CN107018619B - A kind of compact proton beam energy and energy spread control structure - Google Patents
A kind of compact proton beam energy and energy spread control structure Download PDFInfo
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- CN107018619B CN107018619B CN201710334613.2A CN201710334613A CN107018619B CN 107018619 B CN107018619 B CN 107018619B CN 201710334613 A CN201710334613 A CN 201710334613A CN 107018619 B CN107018619 B CN 107018619B
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/001—Arrangements for beam delivery or irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/04—Magnet systems, e.g. undulators, wigglers; Energisation thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/001—Arrangements for beam delivery or irradiation
- H05H2007/004—Arrangements for beam delivery or irradiation for modifying beam energy, e.g. spread out Bragg peak devices
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/001—Arrangements for beam delivery or irradiation
- H05H2007/005—Arrangements for beam delivery or irradiation for modifying beam emittance, e.g. stochastic cooling devices, stripper foils
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Abstract
The invention discloses a kind of compact proton beam energy and energy spread control structure, the structure defocuses level Four iron, two focusing quadrupole iron and a branch of examining system, a selection slit, a vacuum tube by two two pole iron of rectangle, two and forms, and two two pole iron of rectangle are symmetrical arranged in 45 °；The one two pole Tie Tong of rectangle, which crosses vacuum tube and is connected with one in turn, to be defocused level Four iron, one focuses on quadrupole iron, beam examining system and selection slit, is then sequentially connected another focusing quadrupole iron again, another is defocused level Four iron and another two pole iron of rectangle.The present invention can require safe and efficient transmission energy spread to be less than 2% according to treatment, energy is the proton beam of 70 235MeV, realize the beam energy being made of two 45 ° symmetrical two pole iron of rectangle and four quadrupole iron and energy spread control structure, there is safe efficient, high-precision, development to following proton therapeutic technology and extensively using playing facilitation.
Description
Technical field
The invention belongs to medical instrument Proton therapy system beam transfer field, and in particular to a kind of compact proton beam
Energy and energy spread control structure.
Background technology
Since nineteen forty-six Wilson proposes to apply proton therapeutic cancer, widely proton therapeutic research work is just started
Make, its basic principle is identical with X-ray, is all that the ionization for leaning on particle and ray transfers energy to cancer cell, then will
Cancer cell kills.The damage of conventional radiotheraphy normal tissue is larger at present, and side effect is more.But proton therapeutic effect is good, pair is made
With little, its sharpest edges is its remarkable dosage distribution.Proton therapeutic is more convenient clinician and controls injection swollen exactly
The dosage of knurl, reduces the injury to normal surrounding tissue, so as to reduce side effect occurrence probability.
Current proton therapeutic becomes the oncotherapy new and high technology to attract people's attention, to realize proton therapeutic, it is necessary to corresponding
Equipment, be mainly made of following components：Accelerator, beam-flow transmission line, rotary frame, treatment head, therapeutic bed and treatment
Planning system etc..Beam-flow transmission line, which can be divided into, draws section, energy selection section, beam transfer section, achromatism section, matching section etc., and
It is made of a series of quadrupole iron, two pole iron, compensating bar, line detector, selection slit and block device, wherein quadrupole iron is controlled
The swaying of line processed, two pole iron are used for deflected beam, and compensating bar is used to change beam direction, and line detector is used to detect
The position of line and intensity, selection slit are used for the energy spread for controlling line, and block device is used to quickly stop line.
