CN107041769B - The instrument and method of mechanical plug conveying - Google Patents

Abstract

The present invention relates to the instruments and method of mechanical plug conveying, wherein a kind of blood vessel embolism spring ring system includes: the implantation material being made of embolism spring ring；Connect with embolism spring ring free bush Assembly and one is freed delivery guidewire (DDW) assembly；The delivery guidewire DDW assembly of freeing includes: an external push assembly and an internal drawing seal wire；The internal drawing seal wire includes the distal tip region of an increase diameter；The external push assembly further includes the microbore pipe of a remote spring pipe for having flexible distal tip region and a proximal end.The present invention, which can be realized instrument and free system, discharges rapidly the purpose of spring ring, and ensures to free completely, and the present invention takes into account instrument reliability and robustness in operation.

Description

The instrument and method of mechanical plug conveying

This application claims in submission on June 10th, 2016 U.S. Patent Office, application No. is 62348710, it is entitled The U.S. Patent application of " MECHANICAL EMBOLIZATION DELIVERY APPARATUS AND METHODS " it is preferential Power, entire contents are hereby incorporated by reference in the application.

Technical field

The present invention relates to medical instruments fields, the in particular to method for implantation of neural blood vessel implantation instrument and mechanical conveying dress It sets.

Background technique

What is described herein is to place for example in the blood vessel of human body (or animal) or an intracavitary pre-determined place The medical instrument used when the implantation material of embolization device.For example, what is described herein is the plant in order to convey such as one spring ring The release device based on conduit system used when entering object.This device is particularly suitable for through the cerebrovascular to a specified blood The embolization device of one such as embolism spring ring of conveying in position or aneurysm in pipe, and can solve prior art system The existing problems of system, can discuss briefly below.

Very for many years, the conduit of high ductibility is used to place various instruments inside the blood vessel of human body.These instruments Including dilating sacculus, developer solution, liquid preparation and various closure and embolization device, such as sacculus and embolism spring ring.This base Be disclosed in U.S. Patent No. 5 in the example of the instrument of conduit, 108,407, entitled " place the side of embolism spring ring The U.S. Patent application of method and instrument " and U.S. Patent No. 5,122,136, entitled-", arteriovenous, aneurysm, Seal wire head end is freed in the electrolysis that energization forms thrombus in vascular malformation and arteriovenous fistula medium vessels ".These patents disclose for Treatment aneurysm conveys preassigned in embolism spring ring to human vas in a specific location occluding vascular Instrument catheter-based when position.

The spring ring being implanted into the blood vessel can be the spring ring of spiral wound or can be winding shape, circle and circle immediately Staggeredly or other modes are wound.The example of available spring ring is shown in Fig. 1 and Fig. 2；Such spring ring can have complicated Or spiral shape, for adapting to patient's physiological characteristic of wide scope.For example, the spring ring in complicated (3D) shape can be from 3 centimetres of 2 mm length of outer diameter is until 50 centimetres of 15 mm length of outer diameter.Spring ring can be made into ultra-soft, soft or standard Ductility, and may include the stretch-proof object an of polymer or a metal.The example of remaining various spring ring In U.S. Patent No. 5,334,210, entitled, " angiemphraxis is integrated " and U.S. Patent No. 5,382,259, invention U.S. Patent application in entitled " the angiemphraxis spring ring of in succession pipe-type woven or textile fabric package " is disclosed.Embolism Spring ring is generally made of the metal material to develop, such as platinum, gold, the alloy of tungsten or these metals.It can be with a position Multiple spring rings are placed, block the blood flow in blood vessel or inside aneurysm by forming infraction in specific position.

In the past, embolism spring ring is placed on the distal end of conduit.After catheter tip is placed in place, bullet Spring coil can be pushed to the ideal position outside catheter tip by a driving means.This places the operation of embolism spring ring Process can carry out under fluoroscopy systems, carry out to control spring ring movement in the blood vessel and placing in ideal position Monitoring.

In certain modus operandis, glue and welding can be used to one spring ring of connection and a seal wire, then the seal wire It is placed in the good conduit of ductility and is used to previously selected position placement spring ring in the blood vessels.Once spring ring is put It sets in ideal position, spring ring will be limited in current location by conduit and can not move, and then seal wire can be from the proximal end quilt of conduit It stretches, is freed so as to cause spring ring and seal wire, while being also released from conduit.Above spring ring place system is in the U.S. Patent No. 5,263,964, entitled " coaxial tractive force frees instrument and method " U.S. Patent application be disclosed.

The mode that another spring ring is placed is to make a groove in the end of conduit to be used to place a ball, this circle The connection of the proximal end of ball and spring ring.The diameter of this ball is generally higher than the outer diameter of spring ring.This ball is placed on catheter tip After the groove of inside, conduit, which is placed into, to be used to spring ring being delivered to ideal placement location in blood vessel.Position is placed reaching It postpones, a distal end has the push seal wire of piston structure to be pushed from the proximal end of conduit, and top dome is gone out groove to ideal Position release spring circle.This system is in U.S. Patent No. 5,350,397, entitled " axial releasable embolism spring Circle is integrated " U.S. Patent application be disclosed.One similar prior art system is shown in Fig. 3, in U.S. Patent No. 5,895, 391, the U.S. Patent application of entitled " the spherical locking node of vasoocclusive member and import sheath " is disclosed.Herein In example, a matched seal wire of interference is used to one that connects spring ring end big ball and send into instrument one to be used to The groove of fixed ball position.After the end of delivery conduit has been placed on ideal position, vaso-occlusive devices 222 are fixed Device 226 releases and is pushed into the position specified.The matched seal wire 228 of interference keeps whole device leading during this step The state that can be pushed into together in pipe.After the position for being pushed into have specified, it is withdrawn by with the matched seal wire of ball interference, ball It is released with spring ring connected to it, the subsequent matched seal wire of interference, fixed device 226 and conduit are withdrawn by.

Another mode for placing embolism spring ring is the stickiness tie point connecting spring circle and conduit de- with a pyrolysis End.One of device system utilizes fiber optic transmission laser energy, to sticky tie point heating, thus in conduit End release spring circle.Which is in U.S. Patent No. 5,108,407, entitled " places an embolism spring ring Method and apparatus " U.S. Patent application be disclosed.

Another spring ring place system include the inner cavity for having perforation conduit and an end tip in order to solid Fixed and mobile spring circle is to the position specified.The tip of end is can enlarged body fiercely after being pressed in catheter lumen by one kind Material composition of the product release spring circle to designated position.Which is in U.S. Patent No. 6,113,622, entitled " Embolism spring ring hydraulic release system " U.S. Patent application be disclosed.

Another spring ring system includes mechanism chain on a spring ring.Lock on spring ring, which can be combined to, to be pushed away It send on the lock in system.One control seal wire passes through the mechanism of this lock, for keeping the connection at both ends.Supplying system and Embolism spring ring is placed in the intracavitary of conduit when initial.After spring ring is pushed out catheter tip to target location, control is led Silk is retracted, and then spring ring will be separated with supplying system.Which is in U.S. Patent No. 5,925,059, denomination of invention U.S. Patent application for " disengageable embolism spring ring is integrated " is disclosed.

Another spring ring place system includes the separable embolization device for being mounted in driving means end, the instrument Connection is kept by a connecting line or connection fiber and driving means.This fiber passes through the cutting that can a be activated dress It sets.When fiber device to be cut is cut off, embolization device will be released.Which is 2002/ in parent U.S.Patent No number 0165569, the U.S. Patent application of entitled " utilizing the endovascular device releasing mechanism of mechanical ways of relief " is disclosed.

