CN107028877A - A kind of long-acting veterinary analgin injection and preparation method thereof - Google Patents
A kind of long-acting veterinary analgin injection and preparation method thereof Download PDFInfo
- Publication number
- CN107028877A CN107028877A CN201710270968.XA CN201710270968A CN107028877A CN 107028877 A CN107028877 A CN 107028877A CN 201710270968 A CN201710270968 A CN 201710270968A CN 107028877 A CN107028877 A CN 107028877A
- Authority
- CN
- China
- Prior art keywords
- injection
- analgin
- long
- minutes
- fresh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of long-acting veterinary analgin injection and preparation method thereof, belongs to technical field of veterinary.Contain in per 1000L parenteral solutions：200~400kg of injection stage analgin, 50~150kg of PVP K30,1~5kg of sodium hydrogensulfite, 50~150kg of propane diols, surplus are the water for injection of Fresh.The present invention prepares the effective peak concentration of drug retention time of long-acting veterinary analgin injection and extends one times with national standard analgin injection, make to bring down a fever drug effect extension, persistently, reduce times for spraying and to sick pig artificially stress, recover beneficial to sick pig, steady quality, it is not oxidizable.Meanwhile, this product selects specific auxiliary material, sustained release agent and production technology by vein with parenteral solution requirement, and the analgin injection of preparation can be used for being injected intravenously, and be worked well with cephalosporin analog antibiotic drug combination treatment sow hyperpyrexia.
Description
Technical field
The invention belongs to technical field of veterinary, and in particular to a kind of long-acting veterinary analgin injection and its preparation side
Method.
Background technology
Heating is that the common disease of swine disease, pig are usually associated with loss of appetite once generating heat, and spirit is depressed, and simple oral is given
Medicine can not reach ideal effect in time, then easily cause scabies secondary infection so that aggravation.Therefore, clinically generally using note
Penetrate administering mode and first solve exterior syndrome, and it is preferred to bring down a fever.
Analgin is one of the most frequently used ntipyretic analgesic medicine of animal, and it is the chemical combination that aminopyrine and sodium sulfite are combined
Thing, soluble in water, antipyretic, analgesic activity is fast and strong compared with aminopyrine.Analgin injection, cheap, administration takes effect rapidly,
But efficacy time is short, t1/2About 1~4 hour.The heating paresthesia duration length that occurs in current swine disease and repeatedly high thermal phenomenon ratio
More prominent, clinically being brought down a fever using analgin injection, effect is not lasting enough, and body temperature easily rebounds after injection, and injection on the one is secondary then
Time-consuming, effort, and increase sick pig stress.Meanwhile, analgin injection easy oxidation discoloration, many plants can not accomplish to hide
Light, less than 30 DEG C preservations, the analgin injection oxidation stain phenomenon of Clinical practice often occur.
The content of the invention
The problem of existing for prior art, it is an object of the invention to design to provide a kind of long-acting veterinary analgin injection
The technical scheme of liquid and preparation method thereof.
Described a kind of long-acting veterinary analgin injection, it is characterised in that contain in per 1000L parenteral solutions：Injection stage is pacified
It is nearly 200~400kg, 50~150kg of PVP-K30,1~5kg of sodium hydrogensulfite, 50~150kg of propane diols, surplus is fresh
The water for injection of preparation.
Described a kind of long-acting veterinary analgin injection, it is characterised in that contain in per 1000L parenteral solutions：Injection stage is pacified
It is nearly 250~350kg, 80~120kg of PVP-K30,2~4kg of sodium hydrogensulfite, 80~120kg of propane diols, surplus is fresh
The water for injection of preparation.
