CN107028193A - It is a kind of to be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia - Google Patents

It is a kind of to be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia Download PDF

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CN107028193A
CN107028193A CN201610074495.1A CN201610074495A CN107028193A CN 107028193 A CN107028193 A CN 107028193A CN 201610074495 A CN201610074495 A CN 201610074495A CN 107028193 A CN107028193 A CN 107028193A
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food
protein
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senile dementia
amino acid
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张卡卡
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/44—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
    • A23G9/38—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

It is used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia the present invention relates to a kind of, is divided into two types by its chemical composition.First type：The food includes at least one of lysine, threonine, tyrosine, asparagine, histidine, glutamine, arginine and serine.Second of type：The food includes at least one of dipeptides, tripeptides, oligopeptides, peptide and protein, and the gross mass of the wherein amino acid residue of lysine, threonine, tyrosine, asparagine, histidine, glutamine, arginine and serine accounts for more than 30% of the gross mass of all amino acid residues in dipeptides, tripeptides, oligopeptides, peptide and protein.Dipeptides, tripeptides, oligopeptides, peptide and protein in the food of second of type turn into amino acid after human consumption, similar with the chemical composition of the food of the first type through postdigestive chemical composition.

Description

It is a kind of to be used to reduce the protein misfolding disease occurrence risk such as senile dementia Food
Technical field
It is used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia the present invention relates to a kind of.
Background technology
Medically, protein misfolding disease（protein misfolding diseases）, refer to a class due to Some protein structures occur extremely and disease caused by false folding in vivo, and the false folding of protein causes it to lose normally Function, the protein of false folding produces cytotoxicity, upsets the function of body.Protein misfolding disease also known as albumen Matter conformational diseases（Proteopathy or protein conformational disorders）.Protein misfolding disease It is related to the various disease conditions such as dementia and type II diabetes.Dementia includes stages alzheimer's disease（It is commonly called as senile dementia）, vascular type Dementia, Lewy body type dementia, volume temporal lobe type dementia, Parkinson's disease etc..
Protein misfolding disease threatens human health and happiness.By taking dementia as an example, according to the World Health Organization 2015 Year statistics, global Dementia patients' number be 47,500,000, wherein more than half（58%）Live in low income and medium receipts Enter country, annual new cases are 7,700,000.It is estimated that just there is 5 to 8 dementias trouble in every 100 60 years old and above population Person.Stages alzheimer's disease is that senile dementia is the most common cause of disease of dementia, may cause 60-70% dementia.Senile dementia The morbidity of disease has very strong age characteristics.The ratio for suffering from senile dementia in China, over-65s crowd is about 5%, and to 80 In year, this ratio just rises to 15-20%.As China human mortality aging degree is deepened, senile dementia increasingly attracts attention.
The early symptom of senile dementia is forgetful, and early symptom is not obvious, usually ignored.Mid-term is developed into, closely Phase memory impaired degree is deepened, forgetful to nearest event and name, links up difficult increase, it is necessary to the side of personal nursing personnel Help.Develop into late period, it is impossible to detecting period and place, identification friends and family has difficulties, and is had increasing need in terms of self nursing Assist, situation is serious, and sb.'s illness took a turn for the worse does not recognize to company with even summation children, wear the clothes, have a meal, stool and urine can not take care of oneself, giving The people of oneself and surrounding brings greatly pain and worried.
In the past, because the reason for medical condition and personal health aspect, the average life span of people is short, patients of senile dementia When not yet developing into late period, Most patients have died from other illnesss.Now, with medical condition improvement and people is supported The growth of raw knowledge, the average life span of people is greatly prolonged（For example, in the average life span statistics of Shanghai population in 2013, man The average life span of people is 80.2 years old, and woman is 85.2 years old）, the harm of senile dementia highlights.Patients of senile dementia late period supports Drag declines, and is typically easy to occur pulmonary infection, does not control finally.Senile dementia is a kind of incurable disease, but the cause of the death is typically outer In factor, rather than disease is in itself.In fact, senile dementia turns into after cardiovascular disease, cerebrovascular disease and cancer, always " the fourth-largest killer " of people's health.