Another spring ring place system includes the embolization device of a structure with stretch-proof.Stretch resistant structure it is remote End is connect with embolization device, and proximal end is sticked on push structure with adhesive or is tied up on push structure with connection fiber.Closely Structure separation may be implemented by heating to discharge embolization device in end.Which in U.S. Patent No. 2004/0034363, The U.S. Patent application of entitled " anti-drawing therapeutic device " is disclosed.

Another spring ring place system includes that the end in catheter lumen connecting with embolization device is hard The push seal wire of wave-like.Push seal wire is retracted after spring ring is transported to preassigned intravascular site by seal wire, is made Spring ring is obtained to be released.The system in U.S. Patent No. 6,203,547, entitled " contain a controllable machinery Free node with using instrument method angiemphraxis instrument " U.S. Patent application be disclosed.

Various transportation systems described above may be used to convey one or more implantation instruments to designated position.But It can be each modified in these systems.Specifically, for on-mechanical system (such as electronics, it is chemical or hydraulic release Place system), activation system needs time for postponing to system starting, can be likely to result in the tired of mistake or doctor and detest and burnt Consider.Above-mentioned mechanical system is also subject to the problem of reliability and robustness in instrument itself or operating process.In addition, existing Machinery free in system exist with enough strength also can not release spring circle and need directly with the naked eye observation gone confirm Through freeing.The instrument and method described herein can improve these insufficient places.

Summary of the invention

Described here is the mechanical conveying system of neural blood vessel implantation material (including embolic implant).These system packets Include the instrument and transportation system of implantation.For example, described herein is different in order to treat intracranial aneurysm and/or other neural blood vessels , carry out the implantation material for such as embolism spring ring that Endovascular Embolization uses Mechanical conveying system.

These arbitrary instruments include the separated region can deforming connected with implantation material, the part and implantation Object is conveyed together.Although these instruments and method for describing herein are mainly described in the scene of release embolism spring ring, these Instrument and method can be used for conveying implantation material (such as the device similar with embolism spring ring size and measurements of the chest, waist and hips of any similar size Tool), including but not limited to filter device, umbrella, plugging device, support device (such as bracket), close net fabric etc..

These any instruments can use (" guiding catheter " or " delivery conduit ") with a conveying or guiding catheter, wherein The end of conduit or its nearby have a marker.Delivery conduit can be a microtubular (" microtubular ").It is described herein Freed to convey a machinery implantation material instrument include a disengageable delivery guidewire assembly (DDW) can it is following can be more Detail discussion.This assembly can be disposable or can recycle, wherein the microbore pipe comprising a proximal end, one The drawing seal wire that the spring (outside push assembly) of the polymer coating of a distal end and the end of an inside increase is used to connect One is freed bush Assembly.DDW or push assembly can pass through a bush Assembly (solution with delivery guidewire is freed with one De- bushing frees bush Assembly) connection or the implantation material (embolism spring ring) having had connected and one frees and uses handle (handle) is used together.Implantation material and free bush Assembly can in advance in DDW end increase drawing seal wire connect.

For example, in one form, instrument is arranged to a blood vessel embolism spring ring system, and including: one is pre- First and DDW passes through the implantation material (spring ring) of bush Assembly (freeing bush Assembly) connection and optional one is freed handle (DH).(spring and/or microbore pipe outside such as have foot to delivery guidewire with the push assembly that assembly includes an outside is pushed Enough strength can push implantation material to distal end or proximally recall) and an inside drawing seal wire assembly, including one The drawing seal wire for being used to discharge and free of a inside, the tip of wire distal one increase, wire distal one centering Spring is used to make to pull seal wire and pushes the distal tip holding concentric position relationship of assembly.Can have one above the seal wire of DDW A marked region (can develop under fluoroscopy) starts with seal wire one；For example implantation material is discharged when drawing seal wire is activated When, drawing seal wire can move to the near end inside push assembly on the outside.It also may include the packet of a lubrication above DDW Covering layer (such as the outer layer of lubrication), at least partly package drawing seal wire (distal end or intermediate region of drawing seal wire), centering bullet Spring coil and/or marker go to reduce the force of sliding friction when drawing seal wire is mobile to distal end in DDW.Above DDW (such as Outside in DDW pushes assembly) there can also be the region for optionally distally preventing deformation.It is internal for synthesis Drawing seal wire and external push assembly keep drawing seal wire in the pulling force of the distal end DDW by way of compressing and rubbing against.This Pulling force can help to free bushing and which is connected the implantation material distal tip for touching DDW tightly, but in the proximal end from DDW Can overcome easily when drawing seal wire inside stretching this pulling force go to discharge/launch implantation material.

As mentioning just now, these instruments also may include a handle, the hand including one with hand/finger activated Handle go proximally dragline draw seal wire (such as from about 20g between 500g power, 20g between 400g power, 20g is between 300g Power, 20g to power, 20g to power, 20g to power between 100g between 125g between 150g etc.), overcome rubbing between DDW Power is wiped, the mechanical implantation material freeing position distortions and being connected to above bush Assembly to release is then made.The composition of this instrument Object can be can to sterilize and when single patient (such as use) without living body pyrogen.

As mentioning just now, instrument described herein can be used for any applicable implantation material, particularly including blood vessel With spring ring, such as embolism spring ring.Implantation material can be defeated by the intervention means microtubular (MC) of standard under fluoroscopy It is sent to target vascular site.Implantation material (spring ring) then can with handle (DH) by free delivery guidewire carry out it is mechanical It frees.Freeing and discharging for this instrument can especially effectively and simply develop in visible system to confirm implantation material It is successfully delivered/frees.

For example, a spring ring can be made of naked platinum alloy；Spring ring can be in order to adapt to the mesh of different range Vessel size is marked, there is the specification of different shapes, diameter and length.In the example described herein, inner side has one A filamentous is used to place excessive tensile of the spring ring when conveying and recalling.

For synthesis, implantation material be connected to (it is usually permanent, although temporary, removable and/or degradable company Mode is connect also to imagine) it frees on bush Assembly.It is a machine that one, which is freed village's set assembly (also referred to as bush Assembly or HA), The unit of tool links and realizes the connection of implantation material and DDW system with the proximal end of implantation material (spring ring).Free bushing Assembly can be connect with spring ring and DDW system in advance, and more specific details can be discussed below.Freeing bush Assembly may include Two or more parts to link together, including implantation material connector (also referred to as adapter, spring ring adapter or Spring ring connector) and a deformable mechanical release device (also referred to as hanging down or discharge lappet).This deformable mechanical Release device generally comprises one or more (2,3,4 etc.) deformable pawls, and forming one can be by seal wire end The space of locking.For example, deformable pawl can be lappet, bar, bump etc..Pawl is designed to when the power applied (for example, being greater than 20g power, being greater than 30g power, big when (such as stretching drawing seal wire in proximal end) is more than a threshold value being pre-designed In 40g power, be greater than 50g power, be greater than 60g power, be greater than between 70g power, 20-200g power, between 50-200g power, 50-500g power it Between, between 20-400g power, between 20-250g power, between 20-200g power etc.) (outside) can be deformed to from bush Assembly Seal wire end is discharged in lock space.Therefore, the deformable pawl on bush Assembly (deformable mechanical release device) can To fix the distal end of drawing seal wire inside DDW under tension.The distal end of seal wire has the end and/or one an of enlarged diameter A diameter is less than the proximal collar region of distal end, and the distal tip of such seal wire can be in deformable mechanical release struc-ture It is fixed by deformable pawl；After proximally applying enough pulling force to drawing seal wire, the distal end for pulling seal wire will Pawl is deformed, so that the distal end for pulling seal wire be allow to be pulled out from machinery release struc-ture, reaches the release in distal end and plants Enter object (and bush Assembly connected to it).Bush Assembly due to being connected to implantation material proximally applies pulling force, pulls to DDW's Distally.When deformable pawl finally deform and from bush Assembly release drawing seal wire distal tip when, bush Assembly and Implantation material is with a kinetic energy direction far from DDW by from distally releasing.

