CN107028889A - One kind meets water unstable material separation preparation and preparation method thereof - Google Patents

One kind meets water unstable material separation preparation and preparation method thereof Download PDF

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Publication number
CN107028889A
CN107028889A CN201710259310.9A CN201710259310A CN107028889A CN 107028889 A CN107028889 A CN 107028889A CN 201710259310 A CN201710259310 A CN 201710259310A CN 107028889 A CN107028889 A CN 107028889A
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CN
China
Prior art keywords
preparation
sterile
solid
separation
irrigator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710259310.9A
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Chinese (zh)
Inventor
吴广印
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710259310.9A priority Critical patent/CN107028889A/en
Publication of CN107028889A publication Critical patent/CN107028889A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Abstract

Water unstable material separation preparation and preparation method thereof is met the invention discloses one kind, is comprised the steps of：In A, in an aseptic environment, the canned separation of solid and liquid eye drop bottle to cleaning sterile of sterile isotonic solution by sterilizing, after aseptic filtration, sealed with plastic internal stopper, install antitheft enclosing cover additional；B, sterile solid raw material quantitative filled into aseptically filling device；C, before use, by irrigator syringe needle insertion solid separation eye drop bottle rear end bottom；D, irrigator piston is twitched, make sterile isotonic solution all in suction aseptically filling devices, it is repeated multiple times to be contacted with sterile solid raw material, to raw material is complete, uniform dissolution.The present invention is prepared into chance water unstable material by using sterile Indomethacin instant powder 40mg, polyethylene glycol 400 3.392ml, sodium hydrogensulfite 7.3mg, boric acid 176.7mg, borax 55mg, water for injection 8ml and separates preparation jointly, its is simple for production, and production efficiency is high.

Description

One kind meets water unstable material separation preparation and preparation method thereof
Technical field
Water unstable material separation preparation and preparation method thereof is met the present invention relates to one kind.
Background technology
Prior art has certain defect for meeting the liquid preparation long-time storage of water unstable material.Therefore, research and development are needed A kind of solid and liquid separation preparation, it is ensured that stability of its liquid preparation within the effect phase.
The content of the invention
It is above-mentioned to improve it is an object of the invention to solve a kind of chance water unstable material separation preparation and preparation method thereof The problem of being proposed in background technology.
To achieve the above object, technical scheme is as follows：
One kind chance water unstable material separation preparation, including sterile Indomethacin instant powder-40mg, polyethylene glycol 400- 3.392ml, sodium hydrogensulfite -7.3mg, boric acid -176.7mg, borax -55mg, water for injection -8ml.
It is a kind of to meet the preparation method that water unstable material separates preparation, comprise the steps of：
A, in an aseptic environment, the sterile isotonic solution canned solid-liquid to cleaning sterile point by sterilizing, after aseptic filtration From in eye drop bottle, sealed with plastic internal stopper, install antitheft enclosing cover additional；
B, sterile solid raw material quantitative filled into aseptically filling device；
C, before use, by irrigator syringe needle insertion solid separation eye drop bottle rear end bottom；
D, twitch irrigator piston, make sterile isotonic solution all suction aseptically filling devices in, it is repeated multiple times with it is sterile solid Body raw material contact, to raw material completely, uniform dissolution；
E, promotion irrigator piston, make well mixed eye drops be completely forced into eye drop bottle.
It is used as further scheme of the invention：The step A and B realizes operation using bottle placer.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention by using sterile Indomethacin instant powder- 40mg, polyethylene glycol 400-3.392ml, sodium hydrogensulfite-7.3mg, boric acid-176.7mg, borax-55mg, water for injection-8ml Chance water unstable material separation preparation is prepared into jointly, and its is simple for production, and production efficiency is high.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation Example only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected Enclose.
In the embodiment of the present invention, one kind chance water unstable material separation preparation, including sterile Indomethacin instant powder- 40mg, polyethylene glycol 400-3.392ml, sodium hydrogensulfite-7.3mg, boric acid-176.7mg, borax-55mg, water for injection- 8ml。
It is a kind of to meet the preparation method that water unstable material separates preparation, comprise the steps of：
A, in an aseptic environment, the sterile isotonic solution canned solid-liquid to cleaning sterile point by sterilizing, after aseptic filtration From in eye drop bottle, sealed with plastic internal stopper, install antitheft enclosing cover additional；
B, sterile solid raw material quantitative filled into aseptically filling device；
C, before use, by irrigator syringe needle insertion solid separation eye drop bottle rear end bottom；
D, twitch irrigator piston, make sterile isotonic solution all suck in aseptically filling device, are connect with sterile solid raw material Touch, it is repeated multiple times to raw material completely, uniform dissolution；
E, promotion irrigator piston, make well mixed eye drops be completely forced into eye drop bottle.
Step A and B realize operation using bottle placer.
The present invention operation principle be：In an aseptic environment, it is the sterile isotonic solution after sterilizing, aseptic filtration is canned extremely In the separation of solid and liquid eye drop bottle of cleaning sterile, sealed with plastic internal stopper, install antitheft enclosing cover additional；Sterile solid raw material is used into filling Installation is quantitatively filled into aseptically filling device；Before use, by irrigator syringe needle insertion solid separation eye drop bottle rear end bottom；Take out Dynamic irrigator piston, makes sterile isotonic solution all suck in aseptically filling device, repeated multiple times to be contacted with sterile solid raw material, extremely Raw material is complete, uniform dissolution；Irrigator piston is promoted, well mixed eye drops is completely forced into eye drop bottle.
The present invention by using sterile Indomethacin instant powder-40mg, polyethylene glycol 400-3.392ml, sodium hydrogensulfite- 7.3mg, boric acid -176.7mg, borax -55mg, water for injection -8ml are prepared into chance water unstable material separation preparation jointly, its Simple for production, production efficiency is high.

Claims (3)

1. one kind meets water unstable material separation preparation, it is characterised in that including sterile Indomethacin instant powder -40mg, poly- second Glycol 400-3.392ml, sodium hydrogensulfite -7.3mg, boric acid -176.7mg, borax -55mg, water for injection -8ml.
2. a kind of meet the preparation method that water unstable material separates preparation, it is characterised in that comprises the steps of：
A, in an aseptic environment, the canned separation of solid and liquid to cleaning sterile of sterile isotonic solution by sterilizing, after aseptic filtration is dripped In eye agent bottle, sealed with plastic internal stopper, install antitheft enclosing cover additional；
B, sterile solid raw material quantitative filled into aseptically filling device；
C, before use, by irrigator syringe needle insertion solid separation eye drop bottle rear end bottom；
D, twitch irrigator piston, make sterile isotonic solution all suck in aseptically filling device, repeated multiple times former with sterile solid Material contact, to raw material completely, uniform dissolution；
E, promotion irrigator piston, make well mixed eye drops be completely forced into eye drop bottle.
3. a kind of water unstable material of meeting according to claim 1 separates preparation and preparation method thereof, it is characterised in that institute State step A and B and operation is realized using bottle placer.
CN201710259310.9A 2017-04-20 2017-04-20 One kind meets water unstable material separation preparation and preparation method thereof Pending CN107028889A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710259310.9A CN107028889A (en) 2017-04-20 2017-04-20 One kind meets water unstable material separation preparation and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710259310.9A CN107028889A (en) 2017-04-20 2017-04-20 One kind meets water unstable material separation preparation and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107028889A true CN107028889A (en) 2017-08-11

Family

ID=59536605

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710259310.9A Pending CN107028889A (en) 2017-04-20 2017-04-20 One kind meets water unstable material separation preparation and preparation method thereof

Country Status (1)

Country Link
CN (1) CN107028889A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1517089A (en) * 2003-01-15 2004-08-04 珊 赵 Indometacin eyedrops
CN1775206A (en) * 2005-11-21 2006-05-24 武汉五景药业有限公司 Phacolysin eye medicinal formulation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1517089A (en) * 2003-01-15 2004-08-04 珊 赵 Indometacin eyedrops
CN1775206A (en) * 2005-11-21 2006-05-24 武汉五景药业有限公司 Phacolysin eye medicinal formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
空军医学科委会药学专业委员会: "《空军第五届药学专业学术会议论文集》", 31 October 1993 *

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Application publication date: 20170811

RJ01 Rejection of invention patent application after publication