Senile dementia has no specific drug at present, it is impossible to cure, and because of senile dementia, to be related to number in the world huge, And can not cure, developing into late period can be fatal, has scientist to be referred to as " pestilence of 21 century ", with the pestilence in human history The plague in such as 14th century is mentioned in the same breath.Certainly, human-to-human transmission can't occur for senile dementia, this and past The pestilence met with human history is different.
At present, the treatment of senile dementia is typically, come relief of symptoms, to prevent high progression using medicine, and drug administration has Side effect and adverse reaction.The medical expense of senile dementia is high, and middle and later periods minimal invasive treatment can not take care of oneself, it is necessary to accompany and attend to, Patient home and children's financial burden are big.At present in China, senile dementia is not yet by enough attention, and government's public resource is thrown Enter limited, undertaken mainly by family.In big city, the cost of patients of senile dementia monthly is up to 10,000 yuan, including medical treatment, medicine Take, ask someone nurse etc..
Senile dementia belongs to a kind of protein misfolding disease, is the abnormal protein or protein folded of intracerebral Fragment is agglomerated into caused by amyloid fiber.Amyloid fiber Stability Analysis of Structures, solvent medium insoluble in intracerebral itself, Do not occur dissociation and form solable matter, can not be removed by the cleaning mechanism of body itself.Amyloid fiber once formed just Intracerebral is stored in, and the protein or protein fragments of more abnormal foldings can be recruited and is deposited on, is generated larger-sized Amyloid fiber.Amyloid fiber disturbs and destroyed the normal function of brain, there is cytotoxicity.
The abnormal protein folded or protein fragments of intracerebral are derived from：（One）Formed by the endless degradable of protein Protein fragments；（Two）The short chain polypeptides that protein synthesis is interrupted and produced；（Three）Albumen formed by fracture occurs for protein Matter fragment；（Four）Abnormal fold occurs for the protein of some normal sequences.The elderly's body function declines, and intracerebral occurs wrong above The probability increase of abnormal protein or protein fragments is produced by mistake.
Research finds that the amino acid residue that the protein or protein fragments of the folding that makes a mistake contain is generally less than 150 Individual [Chiti, F.; Dobson, C. M. Auun. Rev. Biochem. 2006, 75, 333].Come from amino acid sequence See, be easier to reunite containing the more protein of hydrophobic amino acid residue or protein fragments have continuous several thin in sequence The protein or protein fragments of water amino acid residue are easier to reunite, and occur hydrophilic amino acid-hydrophobic amino acid in sequence The protein or protein fragments that are alternately repeated arrangement be also easier to occur reunite [Tartaglia, G. G. et al. J. Mol. Biol. 2008, 380, 425]。
The mechanism of protein or protein fragments the formation amyloid fiber of studies have shown that false folding is nucleation-growth Mechanism [Knowles, T. P. J.; Vendruscolo, M.; Dobson, C. M. Nature Rev. Mol. Cell Biol. 2014, 15, 384].Protein or protein fragments abnormal first is assembled, and then aggregation occurs certain The structural adjustment of degree and nucleation, then more abnormal proteins or protein fragments, which are deposited on the core to be formed, gives birth to It is long, eventually form amyloid fiber.Amyloid fiber is stablized by hydrophobic interaction and hydrogen bond action.The shape of amyloid fiber During, nucleation process is slow, is that rate determining step is rapid, after nucleation, growth course is very fast.Nucleation process occurs in senile dementia In early days, however, normal function influence of the nucleation on human brain is small, patient is not easy to discover.Once nucleation, growth is fast, amyloid is fine Dimension is very fast to be formed, and process is irreversible.Therefore, find that nucleation is one of key of senile dementia diagnosis and treatment, passes through technology early The speed that the possibility of means reduction nucleation or reduction grow is also very important.In addition, root in crowd it is reported that have seldom The patients of senile dementia for being less than 50 years old of amount, so, take the measure of correlation also meaningful early.