In certain forms, bush Assembly does not include an individual implantation material connector/adapter and deformable Mechanical trip；One individual instrument can complete the effect of the two devices.For example, implantation material (spring ring) can be with It is connected directly between above the bush Assembly of the lock space of one or more deformable pawls.Bush Assembly be usually directly and Securely (such as the modes such as extruding, welding and/or filling) connect over the implant.

For synthesis, freeing delivery guidewire (DDW) to be includes the extension assembly for pulling the DDW of seal wire on the inside of a pipe.It leads The end (or neck area of distal end) for drawing the increase of wire distal can be spherical shape, cylinder etc., and can fill in advance It fits in the lock space of bush Assembly.In addition DDW also generally comprises the push assembly in an outside, and internal is hollow, use To place drawing seal wire.Pushing assembly can be by microbore pipe or several microbore pipe, spring ring or several spring rings, polymerization One or several compositions in the tubing of the tubing of object or several polymer, braided fabric etc., including these portions in parallel and serial Point.For example, DDW may include the distal end of a coating package (arriving distal end, proximally in order to increase end softness and flexibility) Spring collar region.The distal end in the region can have region (the concentric spring ring or microbore pipe of a label spring ring DDW comprehensive hardness and flexibility can be used to adjust together).The proximal end of DDW may include the microbore pipe an of proximal end. In some cases, proximal end region also may include the microbore pipe for preventing deformation, wherein including the elastic region of a longitudinal direction Domain, such as a spring region.Push assembly in pull seal wire setting method (can for extruding, frictional force, inside pawl, Adhesive etc.) it is to keep its distal end tensioned, so as to allow bush Assembly and the implantation material that is connected to resist the distal end of DDW.It prevents The microbore pipe of deformation can provide tension to the distal end of drawing seal wire while DDW has flexibility and bending.DDW's Distal end can be made and can seamlessly be aligned with the proximal end of bush Assembly.DDW can be made of stainless steel material；Coating above It can be therapeutic medical polymer.As above-mentioned, DDW can have one or more marks on the tubing that proximal end pushes assembly Note, such as position label (fluorescence safety label or other witness markings).Label can be provided in implantation material (spring ring) and connect Visual cues when closely but without the end for going out MC completely.Under certain settings, fluorescence safety label can be in the proximal end region of DDW Above domain, it can be let the user know that when implantation material (spring ring) is close to delivery conduit (microtubular) end.The label of safety exists Feedback when can visually be seen under certain settings or operation being provided on hand.For example, a safety label has one or more The region of a dyeing, such as the thermal contraction moulding material of one or more dyeing outside the stainless steel pipe of proximal end.

Just as being described in more detail here, any instrument described here also may include one or more additional Label, such as freeing with label, or " 3cm label " on seal wire.Label on this drawing seal wire can be for inside DDW Conveying/drawing seal wire on fixed spring ring, and it is only visible under real-time fluoroscopy.This label the distal end DDW most End has on a very specific position, such as the proximal end of 30mm probably general from the end of DDW.As above-mentioned one Sample, any DDW described herein can include the wrappage (such as outer layer, coating, interlayer, cuff) of a lubrication, until Small part package drawing seal wire and/or marker (such as centering spring circle and 3cm marker).The wrapping layer of this lubrication is (herein Referred to as lubricate outer layer) can reduce when the drawing seal wire of DDW is proximally pulled inside frictional force.This lubrication outer layer can be with By way of extrusion, shrinkage hose, a deposition or spraying, lubricant or coating and be made into.It is activated, releases when freeing handle After (such as by deforming the pawl in bush Assembly) putting implantation material, as a result caused by movement can by internal drawing seal wire to Proximal end retracts, and the movement that this is retracted can by 3cm label, movement be obtained visually really therewith under fluoroscopy Recognize, to confirm to free to have occurred and that.It can provide and be explained in more detail eventually in following Fig. 5 A-5C and 19A-19B.

In use, implantation material and bush Assembly can be discharged by deforming the pawl in bush Assembly.For example, an instrument It can be designed to block blood vessel inside release one spring ring (blood vessel blockage spring ring) to nervous system to permanent resistance Break the arteriovenous embolism of aneurysmal blood flow or other vascular malformations and peripheral blood vessel.These instruments are used as being implanted into The controllable conveying of object, including vaso-occlusive devices are delivered to the specified of blood vessel or other inner cavities of human body by a conduit Position.

The instrument described herein is connected to implantation material (spring ring) there are also the end of distal end and proximal end is located next to a company Then the bush Assembly of the drawing wire distal of forked type blocking device.This fork-shaped blocking device generally comprise two (or more) The arm that can be shunk when applied force from outside to inside, to reduce the diameter of fork-shaped blocking device.One lock is (certain The lower also referred to as slide lock of axis direction or referred to as slide lock are set) in can be in the hand of fork-shaped blocking device comprising one The lappet placed among arm, for preventing the arm of fork arrangement from curving inwardly.When proximally slide lock (or distal end), Lappet can be removed or remove from the arm of device, and arm is curved inwardly.It is axial in certain settings Slide lock is configured to (proximally) arm of the slide lock in fork-shaped blocking device when applying enough pulling force to drawing seal wire Outside by power proximally；Slide lock and fork-shaped blocking device are arranged to when slide lock receives drawing and proximally slides, to The pulling force of proximal end can pass on fork-shaped blocking device.Since the pulling force of drawing seal wire can pull to fork-shaped blocking device and be close to serve as a contrast Assembly (being close to one or more slope surfaces) is covered, the arm of fork-shaped blocking device can be curved inwardly；Therefore the fork-shaped reduced closes The diameter of locking device can allow them to be released from the proximal end of bush Assembly, and implantation material and bush Assembly are discharged.This The DDW of scheme can be basic as DDW described above, but the distal tip for pulling seal wire can be connected in one with locking device It rises.All locks described herein can include a mechanical resistance device, must first overcome including one Deformable pawl, the lock that slides axially can be by before proximally drawing.For example, pulling seal wire in scheme described here And/or the lock that slides axially can be compressed in the distal tip region of push assembly.In order to activate device, pulling force must first overcome This part squeezed slides lock proximally, so that fork-shaped arm be made to collapse, discharges bushing Assembly and implantation material.

Therefore, for comprehensive, any instrument described herein all includes one and is connected in implantation material (such as angiemphraxis bullet Spring coil) on bush Assembly, one is freed delivery guidewire (DDW).DDW may include an outer layer push assembly and one Its internal drawing seal wire.The distal tip of drawing seal wire is connected with bush Assembly at the beginning (to be had deformable in lock space Pawl and/or the lock that slides axially being connect with fork-shaped blocking device).The part for pulling the more inclined proximal end of seal wire can be pushed assembly A mechanicalness releasable device maintain (such as by extruding, frictional force etc.)；When drawing seal wire is by proximally to be greater than When the power drawing of releases its force (can be the force value set in advance, such as 25-150g power), drawing seal wire can be such that releasable device becomes Then shape activates the release process of bush Assembly and implantation material.Drawing seal wire then can proximally take out.