When carrying out proton therapeutic, the proton of different-energy according to the depth of tumour in itself and thickness, need to be selected, for most
For number Asia tumor patient, most of tumor depth is less than 30cm, and most shallow position is ophthalmo melanoma.Needed for so
Will the proton energy for the treatment of be 70-235MeV.The accelerator for the treatment of at present is broadly divided into two types：Synchrotron can
To draw the proton of different-energy, other energy selection system is no longer wanted；Cyclotron can only export the grain of energy estimate methods
Son, it is necessary to another to select system with an independent proton energy.The function of energy selection system is very simple, simply by fixed energies
Proton become 70-235MeV different-energy proton.Energy selection section is mainly by a removable wedge-shaped graphite, collimater
Formed with beam energy and energy spread control structure, the fixation beam energy that wherein graphite is used to produce in cyclotron changes
The energy needed into treatment.Line energy, energy spread, beam intensity, emittance etc. after energy drops in graphite block can all change
Become, therefore collimater is also needed after degrader, emittance, energy and the energy of beam energy and energy spread control structure control line
Divergence.
Beam energy and energy spread control structure design whether the safe and efficient effect and device that will directly affect treatment
Utilization rate.Therefore need to study various beam transfer elements and the work by the Beam Transport Systems that they are formed to line
With；Study the particle trajectory of line, line envelope, Emittance Shape Measurements, the deflection of beam center track, orbital energy dispersion this
The relation of a little factors and the parameter such as the position of each transfer element, spacing, length, field strength, magnetic field gradient in Transmission system；According to this
Come the parameters for reasonably selecting beam transfer element, determining transfer element, design is a kind of compact for a little relations and actual requirement,
Safety, efficiently, high-precision beam energy and energy spread control structure, will substantially reduce the cost of proton therapeutic appts, take up an area
Area, is effectively promoted the development of proton therapeutic cause.
The content of the invention
It is an object of the invention to provide a kind of safe efficient, high-precision compact proton beam energy and energy spread
Control structure.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of compact proton beam energy and energy spread control structure, the structure are dissipated by two two pole iron of rectangle, two
Burnt level Four iron, two focusing quadrupole iron and a branch of examining system, a selection slit, vacuum tube composition, two rectangles two
Pole iron is symmetrical arranged in 45 °；The one two pole Tie Tong of rectangle cross vacuum tube be connected with turn one defocus level Four iron, one focus on quadrupole
Iron, beam examining system and selection slit, are then sequentially connected another focusing quadrupole iron, another defocus level Four iron and another square again
Two pole iron of shape.
Two two pole iron of rectangle are respectively provided with a vacuum pump interface；Level Four iron and two focusing are defocused described in two
Quadrupole iron length is identical；The a diameter of 70mm of vacuum tube.
Two two pole iron of rectangle have identical radius and import and export edge angle, for changing the direction of line；Its
In, first, dispersion of the two pole iron of rectangle to one horizontal direction of line, then defocus level Four iron and a focusing by one
Quadrupole iron makes the dispersion of line reach maximum.
The selection slit is by adjusting its pore size control energy spread, by varying first two pole ferroelectricity stream tune of rectangle
The beam energy that section passes through selection slit center.
The beam energy and energy spread control structure front end are cyclotron and degrader, and cyclotron output is consolidated
Line is surely measured by a wedge-shaped graphite body, then defocuses, focus on by one, the class FODO structures defocused enter after focusing on
In beam energy and energy spread control structure, beam-flow transmission line is finally entered.
Beneficial effects of the present invention：The present invention mainly realizes a kind of compact proton beam energy and energy spread control knot
Structure designs, and safe and efficient transmission energy spread can be required to be less than 2% according to treatment, and energy is the proton beam of 70-235MeV,
The beam energy being made of two 45 ° symmetrical two pole iron of rectangle and four quadrupole iron and energy spread control structure are realized, its
Symmetrical structure is distributed the number for being effectively reduced independent current source, and the design that it is unique in two pole iron that its line is girdled the waist is effective
The air gap height of two pole iron vertical direction is reduced, reduces cost and the occupation of land face of beam energy and energy spread control structure
Product, is a kind of safety, efficiently, high-precision compact proton beam energy and energy spread control structure, will control following proton
Facilitation is played in the development and extensive use for the treatment of technology.
