 3
Multiple contact test the results are shown in Table 4.
The multiple contact test result of table 4
From table 3, table 4, silicone scar plaster is applied to a rabbit skin, is produced without erythema, oedema, its skin irritatin
Property be 0, test of many times result shows rabbit stimulate the reaction type to be extremely slight.
Rabbit skin irritation test shows that silicone scar plaster is extremely slight to the excitant of skin, can safety be used for people
Body skin.
Conclusion：This kind of silicone scar patch scar effect of dispelling of dispelling is good, ultrathin, soft docile, can Reusability, it is nonirritant, have
Popularizing application prospect.
Claims (2)
- The preparation method that scar ultrathin type is pasted repeatedly 1. a kind of silicone is dispelled, it is characterised in that：Its step is：Silicone gel is weighed respectively 4~5g of component A, 5~6g of B component are mixed evenly, and are placed in vacuumizing and defoaming about 2~4min in vacuum tank；After the completion of deaeration Silica hydrogel is uniformly brushed on pellosil backing, 5~10min is stood, 50~70 DEG C is placed in after silicate gel film surface is smooth Solidify 20~30min in drying box；After taking-up cool down, gel film surface cover one layer of release liners, be cut into 12cm*6cm or 12cm*3cm specification, obtains this product.
- The preparation method that scar ultrathin type is pasted repeatedly 2. silicone according to claim 1 is dispelled, it is characterised in that：It is described to be made 1.5~2.0mm of Silica hydrogel scar patch thickness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710015063.8A CN107041877A (en) | 2017-01-09 | 2017-01-09 | A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710015063.8A CN107041877A (en) | 2017-01-09 | 2017-01-09 | A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107041877A true CN107041877A (en) | 2017-08-15 |
Family
ID=59543920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710015063.8A Withdrawn CN107041877A (en) | 2017-01-09 | 2017-01-09 | A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107041877A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111904952A (en) * | 2020-08-20 | 2020-11-10 | 东南大学苏州医疗器械研究院 | Scar plaster and preparation method thereof |
-
2017
- 2017-01-09 CN CN201710015063.8A patent/CN107041877A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111904952A (en) * | 2020-08-20 | 2020-11-10 | 东南大学苏州医疗器械研究院 | Scar plaster and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7202422B2 (en) | Compositions and methods for skin application | |
| CN1289059C (en) | Pre-formed sheet devices suitable for topical application | |
| CN201782980U (en) | Gel mask | |
| CN104146922B (en) | Sun-blocking and moisturizing composition and preparation method thereof | |
| CN103893157B (en) | Hydrogel eye protective pad dressing and preparation method thereof | |
| JP2016512434A5 (en) | ||
| CN107041877A (en) | A kind of silicone is dispelled the preparation method pasted repeatedly of scar ultrathin type | |
| TW202031237A (en) | Compositions and methods for application over skin | |
| CN104586740A (en) | Moisturizing beauty mask and preparation method thereof | |
| CN104661625A (en) | Silicone/acrylic hybrid adhesives | |
| KR102202588B1 (en) | Brazilian waxing method with multiple pain relief methods | |
| CN1226410A (en) | Device for applying film-forming composition | |
| JP2022528793A (en) | Compositions and methods to be applied to the skin | |
| CN105125464A (en) | Eye cream and preparation method thereof | |
| CN103705396A (en) | Facial mask with skin repairing and nourishing functions and using method thereof | |
| JPS6242913A (en) | Skin care cosmetic composition and manufacture | |
| CN217960988U (en) | Wet tissue for eczema and scald nursing | |
| CN107213341A (en) | A kind of hemostasia and detumescence adhesive bandage | |
| CN116196239A (en) | Composition and application thereof | |
| CN216652634U (en) | Novel application | |
| CN109498598A (en) | A kind of responsive to temperature type Chinese medicinal liquid band-aid and preparation method thereof | |
| EP3124055A1 (en) | Biological fiber membrane and method for preparing the same | |
| CN110151579A (en) | A kind of application of plant component in terms of the cosmetics that preparation promotes skin repair, anti-aging | |
| RANDALL et al. | The effects of various methods of treatment on wound healing: an experimental study | |
| CN107007869A (en) | A kind of adhesive bandage and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170815 |