The preparation method of described a kind of long-acting veterinary analgin injection, it is characterised in that comprise the following steps that：
1）The water for injection of the Fresh of total amount 40% is added in 100000 grades of area's dense preparing tanks, nitrogen is rushed 15 minutes, control water temperature is 50
~55 DEG C, sodium hydrogensulfite, the injection stage analgin of recipe quantity are added immediately, are stirred 5 minutes, are made dissolving, add recipe quantity
PVP-K30, stirs 5 minutes, makes dissolving, then adds recipe quantity propane diols, stirs 3 minutes；
2）The water for injection of the Fresh of total amount 40% is added in ten thousand grades of area's dilute preparing tanks, nitrogen is rushed 15 minutes；
3）Decoction in dense preparing tank is filtered to ten thousand grades of area's dilute preparing tanks by millipore filter, then adds the injection of Fresh
Water is stirred 10 minutes to full dose；
4）Exported by dilute preparing tank after millipore filter filtering, repressurization ultrafiltration is poured into ampoule bottle to ten thousand grades of area's bottling departments,
Rush N2Since sealing, must not exceed 6 hours preparing to the filling end time；
5）115 DEG C of flowing steam sterilizations, are incubated 30 minutes, must not exceed 8 hours to the sterilizing end time since preparing.
A kind of preparation method of described long-acting veterinary analgin injection, it is characterised in that the step 3）With 4）In it is micro-
Hole filter filter condition is 0.45um.
A kind of preparation method of described long-acting veterinary analgin injection, it is characterised in that the step 4）Ultra-filtration conditions
For 0.22um.
The present invention prepares the effective peak concentration of drug retention time of long-acting veterinary analgin injection and national standard analgin injection
Extend one times, the drug effect extension that makes to bring down a fever, persistently, reduce times for spraying and to sick pig artificially stress, recover beneficial to sick pig, matter
Amount is stable, not oxidizable.Meanwhile, this product selects specific auxiliary material, sustained release agent and production technology by vein with parenteral solution requirement,
The analgin injection of preparation can be used for being injected intravenously, and be worked well with cephalosporin analog antibiotic drug combination treatment sow hyperpyrexia.
The invention has the advantages that：
（1）A kind of long-acting veterinary analgin injection prepared by the present invention is increased by adding hydrophilic high molecular material PVP-K30
Long solution viscosity, reduces drug diffusion rate, makes analgin extended durations of action, times for spraying is once a day, you can.
（2）Analgin injection is shown in light easy oxidation discoloration, and addition antioxidant, specification storage can reduce oxidation and become in a short time
Color, but be long placed in rear oxidation discoloration and take place frequently, particularly numerous and diverse changeable using link livestock and poultry farm storage requirement, oxidation becomes
Pornographic condition becomes apparent from；Preferably propane diols of the invention is remarkably improved the stability of analgin injection as stabilizer.
（3）The long-acting analgin injection of a kind of veterinary drug prepared by the present invention is used to dilute cephalosporin analog antibiotic, for being pregnant
Sow drip-feed, effect of bringing down a fever is fast and lasting, hence it is evident that shorten treatment course.
Embodiment
In order that the present invention is easier to understand, with reference to specific embodiment, the present invention is expanded on further.It should be understood that
These embodiments are only illustrative of the invention and is not intended to limit the scope of the invention.
Embodiment 1
A kind of long-acting analgin injection of veterinary drug, contains per 1000L：Analgin（Injection stage）200kg, PVP-K30 50kg, Asia
Niter cake 1kg, propane diols 50kg, surplus are the water for injection of Fresh.