From the pathogenesis of the protein misfolding diseases such as senile dementia and from abnormal protein or protein fragments Molecular structure information start with, it is obvious come the food of developing the reduction protein misfolding disease occurrence risk such as senile dementia It is the rational way of tool.According to document and patent retrieval, and the investigation in the market relevant food, do not find from molecule The example of the food of the protein misfolding disease occurrence risk such as senile dementia is started with and developed to mechanism.
The formation of the protein or protein fragments that reduce abnormal folding by allowing human body to take in more hydrophilic amino acid Probability, and then the protein misfolding disease occurrence risks such as senile dementia are reduced, pathogenetic point of disease is based on according to this The thinking of handset reason and the food developed has no document and patent report, also have no that in the market has relevant food.It may be noted that , in the market has a variety of food or health food containing amino acid, and its effect essentially consists in supplement human nutrition, has no such Mechanism of the amino acid products based on protein misfolding diseases such as senile dementias, and propose reduction senile dementia etc. Effect of protein misfolding disease occurrence risk or similar effect.
The content of the invention
Causing a disease for the protein misfolding diseases such as senile dementia is relevant with the formation of amyloid fiber.Amyloid fiber The molecule mechanism of formation is folds the protein of exception or nucleation-growth mechanism of protein fragments, and nucleating step is slow, growth step Rapid fast, nucleating step is that rate determining step is rapid.The protein or protein fragments for folding exception are more containing hydrophobic amino acid residue, amino There is hydrophilic amino acid-hydrophobic amino acid and is alternately repeated in the sequence that shows as continuous several hydrophobic amino acids occur on acid sequence Sequence.
The present invention starts with from the nosogenetic molecule mechanism of the protein misfolding diseases such as senile dementia, and exploitation is used In the food of the protein misfolding disease occurrence risks such as reduction senile dementia.By allowing human body to take in more hydrophile amino Acid reduces the protein of abnormal folding or the formation probability of protein fragments, and then reduces the protein mistakes such as senile dementia Folding diseases occurrence risk.Hydrophilic amino acid being taken in human body, body can carry out various protein using these hydrophilic amino acids more Synthesis because the hydrophilic amino acid of supply body is more, the average content of the hydrophilic amino acid in the various protein of synthesis compared with It is high.Body produces the protein or protein fragments of abnormal folding because of some error procedures, in these protein or protein In fragment, the average content of hydrophilic amino acid is of a relatively high in sequence, it is possible to decrease occur the risk of amyloid fiber formation.
In 20 kinds of common amino acids for constituting native protein, it is hydrophobic functional group that hydrophobic amino acid, which refers to side chain R group, Amino acid, including glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, methionine and dried meat Propylhomoserin；Hydrophilic amino acid refers to amino acid of the side chain R group for neutral polar functional group, acidic functionality and basic functionality, Including tyrosine, aspartic acid, histidine, asparagine, glutamic acid, lysine, glutamine, arginine, serine, Soviet Union's ammonia Acid and cysteine.If it is reported that the glutamic acid, aspartic acid and cysteine in hydrophilic amino acid are present in a free form Intracerebral, has negative effect to brain.
It is used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia the invention discloses a kind of, It is divided into two types by its chemical composition.First type：The food includes lysine, threonine, tyrosine, asparagus fern acyl At least one of amine, histidine, glutamine, arginine and serine.Second of type：The food comprising dipeptides, tripeptides, At least one of oligopeptides, peptide and protein, wherein lysine, threonine, tyrosine, asparagine, histidine, glutamy The total amount of the amino acid residue of amine, arginine and serine accounts for all amino acid in dipeptides, tripeptides, oligopeptides, peptide and protein More than the 30% of the gross mass of residue.Dipeptides, tripeptides, oligopeptides, peptide and protein in the food of second of type disappear through human body Turn into amino acid after change, it is similar with the chemical composition of the food of the first type through postdigestive chemical composition.It is worth noting , there is the food or health food of compound amino acid in the market, such product is generally to supplement the required amino of needed by human body For the purpose of acid, be not used to the reduction protein misfolding disease occurrence risk such as senile dementia, this be it is of the invention with it is such Where the difference of product.From formula, the required ammonia of compound amino acid food or health food containing needed by human body of in the market Base acid, and the food of the present invention contains hydrophilic amino acid, this is also that the present invention is eaten with the compound amino acid food of in the market or health care The difference of product.
