CN107034508B - A kind of UV auxiliary electrostatic is atomized the preparation method of formation system and coating of titanium dioxide - Google Patents
A kind of UV auxiliary electrostatic is atomized the preparation method of formation system and coating of titanium dioxide Download PDFInfo
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- CN107034508B CN107034508B CN201710176940.XA CN201710176940A CN107034508B CN 107034508 B CN107034508 B CN 107034508B CN 201710176940 A CN201710176940 A CN 201710176940A CN 107034508 B CN107034508 B CN 107034508B
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- titanium dioxide
- titanium
- titanium sheet
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 title claims abstract description 92
- 239000004408 titanium dioxide Substances 0.000 title claims abstract description 44
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000011248 coating agent Substances 0.000 title abstract description 54
- 238000000576 coating method Methods 0.000 title abstract description 54
- 239000010936 titanium Substances 0.000 claims abstract description 43
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 41
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 40
- 230000003647 oxidation Effects 0.000 claims abstract description 38
- 238000000889 atomisation Methods 0.000 claims abstract description 25
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000003792 electrolyte Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 12
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
- 230000003068 static effect Effects 0.000 claims description 10
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 8
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 claims description 7
- 229960001149 dopamine hydrochloride Drugs 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 6
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 229910052697 platinum Inorganic materials 0.000 claims description 5
- 238000005245 sintering Methods 0.000 claims description 5
- 239000004115 Sodium Silicate Substances 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 230000011218 segmentation Effects 0.000 claims description 3
- 235000019795 sodium metasilicate Nutrition 0.000 claims description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 3
- 230000003139 buffering effect Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 19
- 229910052709 silver Inorganic materials 0.000 abstract description 15
- 239000004332 silver Substances 0.000 abstract description 14
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000007540 photo-reduction reaction Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 description 23
- 239000000463 material Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 12
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002086 nanomaterial Substances 0.000 description 4
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical group [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 4
- 238000007745 plasma electrolytic oxidation reaction Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940112869 bone morphogenetic protein Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 229960003753 nitric oxide Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 238000004451 qualitative analysis Methods 0.000 description 1
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- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000001984 sorbitol MacConkey agar Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 150000003608 titanium Chemical class 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/26—Anodisation of refractory metals or alloys based thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses the preparation methods of a kind of UV auxiliary electrostatic atomization formation system and coating of titanium dioxide.The method is to combine differential arc oxidization technique and electrostatic atomization technology, basic step are as follows: the porous silica titanium coating mixed with silver nano-grain is prepared in electrolyte quota, differential arc oxidation, drying, heat treatment, electrostatic atomization, photoreduction.Research shows that the coating of titanium dioxide of silver nano-grain doping has good anti-microbial property and bioactivity.Preparation method of the present invention is simple, strong operability, low raw-material cost, and whole preparation process carries out in air atmosphere, is not necessarily to special device.
Description
Technical field
The present invention relates to bone tissue engineer coating material, in particular to a kind of UV auxiliary electrostatic atomization formation system and (people
Work articular prosthesis surface) preparation method of coating of titanium dioxide.
Background technique
In past half a century, due to biosynthesis new material continue to bring out with surgery operating technology it is continuous into
Step, applications of all kinds of new materials in surgical field of significant boosting, and with the significant growth of all kinds of artificial joint prosthesis.With
This also becomes increasingly conspicuous with complication such as the high infection rate of articular prosthesis and resulting prosthetic loosenings simultaneously.In the past
Research have confirmed, cause the mechanism infected around articular prosthesis to be, adhere to the surface of prosthese by bacterioneuston first, with
After form biomembrane.Therefore, how to inhibit bacterioneuston in the fixation of merging prosthetic surface in time, how to effectively improve prosthese week
The effective antibiotics concentration enclosed is the important topic in the current field to effectively prevent the formation of bacterial biof iotalm.Therefore,
The coating material on the artificial implant surface with bioactivity and anti-microbial property has broad application prospects.