Detailed description of the invention

The novel place of the invention can specify its uniqueness in the following claims.The invention in order to better understand Feature and advantage, be referred to the following detailed description for enumerating characteristic scheme, wherein the principle invented is utilized, And following corresponding drawing:

Fig. 1 and 2 is the example of implantation material, here be blood vessel blockage spring ring, described herein can be used for What instrument.

Fig. 3 is the example of the mechanical conveying spring coil apparatus of prior art.

Fig. 4 is the example (being here set of system) of an instrument, including the implantation material for being connected to bush Assembly, a packet Include an external push assembly and internal drawing seal wire free delivery guidewire (DDW) and one is arranged to and pulls seal wire Handle is freed in proximal end connection.

Fig. 5 A-5C highlights the activation of the instrument of example similar with the instrument in Fig. 4.These pictures are also shown Internal 3cm fluorescent marker is in the position of initial (before freeing, 5A) and final (freeing rear 5C).

Fig. 5 D-5F highlights another deformable pawl (lappet) having alone similar with the example shown in Fig. 4 The activation of instrument.These images also show Internal Fluorescent marker in initial (before release, Fig. 5 D) and final (release Afterwards, Fig. 5 F) position.

Fig. 6 A and 6B highlight the lining of the bush Assembly comprising a pair of deformable pawl structures (here it is shown that for lappet) Cover main body (discharging part in this example for a deformable mechanical of bush Assembly).Liner body is pawl in fig. 6 It is activated, by the state of the distal tip for pulling seal wire latching (not shown in figure).Pawl is the state of not enabled in Fig. 6 B.

Fig. 6 C is the example of liner body in another bush Assembly, including a single deformable pawl (lappet). Main body includes the single pawl not bent inwards in figure 6 c.

Fig. 7 A-7C describes perspective view, side view and the top view of a kind of scheme of bush Assembly, including a bushing master The connector (implantation material adapter) of body (deformable mechanical discharges part) and an implantation material.

Fig. 8 A-8D describe the top view that bush Assembly (not showing implantation material connected to it) connect with DDW, two kinds thoroughly View and side view (distal tip including seal wire in DDW).Compared to 8B, deformable mechanical discharges part and is Fig. 8 C It is bright, for showing the control to drawing wire distal.

Fig. 9 A-9E is the various pieces of entire DDW in a scheme, such as connecting bushing assembly connection in 8A-8D DDW。

Figure 10 A is the region for preventing deformation of a DDW.

Figure 10 B is the spring section of an amplification prevented in deformed region.

Figure 11 is the distal tip of DDW and the disassembled view of bush Assembly, such as described in Fig. 8 A-8D, wherein pulling It include the fluorescent marker of a 3cm in seal wire.

Figure 12 shows the connection type of bush Assembly and implantation material (such as an angiemphraxis spring ring).

Figure 13 A-13B shows the example of another instrument described herein.

Figure 13 A shows that an implantation material (spring is gone) connects with a bush Assembly；Bush Assembly and a fork-shaped close Locking device connection.Fork-shaped blocking device is lockked by axially slidable lock, slide lock may be coupled to DDW drawing seal wire ( This does not show).

Figure 13 B shows the disassembled view of instrument in 13A.

Figure 14 A and 14B show the top view and side view of the instrument of 13A and 13B.

Figure 15 A-15C shows the connection and release of fork-shaped blocking device and bush Assembly under Figure 13 A-13B scheme (respectively For before release, after release neutralization release).

Figure 16 A-16B shows the scheme of the fork-shaped blocking device and bush Assembly similar with Figure 13 A-15C.

Figure 17 A-17C shows that another includes implantation material (angiemphraxis spring ring), bush Assembly connected to it, packet The system for including the conduit for freeing delivery guidewire (DDW) and a conveying of external push assembly and internal drawing seal wire.Figure 17 A Show that implantation material (spring ring) is connect with bush Assembly, the drawing seal wire of subsequent bush Assembly and push assembly (in DDW) connects It connects.17B is shown in the connection of bush Assembly and DDW when not connecting with spring ring.

Figure 17 C shows the distal tip for the delivery conduit that can be used together with push assembly (DDW) with implantation material.

Figure 17 D is that the partition of implantation material (spring ring), bush Assembly and the push assembly including pulling seal wire attempts.

Figure 18 A is shown with pushing that assembly (DDW) is used together to convey the implantation material being connected on bush Assembly One example of handle.

Figure 18 B is the cross-sectional view of Figure 18 A.

Figure 19 A and 19B, which are described, conveys an implantation material by the instrument described here, it is shown that controllably discharges bullet The fluoroscopic image of blood vessel before and after spring coil.Marker and conveying on the drawing seal wire of push assembly (DDW) Supravasal marker can clear and expression implantation material undoubtedly release.

Specific embodiment

In order to preferably technical solution of the present invention be made clearly to show, the present invention is made into one with reference to the accompanying drawing Walk explanation.

Described here is the mechanical delivery instrument and method for conveying neural implant.For synthesis, these machinery are defeated Send device that can quickly and reliably discharge an implantation material (such as angiemphraxis spring ring).This can guarantee implantation material most It is freed under small possible pulling force and any part of implantation material will not be left on blood vessel or artery when filling aneurysm The neck of tumor.These instruments are typically necessary mechanical deformation (deformation of release switch or pawl lock) release and project implantation Object.

For example, Fig. 4 shows an example of system described herein.In this example, system contains a plant Enter object 401 (here it is shown that for dislike spring ring) to be permanently attached on bush Assembly 403.Bush Assembly includes an implantation material Connector (adapter) 405, connected to it is the proximal end of spring ring.Implantation material connector is also to be permanently connected to can be changed On shape mechanical trip 407.Deformable mechanical release device includes the limitation space an of inside, wherein there is one or more More deformable pawls 409.To it is following will describe as, pull seal wire distal tip can for increase outer diameter Therefore (compared with the region of proximal end), end can be maintained at the power in limitation space until proximally applying to drawing seal wire Lead to deformable pawl deformation (outside), to release drawing seal wire and discharge implantation material and bush Assembly connected to it. Wherein, the structure in Fig. 4 further includes freeing handle (Detachment Handle) 415.

Fig. 4 also shows the example that a machinery frees delivery guidewire (DDW) 431 and specific size.In this example, it leads The distal tip 421 of silk 425 is that the region of an increase (is here shown as spherical shape, although it can be any suitable shape (such as cylindrical, triangle)).Pulling seal wire also may include a centering spring collar region 423, in order to help seal wire to exist Concentric positional relationship is kept inside external push assembly 431 in deformable mechanical trip 407 and/or DDW.In this example The external push assembly of DDW includes one and compares down softer distal tip region (Coil Construction) 433 and one The microbore area under control domain (Hypotube Construction) 427 of more proximal end.Pulling can also be from distal tip on seal wire There is a fluorescent marker (probably to wrap centering spring circle and fluorescent marker from distal tip 30mm) and one within 50mm The lubrication outer layer 424 of object.It can be protected when releasable but other states when drawing seal wire and the connection of DDW (not showing herein) are activation Holding on drawing seal wire has lasting pulling force to make implantation material and bush Assembly when pulling seal wire and connecting with bush Assembly It is close to the end of DDW.DDW can also prevent deformed region (not showing in Fig. 4) comprising one, for leading in push assembly Reinforce flexibility when drawing seal wire tensioned.