Food in standard is used according to chinese national standard GB 2760-2014 national food safety standard food additives Food, is divided into 16 major classes by categorizing system,（One）Breast and dairy products；（Two）Fat, oil and emulsified fats-prepd；（Three）It is cold Freeze drink；（Four）Water fruits and vegetables（Including root tuber class）, beans, edible mushroom, algae, nut and seed class etc.；（Five）Cocoa system Product, chocolate and chocolate（Including substitute of cocoa fat chocolate and product）And candy；（Six）Grain and cereal product, bag Include starch that rice, flour, coarse cereals, root crops, beans and corn are extracted etc.；（Seven）Bakery product；（Eight）Meat and meat products； （Nine）Aquatic products and its product（Including aquatic products and its fabricated product etc. such as fish, shell-fish, shellfish, software class, Echinodermatas）；（Ten） Egg and egg products；（11）Sweetening material, including honey；（12）Flavouring；（13）Food for special foods；（14）Beverage Class；（15）Drinks and（16）Other classes.The invention discloses by hydrophilic amino acid or the peptide rich in hydrophilic amino acid add Into various food, the implementation of the food for reducing the protein misfolding disease occurrence risk such as senile dementia is developed Example.
GB16740-1997 health cares（Function）In the food universal standard（Existing health food standard GB/T 16740- 2014 do not include the product classification of health food, therefore this specification is classified using GB16740-1997 healthy food products）, Health food is divided into polysaccharide, such as dietary fiber, lentinan according to functional component；Functional sweetener (agent) class, such as Monose, oligosaccharide, multi-sugar alcohol etc.；Functional grease (aliphatic acid) class, such as polyunsaturated fatty acid, phosphatide, choline；Freely Base scavenger class, such as superoxide dismutase (SOD), glutathione peroxidase；Vitamins, such as vitamin A, vitamin E, vitamin C etc.；Peptide and protein-based, such as glutathione, immunoglobulin；Active mushroom, such as lactic acid bacteria, Bifidobacterium Bifidum Deng；Microelement kind, such as selenium, zinc；Other also have n-octacosanol, phytosterol, saponin (glycosides) etc..The invention discloses will Hydrophilic amino acid or peptide rich in hydrophilic amino acid are added in various health foods, are developed for reducing the eggs such as senile dementia The embodiment of the health food of white matter misfolding diseases occurrence risk.Protein misfolding disease in the present invention is with reference to text Offer Chiti, F.;Sorting technique in Dobson, C. M. Auun. Rev. Biochem. 2006,75,333, part Disease name there is no Chinese translation, therefore still retain its English name.By three classes of protein misfolding disease point, nervus retrogression Disease（neurodegenerative diseases）, non-neurogenic SA（nonneuropathic systemic amyloidoses）With non-neurogenic localized amyloidosis（nonneuropathic localized diseases）.Nerve degenerative diseases include stages alzheimer's disease（It is commonly called as senile dementia, Alzheimer ' s disease）, sea Continuous shape encephalopathic（Mad cow disease, spongiform encephalopathies）, Parkinson's（Parkinson’s disease）, Lewy body type dementia（dementia with Lewy bodies）, volume temporal lobe type dementia （frontotemporal dementia with Parkinsonism）, amyotrophic lateral sclerosis （amyotrophic lateral sclerosis）, Huntington's chorea（Huntington’s disease）, spinocerebellum withers Contracting disease（spinocerebellar ataxias）, the type of Spinocerebellar Atrophy 17（spinocerebellar ataxia 17）、 Spinal and bulbar muscular