Differential arc oxidation (micro arc oxidation, MAO) technology is retaining low-density, nothing possessed by titanium class alloy
Magnetic, the excellent mechanical property such as high-intensitive, corrosion resistance is strong, performance is stable, elasticity modulus is good and excellent biocompatibility
On the basis of, there is the nanometer scale ceramics coating of unique surface characteristic and high surface energy in surface of metal titanium preparation, and life can be mixed
The long factor (bone morphogenetic protein, transforming growth factor-β, insulin-like growth factor etc.), metallic element (silver, copper etc.) or
Nonmetalloid (nitrogen, silicon etc.) etc. forms composite ceramic coat.Coating using differential arc oxidization technique preparation has nanoscale table
Face shape characteristic and high surface area can provide additional site for the absorption of protein, to promote Facing material and cell
Interaction.High-pressure electrostatic atomization has many advantages, such as that mist droplet particle size is tiny, partial size scale is single, spatial dispersion degree is wide, extensively
It is general to be applied to the fields such as the pesticide herd forestry prevention and control of plant diseases, pest control, industry spraying and material film preparation.High-pressure electrostatic reduces liquid
Surface tension and viscosity resistance make liquid be easily broken into more tiny drop, make fog drop size distribution more evenly.Droplet lotus
After electricity, Charged Droplet is easy to happen secondary-atomizing under the action of high-voltage electrostatic field, further decreases mist droplet particle size；It charges simultaneously
Between charge under repulsion effect, disperse degree increases droplet, and can induce in object opposite with charge polarity itself
Charge, to be easier to be captured by object under the polarization force, gravitation the effects of.
The implant surface antibiotic paint studied at present include vancomycin, gentamicin, nitric oxide releasing gel,
Iodine and silver-colored (Ag) etc..In the active factors of incorporation titanium-based matter composite coating, has with metallic element and generated with matrix titanium elements
Keyness bonding keeps surface modified more lasting and has attracted much attention.Silver has used for many years as the antibacterial agent of wide spectrum, is to study most
For popular inorganic antiseptic.Document report, silver have stronger kill to gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria
Bacterium ability.In metal ion known today, anti-microbial property be only second to mercury come all inorganic metals second (mercury by
It is huge in toxicity, it is not used in antibacterial agent).Studies have shown that silver is far longer than it for eukaryocyte for prokaryotic cell toxicity
Toxicity, therefore relatively low cytotoxicity can be maintained while guaranteeing good antibacterial efficacy.However, conventional silver is antibacterial
Agent is there are silver ion rate of release is too fast, the poor disadvantage of Durability of antimicrobial effect.With the rapid development of nano materials research, people
Start sight turning to nano silver antibacterial material.The antibacterial effect of nanometer-level silver particle is 200 times of micro nanometer silver particle or more,
The release dynamics of silver ion obviously slow down.Relative to traditional silver particles, the silver particles of nanoscale due to its high-specific surface area,
Surface atom number increases and the contact probability of bacterium is significantly increased therewith.Nano silver particles have very strong chemical activity, table
Easily with other chemical groups bonding reaction occurs for the atom in face, so as to prepare the nano silver composite material of rock-steady structure.Therefore,
The silver-carrying nano particulate titanium dioxide structure coating on the artificial implant surface with bioactivity and anti-microbial property has wide
Application prospect.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of UV auxiliary electrostatic atomization formation system and two
The preparation method of titania coating.
The purpose of the present invention is what is be achieved through the following technical solutions: a kind of UV auxiliary electrostatic atomization formation system, including
Cabinet, the cabinet lower end surface opening, top surface is equipped with static nozzle；Four sides of the cabinet are horizontally installed with ultraviolet
Lamp.
A kind of preparation method of (artificial prosthesis surface) coating of titanium dioxide with biocompatibility and anti-microbial property,
The following steps are included:
1) it is mixed using anhydrous sodium metasilicate and sodium hydroxide as electrolyte (wherein, Na2SiO3Concentration be 0.5mol/L,
The concentration of NaOH is 0.05mol/L), using titanium sheet as anode, platinized platinum is cathode, and titanium sheet is in 220V, 1min；Point of 235V, 1min
Differential arc oxidation 2 minutes under section voltage；
2) titanium sheet that step 1 differential arc oxidation obtains is placed on drying in 80 DEG C of baking ovens, is taken out after dry, be put into sintering furnace heat
Processing keeps the temperature 3~4h with 5 DEG C/min heating rate to 450 DEG C.
3) step 2 treated titanium sheet immerses in Dopamine hydrochloride Tris-HCl buffer (10mM, pH=8.5), is put into
37 DEG C of constant-temperature table vibrates 24 hours under dark condition.
4) solution tank for being loaded with 0.1M silver nitrate solution is connected with static nozzle, titanium sheet is placed in cabinet, so that quiet
Electric injector face titanium sheet, opens simultaneously ultraviolet lamp in cabinet, carries out atomization reduction treatment 30 minutes to the titanium sheet of step 3 processing:
Wherein, the atomization voltage value between static nozzle and titanium sheet is 5-6kV, and the atomization flow velocity of silver nitrate solution is 6-8 μ L/min.