Brief description of the drawings
In order to facilitate the understanding of those skilled in the art, the present invention is further illustrated below in conjunction with the accompanying drawings.
Fig. 1 is beam transfer flow chart of the present invention；
Fig. 2 is beam energy of the present invention and energy spread control structure layout；
Fig. 3 is line envelope of the present invention and dispersion map；
Wherein, attached figure label：1st, cyclotron；2nd, degrader；3rd, beam energy and control structure can be dissipated；4th, line
Transit；5th, two pole iron of rectangle；6th, level Four iron is defocused；7th, quadrupole iron is focused on；8th, beam examining system；9th, selection slit；10th, vacuum pump
Interface；11st, vacuum tube；12nd, the Beam Envelope for 0 can be dissipated；13rd, the Beam Envelope for 1% can be dissipated；14th, horizontal direction beam
Flow envelope (2 σ)；15th, two pole iron vertical direction beam waist position；16th, 1% Dispersion Function track；17th, Nogata is to line envelope (2
σ)。
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is only part of the embodiment of the present invention to apply example, instead of all the embodiments.Based on the embodiments of the present invention, this area is general
All other embodiment that logical technical staff is obtained without creative efforts, belongs to what the present invention protected
Scope.
As shown in Figure 1, beam energy and energy spread control structure 3, its front end is cyclotron 1 and degrader 2, is circled round
The fixed energies line that accelerator 1 exports can pass through side that is separated and drawing close by a wedge-shaped graphite body, wedge-shaped graphite body
Formula changes graphite thickness, line pass through different-thickness graphite energy drops and after, its energy reduces, emittance becomes larger；In order to send out
The proton stream that degree of penetrating is more than permissible value excludes, and controls emittance with collimater, then defocuses, focuses on by one, the class defocused
FODO structures enter in beam energy and energy spread control structure 3 after focusing on, and finally enter beam-flow transmission line 4；Beam energy and
Energy spread control structure 3, its is compact-sized, and floor space is small；
As shown in Fig. 2, above-mentioned compact proton beam energy and energy spread control structure, by two two pole iron 5, two of rectangle
It is a to defocus that level Four iron 6, two focuses on quadrupole iron 7 and a branch of examining system 8, a selection slit 9, a vacuum tube 11 form；
Specifically, two two pole iron 5 of rectangle are symmetrical arranged in 45 °, it has a vacuum pump interface 10；Two defocus level Four
Iron 6 is identical with two focusing quadrupole 7 length of iron；11 a diameter of 70mm of vacuum tube；Wherein, two pole Tie Tong of a rectangle cross vacuum tube according to
It is secondary to be connected with one and defocus level Four iron, one focus on quadrupole iron, beam examining system and selection slit, then it is sequentially connected again and another focuses on four
Pole iron, another defocus level Four iron and another two pole iron of rectangle；
As shown in Figures 2 and 3,45 ° of symmetrical two rectangles, two pole iron 5 are with identical radius and import and export edge
Angle, for changing the direction of line；Wherein, first two pole iron of (being located at top in Fig. 2) rectangle gives line one horizontal direction
Dispersion be sufficiently separated the proton beam of different-energy, the wherein low line of energy deviates inwardly, the high line of energy
Outwardly away from then defocusing level Four iron 6 and a focusing quadrupole iron 7 by one makes the dispersion of line reach maximum, can dissipate
It is big to spend big proton deviation beam center track amplitude, therefore the with a tight waist of horizontal direction is arranged at symmetrical quadrupole iron interposition
Put, wherein beam examining system 8 is used to detect beam parameters, in order to obtain the line of different energy spreads, needs to set in middle position
A selection slit 9 is put, by adjusting the pore size control beam energy divergence of selection slit 9, by varying first rectangle two
The beam energy that pole iron current regulation passes through 9 center of selection slit；Involved beam examining system and selection in above-mentioned technical proposal
Slit is to use in the prior art, and the application is not restricted explanation.