atrophy（spinal and bulbar muscular atrophy）, dentation rubrum pallidal atrophy disease （hereditary dentatorubral-pallidoluysian atrophy）, Britain of family senile dementia（familial British dementia）With Denmark of family senile dementia（familial Danish dementia）.Non- neurogenic SA includes AL amyloidosis（AL amyloidosis）, AA type amyloidosis（AA amyloidosis）, familial Mediterranean fever（familial Mediterranean fever）, old systemic amyloidosis Property（senile systemic amyloidosis）, familial amyloid sample polyneuropathy（familial amyloidotic polyneuropathy）、hemodialysis-related amyloidosis、ApoAI Amyloidosis, ApoAII amyloidosis, ApoAIV amyloidosis, amyloidosis Finnish type（Finnish hereditary amyloidosis）, lysozyme systemic amyloidosis sample disease（lysozyme amyloidosis）, people's fiber egg White original α chain amyloid diseases（fibrinogen amyloidosis）With Icelandic hereditary cerebral amyloid angiopathy.Non- neurogenic localized amyloidosis includes type II diabetes（type II diabetes）, medullary carcinoma of the thyroid（medullary carcinoma of the thyroid）, atrium amyloidosis （atrial amyloidosis）, amyloidosis hereditary cerebral hemorrhage（hereditary cerebral haemorrhage with amyloidosis）, pituitary prolactinoma（pituitary prolactinoma）、injection-localized amyloidosis、aortic medial amyloidosis、hereditary lattice corneal dystrophy、 Corneal amylodosis associated with trichiasis, cataract（cataract）, Odontogenic cysts calcification epithelium Knurl（calcifying epithelial odontogenic tumors）, pulmonary alveolar proteinosis（pulmonary alveolar proteinosis）, inclusion body myositis（inclusion-body myositis）And lichen amyloidosis （cutaneous lichen amyloidosis）.The protein folding diseases such as the senile dementia mentioned in the present invention refer to just It is the disease in above-mentioned sorting technique.
The food of the present invention is to be used to reduce the protein misfolding disease occurrence risk such as senile dementia, other meanings Close statement all should belong to the scope of the present invention, for example, keeping memory of the elder, mitigating senile dementia symptom, auxiliary Improve memory.
The definition of the word of some in this specification：
Peptide, the compound being connected into that is connected by two or more amino acid with peptide bond claims peptide.For example it is made up of glycine and alanine Peptide, claims dipeptides；3 peptides being made up of 3 amino acid, claim tripeptides；Generally by the peptide of less than 10 amino acid compositions oligopeptides；11 Claim polypeptide with the peptide that upper amino acid is constituted.Protein is also a kind of peptide.
Amino acid residue, the amino acid in dipeptides, tripeptides, oligopeptides, polypeptide or protein, because its moieties is participated in The formation of peptide bond, remaining structure division then claims amino acid residue.Amino acid residue is a part for a molecule, rather than One molecule.
Essential amino acid, in more than 20 kind amino acid of human body and food protein, only some can be closed in vivo Into remaining can not then be synthesized or aggregate velocity is not fast enough.It can not synthesize or aggregate velocity not enough fast amino acid, it is necessary to by eating Thing is supplied, therefore referred to as essential amino acid；What can be synthesized in vivo is then referred to as nonessential amino acid.Nonessential amino acid is not internal Need not, it can simply synthesize in vivo, even having lacked in food.So far, it is known that the essential amino acid of human body has 9 kinds, is Isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and histidine.