The beneficial effects of the present invention are:
The present invention realizes silver nano-grain in titanium dioxide by the spraying method of material surface modifying and UV auxiliary electrostatic
The uniform and stable load on titanium coating surface, so that silver nano-grain slow sustained release in body fluid, is guaranteeing prolonged resist
While bacterium performance, the biocompatibility of material ensure that, enrich bioactivity titanium dioxide nanostructure coating in bone group
Knit the application of engineering field.
Detailed description of the invention
Fig. 1 UV auxiliary electrostatic atomization molding system schematic.
The SEM photograph of Fig. 2 Examples 1 to 3 coating of titanium dioxide.
The EDS power spectrum picture of the differential arc oxidation coating of titanium dioxide for the Ag nano particles doping that Fig. 3 is prepared.
The XRD spectrum of the differential arc oxidation coating of titanium dioxide for the Ag nano particles doping that Fig. 4 is prepared.
The Ag of the differential arc oxidation coating of titanium dioxide for the Ag nano particles doping that Fig. 5 Examples 1 to 3 is prepared+Release is bent
Line chart
The antibacterial ring size photo for the Ag nano particles doping differential arc oxidation coating of titanium dioxide that Fig. 6 is prepared.
The cell compatibility MTT experiment result for the Ag nano particles doping differential arc oxidation coating of titanium dioxide that Fig. 7 is prepared.
Specific embodiment
Carry out the technical solution that the present invention will be described in detail in the following with reference to the drawings and specific embodiments, but the present invention is not limited to reality
Example is applied, those skilled in the art can be adjusted according to the actual situation.
Example 1
1) by 0.5mol/L Na2SiO3Mixed solution with 0.05mol/L NaOH is as electrolyte；
2) using the titanium sheet after cleaning as anode, platinized platinum is cathode, and titanium sheet is in 220V, 1min；The segmentation voltage of 235V, 1min
Lower differential arc oxidation 2 minutes；
3) the unformed coating of titanium dioxide material for obtaining step 2 differential arc oxidation is placed in 80 DEG C of baking ovens dry, dry
After take out, be put into sintering furnace heat treatment, with 5 DEG C/min heating rate to 450 DEG C, heat preservation 3~4h remove organic principle.
4) under dark condition, the differential arc oxidation coating of titanium dioxide material after step 3 heat treatment is immersed into 0.1M nitric acid
Silver-colored solution 4 hours.
5) by step 4 treated titanium sheet washing it is dry after, with ultraviolet light (wavelength is~250nm) irradiation 30 minutes,
Titanium plate surface obtains the titanium dioxide nanostructure coating with biocompatibility and anti-microbial property.
Shown in the differential arc oxidation coating of titanium dioxide structure such as Fig. 2 (a) for the Ag nano particles doping that embodiment 1 obtains.
Example 2
Ag nano particles load on the differential arc oxidation coating of titanium dioxide obtained in view of use 1 method of embodiment is not
It is enough uniform and stable.Therefore method is improved, the modified differential of the arc that Ag nano particles doping is prepared in surface is carried out to material
Ferric oxide/titanium dioxide coating.
1) by 0.5mol/L Na2SiO3Mixed solution with 0.05mol/L NaOH is as electrolyte；
2) using the titanium sheet after cleaning as anode, platinized platinum is cathode, and titanium sheet is in 220V, 1min；The segmentation voltage of 235V, 1min
Lower differential arc oxidation 2 minutes；
3) the unformed coating of titanium dioxide material for obtaining step 2 differential arc oxidation is placed in 80 DEG C of baking ovens dry, dry
After take out, be put into sintering furnace heat treatment, with 5 DEG C/min heating rate to 450 DEG C, heat preservation 3~4h remove organic principle.
4) step 3 treated coating of titanium dioxide immerses Dopamine hydrochloride Tris-HCl buffer (10mM, pH=8.5)
In, it is put into 37 DEG C of constant-temperature table and is vibrated 24 hours under dark condition.It takes out, washing, drying.
5) under dark condition, the differential arc oxidation coating of titanium dioxide material after step 4 heat treatment is immersed into 0.1M nitric acid
Silver-colored solution 4 hours.