It frees handle and is also depicted schematically in Figure 18 A-18B.For synthesis, frees handle and can be set to be connected to and lead The proximal end of seal wire is drawn, so that allowing to pull seal wire is activated (drawing) with hand, mechanical deformation is reached and is released from instrument Put (pop-up) implantation material.

Fig. 5 A-5C and 5D-5F show an example similar with the instrument shown in Fig. 4, including an implantation material 503 It is connected to bush Assembly 505.In fig. 5, the distal tip 507 for pulling seal wire is trapped in the lock of bush Assembly by deformable pawl Determine in space, and implantation material and bush Assembly are close to the distal tip 511 of DDW under the pulling force of drawing seal wire.For example, drawing is led Silk can be extruded or other are releasably connected in the push assembly (not shown) of DDW, such as in proximal end.Scheming (being in this example the fluorescent marker of 30mm) and the lubrication outer layer of label 513 in 5A on (non-actual ratio) drawing seal wire 515 are connected on the drawing seal wire of DDW.

In figure 5B, enough proximal end pulling force 554 are applied on drawing seal wire, cause to pull the end that wire distal increases End 507 makes pawl (deformable mechanical discharges part in the bush Assembly) deformation being latched in space in bush Assembly.Drawing is led Silk is then retracted into the inside of push assembly；When drawing seal wire (is herein 3cm mark with the label that can develop under fluoroscopy When note connects 513), the release of implantation material can be confirmed immediately by doctor.And then, as shown in Fig. 5 C, implantation material and bushing Assembly 503 and fracture 555 (arrow).

Fig. 5 D-5F highlights another example similar with the instrument shown in Fig. 5 A-5C, but include that only one can Deform the bush Assembly of lappet 520.For synthesis, any number of deformable lappet (deformable pawl) can be used.

Fig. 6 A shows that is similar to a deformable mechanical release part 602 in bush Assembly described in Fig. 5 A-5D. In fig. 6, deformable mechanical release part 602 includes two deformable pawls 603 and 605.Pawl is can by cutting The outer wall of the mechanical release part of deformation is in flat sheet-like, then goes limitation to pull to infolding (in the limitation space of inside) them The movement (not showing herein) of the end augmenting portion of seal wire.Deformable pawl in this, which is set as working as, a proximal end When power (axis direction 609 in proximal end), lappet can be topped back the superficies of deformable mechanical release part, as Fig. 6 B is shown. The deformable mechanical release part of bush Assembly includes can be by the chamber for the inside that proximal openings 611 enter；Drawing Seal wire can enter from here.

Similarly, Fig. 6 C shows that the deformable machinery of a bush Assembly 608 similar with what is shown in Fig. 5 A-5B is released Put part.However in figure 5 c, deformable mechanical release part only includes a single deformable pawl 603.

Fig. 7 A-7C describes that (implantation material is suitable by deformable mechanical release part 703 and implantation material connector connected to it Orchestration) 707 composition bush Assemblies different perspectives figure.For synthesis, bush Assembly dimerous can pass through connection It is whole that (such as welding, stickup etc.) deformable mechanical release part 703 and implantation material connector 707 reach a set.One Implantation material can be connect before or after implantation material connector 707 is connect with deformable mechanical release part 703 with implantation material Device connection.As mentioned above, bush Assembly is can individually to complete above-mentioned two use by one in certain schemes The component on way forms, rather than separated implantation material connector and deformable mechanical release part.

Fig. 8 A-8D describes the connection such as the bush Assembly and DDW distal tip mentioned in Fig. 7 A-7C.It is specific next It says, Fig. 8 C shows the deformable mechanical release part in a partially transparent bush Assembly, the distal end of display drawing seal wire Increase end to be trapped in limitation space by pawl.

Similar, Fig. 9 A-9E describes the segmentation of an independent instrument, is to free delivery guidewire (DDW) in this instrument. In figure 9 a, bush Assembly 901 is connect with the drawing wire distal end 903 of DDW.DDW includes internal 905 He of drawing seal wire Outside push assembly 907.The region that the distal tip of push component is made of one section of spring ring.The proximal end tegillum of spring collar region Cover covers.DDW can also have other parts except Fig. 9 A-9E is shown, so described herein do not represent its overall length.Than Such as, in the push component area in Fig. 9 B or between the region that Fig. 9 A and 9B are shown, outer section (the push assembly of DDW Or driving means) can there are the label (such as a fluorescence protection marker) or a visibility region in an outside.This mark Remember that label or labels on the drawing seal wire of object or marked region and DDW are visually easy to differentiate, it in more detail can be under Face describes (Figure 17 A-18B).In Fig. 9 C, there are a remote spring collar region and proximal end microbore pipe (harder) region transfers Region 913.Fig. 9 D shows the part 915 for preventing deformation, including a spring region 917 (in Figure 10 A-10B It is described in more detail).Internal drawing seal wire 903 can be extruded or be releasably secured to external push in this instance Assembly reaches enough tension for making implantation material and bush Assembly be close to the distal tip of instrument.

One prevents to pull on seal wire effective for holding described in deformation position such as Fig. 9 D and 10A-10B The flexibility of DDW is maintained while tension to make its conveying as requested.For example deformation prevents region 915 from wrapping in Figure 10 A A central spring type shape region 917 (spring region) is included, which is made of the region of the cutting profile of sinusoidal curve.The bullet Pulling force effect when spring region 917 can be bent (such as when by being bent complicated blood vessel and/or inner cavity in vivo) in drawing seal wire Allow unbalanced compression in the case that outer layer pushes assembly.

Figure 11 shows the disassembled view in the distal tip region of instrument, including a bush Assembly 1103, a drawing Seal wire 1105 and its distal end increase the end 1107 of diameter, a center alignment spring ring 1109 and 3cm fluorescent marker 1117.Outside Layer push assembly 1115 in distal portions (slinky spring circle tip portion) also here it is shown that.This instrument is when being shipped for buyer Bush Assembly can be placed on to be connected to implantation material (not showing herein) and drawing wire distal end on bush Assembly Form in intracavitary control section.Drawing seal wire can be pushed on the outside inside the inner cavity of assembly.

Figure 12 show implantation material (in this example for blood vessel blockage spring ring 1203) and bush Assembly (here it is shown that For implantation material connector/adapter portion 1205 in a bush Assembly 1204 and deformable mechanical trip 1207) it connect The enlarged view of (permanent).

In a typical application method, a puncture sheath is placed on femoral artery.One guiding catheter (GC) is put It is placed in puncture sheath and reaches specified vessel position along seal wire.One microtubular (MC) then can from GC along seal wire to Up to specified position.DDW/ spring ring in inducting device can enter in microtubular from from haemostatic valve.Subsequent DDW/ spring ring can All to be taken out inducting device and prepare the release of implantation material by MC.The distal tip of MC is placed on specified blood vessel Position.Spring ring is released to the confirmation that the laggard line position in specified position is set.It may be selected to withdraw after spring ring again from MC herein It places or withdraws from from the patient.Free the end that handle (DH) then can be connected to the proximal end DDW.Activate spring ring after DH can To be freed in specified angiosomes.Finally, the position of spring ring can be identified, additional spring ring is decided whether.