A kind of preparing process of the long-acting analgin injection of veterinary drug, its preparation method：
（1）The water for injection of the Fresh of total amount 40% is added in 100000 grades of area's dense preparing tanks, nitrogen is rushed 15 minutes, control water temperature exists
50-55 DEG C, sodium hydrogensulfite 1kg, analgin are added immediately（Injection stage）200kg, stirs 5 minutes, makes dissolving；Add PVP-
K30 50kg, stir 5 minutes, make dissolving；Propane diols 50kg is added, is stirred 3 minutes；
（2）The water for injection of the Fresh of total amount 40% is added in ten thousand grades of area's dilute preparing tanks, nitrogen is rushed 15 minutes；
（3）Decoction in dense preparing tank is passed through into millipore filter（0.45um）Filter to ten thousand grades of area's dilute preparing tanks；Plus Fresh
Water for injection is stirred 10 minutes to 1000L；
（4）Millipore filter is exported by dilute preparing tank（0.45um）After filtering, repressurization ultrafiltration（0.22um）It is filling to ten thousand grades of areas
Between, it is poured into ampoule bottle, rushes N2 sealings, must not exceed 6 hours to the filling end time since preparing；
（5）115 DEG C of flowing steam sterilizations, are incubated 30 minutes, must not exceed 8 hours to the sterilizing end time since preparing.
Embodiment 2
A kind of long-acting analgin injection of veterinary drug, contains per 1000ml：Analgin（Injection stage）300kg、PVP-K30 100kg、
Sodium hydrogensulfite 2kg, propane diols 100kg, surplus are the water for injection of Fresh.
A kind of preparing process of the long-acting analgin injection of veterinary drug, its preparation method：
（1）The water for injection of the Fresh of total amount 40% is added in 100000 grades of area's dense preparing tanks, nitrogen is rushed 15 minutes, control water temperature exists
50-55 DEG C, sodium hydrogensulfite 2kg, analgin are added immediately（Injection stage）300kg, stirs 5 minutes, makes dissolving；Add PVP-
K30 100kg, stir 5 minutes, make dissolving；Propane diols 100kg is added, is stirred 3 minutes；
（2）The water for injection of the Fresh of total amount 40% is added in ten thousand grades of area's dilute preparing tanks, nitrogen is rushed 15 minutes；
（3）Decoction in dense preparing tank is passed through into millipore filter（0.45um）Filter to ten thousand grades of area's dilute preparing tanks；Plus Fresh
Water for injection is stirred 10 minutes to 1000L；
（4）Millipore filter is exported by dilute preparing tank（0.45um）After filtering, repressurization ultrafiltration（0.22um）It is filling to ten thousand grades of areas
Between, it is poured into ampoule bottle, rushes N2 sealings, must not exceed 6 hours to the filling end time since preparing；
（5）115 DEG C of flowing steam sterilizations, are incubated 30 minutes, must not exceed 8 hours to the sterilizing end time since preparing.
Embodiment 3
A kind of long-acting veterinary analgin injection, contains per 1000L：Analgin（Injection stage）400kg, PVP-K30 150kg, Asia
Niter cake 5kg, propane diols 150kg, surplus are the water for injection of Fresh.
A kind of preparing process of the long-acting analgin injection of veterinary drug, its preparation method：
（1）The water for injection of the Fresh of total amount 40% is added in 100000 grades of area's dense preparing tanks, nitrogen is rushed 15 minutes, control water temperature exists
50-55 DEG C, sodium hydrogensulfite 5kg, analgin are added immediately（Injection stage）400kg, stirs 5 minutes, makes dissolving；Add PVP-
K30 150kg, stir 5 minutes, make dissolving；Propane diols 150kg is added, is stirred 3 minutes；
（2）The water for injection of the Fresh of total amount 40% is added in ten thousand grades of area's dilute preparing tanks, nitrogen is rushed 15 minutes；
（3）Decoction in dense preparing tank is passed through into millipore filter（0.45um）Filter to ten thousand grades of area's dilute preparing tanks；Plus Fresh
Water for injection is stirred 10 minutes to 1000L；
（4）Millipore filter is exported by dilute preparing tank（0.45um）After filtering, repressurization ultrafiltration（0.22um）It is filling to ten thousand grades of areas
Between, it is poured into ampoule bottle, rushes N2 sealings, must not exceed 6 hours to the filling end time since preparing；
（5）115 DEG C of flowing steam sterilizations, are incubated 30 minutes, must not exceed 8 hours to the sterilizing end time since preparing.