6) by step 5 treated titanium sheet washing it is dry after, with ultraviolet light (wavelength is~250nm) irradiation 30 minutes,
Titanium plate surface obtains the titanium dioxide nanostructure coating with biocompatibility and anti-microbial property.
Shown in the differential arc oxidation coating of titanium dioxide structure such as Fig. 2 (b) for the Ag nano particles doping that embodiment 2 obtains.
Example 3
The Ag nano particles agglomeration on differential arc oxidation coating of titanium dioxide being prepared due to embodiment 2 is serious,
Therefore a kind of UV auxiliary electrostatic atomization formation system is used to prepare nano particle containing Ag (artificial prosthesis surface) coating of titanium dioxide,
The following steps are included:
1) it is mixed using anhydrous sodium metasilicate and sodium hydroxide as electrolyte (wherein, Na2SiO3Concentration be 0.5mol/L,
The concentration of NaOH is 0.05mol/L), using titanium sheet as anode, platinized platinum is cathode, and titanium sheet is in 220V, 1min；Point of 235V, 1min
Differential arc oxidation 2 minutes under section voltage；
2) titanium sheet that step 1 differential arc oxidation obtains is placed on drying in 80 DEG C of baking ovens, is taken out after dry, be put into sintering furnace heat
Processing, with 5 DEG C/min heating rate to 450 DEG C, 3~4h of heat preservation removes organic principle.
3) step 2 treated titanium sheet immerses in Dopamine hydrochloride Tris-HCl buffer (10mM, pH=8.5), is put into
37 DEG C of constant-temperature table vibrates 24 hours under dark condition.
4) atomization process is carried out to titanium sheet using UV auxiliary electrostatic atomization formation system, wherein UV auxiliary electrostatic atomization molding
System includes cabinet, and the cabinet lower end surface opening, top surface is equipped with static nozzle；The horizontal peace in four sides of the cabinet
Equipped with ultraviolet lamp, as shown in Figure 1.The solution tank for being loaded with 0.1M silver nitrate solution is connected with static nozzle, titanium sheet is placed in case
In vivo, so that static nozzle face titanium sheet, opens simultaneously ultraviolet lamp in cabinet, atomization reduction is carried out to the titanium sheet of step 3 processing
Processing 30 minutes: where the atomization voltage value between static nozzle and titanium sheet is 5-6kV, and the atomization flow velocity of silver nitrate solution is
6-8μL/min。
Shown in the differential arc oxidation coating of titanium dioxide structure such as Fig. 2 (c) for the Ag nano particles doping that embodiment 3 obtains.Phase
Than embodiment 1, obtained Ag nano particles more uniformly spread densification on coating of titanium dioxide, reduce the group of Argent grain
It is poly-.Compared to embodiment 2, reunion of the Ag nano particles on coating of titanium dioxide is reduced.
The differential arc oxidation coating of titanium dioxide EDS for the Ag nano particles doping that embodiment 3 is prepared is to titanium dioxide
The Elemental redistribution of the microcosmos area of coating material carries out qualitative and quantitative analysis.As shown in figure 3, in differential arc oxidation coating of titanium dioxide
Element ti, tri- kinds of elements of O, Ag have, and (a) is silver element, (b) is oxygen element, (c) is Ti element, (d) are electronic image；Table
Bright Ag element smoothly mixes differential arc oxidation coating of titanium dioxide.
X-ray diffractogram (Fig. 4) shows that the differential arc oxidation titanium dioxide for the Ag nano particles doping that embodiment 3 is prepared applies
Containing silver-colored simple substance in layer, show that Ag element is that anodic oxidation titania nanotube knot is smoothly mixed in the form of Nano silver grain
Structure coating.
The Ag of Examples 1 to 3+Releasing curve diagram is as shown in figure 5, compare example 1 (example1) and example 2
(example2), hence it is evident that it can be seen that release of embodiment 3 (example3) silver ion in PBS is more slow lasting.
Fig. 6 is that the antibacterial ring size of the differential arc oxidation coating of titanium dioxide for the Ag nano particles doping that embodiment 3 is prepared is shone
Piece.The coating of titanium dioxide that differential arc oxidation is prepared, Dopamine hydrochloride treated differential arc oxidation coating of titanium dioxide, nanometer
Differential arc oxidation coating of titanium dioxide and the pure titanium sheet of control sample after the doping of Ag particle carry out antibacterial ring size experiment.When activation
It is that sorbitol-MacConkey agar is basic (culture medium), that when bacteria is Brain Heart Infusion (BHI)
Culture medium.Steps are as follows:
(1) 1mL bacterium solution is taken to be added in 9mL BHI culture medium from -80 DEG C, shaking table shakes 20h activation；
(2) being rule of thumb gradually diluted to concentration is 10^9,10^8,10^7,10^6,10^5,10^4, takes 10^5 concentration bacterium
Ti piece is gently attached to media surface by 100 μ L of liquid, even spread to planar surface；
(3) 37 DEG C of constant incubator culture observations.