Figure 13-16B shows the example of another instrument (Hub Assemble) 1300 described herein.Such as in Figure 13 Show that an implantation material (Coil) (spring ring 1301) is connected to bush Assembly 1303,1305,1307, including adding Long and cylinder (non-perfect or closed) liner body (Hub Body) 1303, one can be with the drawing seal wire of DDW (herein Do not show) connection the lock that slides axially (Lock Pin) 1307.The lock that slides axially receives proximally (drawing seal wire) under tension When can by deforming pawl, from liner body 1303 discharge fork-shaped blocking device (Locking Fork Retainer) 1305。

Figure 14 is the disassembled view of the instrument shown in Figure 13, it is shown that spring ring 1301 is connected to liner body Proximal end.The distal end of liner body 1303 is connect with fork-shaped blocking device 1305 and a lock latch 1307.In Figure 14, fork-shaped is closed The component of locking device 1305 and lock latch 1307 is releasedly locking connection, for limiting fork-shaped blocking device 1305 and locking The movement of the distal direction of door bolt 1307.For example, lock latch can with one individually drawing seal wire it is (plural in other schemes Release lock respectively can be used to and/or proximally pull fork-shaped blocking device 1305 by pulling seal wire) connection, for overcoming some thresholds It is worth power, removing the tension guaranteed pull on seal wire, (proximal end is connect with bush Assembly, we have begged for before touching to control implantation material By cross prior art instrument) movement.

Figure 15 A and 15B distinguish the top view and side view of instrument in Figure 13.In Figure 15 A, key and lock bolt are configured to The advantages of geometry of bush Assembly 1400 can be utilized, including (passing through the drawing seal wire of connection) when proximal end under tension The setting of fork-shaped blocking device 1405.In Figure 15 B, lock bolt 1403 is proximally slided, fork arrangement 1403 also therewith to Proximal slide, so that implantation material (being still connected to the main body of bush Assembly) is released.It is noted here that scheme described above In, such as this example pulls the tension on seal wire and can permit and penetrates implantation material (and bush Assembly) under enough strength Out.This is freed process therefore may be used as the expansion for launching obstruction in implantation material, such as neural blood vessel system to target area Open sacculus.Figure 15 A-15C shows the process of this ejection.

The operation of bush Assembly described in fork-shaped blocking device and Figure 13 is shown in Figure 15 A-15C, including logical After first moving first lock bolt (Locking Pin) 1504, then proximally (arrow direction) moves fork-shaped blocking device (Locking Fork Retainer) 1503 passes through the opening indicated in Figure 15 C until the tip of fork arrangement deformation/bending Liner body (Hub Body) 1505 in discharge, lead to the release of the bush Assembly any implantation material of connection (and its).

Figure 16 A-16B shows other schemes for being similar to the fork-shaped blocking device and bush Assembly that describe above, emphasizes In order to by lock bolt and lock fork release, allow it to be pulled and (draw seal wire by proximally dragline) or proximally slide and enhances The part of tension and frictional force.For example, in Figure 16 A, a pawl 1604 on lock bolt or lock fork can prevent lock bolt to Proximal end is mobile.The remote area of instrument in fig. 16b similar to its includes one and prevents drawing seal wire by reinforcing frictional force It is pulled proximally the part of release lock bolt and lock fork；Enough pulling force must be applied to go to overcome the frictional force in this region 1606。

Figure 17 A-17D describes the scheme of another system, and scheme is set as blood vessel embolism spring ring system, wherein wrapping It includes: an implantation material being made of embolism spring ring (Coil) 1701；In succession one of spring ring frees bush Assembly (Detachment Hub) 1705 includes wherein one or more deformable release lappets in bush Assembly (in Figure 17 A- It is invisible in 17D, but similar scheme is shown in Fig. 6 A-7C)；It includes: one that one, which is freed delivery guidewire (DDW) assembly, Outside push assembly (Pusher Assembly) 1715, an internal drawing seal wire 1709 is wherein away from drawing wire distal end The distal tip region 1713 an of fluorescent marker (Marker) 1721 and an increase diameter is connected at the 30mm of end, this A region is maintained at by one or more deformable release lappets frees inside liner body.Deformable release lappet is set Be set to flexible deformation, fluorescent marker inside drawing seal wire proximally under tension and from the distal tip of DDW assembly Release can move to the near end when freeing bush Assembly.In any instrument described here, the polymeric outer layer of a lubrication It can be used to a part of package instrument, such as drawing seal wire (the distal tip region as pulled seal wire), centering spring circle With the marker shown in Figure 17 D.

Implantation material (spring ring 1701) in these schemes is shown in Figure 17 A to be pre-arranged or be connected on bush Assembly (passing through the implantation material connector connected on liner body), then bush Assembly is close to kiss with the distal tip of DDW assembly It closes, is shown in Figure 17 A.Figure 17 B is a view slightly amplified.Shown in two figures one in DDW distal tip area The developing mark object 911 of the proximal end (on internal drawing seal wire) in domain.Any suitable development object (under fluoroscopy may be used See) this can be used in.This marker can be in arbitrarily suitable position, such as from distal tip 3mm to 50mm.

The marker of second development can be placed on input/guiding/microtubular (Delivery Cannula) 1744 In a fixed position.This conduit may include (or can be used together with system) in system described here.Picture As mentioned above, the label of second development can be placed on the one of the external tubing main body of DDW (not showing herein) On a fixed position.This position is overlapped with the developing mark object on drawing seal wire, therefore can provide the position of activation instrument phase pair Move variation.In Figure 17 C, developing mark (Marker Region) 1741 is also placed on probably away from input/guiding/microtubular The distally position of (opening) end 3cm.Input/guiding/microtubular internal diameter generally all allows instrument described herein (packet enough Include the implantation material of connection) pass through.

Figure 17 D is that the fractionation of the system shown in 17A attempts, and includes that the distal tip increased (is shown in this instance Be shown as cylindrical, although other shapes also can be used, such as circle/spherical, ellipse/ellipsoid, square) inside pull Seal wire and a centering spring ring 1711.Centering spring ring may be the polymer hose of extrusion or be heat-shrinked to interior Portion pulls on seal wire (Pull Wire) 1709.Free bushing (including liner body (Hub Body) 1708 and bushing connector (Hub Coupler) 1707) also shown by emphasis；Spring ring 1701 can be connected on bushing connector and it can releasedly connect (DDW) is connected in delivery instrument.In spring ring may include one prevents spring ring from stretching in operation and implantation process, helps The fiber (Fiber) 1703 of spring ring holding shape.

It should be noted that in Figure 17 D 1711 be centering spring ring (Centering Coil), 1713 for increase internal diameter Drawing seal wire head end (Enlarged Pull Wire Tip), 1723 be smooth polyester jacket (Lubricious polymer Jacket), 1717 be remote spring pipe flexible distal tip region (Distal Coil Soft Distal Region), 1719 are Remote spring pipe (Distal Coil).

Figure 18 A and 18B show the one of the handle that can be used with any instrument (such as in Figure 17 A-17D) described herein A example.In this instance, handle includes a controller (Silder, carriage 1805) on handle theme, can be with For proximally dragline draw seal wire proximal end, at the same time handle can also maintain outside push assembly part (from Proximal end), therefore the lappet of bush Assembly can be made to deform to discharge implantation material (and bush Assembly) to distal end.Figure 18 B is shown The sectional view of one handle example.The proximal end of DDW is inserted into the distal openings of handle, and internal drawing in this way is led Silk and external push assembly can be by separated controls.