As shown in Figures 2 and 3, the line in compact proton beam energy and energy spread control structure has in the horizontal direction
One big dispersion, therefore quadrupole iron 6 and second square are defocused by a focusing quadrupole iron 7 and one after selection slit 9
Two pole iron of shape eliminates dispersion, i.e., line is scatter due to that can dissipate when line enters first two pole iron of rectangle, and leaves second
Central orbit is come back to from the track of deviation again during a two pole iron of rectangle, wherein the off-center rail of line of different energy spreads
The distance in road also differs, and can dissipate and is for 0 Beam Envelope 12：Energy spread is the envelope of the 0 off-center track of line,
It can dissipate and be for 1% Beam Envelope 13：Energy spread is the envelope of the 1% off-center track of line, it is known that energy spread is small
The distance of the off-center track of line be less than the big line of energy spread, 1% Dispersion Function track 16 is can dissipate the beam for being 1%
Dispersion Function track is flowed, it is worth, and smaller Beam Envelope 13 is smaller, and whole system forms a double De-dispersion (i.e. R16=R26
=0) beam energy and control structure can be dissipated, the line of different energy spreads has returned on identical track again, in level
With all there is identical line envelope (horizontal direction line envelope 14 and Nogata to line envelope 17) in vertical direction, avoid
Dispersion has an impact line envelope, while in order to reduce by two pole iron costs, and by line vertical direction with a tight waist, (two pole iron are vertical
Direction beam waist position 15) it is arranged in two pole iron and reduces two pole iron in vertical direction air gap height.
As shown in figure 3, beam energy and energy spread control structure are compacter, it can safely and efficiently transmit energy spread and be less than
2% (wherein 12 be the Beam Envelope that energy spread is 0, and 13 be the Beam Envelope that energy spread is 2%), energy 70-
The proton of 235MeV enters beam transfer section；Beam transfer section is identical with beam energy and energy spread control structure front-end architecture
A class FODO structure, line by class FODO structures by beam focusing at beam waist position.
Floor space of the present invention is small, compact-sized, and cost is low, can safely and efficiently transmit energy spread less than 2%, energy is
The proton of 70-235MeV, is a kind of compact beam transfer structure for meeting Proton therapy system requirement, can be applied to current
In Proton therapy system, facilitation will be played to following proton therapeutic technology.
Present invention disclosed above preferred embodiment is only intended to help and illustrates the present invention.Preferred embodiment is not detailed
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.This specification is chosen and specifically describes these embodiments, is in order to preferably explain the present invention
Principle and practical application so that skilled artisan can be best understood by and utilize the present invention.The present invention is only
Limited by claims and its four corner and equivalent.
Claims (2)
1. a kind of compact proton beam energy and energy spread control structure, which is defocused by two two pole iron of rectangle, two
Level Four iron, two focusing quadrupole iron and a branch of examining system, a selection slit, vacuum tube composition, it is characterised in that：
Two two pole iron of rectangle are symmetrical arranged in 45 °；The one two pole Tie Tong of rectangle cross vacuum tube be connected with turn one dissipate
Burnt level Four iron, one focus on quadrupole iron, beam examining system and selection slit, are then sequentially connected another focusing quadrupole iron again, another dissipate
Burnt level Four iron and another two pole iron of rectangle；
Two two pole iron of rectangle are respectively provided with a vacuum pump interface；Level Four iron and two focusing quadrupoles are defocused described in two
Iron length is identical；The a diameter of 70mm of vacuum tube；
Two two pole iron of rectangle have identical radius and import and export edge angle, for changing the direction of line；
Wherein, first two pole iron of rectangle makes the proton beam of different-energy fully divide to the dispersion of one horizontal direction of line
From the wherein low line of energy deviates inwardly, then the high line of energy by one outwardly away from defocusing level Four iron and one
A focusing quadrupole iron makes the dispersion of line reach maximum, and the big proton deviation beam center track amplitude of energy spread is big, by water
Square to it is with a tight waist be arranged at symmetrical quadrupole iron centre position, wherein beam examining system is used to detect beam parameters, in centre position
Place needs to set a selection slit, by adjusting the pore size control beam energy divergence of selection slit, by varying first
The beam energy that two pole iron current regulation of rectangle passes through selection slit center；
Quadrupole iron is defocused with another by another focusing quadrupole iron again and second two pole iron of rectangle eliminates dispersion, i.e. line
From deviation when being scatter into line during first two pole iron of rectangle due to that can dissipate, and leaving second two pole iron of rectangle
Central orbit is come back on track, wherein the distance of the off-center track of line of different energy spreads differs；
Control structure transmission energy spread is less than 2%, and energy is the proton beam of 70-235MeV.