Antibacterial ring size experiment can whether there is or not the analyses of bacteriostasis property to the coating of titanium dioxide progress after Ag nano particles doping.Such as
Shown in Fig. 6, there is antibacterial ring size (d) in the differential arc oxidation coating of titanium dioxide sample periphery for having Ag nano particles to adulterate, and control group is pure
Titanium sheet (a), the differential arc oxidation coating of titanium dioxide sample (b) without Ag nano particles doping, Dopamine hydrochloride treated the differential of the arc
There is not antibacterial ring size in ferric oxide/titanium dioxide coating sample (c) periphery.Experiment shows Ag nano particles doping prepared by embodiment 3
Differential arc oxidation coating of titanium dioxide have anti-microbial property.
Fig. 7 is the cytocompatibility of the differential arc oxidation coating of titanium dioxide for the Ag nano particles doping that embodiment 3 is prepared
Property MTT experiment result.Specific step is as follows: (1) taking MG-63 cell, cell suspension is prepared in digestion and degree of thickening is 4x 104/
ml.(2) Ti, MAO, MAO/PD, MAO/PD/Ag sample are placed in 24 orifice plates, above-mentioned concentrations of cells suspension 1ml is added simultaneously in every hole
It blows even.(3) culture termination in 24 hours is cultivated and is cleaned 3 times using PBS in incubator, and 200 μ l MTT liquid (5mg/ are added in every hole
Ml) and 800 μ l continue to cultivate 4h without phenol red DMEM culture solution.(4) the micro concussion dissolution institute's shape of 1ml DMSO room temperature is added in every hole
(being protected from light operation) is crystallized at formazan, every hole takes 200 μ l mixed liquors to be added in 96 orifice plates, and microplate reader is used under 490nm wavelength
Measurement OD value simultaneously sets zeroing hole.It can thus be seen that the differential arc oxidation titanium dioxide for the Ag nano particles doping that embodiment 3 is prepared
Titanium coating is while with relatively stable anti-microbial property, it may have preferable biocompatibility.
Claims (1)
1. a kind of using the atomization formation system preparation of UV auxiliary electrostatic there is the titanium dioxide of biocompatibility and anti-microbial property to apply
The method of layer, the UV auxiliary electrostatic atomization formation system includes cabinet, and the cabinet lower end surface opening, top surface is equipped with electrostatic
Spray head；Four sides of the cabinet are horizontally installed with ultraviolet lamp, which comprises the following steps:
1) it is mixed using anhydrous sodium metasilicate and sodium hydroxide as electrolyte, wherein Na2SiO3Concentration be 0.5mol/L, NaOH
Concentration be 0.05mol/L, using titanium sheet as anode, platinized platinum is cathode, and titanium sheet is in 220V, 1min；The segmentation voltage of 235V, 1min
Lower differential arc oxidation 2 minutes；
2) titanium sheet that step 1 differential arc oxidation obtains is placed on drying in 80 DEG C of baking ovens, is taken out after dry, is put into sintering furnace treatment
Reason keeps the temperature 3 ~ 4h with 5 DEG C/min heating rate to 450 DEG C；
3) step 2 treated titanium sheet immerses in Dopamine hydrochloride Tris-HCl buffer, Dopamine hydrochloride Tris-HCl buffering
Liquid concentration is 10mM, and pH=8.5 are put into 37 DEG C of constant-temperature table and vibrate 24 hours under dark condition；
4) solution tank for being loaded with 0.1M silver nitrate solution is connected with the static nozzle of UV auxiliary electrostatic atomization formation system, by titanium
Piece is placed in the cabinet of UV auxiliary electrostatic atomization formation system, so that static nozzle face titanium sheet, opens simultaneously ultraviolet in cabinet
Lamp carries out atomization reduction treatment 30 minutes to the titanium sheet of step 3 processing: where the atomization voltage between static nozzle and titanium sheet
Value is 5-6kV, and the atomization flow velocity of silver nitrate solution is 6-8 μ L/min.
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