Embodiment 4：Long-acting veterinary analgin injection stability test prepared by the present invention
（1）Accelerated test
The long-acting veterinary analgin injection three batches prepared by invention is taken to be packed by listing, in temperature (40 ± 2) DEG C, relative humidity
Place six months, monthly sampled once under conditions of (75 ± 5) %, it is as a result as follows：
Accelerated test observes result experimental condition：Temperature (40 ± 2) DEG C, relative humidity (75 ± 5) %
（2）Long term test
Three batches are taken by the long-acting veterinary analgin injection for preparing of the present invention to be packed by listing, in temperature (25 ± 2) DEG C, relatively wet
Placed 24 months under conditions of degree (60 ± 5) %.Sampling in every 3 months first 12 months once, after 12 months respectively at 18,24 months
Sampling, carries out relevant item investigation, as a result as follows：
Long term test observes result experimental condition：Temperature (25 ± 2) DEG C, relative humidity (60 ± 5) %
Conclusion：Accelerated experiment, long-term test results show that analgin injection for animals prepared by the present invention is packed by listing
In (40 ± 2) DEG C storage 6 months, room temperature storage 24 months, no discoloration oxidative phenomena, steady quality, antioxygenic property is protruded.
Embodiment 5：Antipyretic effect clinical trial
We have done clinical trial in December, 2016 to the growing and fattening pigs of Jinhua Wuyi 300 sow fever to 40-41 degree,
The random growing and fattening pigs for picking 30 hairs burning, are divided into 3 groups, every group 12, the analgin injection that national standard is injected is pressed in one group of injection,
The Synergetic compound analgin injection that publication number CN103083338A is prepared, the long-acting peace of one group of injection present invention are pressed in one group of injection
It is nearly parenteral solution（Embodiment 2）.Three groups of parenteral solution Determination of Analgin are uniformly 30%, use, have injected according to Products Show consumption
After 1 hour, 3 hours, 6 hours, 9 hours, 12 hours, 24 hours measurement body temperature in 38-39.5 degree（Pig normal body temperature）Pig
Head number.
Fever pig has injected the normal head number of temperature recovery after different medicines
As seen from the above table, injection national standard analgin injection after 1 hour most of swinery bring down a fever, but duration of efficacy is short, note
Penetrating latter 3-6 hours just has pig to have a fever again；The Synergetic compound analgin injection 1 that injection is prepared by publication number CN103083338A
After hour, all growing and fattening pigs are all brought down a fever, and effect of bringing down a fever is good but imitates and holds time short, just has pig to have a fever again within 6 hours or so；Note
The long-acting analgin injection of the present invention is shot away after 1 hour, all growing and fattening pigs are all brought down a fever, and drug effect is maintained 12-24 hours；
Illustrate that long-acting analgin injection duration of efficacy prepared by the present invention is longer, with significant long-acting.
Embodiment 6：Farrowing sow clinical trial is treated in drip-feed
We are in January, 2017 to 800, Jinhua Lanxi sow, and postpartum fever has done curative effect to more than 39.5 degree of sow
Experiment, the sow of 10 postpartum fevers is picked in delivery room at random, is divided into 2 groups, every group 5, control group intravenous injection A Moxi
Lin Fenzhen；Test group also takes intravenous injection, but uses the long-acting analgin dilution amoxicillin powder injection of the present invention, according to
Recommend consumption to use, injected and existed after 0.5 hour, 1 hour, 2 hours, 6 hours, 12 hours, 18 hours, 24 measurement body temperature
38-39.5 degree（Pig normal body temperature）The head number of pig.