Embodiment
The creative work of the present invention is mainly reflected in the cause of disease i.e. amyloid fibre from protein folding diseases such as senile dementias The formation mechenism of dimension is started with, it is proposed that take in more hydrophilic amino acid by human body to reduce the protein or albumen of abnormal folding The formation probability of matter fragment, and then reduce the technological means of the protein misfolding disease occurrence risks such as senile dementia.Parent Peptide of the source of water amino acid for free hydrophilic amino acid or containing hydrophilic amino acid residue compared with horn of plenty, both of which can pass through food With, through human consumption absorb and be immediately used by the body.Therefore, it is appropriate to be developed as food.Free amino acid and containing hydrophilic Amino acid residue is solid compared with the peptide of horn of plenty, in powdered or crystallization, is dissolved in water, and chemical property is stablized relatively, therefore, will It is combined with food, only need to be in food production process one link of addition, have no effect on the normal production of food.Value It must propose there is the grain and cereal product that with the addition of lysine in the market, the lysine added is strong as nutrition Agent is used, and is not used to the reduction protein misfolding disease occurrence risk such as senile dementia, this be it is of the invention with it is such Where the difference of food.
Embodiment of the present invention is described below in conjunction with embodiment, but those skilled in the art will manage Solution, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.
Embodiment 1：Coating butter containing hydrophilic amino acid
100 parts of butter, 1 part of salt, 1 part of lysine, agitated, uniform, shaping, packaging are formed.
Embodiment 2：Ice cream containing hydrophilic amino acid
250 parts of milk, 150 parts of whipping cream, 20 parts of sugar, 1 part of lysine, 1 part of threonine, blended, homogeneous, aging, congeal, Hardening is formed.
Embodiment 3：Preserved fruit containing hydrophilic amino acid
500 parts of apple, through peeling, stoning, syrup boiling, immersion, immersion take out when mixed with 1 part of lysine, then drying with Finishing and packing is formed.
Embodiment 4：Chocolate containing hydrophilic amino acid
500 parts of cocoa bean, baked, crushing, allotment are with grinding, refining, go acid, tempering casting mold to form, the addition group in allotment 1 part of propylhomoserin, 1 part of arginine and serine are a.
Embodiment 5：Wheat flour containing hydrophilic amino acid
500 parts of wheat flour, 1 part of lysine, 1 part of threonine, it is blended to form.This is preferred embodiment, and wheat flour is that staple food is former Material, can facilitate long-term intake of the suitable population to hydrophilic amino acid.
Embodiment 6：Bread containing hydrophilic amino acid
300 parts of wheat flour, 50 parts of egg, 100 parts of milk, 6 parts of dry ferment powder, 16 parts of sugar, 6 parts of salt, 10 parts of butter, threonine 1 Part, add water and be modulated into dough, by fermentation, split, shape, proofing, baking, cooling down and form.
Embodiment 7：Sugar containing hydrophilic amino acid
800 parts of sugar, 1 part of lysine, 1 part of threonine, it is blended to form.
Embodiment 8：Monosodium glutamate containing hydrophilic amino acid
500 parts of monosodium glutamate, 1 part of lysine, 1 part of threonine, it is blended to form.
Embodiment 9：Tea beverage containing hydrophilic amino acid
800 parts of tea beverage, 1 part of lysine, 1 part of glutamine, blended, packaging are formed.
Embodiment 10：Jelly containing hydrophilic amino acid
500 parts of jelly liquid, 1 part of lysine, 1 part of asparagine, are formed through die-filling, refrigeration shaping, the demoulding.
Embodiment 11：Hydrophilic amino acid piece
1 part of lysine, 1 part of threonine, 0.5 part of tyrosine, 0.5 part of asparagine, 0.5 part of histidine, 0.5 part of glutamine, 0.5 part of 0.5 part of arginine and serine, plus auxiliary material, blended, crushing, tabletting are formed.
Embodiment 12：VITAMIN C TABLET containing hydrophilic amino acid
10 parts of vitamin Cs, 1 part of lysine, 1 part of threonines, plus auxiliary material, blended, crushing, tabletting are formed.
Embodiment 13：VITAMIN C TABLET containing peptide
10 parts of vitamin Cs, 5 parts of peptides, plus auxiliary material, blended, crushing, tabletting are formed.
Embodiment 14：Preserved fruit containing peptide
500 parts of apple, is mixed when being taken out through peeling, stoning, syrup boiling, immersion, immersion with 2 parts of peptides, then drying and arrangement Packaging is formed.

Claims (6)

1. a kind of be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, it is characterised in that bag Containing at least one of lysine, threonine, tyrosine, asparagine, histidine, glutamine, arginine and serine.
2. as claimed in claim 1 be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, Characterized in that, also including（One）Breast and dairy products；（Two）Fat, oil and emulsified fats-prepd；（Three）Frozen；（Four）Water Fruits and vegetables（Including root tuber class）, beans, edible mushroom, algae, nut and seed class etc.；（Five）Cocoa products, chocolate and chalk Power product（Including substitute of cocoa fat chocolate and product）And candy；（Six）Grain and cereal product, including it is rice, flour, miscellaneous Starch that grain, root crops, beans and corn are extracted etc.；（Seven）Bakery product；（Eight）Meat and meat products；（Nine）Aquatic products and its system Product（Including aquatic products and its fabricated product etc. such as fish, shell-fish, shellfish, software class, Echinodermatas）；（Ten）Egg and egg products；（Ten One）Sweetening material, including honey；（12）Flavouring；（13）Food for special foods；（14）Beverage class；（15）Drinks With（16）One kind in other classes.
3. as claimed in claim 1 be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, Characterized in that, also comprising Polysaccharides, functional sweetener (agent), functional grease (aliphatic acid) class, free radical scavenger class, Vitamins, peptide and one kind in protein-based, active mushroom, microelement kind and other class health foods.
4. a kind of be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, it is characterised in that bag Containing at least one of dipeptides, tripeptides, oligopeptides, peptide and protein, wherein lysine, threonine, tyrosine, asparagine, Histidine, glutamine, the gross mass of the amino acid residue of arginine and serine account for dipeptides, tripeptides, oligopeptides, polypeptide and albumen More than the 30% of the gross mass of all amino acid residues in matter.
5. as claimed in claim 4 be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, Characterized in that, also including（One）Breast and dairy products；（Two）Fat, oil and emulsified fats-prepd；（Three）Frozen；（Four）Water Fruits and vegetables（Including root tuber class）, beans, edible mushroom, algae, nut and seed class etc.；（Five）Cocoa products, chocolate and chalk Power product（Including substitute of cocoa fat chocolate and product）And candy；（Six）Grain and cereal product, including it is rice, flour, miscellaneous Starch that grain, root crops, beans and corn are extracted etc.；（Seven）Bakery product；（Eight）Meat and meat products；（Nine）Aquatic products and its system Product（Including aquatic products and its fabricated product etc. such as fish, shell-fish, shellfish, software class, Echinodermatas）；（Ten）Egg and egg products；（Ten One）Sweetening material, including honey；（12）Flavouring；（13）Food for special foods；（14）Beverage class；（15）Drinks With（16）One kind in other classes.
6. as claimed in claim 4 be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia, Characterized in that, also comprising Polysaccharides, functional sweetener (agent), functional grease (aliphatic acid) class, free radical scavenger class, Vitamins, peptide and one kind in protein-based, active mushroom, microelement kind and other class health foods.
CN201610074495.1A 2016-02-03 2016-02-03 It is a kind of to be used to reduce the food of the protein misfolding disease occurrence risk such as senile dementia Pending CN107028193A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021032755A1 (en) * 2019-08-22 2021-02-25 Unilever Ip Holdings B.V. Frozen confection
EP4037490B1 (en) * 2019-10-01 2023-07-12 Unilever IP Holdings B.V. Frozen confection

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021032755A1 (en) * 2019-08-22 2021-02-25 Unilever Ip Holdings B.V. Frozen confection
CN114269164A (en) * 2019-08-22 2022-04-01 联合利华知识产权控股有限公司 Frozen confections
CN114269164B (en) * 2019-08-22 2024-08-23 联合利华知识产权控股有限公司 Frozen dessert
EP4037490B1 (en) * 2019-10-01 2023-07-12 Unilever IP Holdings B.V. Frozen confection

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