2. a kind of compact proton beam energy according to claim 1 and energy spread control structure, it is characterised in that should
Beam energy and energy spread control structure front end are cyclotron and degrader, the fixed energies line of cyclotron output
By a wedge-shaped graphite body, then defocus, focus on by one, the class FODO structures defocused enter after focusing on beam energy and
In energy spread control structure, beam-flow transmission line is finally entered.
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| CN107635348B (en) * | 2017-09-25 | 2018-08-14 | 合肥中科离子医学技术装备有限公司 | A kind of superconduction proton device energy selection system and its implementation |
| CN107864546B (en) * | 2017-10-31 | 2019-06-07 | 华中科技大学 | A kind of stable modulating device of the beam intensity of cyclotron |
| CN108387924A (en) * | 2018-03-08 | 2018-08-10 | 西北核技术研究所 | A kind of high-precision beam energy analysis slit arrangement |
| CN108566720B (en) * | 2018-03-08 | 2019-05-03 | 西北核技术研究所 | A kind of selection of particle accelerator energy and analysis system |
| CN108785874A (en) * | 2018-04-18 | 2018-11-13 | 合肥中科离子医学技术装备有限公司 | A kind of compact single chamber Proton therapy system |
| CN111249633A (en) * | 2020-03-21 | 2020-06-09 | 华中科技大学 | High momentum acceptance superconducting rotating gantry for proton therapy |
| CN114501767B (en) * | 2022-01-24 | 2023-02-28 | 北京大学 | Laser acceleration proton beam homogenization method and device |
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| WO2009039884A1 (en) * | 2007-09-26 | 2009-04-02 | Ion Beam Applications S.A. | Particle beam transport apparatus and method of transporting a particle beam with small beam spot size |
| EP2247339B1 (en) * | 2008-02-27 | 2014-04-02 | Cryoelectra Gmbh | Proton beam treatment system |
| CN102695544B (en) * | 2009-10-23 | 2016-05-11 | 离子束应用公司 | For the frame that comprises beam analysis instrument of particle therapy |
| DE102015111060A1 (en) * | 2015-07-08 | 2017-01-12 | Cryoelectra Gmbh | Particle Beam Therapy System with Solenoid Magnet |
| CN105392270B (en) * | 2015-10-16 | 2017-10-31 | 中国科学院上海应用物理研究所 | A kind of medical proton-synchrotron |
| CN105357856B (en) * | 2015-10-16 | 2017-09-15 | 中国科学院上海应用物理研究所 | A kind of injection device and method for implanting of medical proton-synchrotron |
| CN106139420B (en) * | 2016-07-29 | 2023-03-21 | 中国原子能科学研究院 | Proton treatment system based on cyclotron |
| CN106139419B (en) * | 2016-07-29 | 2022-10-28 | 中国原子能科学研究院 | Rotating frame for treating tumors |
| CN206759798U (en) * | 2017-05-12 | 2017-12-15 | 合肥中科离子医学技术装备有限公司 | A kind of compact proton beam energy and energy spread control structure |
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