Fever sow has injected the normal head number of temperature recovery after different medicines
As seen from the above table, after being injected intravenously 0.5 hour using the long-acting analgin dilution Amoxicillin of the present invention, most of sow
Bring down a fever, all brought down a fever after 1 hour, and drug effect is maintained more than 18 hours；And amoxicillin powder injection is injected intravenously, after half an hour only
There is 1 sow to bring down a fever, only have 2 sows to bring down a fever after 1 hour, and drug effect is only maintained 12 hours or so, is illustrated using the present invention
Long-acting analgin dilution amoxicillin powder injection intravenous injection brings down a fever effect more preferably than simple intravenous injection amoxicillin powder injection, drug effect
Hold time longer, more conducively disease recovery.
Claims (5)
1. a kind of long-acting veterinary analgin injection, it is characterised in that contain in per 1000L parenteral solutions：Injection stage analgin 200
~400kg, 50~150kg of PVP-K30,1~5kg of sodium hydrogensulfite, 50~150kg of propane diols, surplus are the note of Fresh
Penetrate and use water.
2. a kind of long-acting veterinary analgin injection as claimed in claim 1, it is characterised in that contain in per 1000L parenteral solutions
Have：250~350kg of injection stage analgin, 80~120kg of PVP-K30,2~4kg of sodium hydrogensulfite, 80~120kg of propane diols,
Surplus is the water for injection of Fresh.
3. a kind of preparation method of long-acting veterinary analgin injection as claimed in claim 1 or 2, it is characterised in that including with
Lower processing step：
1）The water for injection of the Fresh of total amount 40% is added in 100000 grades of area's dense preparing tanks, nitrogen is rushed 15 minutes, control water temperature is 50
~55 DEG C, sodium hydrogensulfite, the injection stage analgin of recipe quantity are added immediately, are stirred 5 minutes, are made dissolving, add recipe quantity
PVP-K30, stirs 5 minutes, makes dissolving, then adds recipe quantity propane diols, stirs 3 minutes；
2）The water for injection of the Fresh of total amount 40% is added in ten thousand grades of area's dilute preparing tanks, nitrogen is rushed 15 minutes；
3）Decoction in dense preparing tank is filtered to ten thousand grades of area's dilute preparing tanks by millipore filter, then adds the injection of Fresh
Water is stirred 10 minutes to full dose；
4）Exported by dilute preparing tank after millipore filter filtering, repressurization ultrafiltration is poured into ampoule bottle to ten thousand grades of area's bottling departments,
Rush N2Since sealing, must not exceed 6 hours preparing to the filling end time；
5）115 DEG C of flowing steam sterilizations, are incubated 30 minutes, must not exceed 8 hours to the sterilizing end time since preparing.
4. a kind of preparation method of long-acting veterinary analgin injection as claimed in claim 3, it is characterised in that the step
3）With 4）Middle millipore filter filter condition is 0.45um.
5. a kind of preparation method of long-acting veterinary analgin injection as claimed in claim 3, it is characterised in that the step
4）Ultra-filtration conditions are 0.22um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710270968.XA CN107028877B (en) | 2017-04-24 | 2017-04-24 | Veterinary long-acting analgin injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710270968.XA CN107028877B (en) | 2017-04-24 | 2017-04-24 | Veterinary long-acting analgin injection and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107028877A true CN107028877A (en) | 2017-08-11 |
| CN107028877B CN107028877B (en) | 2020-10-27 |
Family
ID=59536728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710270968.XA Active CN107028877B (en) | 2017-04-24 | 2017-04-24 | Veterinary long-acting analgin injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107028877B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010266A (en) * | 2018-09-10 | 2018-12-18 | 贵州天地药业有限责任公司 | A kind of preparation method of analgin injection |