In addition, in Figure 18 1815 be front end lid (Front), 1807 be clip (Clamp), 1805 be sliding block (Slider), 1819 be compressed spring (Compression Spring), and 1813 be shell (Housing)

Figure 19 A and 19B show that system described herein (such as Figure 17 A-17D) is placed in human body by lumen of vessels and are implanted into The process of object (spring ring).In this instance, system 1905 enters blood vessel by microtubular.The distal tip of microtubular is placed on Near ideal implantation position.This system ins succession including one and frees the implantation material of bush Assembly, and implantation material is by freeing bushing It is connected to the distal tip of DDW, can be entered from microtubular, so that implantation material reaches the position of implantation.Behind in-position, closely The handle at end can be activated proximally to pull internal drawing seal wire, be drawn after overcoming internal resistance by proximally dragline The lappet deformation that the end augmenting portion of seal wire made to be in contact with it free liner body, the 3cm marker of the proximal end DDW also can be with Move to the near end.After lappet deformation, the distal tip disengaging liner body for allowing to pull seal wire, bushing and implantation material are freed Just it is freed.This frees process simply and clearly to be seen by fluoroscopy, more than existing system to freeing really Verifying method.In this instance, Figure 19 A shows the initial position before system discharges in vivo.Pull the label 1902 on seal wire (3cm Marker On Pull Wire, " 3cm marker ", or marker is freed, although it can be placed on drawing seal wire Any suitable position) and guiding catheter on label 1904 (3cm Marker On Catheter, " 3cm guiding catheter ", to the greatest extent Guan Qike is placed on any position of guiding catheter) it is high-visible and also in this instance position it is opposite very close to.In Figure 19 B In, drawing seal wire pulls to proximal end by enough power (such as larger than the power of 20g, between 20g-150g power etc.) and makes bushing and drawing Seal wire separation.The mark pulled on seal wire that can be confirmed rapidly and simply can be shown in image system (such as fluoroscopy) Remember that the relative position of object 1902 and static guiding catheter marker 1904 changes.Therefore, freeing can be by under fluoroscopy The movement (several millimeters or more mobile to distal end) of marker is confirmed on drawing seal wire.The confirmation freed also may include One variation acoustically and in feel, but vision imaging can be used as the surgical procedure that simply can be confirmed and record.

When a feature or element are referred to herein as in another feature or element "upper", it can be directly another It is intermediate in a feature or element or both also to have other features and/or element.Opposite, when a feature or element are claimed It is " direct " in another feature or element "upper", between the two without other features or element.In addition, when a feature or member When element is referred to herein as with another feature or element " connection ", " being connected in ", " ining succession ", it can be to be directly connected to separately Can also there are other features and/or element among one feature or element or both.It is opposite, when a feature or element are at this In be referred to as with another feature or element " being directly connected to ", " being directly coupled to ", " directly ining succession " when, between the two without it His feature or element.Although being shown in or being described in a kind of scheme, here it is shown that or the feature or element of description equally can be with Applied to other schemes.Here corresponding with a structure or feature " adjacent " for fields professional technician Another structure or feature may have the overlapping of part with adjacent feature.

The purpose of term in this is just for the sake of describing specific scheme and the intention of there is no restriction invention.For example, This description singular number "one" " this " also include plural form, except it is non-depicted when clearly point out this non-feelings Condition.In addition term " composition " and/or " consist of " herein is used to indicate feature, step, operation, element and/or composition The presence of component, but one or more others are not excluded for for indicating feature, step, operation, element and/or building block Presence.Term "and/or" as used herein includes all combinations for the article that all front and backs are mentioned and can be omitted For "/".

The term of space correlation, such as "lower", " being lower than ", " low ", " top " etc. can be used to description figure herein In an easy relationship between element or feature and other elements or feature.Here the term of space correlation includes using Instrument or when operation direction and viewpoint different other than direction as depicted in the drawings.For example, if instrument quilt in figure Reversion, be described as "lower" or other elements " below " element then will become other elements " on ".Therefore, example In "lower" may include above and below two orientation.This instrument be in other directions when (90 degree rotate or other When direction), the narration term of space correlation here also returns to be changed therewith.Similarly, term " upward ", " downward ", " hang down It is straight ", " horizontal " etc. be served only for the purpose explained herein, unless indicating this non-situation.

Although term " first " and " second " can be used to describe various features/elements (including step herein Suddenly), these features/elements should not be limited by these terms, unless indicating this non-situation.These terms are used to distinguish a spy Sign/element is in another features/elements.Therefore, first features/elements described below can be referred to as second feature/ Element.Similarly, second features/elements described below hold also referred to as first not departing from existing invention Features/elements.

In following specification detail and claim, unless otherwise noted, otherwise noun " composition " and its variant " consist of " " comprising " means that different component parts can be together in method and claim (such as part and instrument packet Include instrument and method) in application.For example, term " composition " be construed as include any element described and step but It is not excluded for any other element and step.

Used in the specification detail and claim herein and number including using in the example shown, unless in addition It points out, otherwise all numbers, which are considered as front, noun " general " or " about ", although not explicitly indicating that in term.With Indicate value in description and/or position in rational expectation come word " general " when describing quantity and/or position or " about " In value and/or position range.For example, numerical value can for +/- the 0.1% of the numerical value (or numberical range) of narration within, Within +/- the 1% of the numerical value (or numberical range) of narration, narration numerical value (or numberical range) +/- 2% within, narration Within +/- the 5% of numerical value (or numberical range), narration numerical value (or numberical range) +/- 10% within etc..It is given here Any numerical value should also be considered as comprising probably or about that numerical value, unless otherwise noted.For example, if numerical value " 10 " is public It opens, then " about 10 " are similarly disclosed.Here any numberical range is considered as including all subranges.Moreover, when a number When value is disclosed, " being less than or equal to certain value ", " being greater than or equal to certain value " and the range including the value are similarly disclosed.Than Such as.If value " X " is disclosed, " being less than or equal to X " and " being greater than or equal to X " is also disclosed (when X is numerical value).And In this application, data are provided in a different format, then this data, represent any group of starting point and terminal and data point It closes.For example, be greater than, be greater than or equal to if a special data point " 10 " and a special data point " 15 " are disclosed, Be less than, be less than or equal to, equal to be also regarded as between 10 and 15 or 10-15 disclosure.And the numerical value between any two numerical value It is also regarded as disclosure.For example, being also disclosed if 10 and 15 are disclosed, 11,12,13,14.

Although various schemes are described above, the invention scope described in without departing from claim, can be right Scheme carries out the change of arbitrary quantity.For example, the sequence of the method and step of various descriptions can be by other scheme Change, and one or more method and steps can be entirely skipped in other schemes.It is optional in various instruments and system schema Feature can be included in certain schemes and be not included in other schemes.Therefore, above content mainly provides citing Range of the purpose without invention should be limited in claim.

Here example and narration show the scheme that can be specifically carried out with the mode emphasized rather than limited.Upwards It states as mentioning, other schemes under the range without departing from the displosure, the replacement and variation of structural and logicality can be by With or derive.Scheme so related with invention topic can one by one or entirety is known as " inventing " with term, only For convenience without being intended to limit the range of this application in the concept of any individual invention or invention, if in fact more than One invention or concept are disclosed.Therefore, any in order to reach same mesh although specific scheme is emphasised and describes herein And meticulous advised reorganization scheme can substitute above-mentioned scheme.The disclosure is intended to encompass any and all to various schemes Change and adjustment.The combination of scheme above and other schemes not specifically described herein, fields professional technique It should be aobvious and understandable after personnel's audit.

Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow Ring substantive content of the invention.

Claims (12)

1. a kind of blood vessel embolism spring ring system characterized by comprising

One implantation material being made of embolism spring ring；

One is freed bush Assembly with what embolism spring ring was connect, wherein freeing bush Assembly includes deformable mechanical release portion Divide and one is freed delivery guidewire assembly；

The main body of the deformable mechanical release part is cylindrical barrel, and including one or two deformable release Lappet；

The delivery guidewire assembly of freeing includes:

One external push assembly；With,

One internal drawing seal wire；Wherein, the internal drawing seal wire includes the distal tip region of an increase diameter；Wherein The distal tip region of the increase diameter by one or two deformable release lappet be maintained at it is described free bush Assembly it Interior, the distal tip of the internal drawing seal wire is made of a centering with spring ring, and the centering spring ring is used to make institute The center that internal drawing seal wire is in external push assembly is stated, the deformable release lappet is arranged to proximally to pull It is deformable when the drawing seal wire of inside, to free bush Assembly from the distal tip release for freeing delivery guidewire assembly；

Further, on one or two deformable release lappets sides for being located at the cylindrical barrel outer walls or On monosymmetric outer wall, substantially " ∩ " shape is formed or in the monosymmetric outer wall by cutting on the side outer wall Upper cutting forms the notch of substantially " Π " shape, then leads one or two deformable inside cracking-off limitations of release lappet The movement of the end augmenting portion of seal wire is drawn, it is one when the power for having a proximal end is applied to deformable release lappet Or two deformable release lappets can be by top to the superficies of the deformable mechanical release part；

The implantation material is connected to the distal tip for freeing delivery guidewire assembly by the bush Assembly of freeing, by leading Drawing seal wire inside drawing makes to free bushing after overcoming internal resistance by the end augmenting portion of proximally dragline drawing seal wire The lappet of assembly deforms, the 3cm marker for freeing delivery guidewire assembly proximal end also can with the internal drawing seal wire to Proximal end is mobile.

2. the system as claimed in claim 1, which is characterized in that further include one and free handle.

3. the system as claimed in claim 1, which is characterized in that the external assembly that pushes is by the spring ring and one of an outside It is a or it is multiple by enough column intensity and can distal end push implantation material microbore pipe form.

4. the system as claimed in claim 1, which is characterized in that the distal tip region for increasing diameter than inside by pulling The big spherical shape of the regional diameter of the distal tip region proximal end of the increase diameter of seal wire, cylinder, square or ellipsoid composition.

5. the system as claimed in claim 1, which is characterized in that the external push assembly prevents deformed area by proximal end Domain composition.

6. the system as claimed in claim 1, which is characterized in that further include: one is at least partly wrapped up the internal drawing and led The lubrication wrappage of silk.

7. the system as claimed in claim 1, which is characterized in that be to rub between the internal drawing seal wire and external push assembly The connection of power is wiped, so that internal drawing seal wire is tensioned in the distal tip for freeing delivery guidewire assembly, to make to free The distal tip of delivery guidewire assembly is freed described in bush Assembly abutting.

8. the system as claimed in claim 1, which is characterized in that one or more deformable release lappets are arranged to Lappet can deform when inside drawing seal wire proximally applies 20g power or more.

9. the system as claimed in claim 1, which is characterized in that deformable release lappet is arranged in the internal drawing Lappet can deform when seal wire proximally applies the power between 20g-500g.

10. the system as claimed in claim 1, which is characterized in that described to free bush Assembly and have opening in proximal end by one Liner body composition, opening portion are closed by one or more deformable release lappets；The distal tip area of liner body Domain is connected to an implantation material connector, is connected to embolism spring ring above.

11. a kind of blood vessel embolism spring ring system characterized by comprising

One distal tip frees bush Assembly with what embolism spring ring was connect, wherein it includes one or more for freeing bush Assembly Deformable release lappet, the lappet close described in free bush Assembly open end a part；

One is freed delivery guidewire assembly；

One internal drawing seal wire；Wherein, the internal drawing seal wire includes the distal tip region and the of an increase diameter The developing mark of the proximal segment side of one distal tip；

The distal tip region for increasing diameter is maintained at described by one or more deformable release lappets and frees bushing In assembly, deformable release lappet is arranged to deform when proximally drawing internal drawing seal wire, to free from described Bush Assembly is freed in the distal tip release of delivery guidewire assembly；

The release can be aobvious by second on first developing mark and external push assembly or delivery conduit It detects relative position between shadow label；

Further, one or more deformable release lappet is located at the cylindrical barrel master for freeing bush Assembly On the outer wall of the side of body or on monosymmetric outer wall, by the side outer wall cut formed substantially " ∩ " shape or Cutting forms the notch of substantially " Π " shape on the monosymmetric outer wall, then deformable releases one or more The movement for putting the end augmenting portion of lappet inside cracking-off limitation drawing seal wire, when the power for having a proximal end be applied to it is deformable When discharging lappet, one or more deformable release lappet can be freed the outer layer table of bush Assembly by top described in Face；

Implantation material is connected to the distal tip for freeing delivery guidewire assembly by the bush Assembly of freeing, by pulling institute Internal drawing seal wire is stated, passes through the distal tip area that proximally dragline draws the increase diameter of seal wire after overcoming internal resistance Domain makes the release lappet deformation for freeing liner body, and the 3cm marker for freeing delivery guidewire assembly proximal end also can be with institute Internal drawing seal wire is stated to move to the near end.

12. a kind of blood vessel embolism spring ring system characterized by comprising

One is freed bush Assembly with what embolism spring ring was connect, wherein freeing bush Assembly includes deformable mechanical release portion Divide and one is freed delivery guidewire assembly；

The main body of deformable mechanical release part is cylindrical barrel, and is hung down including one or two deformable release Piece；

The delivery guidewire assembly of freeing includes:

One external push assembly, and,

One internal drawing seal wire, wherein the internal drawing seal wire includes the distal tip region and first of an increase diameter The developing mark of the proximal segment side of a distal tip；With

One can have with the delivery conduit freeing delivery guidewire assembly and being adapted to, the slightly proximal end of the distal tip of this conduit Two developing marks；

The distal tip region for increasing diameter is maintained at described by one or two deformable release lappets and frees In bush Assembly, deformable release lappet is arranged to the deformation when proximally drawing internal drawing seal wire, thus from the solution Bush Assembly is freed in the distal tip release of de- delivery guidewire assembly；

The release can pass through the developing mark and second developing mark of the proximal segment side of first distal tip Between relative position detect；

Further, on one or two deformable release lappets sides for being located at the cylindrical barrel outer walls or On monosymmetric outer wall, substantially " ∩ " shape is formed or in the monosymmetric outer wall by cutting on the side outer wall Upper cutting forms the notch of substantially " Π " shape, then leads one or two deformable inside cracking-off limitations of release lappet The movement for drawing the distal tip region of the increase diameter of seal wire is hung down when the power for having a proximal end is applied to deformable release When piece, one or two deformable release lappets can be by top to the outer layer table of deformable mechanical release part Face；

Implantation material is connected to the distal tip for freeing delivery guidewire assembly by the bush Assembly of freeing, by drawing Portion pulls seal wire, is made after overcoming internal resistance by the distal tip region of the increase diameter of proximally dragline drawing seal wire The deformable release lappet deformation, the 3cm marker for freeing delivery guidewire assembly proximal end also can be with the inside Drawing seal wire moves to the near end.