| CN113694089A (en) * | 2021-08-23 | 2021-11-26 | 陈启才 | Medicinal preparation applied to prevention and treatment of white scour of piglets |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103292A (en) * | 1994-06-14 | 1995-06-07 | 沈阳药科大学 | Analgin nasal drops |
| CN101467997A (en) * | 2007-12-26 | 2009-07-01 | 北京大北农动物保健科技有限责任公司 | Compound medicament composition for animals and uses thereof |
| CN103083229A (en) * | 2012-04-23 | 2013-05-08 | 重庆金邦动物药业有限公司 | Preparation method of compound analgin injection for livestock |
-
2017
- 2017-04-24 CN CN201710270968.XA patent/CN107028877B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103292A (en) * | 1994-06-14 | 1995-06-07 | 沈阳药科大学 | Analgin nasal drops |
| CN101467997A (en) * | 2007-12-26 | 2009-07-01 | 北京大北农动物保健科技有限责任公司 | Compound medicament composition for animals and uses thereof |
| CN103083229A (en) * | 2012-04-23 | 2013-05-08 | 重庆金邦动物药业有限公司 | Preparation method of compound analgin injection for livestock |
Non-Patent Citations (4)
| Title |
|---|
| 张中举，等: "如何克服安乃近注射液的变色现象", 《河南畜牧医药》 * |
| 李捷玮，等: "《常用药物辅料手册》", 30 June 2000, 上海：第二军医大学出版社 * |
| 樊点连: "安乃近注射液处方改进及稳定性研究", 《中国医药指南》 * |
| 汤光，等: "《药物制剂化学》", 31 October 1981, 北京：人民卫生出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010266A (en) * | 2018-09-10 | 2018-12-18 | 贵州天地药业有限责任公司 | A kind of preparation method of analgin injection |
| CN113694089A (en) * | 2021-08-23 | 2021-11-26 | 陈启才 | Medicinal preparation applied to prevention and treatment of white scour of piglets |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107028877B (en) | 2020-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102697730A (en) | Florfenicol soluble power and preparation method thereof | |
| CN102772360B (en) | Doxycycline hydrochloride injection for animals and preparation method for doxycycline hydrochloride injection | |
| CN104473876A (en) | Tilmicosin soluble powder and preparation method thereof | |
| CN107028877A (en) | A kind of long-acting veterinary analgin injection and preparation method thereof | |
| CN105267142A (en) | Enrofloxacin injection and preparation method thereof | |
| CN104800167A (en) | Florfenicol soluble powder and preparation method thereof | |
| CN102920655A (en) | Florfenicol suspension injection and preparation procedure thereof | |
| CN101496811A (en) | Soluble and stable tilmicosin composition | |
| CN110302141A (en) | Diclofenac sodium injection situ-gel and preparation method thereof | |
| CN103622987B (en) | A kind of long-acting veterinary compound lincomycin hydrochloride injection and preparation method thereof | |
| CN105147598B (en) | A kind of veterinary ciprofloxacin lactate injection and preparation method thereof | |
| CN104586777B (en) | Ceftiofur Hydrochloride powder-injection and preparation method and application | |
| CN103211818B (en) | Pharmaceutical composition for treating or preventing bacterial and mycoplasma diseases of livestock and use thereof | |
| CN109431983A (en) | A kind of compound ivermectin injection and preparation method thereof | |
| US20150351428A1 (en) | Methods and compositions for orally dosing postnatal swine | |
| CN102755337B (en) | Compound florfenicol injection and preparation method thereof | |
| CN105902499B (en) | Enrofloxacin soluble powder and preparation method thereof | |
| CN102440952A (en) | Iron-dextrin long-acting injection and preparation method thereof | |
| CN107348147A (en) | Fragrant duck feed addictive | |
| CN102697725A (en) | Veterinary ciprofloxacin lactate injection and preparation method thereof | |
| CN106539754A (en) | Hydrobromic acid antifebrile dichroanone solution and preparation method thereof | |
| CN113476457A (en) | Composition of veterinary altrenogest, veterinary altrenogest soft capsule, preparation method and application thereof | |
| JPS6383022A (en) | Vetrinary remedy | |
| CN101347406A (en) | Injection with high-content praziquantel and method of preparing the same | |
| CN104288152A (en) | Compound berberine sulfate injection for veterinary use and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |